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Drosophila melanogaster neprilysin 1, transcript variant C (Nep1),


LOCUS       NM_001297996            3557 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001297996
VERSION     NM_001297996.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3557)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3557)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3557)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3557)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3557)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3557)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3557)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3557)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3557)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3557)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3557)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3557)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3557)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3557)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3557)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3557)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3557)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3557)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3557)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3557)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3557)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3557)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3557)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3557
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3557
                     /gene="Nep1"
                     /locus_tag="Dmel_CG5905"
                     /gene_synonym="CG5894; CG5905; CG5914; Dmel\CG5905;
                     DmeNEP1; dNEP1; NEP; nep1; NEP1"
                     /note="Neprilysin 1"
                     /map="5D4-5D5"
                     /db_xref="FLYBASE:FBgn0029843"
                     /db_xref="GeneID:31547"
     CDS             636..3185
                     /gene="Nep1"
                     /locus_tag="Dmel_CG5905"
                     /gene_synonym="CG5894; CG5905; CG5914; Dmel\CG5905;
                     DmeNEP1; dNEP1; NEP; nep1; NEP1"
                     /EC_number="3.4.24.-"
                     /note="CG5905 gene product from transcript CG5905-RC;
                     CG5905-PC; Nep1-PC; neprilysin 1"
                     /codon_start=1
                     /product="neprilysin 1, isoform C"
                     /protein_id="NP_001284925.1"
                     /db_xref="FLYBASE:FBpp0309046"
                     /db_xref="GeneID:31547"
                     /db_xref="FLYBASE:FBgn0029843"
                     /translation="MSQQHEATAAAAEKPLNNGYLQANAPLEELSATVVSPLLGQQQV
                     QHQAPHQMQQQQQQQQQNKLPTVVFLAPDGSGGVGIQRGNPAQGNPGMVTGTGSHSDW
                     LLKESQQRRRLLVLAIAFTVLGAAIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQ
                     DSGSAHEGQDNICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRS
                     SISTFEVLSDQQQVILRAVLEEPIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQ
                     VLQSLGGWPVIERNWSPPADLSVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQM
                     DQLQYALPSRDYYLKESSANDRRAYHRYMTQVALLLGADPATAAAELEKVVLFETQLV
                     NVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQAALGPGIPLQEDEPLVTYGL
                     HYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTR
                     WSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAFNELLAENDWMDDET
                     RAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLR
                     LLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVI
                     GHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDG
                     RMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMR
                     PEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW"
     misc_feature    1215..3176
                     /gene="Nep1"
                     /locus_tag="Dmel_CG5905"
                     /gene_synonym="CG5894; CG5905; CG5914; Dmel\CG5905;
                     DmeNEP1; dNEP1; NEP; nep1; NEP1"
