Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

Drosophila melanogaster C3G guanyl-nucleotide exchange factor


LOCUS       NM_001298037            6103 bp    mRNA    linear   INV 26-DEC-2023
            (C3G), transcript variant L, mRNA.
ACCESSION   NM_001298037
VERSION     NM_001298037.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6103)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6103)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6103)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6103)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6103)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6103)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6103)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6103)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6103)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6103)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6103)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6103)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6103)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6103)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6103)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6103)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6103)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6103)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6103)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6103)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6103)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6103)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6103)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6103
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6103
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="C3G guanyl-nucleotide exchange factor"
                     /map="6D1-6D2"
                     /db_xref="FLYBASE:FBgn0259228"
                     /db_xref="GeneID:31618"
     CDS             466..4539
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="CG42328 gene product from transcript CG42328-RL;
                     CG42328-PL; C3G-PL; C3G ortholog"
                     /codon_start=1
                     /product="C3G guanyl-nucleotide exchange factor, isoform
                     L"
                     /protein_id="NP_001284966.1"
                     /db_xref="FLYBASE:FBpp0309086"
                     /db_xref="GeneID:31618"
                     /db_xref="FLYBASE:FBgn0259228"
                     /translation="MNILQKIDGSISSPSTPGTCSSGIGVGGGGCSSSSNNSINSGSY
                     STACTPPPPTHQHHSQHQQLQGTPGGSSRVGGAGAGGGGGVPPAPPSAGSSGHKNSLK
                     GTKLARRARSFKDDLIEKISLMRTTNNTLGRSHSPHSPRTKHGTKAPPTTEEVLRSTQ
                     TLETHVKDISNALKHFRDVILKKKLEVLPGNGTVILETIASMYSVIQTYTLNENSAIM
                     SSATLQVYQSLGKLIKLCDEVMLSEDSGECASLSNENVREVIDLLEDAVRNLVTLAQG
                     KLKEQDQCAFRYSGSGLGGIGAAAEIMGAVTASPGASVPGTGVMRVSAAESAAQRTSL
                     PDIALTPKERDILEQHNVNPMRGSHSTESILRDTSPPPKPPLPNRASNPPPLPPKRRS
                     QPSASAGTVGVGCSSSTSTSNQASPLPYAQSHNISLNSDLDCSSNISLLNYGVDRLSV
                     RSRSPDENSQCSFDSALNHSREEEDQQQQHQHLRSFPKLAAMMDEDMDKMVSYSFVSM
                     REFRTSTQTTDYSVQSSTKSSSSNSEIAFSISESTAVGSSSEYQQISQLVSHSQRHIS
