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Drosophila melanogaster detonator (dtn), transcript variant E,


LOCUS       NM_001298004            6311 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001298004
VERSION     NM_001298004.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6311)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6311)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6311)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6311)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6311)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6311)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6311)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6311)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6311)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6311)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6311)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6311)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6311)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6311)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6311)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6311)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6311)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6311)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6311)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6311)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6311)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6311)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6311)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6311
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6311
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="detonator"
                     /map="5E1-5E1"
                     /db_xref="FLYBASE:FBgn0262730"
                     /db_xref="GeneID:31555"
     CDS             240..4463
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="CG14446 gene product from transcript CG14446-RE;
                     CG14446-PE; dtn-PE; mRNA-like ncRNA in embryogenesis 2"
                     /codon_start=1
                     /transl_except=(pos:4200..4202,aa:OTHER)
                     /product="detonator, isoform E"
                     /protein_id="NP_001284933.1"
                     /db_xref="FLYBASE:FBpp0308754"
                     /db_xref="GeneID:31555"
                     /db_xref="FLYBASE:FBgn0262730"
                     /translation="MMRYCLIIALQLSLAYSVEVHFEAPDSGFFLKHARQPPVTPEIA
                     NVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIRASYGPFSTKQTVPARYIVPD
                     TMDSQSGDYMNNATLLELQQPNMHLDISAHLVRSSVSQDAPVLRVLFHAGADPGGHLQ
                     RQKVCVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWWPQLPAPTQDGSGQAPP
                     KVPQRYAQVSYSVFEPPLRNPEQCEPKVQIQPLTTFAQVPLLAARTPYRMLRADDAVT
                     FLLPQHPLYPLSRLHVPVFLHQYPDQRVAAFTVRARVKAGLKILGATASTDQWSVSVE
                     KENPKHTTARVTAFRKEAESSLESGGNLTSEVFEVFSWLLEVAEDTNDIVDGGKIVWS
                     VTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQAVLPMAKIWEVMNTAVLTGR
                     QVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQRGSSNASV
                     IVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKVTDDNHYLHNKQSRRRKKRS
