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Drosophila melanogaster detonator (dtn), transcript variant D,


LOCUS       NM_001298003            9366 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001298003
VERSION     NM_001298003.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 9366)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9366)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9366)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 9366)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 9366)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 9366)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 9366)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 9366)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 9366)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 9366)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 9366)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 9366)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 9366)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 9366)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 9366)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 9366)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 9366)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 9366)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 9366)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 9366)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 9366)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 9366)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 9366)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9366
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..9366
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="detonator"
                     /map="5E1-5E1"
                     /db_xref="FLYBASE:FBgn0262730"
                     /db_xref="GeneID:31555"
     CDS             240..4205
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="CG14446 gene product from transcript CG14446-RD;
                     CG14446-PD; dtn-PD; mRNA-like ncRNA in embryogenesis 2"
                     /codon_start=1
                     /product="detonator, isoform D"
                     /protein_id="NP_001284932.1"
                     /db_xref="FLYBASE:FBpp0308753"
                     /db_xref="GeneID:31555"
                     /db_xref="FLYBASE:FBgn0262730"
                     /translation="MMRYCLIIALQLSLAYSVEVHFEAPDSGFFLKHARQPPVTPEIA
                     NVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIRASYGPFSTKQTVPARYIVPD
                     TMDSQSGDYMNNATLLELQQPNMHLDISAHLVRSSVSQDAPVLRVLFHAGADPGGHLQ
                     RQKVCVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWWPQLPAPTQDGSGQAPP
                     KVPQRYAQVSYSVFEPPLRNPEQCEPKVQIQPLTTFAQVPLLAARTPYRMLRADDAVT
                     FLLPQHPLYPLSRLHVPVFLHQYPDQRVAAFTVRARVKAGLKILGATASTDQWSVSVE
                     KENPKHTTARVTAFRKEAESSLESGGNLTSEVFEVFSWLLEVAEDTNDIVDGGKIVWS
                     VTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQAVLPMAKIWEVMNTAVLTGR
                     QVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQRGSSNASV
                     IVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKVTDDNHYLHNKQSRRRKKRS
                     YVWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQNSGRTSYFISRRTGLRV
                     TDLVQPLLRVADPKIASLKGRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNL
                     SKLIVRVISGLQLTISPDNTIENGYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTPL
                     RDIAVEDYFLLVESLDTEVVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECRQRR
                     GTLSSSKQNKSNAAPLASALASIEVDFNNVDIVSKQEAIQNDGTVGRERKNYRQTGDL
                     ADIIVGIPLRDSSQLYEPTVQARQHRGSIQAVHKGHHGKGLAGTGTMTTMELGMYVLL
                     TAFCFAIIVFVISCVVYASKFRPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKESTTN
                     AHDWVWLGRSTIDRQSIVAETNTHLNPRADSRMRITSNPIVNYDNGRRVSSFDQQPKL
                     QTHIVPASNLNKQHADHYLANERKDNALDYKPPVPPHRNVGARACLPVQPVLGTGSVK
                     DAAPNKRHSQLYRREHLQNSDSNANSQQSTPQPNQQLPTERPHPLAQAHPHPHPHQHQ
                     RSHSHSHNFSQEPLIKAAHNKIKQQQQQQQQQQHEELHNAEKLVEYTNPHQKNAFQFD
                     SLTPKRVTKAAASSPATPSTSAVQGKAKENHSMASSTGDAANSNGTDEIIRLPASAVS
                     QEPTTKSSRVKRATVVGNPMFSATVDESVAPGERLGLDDLDMDYEQIMHYFDNLKESN
                     A"
     misc_feature    291..749
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="Mature oligodendrocyte transmembrane protein,
                     TMEM132D, N-term; Region: TMEM132D_N; pfam15705"
                     /db_xref="CDD:464813"
     misc_feature    1557..2627
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="Transmembrane protein family 132; Region: TMEM132;
                     pfam16070"
                     /db_xref="CDD:465003"
     misc_feature    2880..3185
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="Mature oligodendrocyte transmembrane protein,
                     TMEM132D, C-term; Region: TMEM132D_C; pfam15706"
                     /db_xref="CDD:464814"
ORIGIN      
        1 aatcaataaa ggatgtgctg cggattgctg agcgagaaaa aaggacgaaa agtgctagcc
       61 agcgcgaatt aacggttgac ttttggcacg attaacggaa taacggtcaa ataagccaca
      121 caagcgagag aacagtgaaa ataacgaaag tgcgggcaca gttaattagc aaattaacga
      181 gtgggtgggc acaggatttc aggatttcga tatattttgg attcctgcac acgaacaaga
      241 tgatgagata ctgcctcata attgctttgc agctgtcgtt ggcatactcc gtggaggtgc
      301 acttcgaggc gccggacagc ggcttctttc tgaagcacgc ccgccaacca cctgtgacgc
      361 cggagatcgc caatgtgcag acatcctcgg cggtgccgcc gttacggcaa cgatcctcct
      421 atgattccgt gttatctctg gacagattca ctgtggtcga gaccacgcag ccggtgtcca
      481 tacgcgccag ctatggaccg ttttccacga aacaaacggt gccagcccgc tacattgtgc
      541 cggacacaat ggacagccag tcgggcgatt atatgaacaa tgccactcta ctggagctcc
      601 agcagccaaa tatgcacctg gacatatccg cccatttggt tcgctccagt gtatcgcagg
      661 atgctcccgt gcttcgggta ctattccacg ccggagccga tccgggtggt catttgcagc
      721 gccagaaggt ctgtgtactc ctgcacgtgg cgatgggttc ggagcagccg ctcaaaggac
      781 gctgcatgcc ggagggcgag gacggtgtct gcgtagccga agtggtcgtg cccctgggct
      841 ggtggcccca gctgccggcg cccacacaag atggcagtgg tcaggcgcca cccaaagtac
      901 cgcagcggta tgcccaggtc tcgtacagtg tctttgaacc gcctttgcgt aatcccgagc
      961 aatgcgagcc gaaggtgcag atccaaccgt tgaccacatt cgcccaggtg cctttgttgg
     1021 ccgccaggac tccctatcgt atgttgcgcg ccgatgatgc cgtcaccttt ctcctgccac
     1081 aacatccgct gtatccactc tcccgtctac atgtgcccgt ctttttacat caatatcccg
     1141 atcagcgggt ggccgccttc actgtgagag ctcgtgttaa ggcgggctta aagattctgg
     1201 gcgccaccgc ctccacagac caatggagcg tttctgtaga gaaggaaaat cccaaacaca
     1261 ctaccgctcg cgttactgct ttccgcaaag aggccgaatc cagtctggaa agtggtggca