                     SSSSSCTTTTTSSSTTTGYGSSEVEQLQQQQQQQTTTTPADLAPALPPKSIQRSSLTR
                     HDSPGVGDELDEVQSSSGWASHRSSQSEVAELRQLSPLHHLNHHPHTASAGQLQQWHS
                     KHHSLIEGPRLQLAGSGSCSAFDQRHLDQEPPPLPIKKKHILAYMEICSASTRSIEQH
                     RHTMHACNISRNISHSQTMNIMPMSKELSPELEMPPALPPKNYKQRKATSMVASPTLQ
                     PVIVTTPPPSPKPTLGENGSTGRPDSRMATVCEELNDAVASEDAMPEPRSPVLDSNEN
                     VSAVDDGQTFYCHSHQLPAAEMEMSEDASSADNQPITTPQVLEEQEEPTAESRPLVAV
                     HESVKPANVDEDEEAERADMLINMLEEVNITRYLILKKREEDGPEVKGGYIDALIVHA
                     SRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFALL
                     VRVVNDLTSTDLTSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYKEPKVYGF
                     VGELGGAGSVGGAGIAGSGGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEI
                     PEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKH
                     LRKMNNYNSYLALLSALDSGPIRRLEWQKGITEEVRSFCALIDSSSSFRAYRQALAET
                     NPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKCAYPFRR
                     NERIIRFFDNFKDFMGEEEMWQISEKIKPRGRRPVNY"
     misc_feature    3331..3741
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; Region: RasGEFN; smart00229"
                     /db_xref="CDD:214571"
     misc_feature    order(3388..3390,3523..3525,3535..3540,3547..3549,
                     3556..3561,3658..3660,3667..3669)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:100121"
     misc_feature    3826..4497
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; Region: RasGEF; cd00155"
                     /db_xref="CDD:238087"
     misc_feature    order(3925..3933,3955..3960,3964..3972,3976..3981,
                     3988..3993,4000..4002,4099..4101,4108..4113,4117..4125,
                     4129..4140,4144..4149,4201..4203,4216..4224,4231..4233,
                     4270..4278,4285..4293,4297..4305,4309..4320,4363..4365,
                     4375..4377,4477..4479,4486..4491)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Ras interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238087"
ORIGIN      
        1 cacattgttt gggaagcatt ttagcagcac tgcgcgacgg tcaccgcatt ttgttgttgt
       61 gttgcgcgtt taaaattgta ttgttatttt ttatattttc ttttttttgg accgaatgag
      121 agccggccaa aagtgcagtg cgagtgcgat tgaatttaag tgaatacaaa gtgcggatcg
      181 caacacaact ttataaatat atgtacatat atgtgtagtt agagcgagac ggggcgaaat
      241 atcaaataaa aatactgtac tgtgtgtgtg agcaaatact aatactactc aagcggagaa
      301 cgatgaaaat gtgcgtgtga gaggaaaaga gaatttagtg ttttttatat tatttactgg
      361 cctgcggcta tgagcaaaaa gaaccgaata tcattgcgga aaaaggagaa tgaaaattgc
      421 caagagggaa atctgtgaat cctggcggaa acacacggcc tcatcatgaa tatactgcag
      481 aaaatcgacg gcagcatcag ttctccatcc acgcccggca cctgttccag tggcatcgga
      541 gtgggcggtg gcggctgcag cagcagcagc aacaatagca tcaacagcgg cagctactcc
      601 accgcctgca ctccgccacc acccacgcat cagcatcact cgcagcacca gcagctgcag
      661 ggcacgccgg gaggatctag tcgggtaggg ggagcaggag caggcggagg tggtggtgta
      721 ccaccggcac cacccagtgc cggatcctcg ggccacaaga acagtctcaa gggcaccaag
      781 ctagcgcgcc gggcgcgttc ctttaaggac gacctcatcg agaagatttc cctgatgcga
      841 accaccaaca atacactggg tcgctcccac tcgccgcaca gtccgcgcac caagcacggc