                     YVWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQNSGRTSYFISRRTGLRV
                     TDLVQPLLRVADPKIASLKGRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNL
                     SKLIVRVISGLQLTISPDNTIENGYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTPL
                     RDIAVEDYFLLVESLDTEVVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECRQRR
                     GTLSSSKQNKSNAAPLASALASIEVDFNNVDIVSKQEAIQNDGTVGRERKNYRQTGDL
                     ADIIVGIPLRDSSQLYEPTVQARQHRGSIQAVHKGHHGKGLAGTGTMTTMELGMYVLL
                     TAFCFAIIVFVISCVVYASKFRPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKESTTN
                     AHDWVWLGRSTIDRQSIVAETNTHLNPRDSRMRITSNPIVNYDNGRRVSSFDQQPKLQ
                     THIVPASNLNKQHADHYLANERKDNALDYKPPVPPHRNVGARACLPVQPVLGTGSVKD
                     AAPNKRHSQLYRREHLQNSDSNANSQQSTPQPNQQLPTERPHPLAQAHPHPHPHQHQR
                     SHSHSHNFSQEPLIKAAHNKIKQQQQQQQQQQHEELHNAEKLVEYTNPHQKNAFQFDS
                     LTPKRVTKAAASSPATPSTSAVQGKAKENHSMASSTGDAANSNGTDEIIRLPASAVSQ
                     EPTTKSSRVKRATVVGNPMFSATVDESVAPGERLGLDDLDMDYEQIMHYFDNLKESNA
                     XVQEIIAKIREILSTFHHRYQTVATPLTSPTRQQMQLLDELVAGVATATAITAAKPTP
                     LVLDGGEGDESADAFDAYDGALDIESRQF"
     misc_feature    291..749
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="Mature oligodendrocyte transmembrane protein,
                     TMEM132D, N-term; Region: TMEM132D_N; pfam15705"
                     /db_xref="CDD:464813"
     misc_feature    1557..2627
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="Transmembrane protein family 132; Region: TMEM132;
                     pfam16070"
                     /db_xref="CDD:465003"
     misc_feature    2880..3185
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="Mature oligodendrocyte transmembrane protein,
                     TMEM132D, C-term; Region: TMEM132D_C; pfam15706"
                     /db_xref="CDD:464814"
ORIGIN      
        1 aatcaataaa ggatgtgctg cggattgctg agcgagaaaa aaggacgaaa agtgctagcc
       61 agcgcgaatt aacggttgac ttttggcacg attaacggaa taacggtcaa ataagccaca
      121 caagcgagag aacagtgaaa ataacgaaag tgcgggcaca gttaattagc aaattaacga
      181 gtgggtgggc acaggatttc aggatttcga tatattttgg attcctgcac acgaacaaga
      241 tgatgagata ctgcctcata attgctttgc agctgtcgtt ggcatactcc gtggaggtgc
      301 acttcgaggc gccggacagc ggcttctttc tgaagcacgc ccgccaacca cctgtgacgc
      361 cggagatcgc caatgtgcag acatcctcgg cggtgccgcc gttacggcaa cgatcctcct
      421 atgattccgt gttatctctg gacagattca ctgtggtcga gaccacgcag ccggtgtcca
      481 tacgcgccag ctatggaccg ttttccacga aacaaacggt gccagcccgc tacattgtgc
      541 cggacacaat ggacagccag tcgggcgatt atatgaacaa tgccactcta ctggagctcc
      601 agcagccaaa tatgcacctg gacatatccg cccatttggt tcgctccagt gtatcgcagg
      661 atgctcccgt gcttcgggta ctattccacg ccggagccga tccgggtggt catttgcagc
      721 gccagaaggt ctgtgtactc ctgcacgtgg cgatgggttc ggagcagccg ctcaaaggac
      781 gctgcatgcc ggagggcgag gacggtgtct gcgtagccga agtggtcgtg cccctgggct
      841 ggtggcccca gctgccggcg cccacacaag atggcagtgg tcaggcgcca cccaaagtac
      901 cgcagcggta tgcccaggtc tcgtacagtg tctttgaacc gcctttgcgt aatcccgagc
      961 aatgcgagcc gaaggtgcag atccaaccgt tgaccacatt cgcccaggtg cctttgttgg
     1021 ccgccaggac tccctatcgt atgttgcgcg ccgatgatgc cgtcaccttt ctcctgccac