     1321 acctaaccag cgaggtgttt gaagtattct catggctgct cgaggtggcc gaggacacca
     1381 atgatattgt ggacggtggc aagattgtgt ggtccgtgac gcatgtctat gacacgccaa
     1441 aggacaagga ttccggggaa ctggttatac ccgatgacaa caagaagcga ctaattgcca
     1501 agctggagat caacaaggat gacattcagg cggtgctacc gatggccaaa atctgggagg
     1561 tgatgaacac ggcggtgcta acgggcagac aggtggccca ggcgatgaag gtgttcatcg
     1621 tttcgcaggc aggcaaggtg gccgatgtga cgctacagag ctcctgtcac gccgaagatg
     1681 aaagtgtaat caaggtctcc tcctcctgca gctctgttta tgtggatggc tccgagcagc
     1741 gcggctcatc caatgcctcg gtcattgtca agtatggcac ctatgtgggc gtggccaagt
     1801 tcatcgtttg gatgcccgag tttccgctgg aagtttacat atccgatttc cgtctctccc
     1861 aaatcaaagg atggaaagta accgatgaca atcactatct acacaacaag cagtctcgtc
     1921 gaagaaagaa gagatcctac gtttggggtc agcatggaac gaactactat aacaatctgg
     1981 gagcggacaa gacgatttgt cgcgctcgct accagcaaag tcccgtggag gtgtatgcca
     2041 agttcctggc cgtggaccag aactctggac gcaccagcta ctttatctca cggcgtacag
     2101 gcttaagagt gacggatctg gtgcaaccgc tgctccgtgt ggccgatccc aagatcgcat
     2161 ctctgaaggg tcgaattctg cagggcaagt ccatgggacg caccgatgtc caggtcctgt
     2221 cacccataac gggtcgagta attggcacca aggaaatccg tgtgggcagc gacaaggtga
     2281 acctttccaa gctcatcgtg cgcgttattt cgggtctgca gcttaccatc agtccggaca
     2341 acacgattga gaacggctac ctggcggaga cttctgtcac acacaagcta actgctcagt
     2401 accaggaggg attgcttgac atcgatctgg agtttaccga tggctccaaa actcctttgc
     2461 gagatattgc cgtggaggac tacttcctgc tggtggagag tttggatacc gaggtggtgg
     2521 catttgctcc catgctggct tcccatcatc cacgtgtcat agccgtcggc gagggcaatg
     2581 gtaacctgct gcgcgtgacc cttctattat ccgaggaatg ccgtcagcga cgtggcacgt
     2641 tgagcagctc caaacagaac aaatcgaatg cagcaccatt ggccagtgca ttggcatcta
     2701 ttgaagtgga tttcaacaat gtggatatcg tgagcaagca ggaggctatc caaaatgatg
     2761 gcactgtggg cagggagaga aagaactata ggcaaacagg agatctggcc gatattatag
     2821 tgggcatccc cttgagggac tccagccagc tgtacgagcc tactgttcag gcgcgtcagc
     2881 atcggggcag cattcaggcg gttcataagg gtcatcatgg caagggacta gctggcacag
     2941 gcaccatgac caccatggaa ctgggcatgt acgttctgct cacggcgttc tgcttcgcaa
     3001 ttattgtgtt tgtgatctct tgcgttgtgt atgcctccaa atttcggcca gcaatgattg
     3061 aatctggctt ggatcctctg tcggcgggca agagcaatgg ttctggtgga tcgggtggct
     3121 tccgggatgt gcgcctgaag gagtcgacaa cgaatgcaca cgattgggtc tggctgggac
     3181 gctccaccat cgaccgccag tccattgtgg ccgagaccaa cacgcatctg aatccgagag
     3241 cagattcccg catgcgcatc actagcaatc cgattgtcaa ctacgacaat ggacgccgtg
     3301 ttagctcctt tgaccaacag cccaagctgc agacacatat cgtgccggcc tccaatctaa
     3361 acaagcagca cgccgaccac tatttggcca acgagcgcaa ggataatgcc ctggactaca
     3421 agccaccagt gccgccgcac aggaatgtgg gcgctcgagc ctgcctgccg gtacagcctg
     3481 tgctcggtac tggatctgta aaggatgcgg cacccaacaa gcgacacagt cagctgtaca
     3541 gacgtgagca tttgcagaac agcgatagca atgccaatag ccaacagtcg acaccgcagc
     3601 cgaatcagca attgccaaca gaacgcccac atccactggc ccaagcccat ccacatcctc
     3661 atccacatca gcatcagcgc agccatagcc atagccacaa cttcagtcag gagccactca
     3721 ttaaggcggc gcacaacaaa atcaagcagc agcaacaaca acaacagcag cagcaacacg
     3781 aggagctgca caacgccgag aagctggtgg agtacacgaa tccgcaccag aagaacgcgt
     3841 tccagttcga ttcgctgaca ccaaagagag ttaccaaagc agccgcgtcc tcgccggcaa
     3901 cgccgtccac atcagcagtc cagggcaaag ctaaagaaaa ccatagcatg gccagcagca