      901 acaaaggcac cgcccaccac cgaggaggtg ctacggtcca cccaaaccct ggagacgcac
      961 gtcaaggaca tttcgaatgc cctgaagcac ttccgggatg ttatactcaa gaagaagctg
     1021 gaggtgttgc cgggcaacgg aacggtcatt ctggaaacca tagccagcat gtactccgtg
     1081 atccaaacct ataccctgaa tgaaaacagt gccatcatga gcagcgccac gctgcaggtt
     1141 taccagagcc tgggcaagct catcaagctc tgcgacgagg tgatgctctc cgaggacagc
     1201 ggcgagtgcg cctccctgag caacgagaat gtgcgggaag tcattgatct tctcgaggat
     1261 gctgtgcgga atctcgttac gctggcgcag ggcaagctga aggagcagga tcagtgcgcc
     1321 tttcgctaca gtggatctgg cttgggcggc attggagcgg cggcggagat catgggtgcg
     1381 gtcaccgcct cgccgggagc gagtgttccc ggtactggag tcatgcgcgt ttcggccgcc
     1441 gaatcagctg cccagcgtac ttcgttgccg gacatagcgc tcacgcccaa ggagcgcgac
     1501 atactggagc agcacaatgt gaacccgatg cgcggctccc acagcaccga aagtatcctg
     1561 cgcgacacga gtccaccgcc gaagccaccg ctacccaata gggccagtaa tccgccgccg
     1621 ttgccaccaa agcgacgcag ccagccgagc gcatcagctg gtacagtggg cgtaggctgc
     1681 tcatcgtcga catccacctc caatcaggcc agtccactgc cctacgccca gtcccataat
     1741 attagtctga actcggacct ggactgcagt tccaatatct cgctgctgaa ttatggcgtg
     1801 gatcgcctat ccgtgcgttc acggtcaccg gatgagaata gtcagtgctc ctttgactcg
     1861 gcgttgaatc actcacgcga ggaggaggac cagcaacagc aacatcagca tctgaggtca
     1921 tttccaaagt tggctgcgat gatggacgaa gacatggaca agatggtcag ctacagtttc
     1981 gtgtcgatgc gtgagtttcg cacttccaca cagacgacgg actacagtgt ccagtcctcc
     2041 acgaagtcgt ccagcagcaa ttcggagatt gcgttcagca tcagtgagtc gacggcggtc
     2101 ggcagcagta gcgagtacca gcagattagc cagttggtgt cgcacagcca gcgtcatata
     2161 tcctcgagca gtagcagctg caccaccacg accaccagca gcagcacaac caccggctat
     2221 ggcagcagcg aagtggagca gctgcagcag cagcagcagc agcagacgac gacgacgccg
     2281 gccgatctgg cgcccgcctt gccgccaaag agcatccaac ggagcagcct aacccgccac
     2341 gactcgcccg gagttggcga tgagctggac gaggtgcagt cctcctccgg ctgggccagc
     2401 catcggagca gccagtcgga ggtggccgag ctgcgtcagc tgtcgccgct ccatcacctc
     2461 aatcaccatc cgcatactgc gtccgccggt caactgcagc agtggcactc caagcaccac
     2521 agcctgatcg agggaccccg cctccagctg gcggggagtg gcagctgcag tgcgttcgat
     2581 cagcgacact tggatcagga gccaccgccg ctgccaataa aaaagaagca cattctggcg
     2641 tacatggaaa tctgttcggc gtccacgcga tccattgagc agcatcgtca cacaatgcac
     2701 gcctgcaaca taagtcgcaa catctcgcac agccagacca tgaacattat gcccatgagc
     2761 aaggaactgt cgccggagct cgagatgcca cctgccctgc cgccaaagaa ctacaagcag
     2821 cgcaaggcga caagcatggt agcatcaccc acgctgcagc ccgtcattgt gaccacgcca
     2881 ccgccgagtc cgaagccgac gctgggcgag aatgggtcga cgggcaggcc ggacagccgg
     2941 atggccaccg tatgcgagga gctgaacgat gcagtggcca gcgaggatgc gatgccggag
     3001 ccccgttcgc ccgtgctgga cagcaatgag aatgtgagcg ccgtcgatga tggacagact
     3061 ttctactgtc actcacatca gttgcccgcc gccgaaatgg agatgagcga ggatgcgagc
     3121 agtgccgaca accagccaat aaccacgccc caagtgctcg aggagcagga ggagccaacg
     3181 gcggagtccc gaccactggt cgctgtgcac gagtcggtta agccagcgaa cgtcgacgag
     3241 gatgaggagg cggagcgagc ggatatgctg atcaacatgc tggaagaggt caacatcaca
     3301 cggtacctga tactcaagaa gagagaggag gacgggcccg aggtgaaggg cggctacatc
     3361 gatgccctca tcgtgcacgc cagccgtgtc caaaaggtcg ccgacaatgc attctgcgag
     3421 gccttcatca ccacctttcg caccttcatc cagccgatcg acgtgatcga gaagctgacc