     1081 aacatccgct gtatccactc tcccgtctac atgtgcccgt ctttttacat caatatcccg
     1141 atcagcgggt ggccgccttc actgtgagag ctcgtgttaa ggcgggctta aagattctgg
     1201 gcgccaccgc ctccacagac caatggagcg tttctgtaga gaaggaaaat cccaaacaca
     1261 ctaccgctcg cgttactgct ttccgcaaag aggccgaatc cagtctggaa agtggtggca
     1321 acctaaccag cgaggtgttt gaagtattct catggctgct cgaggtggcc gaggacacca
     1381 atgatattgt ggacggtggc aagattgtgt ggtccgtgac gcatgtctat gacacgccaa
     1441 aggacaagga ttccggggaa ctggttatac ccgatgacaa caagaagcga ctaattgcca
     1501 agctggagat caacaaggat gacattcagg cggtgctacc gatggccaaa atctgggagg
     1561 tgatgaacac ggcggtgcta acgggcagac aggtggccca ggcgatgaag gtgttcatcg
     1621 tttcgcaggc aggcaaggtg gccgatgtga cgctacagag ctcctgtcac gccgaagatg
     1681 aaagtgtaat caaggtctcc tcctcctgca gctctgttta tgtggatggc tccgagcagc
     1741 gcggctcatc caatgcctcg gtcattgtca agtatggcac ctatgtgggc gtggccaagt
     1801 tcatcgtttg gatgcccgag tttccgctgg aagtttacat atccgatttc cgtctctccc
     1861 aaatcaaagg atggaaagta accgatgaca atcactatct acacaacaag cagtctcgtc
     1921 gaagaaagaa gagatcctac gtttggggtc agcatggaac gaactactat aacaatctgg
     1981 gagcggacaa gacgatttgt cgcgctcgct accagcaaag tcccgtggag gtgtatgcca
     2041 agttcctggc cgtggaccag aactctggac gcaccagcta ctttatctca cggcgtacag
     2101 gcttaagagt gacggatctg gtgcaaccgc tgctccgtgt ggccgatccc aagatcgcat
     2161 ctctgaaggg tcgaattctg cagggcaagt ccatgggacg caccgatgtc caggtcctgt
     2221 cacccataac gggtcgagta attggcacca aggaaatccg tgtgggcagc gacaaggtga
     2281 acctttccaa gctcatcgtg cgcgttattt cgggtctgca gcttaccatc agtccggaca
     2341 acacgattga gaacggctac ctggcggaga cttctgtcac acacaagcta actgctcagt
     2401 accaggaggg attgcttgac atcgatctgg agtttaccga tggctccaaa actcctttgc
     2461 gagatattgc cgtggaggac tacttcctgc tggtggagag tttggatacc gaggtggtgg
     2521 catttgctcc catgctggct tcccatcatc cacgtgtcat agccgtcggc gagggcaatg
     2581 gtaacctgct gcgcgtgacc cttctattat ccgaggaatg ccgtcagcga cgtggcacgt
     2641 tgagcagctc caaacagaac aaatcgaatg cagcaccatt ggccagtgca ttggcatcta
     2701 ttgaagtgga tttcaacaat gtggatatcg tgagcaagca ggaggctatc caaaatgatg
     2761 gcactgtggg cagggagaga aagaactata ggcaaacagg agatctggcc gatattatag
     2821 tgggcatccc cttgagggac tccagccagc tgtacgagcc tactgttcag gcgcgtcagc
     2881 atcggggcag cattcaggcg gttcataagg gtcatcatgg caagggacta gctggcacag
     2941 gcaccatgac caccatggaa ctgggcatgt acgttctgct cacggcgttc tgcttcgcaa
     3001 ttattgtgtt tgtgatctct tgcgttgtgt atgcctccaa atttcggcca gcaatgattg
     3061 aatctggctt ggatcctctg tcggcgggca agagcaatgg ttctggtgga tcgggtggct
     3121 tccgggatgt gcgcctgaag gagtcgacaa cgaatgcaca cgattgggtc tggctgggac
     3181 gctccaccat cgaccgccag tccattgtgg ccgagaccaa cacgcatctg aatccgagag
     3241 attcccgcat gcgcatcact agcaatccga ttgtcaacta cgacaatgga cgccgtgtta
     3301 gctcctttga ccaacagccc aagctgcaga cacatatcgt gccggcctcc aatctaaaca
     3361 agcagcacgc cgaccactat ttggccaacg agcgcaagga taatgccctg gactacaagc
     3421 caccagtgcc gccgcacagg aatgtgggcg ctcgagcctg cctgccggta cagcctgtgc
     3481 tcggtactgg atctgtaaag gatgcggcac ccaacaagcg acacagtcag ctgtacagac
     3541 gtgagcattt gcagaacagc gatagcaatg ccaatagcca acagtcgaca ccgcagccga
     3601 atcagcaatt gccaacagaa cgcccacatc cactggccca agcccatcca catcctcatc