     3961 ctggggatgc ggccaactca aatggaacgg acgagattat aaggctgcca gccagcgccg
     4021 tcagccagga gcccaccacg aaatcgtcgc gtgttaagcg cgccaccgtg gtgggcaatc
     4081 cgatgttctc ggccaccgtc gatgagtctg tcgcccccgg agagcgtctt ggcctggacg
     4141 atctcgacat ggattacgag cagatcatgc actactttga caacctaaag gagtcaaatg
     4201 cctgagtaca ggagatcatt gctaaaattc gcgagatatt gtcgacgttc catcaccgat
     4261 atcaaacggt tgccacgccc ctgacctcgc ccactcgaca gcagatgcag ctgctcgacg
     4321 aactggtcgc cggcgtggca acggccacag ccatcaccgc agccaagcca acaccattgg
     4381 tcctggatgg tggagaggga gacgagtcgg ctgatgcatt cgatgcctac gatggagcgt
     4441 tggacatcga gagcaggcag ttctagacgt catcctggca cacatctaaa cgcaattcta
     4501 gcaataaccc ccccactcag tactctaaaa gcaaacctta aggccgttcc atcaactccg
     4561 aaaagaatcc atgctgtggt cgagcaaggc agcccggaaa cggacttggt cagccgagca
     4621 taggggcaag gcaaaaggag ataagtcgat ggataaacat atttattgct aggctaagtt
     4681 catatttaaa gcatacacct ataggcatat gtaaacgtgg agatataatc caagtgtatc
     4741 tcgaggagcg cgtgcctgac acaatcggaa tcgacgggca agcatatata gtatacaact
     4801 atctatatct ctgtaactgt aactgtatct gtatctgtat cagtatctgc ataagtacta
     4861 tggtgtagtt aaggatcagc catctaaagc atagcttaat ccagacattt ttttccattc
     4921 tcttcgcttc acacacacgc atccttagat aatgtcgcat gtcccatctg tctggttcga
     4981 ttcaactttt ctatatatat atttatatat attcagacga tctctgcccg atcttgcata
     5041 tcctatatct tactctctgt tgtgtctgtg cgagtgtgag tgtgagtgca ttttgcgtgc
     5101 gtgtgtgtgt gtgcgtgcgc cagagaaagt gagatagaga gagagagaga gcgagcgaga
     5161 gcgaaagtga gggagacagc gacagagaga agttaagaga aagaggagag tttccaaaat
     5221 gtgccgggca ccgctcccaa aagtcgctag aacttaaaaa ctgaataata tacatgctat
     5281 acacacgtat atataaatat atatatatat atatttatga ttatatagcg cgcgctaaaa
     5341 tttaaagcaa atcaaaggat aatccaaaat gctacattgt gtaaaatgga aacttgaaca
     5401 gaaatcgtcg ctttataagt tggcaatcga agcccaatac ctaataccaa tcataaatcg
     5461 agaaacctag aaagaaacac acaacaacac acaccacaca gatcacaaat cacagatcac
     5521 aaataatata tagacgctta tgagctttat ttgatcgatt gcattgaaaa ggaagcagct
     5581 aaaagcagaa cagaacccca aaaaccgaat cacaaagaag tagcggggaa atgtgtaacc
     5641 aaatattata tgatattacc gagcgatcca agctttatat aacaaattta ccatatttat
     5701 agcatacgtg catatttatt accattatta ttattacgat tattattatt atcttgtctt
     5761 acgattatca ttatcattac tgtatttatt accaacgaga aaaggaacaa gtgcaaaatt
     5821 acttcaaact caagtcgaga agctttgaat agcgaaatta gccacgaatc gaggacacac
     5881 ctgtaacacg caaggataaa tcaaatgcca cgtcctttcc cccaacttac gcctctctat
     5941 atacagatat atatatatat atatatatat atttgattat atattcattt acttgtgtgt
     6001 cacaatagcg cggaaggaga ttctacgtta atttttgaaa ttgtaattgc atctgttcgt
     6061 tttccttata aaagttgtaa gaatttatca tagcacccga aagctacttc attccattag
     6121 caaatcatat atgtagccac taaatgcgtt tttgtcttct ttcgtttctg tgtaagtctg
     6181 tttaatttcg ttcgtaagat cctgtagcta tgcataagtg tctcatccga ttagtttata
     6241 ttttagaggc catctaagta ttatgttcgt ttctctcatt gtttcataat catatgttgt
     6301 aaattgttcc gtccaaaaaa aaaaaaaaaa aaatatgaaa tgagaaacaa aaaaacaaaa
     6361 caaaagctga atgaaacgat aaacaaaagc aaacgaaact aagcaaatgc aaatgcaaat
     6421 gccgaagcaa aagcaaagca aacaattgta aaacgaaatt aagcaatcta tatctcattt
     6481 tttgtaaggc tccaaacgag gcccacaatg aagcgcacga atgcattgtt tgtaaactaa
     6541 atttgtagtc cttgtcagac gctcggacat ctagtgcact gtatactgta cataacgtgt
     6601 tgaaagtgca gtgcgtttcg cggccataag gcagacgacg ggctgggaaa taagatgaag