     3481 catcgctaca catacttctt ctgtcaagtg caggacaaca agcagaaggc cgctaaggag
     3541 acctttgcgc tgctggtccg agtcgtcaac gatctaacgt cgacggatct aaccagccag
     3601 ctgttgagcc tgctggtgga gttcgtctat cagttggttt gctctgggca attgtacttg
     3661 gccaagttgc tgcgcaacaa gttcgtggag aaggtgacgc tgtacaagga gcccaaggtg
     3721 tacggctttg ttggggagtt gggcggagcc ggtagtgtcg gcggagcagg aatcgccggc
     3781 agtggtggat gcagtggtac agctggtggt ggaaaccagc ctagtctgct cgacctcaag
     3841 tcgctggaga ttgccgaaca gatgacgctg ctggatgcgg agctgttcac gaagatcgag
     3901 atacccgaag tattactatt tgccaaagat cagtgcgagg agaagtcgcc caacctaaac
     3961 aagttcaccg agcacttcaa caagatgtcc tactgggcgc gctccaaaat cctgcgcctg
     4021 caggatgcca aggagcggga gaagcatgtg aacaagttta tcaaaatcat gaagcatcta
     4081 cgcaagatga acaactacaa ctcgtatctg gcgttgttgt cggccctcga ttcgggtccc
     4141 ataagaagat tggagtggca aaaaggcatc accgaggagg tgcgatcatt ctgcgccctc
     4201 atcgattcca gctccagttt tcgcgcctat cgacaggcgc tggccgaaac taatccgccc
     4261 tgcataccct acatcggcct aattctgcag gatctaacgt ttgtgcatgt gggcaaccag
     4321 gactacttgt ccaagggcgt cataaacttc tccaagcgct ggcagcagta caacataatt
     4381 gacaacatga aacgttttaa gaaatgtgcc tatccatttc gacgcaacga gcgcattata
     4441 cgcttctttg ataacttcaa ggactttatg ggcgaggagg agatgtggca gatatcggag
     4501 aagatcaagc cgcgtggacg ccgccccgtt aactattagt cttcaagcag caacagcaaa
     4561 acaccaatat tatatatgat aaagtatata caccgtatta attaaacagt tcaaaacggt
     4621 tgccacgtct aggaggagga tcagcatcgg gagcagccaa caactattct aatgggtctg
     4681 agcaataatg ttcgctattc tctgtctata tatatacaat tatacaagat atttagctgt
     4741 aattaccagc cgatgccgaa tcggaaatac atatacatac ttacttaaga tgtagcgatt
     4801 cagatacgga tacggataca tgtagccgcg tacaaataac gagccgatct gtagtttaac
     4861 tattaagctc tatgagtcat tgggtcgatg gacctaacct cagctaactc cccaccaata
     4921 ttcgaatccg aatccctgtc tgcgagtccc aaaaactttt tcccggactt ttgccagcac
     4981 tagaacacca aactaactaa ctaacttact taccaccaga gacaaccaat caagaaatca
     5041 gcaattttcg cttttgtttt gagatctctt ttttacacaa gaacacaacg aattttgaaa
     5101 gcaagctacg tgaacgtaga ggccaaccga caaactatat tcgacgatat atgtagcgat
     5161 atctcggact ataaatcgat gcaatccacg agcagaacac caagcgaacc ctagcacaaa
     5221 gcgcgttata tgcaattctc tctccaaaca accaatatta aatacccgtg tgtgtgtatg
     5281 tgtgttagaa gttattcaaa ttgaaattga actcaaaatc aaaatcagag atttcagagt
     5341 gcacgaaaca gaaaacagaa ggcggtatct atcgatcaaa tcaatcaatc aatgaaatca
     5401 atcaaaaatt cattttgcga ctcaattaat tgaagaaact tttaaagtta caaaacaaaa
     5461 caaaatacaa aaaatacaaa aaaaaaaaaa aaaacaaaaa aggcgaggaa cctgtggaag
     5521 agattaacta aattcaattt gcttttaaat gtacgactaa cattaaaaat atttatgggc
     5581 atgtaataat agttctaaat aacgctttga cttctccttt caattctgtg aggaataaat
     5641 ttattgatat tgcgtgtaaa aatattaatc atgagaagaa atctgaaagc agagttaaaa
     5701 ctgaatgaaa tcgacctcaa gttgttttta ctaagcaata ctctgtctcg tctgagaata
     5761 atgtcttctt atttagaaat gggaaacaga aaaaaaggct gcttacttga agaatttaat
     5821 tcccgatcac catagccatt ttaataaaca aaaagaaaag tcaatttttt tttttaattt
     5881 gtgttgagtg aattcgatct tctttttgct gctgcttccg ctgccgctgg cgcatcaatt
     5941 gtgtttacta agctaacgaa cctagggaca acaatttatt cttgtttttt tttttcacct
     6001 atttttaaat taaatatttt gtatatgtag agaaaatttt caattgtaaa tgtatttgta
     6061 tttaaatgtt atgtgtgtat tcataagaat gaaaatagct acc