     3661 cacatcagca tcagcgcagc catagccata gccacaactt cagtcaggag ccactcatta
     3721 aggcggcgca caacaaaatc aagcagcagc aacaacaaca acagcagcag caacacgagg
     3781 agctgcacaa cgccgagaag ctggtggagt acacgaatcc gcaccagaag aacgcgttcc
     3841 agttcgattc gctgacacca aagagagtta ccaaagcagc cgcgtcctcg ccggcaacgc
     3901 cgtccacatc agcagtccag ggcaaagcta aagaaaacca tagcatggcc agcagcactg
     3961 gggatgcggc caactcaaat ggaacggacg agattataag gctgccagcc agcgccgtca
     4021 gccaggagcc caccacgaaa tcgtcgcgtg ttaagcgcgc caccgtggtg ggcaatccga
     4081 tgttctcggc caccgtcgat gagtctgtcg cccccggaga gcgtcttggc ctggacgatc
     4141 tcgacatgga ttacgagcag atcatgcact actttgacaa cctaaaggag tcaaatgcct
     4201 gagtacagga gatcattgct aaaattcgcg agatattgtc gacgttccat caccgatatc
     4261 aaacggttgc cacgcccctg acctcgccca ctcgacagca gatgcagctg ctcgacgaac
     4321 tggtcgccgg cgtggcaacg gccacagcca tcaccgcagc caagccaaca ccattggtcc
     4381 tggatggtgg agagggagac gagtcggctg atgcattcga tgcctacgat ggagcgttgg
     4441 acatcgagag caggcagttc tagacgtcat cctggcacac atctaaacgc aattctagca
     4501 ataacccccc cactcagtac tctaaaagca aaccttaagg ccgttccatc aactccgaaa
     4561 agaatccatg ctgtggtcga gcaaggcagc ccggaaacgg acttggtcag ccgagcatag
     4621 gggcaaggca aaaggagata agtcgatgga taaacatatt tattgctagg ctaagttcat
     4681 atttaaagca tacacctata ggcatatgta aacgtggaga tataatccaa gtgtatctcg
     4741 aggagcgcgt gcctgacaca atcggaatcg acgggcaagc atatatagta tacaactatc
     4801 tatatctctg taactgtaac tgtatctgta tctgtatcag tatctgcata agtactatgg
     4861 tgtagttaag gatcagccat ctaaagcata gcttaatcca gacatttttt tccattctct
     4921 tcgcttcaca cacacgcatc cttagataat gtcgcatgtc ccatctgtct ggttcgattc
     4981 aacttttcta tatatatatt tatatatatt cagacgatct ctgcccgatc ttgcatatcc
     5041 tatatcttac tctctgttgt gtctgtgcga gtgtgagtgt gagtgcattt tgcgtgcgtg
     5101 tgtgtgtgtg cgtgcgccag agaaagtgag atagagagag agagagagcg agcgagagcg
     5161 aaagtgaggg agacagcgac agagagaagt taagagaaag aggagagttt ccaaaatgtg
     5221 ccgggcaccg ctcccaaaag tcgctagaac ttaaaaactg aataatatac atgctataca
     5281 cacgtatata taaatatata tatatatata tttatgatta tatagcgcgc gctaaaattt
     5341 aaagcaaatc aaaggataat ccaaaatgct acattgtgta aaatggaaac ttgaacagaa
     5401 atcgtcgctt tataagttgg caatcgaagc ccaataccta ataccaatca taaatcgaga
     5461 aacctagaaa gaaacacaca acaacacaca ccacacagat cacaaatcac agatcacaaa
     5521 taatatatag acgcttatga gctttatttg atcgattgca ttgaaaagga agcagctaaa
     5581 agcagaacag aaccccaaaa accgaatcac aaagaagtag cggggaaatg tgtaaccaaa
     5641 tattatatga tattaccgag cgatccaagc tttatataac aaatttacca tatttatagc
     5701 atacgtgcat atttattacc attattatta ttacgattat tattattatc ttgtcttacg
     5761 attatcatta tcattactgt atttattacc aacgagaaaa ggaacaagtg caaaattact
     5821 tcaaactcaa gtcgagaagc tttgaatagc gaaattagcc acgaatcgag gacacacctg
     5881 taacacgcaa ggataaatca aatgccacgt cctttccccc aacttacgcc tctctatata
     5941 cagatatata tatatatata tatatatatt tgattatata ttcatttact tgtgtgtcac
     6001 aatagcgcgg aaggagattc tacgttaatt tttgaaattg taattgcatc tgttcgtttt
     6061 ccttataaaa gttgtaagaa tttatcatag cacccgaaag ctacttcatt ccattagcaa
     6121 atcatatatg tagccactaa atgcgttttt gtcttctttc gtttctgtgt aagtctgttt
     6181 aatttcgttc gtaagatcct gtagctatgc ataagtgtct catccgatta gtttatattt
     6241 tagaggccat ctaagtatta tgttcgtttc tctcattgtt tcataatcat atgttgtaaa
     6301 ttgttccgtc c