     6661 agtctttgaa ttaactgaaa tagatctcga cttggtctta tagcacgcaa acgcactgta
     6721 ccgtattatt atacttagtc ctgagttgct ccctatcgat ctaaggactg caaagacaca
     6781 cgcctacatc aaggacacat cactggacac atcctgttga tttcgacctg taatatcatt
     6841 agcatatagt actagatgca attgcctgtt gtccctgaca tatccccgat cctagtccgc
     6901 acaagccaat cgaaacatac accaacacac cacacacact ctcagtcgag ctgcactgcc
     6961 attggtgaaa gtgaaaatga gatttaggcc tattgaagct tccagcattt accagtgcca
     7021 taactttata actttatata actttacccg cacgcccagc ccagcccagt atgccgatca
     7081 atccgatcga ttgatctcgg ctagcatcga gcttagcact agctttcttc cgagcttgct
     7141 tgttggacag acagtgagaa cgaacgaaga gacatcagcc tccatccatt aaagaactta
     7201 gtcttagccg atctggagtc caaaatttca ttggaaattc cgccatgcgg atcggaacca
     7261 cctagtgaaa attgtaatgg cgtgaggcga ttgatgacta ttagcatttt taatctagac
     7321 aaatgcttgg cttcaattcg cggatcggct taatccttct tgtacttgta tgtatgtgtt
     7381 taacgattcc aatgcaaaga cttttatata tctttttttt ttaaactaaa tatatatata
     7441 tacatatata cgtatacacc catatattag attgtacatt attgtttagc atgtttcgac
     7501 tgcaatttaa gccgaatttt agatcttctc tagtcagttc aaagcgtttt ttgttcgttt
     7561 tgtcacgccc atcatacaca cacacgcata cacaccaaca caaacacact catagtttta
     7621 tatagtcaag gcaagctttt aacgccccct gccacgcccc ctgccacgcc cccgccccta
     7681 aacctaagct gtatgtactt gtatgtaata tcgaaacaca caaaagcaac aaaaaaaatc
     7741 acaaaagaac atgaaaagaa tgcacttcaa atatgaaaac aattcaaaat gaaactcttg
     7801 attttttttt cgaacccatt gaaacttgga aattcatcga tttatatagt taataatact
     7861 acctatatcg tgctaaacaa aaaaggcgcc ggctaagtgt aatgcaaact aaaaacataa
     7921 aaagcaaaac atatgcatat gaaatataat cgaaaaatta tacaaatgct aagaaaaagg
     7981 agaatcacaa aagttgttta tgctgctttt tgcaaaaaaa aaaataattg aaaatgaaaa
     8041 tgaaaaccgg aaaattaggc tatacttaaa tatacataca aattaaatac gtatatgttt
     8101 aaattgaata taaatgagtg tgtacgcttg gcacaaaaag taaaccaaaa ccataaacaa
     8161 tccaaaaaga gaaaaaaaaa aacgaaacaa aaaaaaagca agaaaaataa ctaattacgc
     8221 taaggagcag aagaatcgga gtaattcgga aaactactat acgaatctaa tgttttgcca
     8281 tgtaagttct atgaatgtcc cacctgcctg atgtccccgc ttcaagaaaa tgcctagatg
     8341 caatccacac ctcccccccc cccccaagct acccgctgat ttgcaccgcc cctcccaact
     8401 acccaacacc tcgccaaggt cgttggggaa tttttgtgcg atgtagtgta cttctatgtc
     8461 catcgatccg ccgcataatt gttaacattt gtatcggtta ttaacgtagt tgttgtgtat
     8521 gtatgtatgt aagtatgtaa atgtgtgctt acccccaatg ccagcgccca cgccccgccc
     8581 ccgctcccct tcgccaaccc tgagaaaata acgattacga ttaacggtaa agatagcgat
     8641 actcaattct tgttgttatt ggcagcgcat gtctttttaa gagctagtga tatatgattt
     8701 atcctcgatt cttctcccaa aaatcagacg ttttttagca agcaaaacca cacacacaca
     8761 cacacaccat atacacaccc aaacacacac acactaggac acaagagagt gatctccacg
     8821 aaatgcttat attactatat agtatataca cacccatata taaacagcgt ataaagatta
     8881 taaaagtata tatatatata taaatcatac caattgtata acaccacttt cgagcagtga
     8941 aattccaaaa ccctatcatc atatagaaga cgatcaaatc caaatgagac gtacactttt
     9001 gcttgctcct cagttccatc aatcagttca atgccgatcc ttccgatcgt tgagtccttg
     9061 tttatcatcc aacaccgaaa accaaatcga atccatcata acgaggcgaa acgaaccgaa
     9121 tcgaatcgaa acgaaatgaa attaaatgtt gccatgtata acactttagt agtttattat
     9181 tataattatt attattatta ttattactac gattattaca atattattaa gcgaaggaca
     9241 cattttgttt aaacgaagga aggcaaacga agaagcaaac aaaaatatta taaatattca
     9301 aaaatgaaaa ctgacaaaat taatttaaat aaaataattt attaataaac cacatattat
     9361 aaaatg