                     /note="Peptidase family M13 includes neprilysin and
                     endothelin-converting enzyme I; Region: M13; cd08662"
                     /db_xref="CDD:341056"
     misc_feature    order(1302..1304,2544..2546,2559..2570,2625..2627,
                     2673..2678,2685..2690,2697..2699,2871..2873,3000..3002,
                     3009..3014,3063..3068,3084..3086)
                     /gene="Nep1"
                     /locus_tag="Dmel_CG5905"
                     /gene_synonym="CG5894; CG5905; CG5914; Dmel\CG5905;
                     DmeNEP1; dNEP1; NEP; nep1; NEP1"
                     /note="active site"
                     /db_xref="CDD:341056"
ORIGIN      
        1 tagtttgtgt cgcaccgttc gagtttcttc cccatgtgaa aaaaaaagaa taaatacgaa
       61 ataatacagc gactgtatcg aatttcacgt ggctcatcag aagcgcccaa ttttcaaaac
      121 gatcgcgagc cgagaatatt gtgaatatta agtattcaac agcgtcacga tattgggctc
      181 tggatttccg atgggcattc gagatctgtc atctgccatc ggatcggatc agatcagatc
      241 aaatcaaatc aaatcgaatc ggcttggaga cagtatatag acgatatagt ctgctgcctt
      301 cgtcgacgtc gctgcccatt cgcagctggg ttaactagtt tcgagttttg caaaatttgc
      361 cgcgcattaa tccgagcttc cagtcacagt gaatatcggt tagaaagtaa ggtcgccgca
      421 tgtgccgaat atatacacat atcactttgt gaacaaaaga cataaccaac tgctgccttg
      481 gcatcgaggc tgatgttgcc agcgtcgccg gcgctgtctc tctaactgcg aacggtacgc
      541 cgtccgctga accgctgata cgccgcaccg ctgcaccgct tcacctgtcc gccgatcgct
      601 gagcggtcca caaatcaggc gccccatagt agaagatgtc gcagcaacat gaggcaacag
      661 cggcggccgc ggagaagccg ctaaataacg gctacctgca ggcgaatgcg ccgctggagg
      721 agctgagtgc cacggtggtg tcgccactcc tgggacagca acaggtgcag caccaggcgc
      781 cacatcagat gcagcagcaa cagcagcagc agcagcagaa caagctgccc actgtcgttt
      841 tcctggcgcc cgacggcagc ggaggcgtgg gaatccagcg aggaaatcca gcgcagggca
      901 atcccggcat ggtaacgggc accggcagcc acagcgactg gctgctcaag gagtcgcagc
      961 agcggcgccg cctgctcgtc ctggccatcg cctttaccgt tctgggcgcg gccatcgggg
     1021 cactggccat ctacttcgcc agcgtccatc agcgttgcca tctgtatcgc ctggagccag
     1081 acaacgatga cagaccgaac ggcaggtgga accaggattc gggatccgcc cacgaggggc
     1141 aggataacat ttgcatgacc caggagtgcg tgagaacagc cgcctccctg ctctcggcca
     1201 tggacctcaa ctccgatccc tgcgaggact ttttccagta cgcgtgcggc acgtggaaca
     1261 agatgcatcc cattcccgag gaccgcagct ccatcagcac gtttgaggtc ctgtccgatc
     1321 agcagcaggt tatcctgcgc gcagttctgg aggaacccat cgatgaacgc gacaacaaag
     1381 ccaccataaa ggccaaaacc ttcttcaaga gctgcatgga tattcctcaa atccgcaaaa
     1441 tcggaacggg tcgactcaag caggtactgc aatccctggg cggctggccg gtcatcgagc
     1501 ggaactggag tccgccggcg gatctctccg tggagcggct aatgggtcag ctccgactga
     1561 actacagcga gccggtgatg atcgagctgt acgtgggcgc cgacgacaag aacagctcgg
     1621 tgaacatcct gcagatggac cagctgcagt atgccctgcc ctcgagggac tactacctga
     1681 aggagagcag tgcgaacgac cgaagggcct accatcggta tatgacacag gtggcgctgc
     1741 tcctgggagc ggatccggcc accgccgccg cggaactgga gaaagttgtg ctcttcgaga
     1801 cgcagctagt gaatgtttcc ttgccggagg cggatcgtca tgacactagc ctggtctatc
     1861 gtaagatgtt gctgcccgag ctgcaggaac tggtgcccga ggtgcagtgg caggagtatc
     1921 tacaggcagc tctgggtccg gggattcccc tgcaggagga cgagccgctg gtcacctacg
     1981 ggctgcacta tctcaccgaa atgggcaaga tactggcgca caccgatcgc cgtgtggtgc
     2041 acaactatat gctgtggcgc ctggtcatgt ccttgatgtc acacatgatc gatgagtatc
     2101 agcgtgagcg ggtggagttc cgcaagatcc taatgggcat ccagtcggag aggacacgct
     2161 ggtcacagtg cgtcgagtgg actaacaaga agctgggtgt cgccgtggga gccctcttca
     2221 tccgggacaa cttcaatcag gagagcaagg aggtggccct cgagatgatc cacactatac
     2281 gtgcggcgtt caacgagctt ctggccgaga acgattggat ggacgacgag acgcgggcgg
     2341 tggccaagga gaaggcggac tcgatgaacg agcggattgg ttatccggag ctgctcacca
     2401 atgccaccga gctggagcag gagtacgtga atctaacaat tgtccccgac aacttcatca
     2461 acaatgtcct tagcattctg caatgggagt cggagaagat gctgcgactt cttcgccagc
     2521 cggtggacaa ggaaaagtgg accaccgaac cggcggtggt gaatgccttc tacaacccga
     2581 ataaaaacga tatagtattt cctgctggca tcctgcagcc gctattctac agccagcact
     2641 ttcccaagtc cttgaattac ggcggaatcg gagtggtcat tggccacgag attacccacg
     2701 gattcgacga caagggcagg cagttcgaca aggagggcaa catgatgcag tggtggaaca
     2761 atgccaccat cgaggccttt cgcgaacgga cgcagtgcgt catcgatcag tactcgcgct
     2821 acaagattaa cgaggtggac atgttcatgg acggacggat gacgcagggc gagaacatcg
     2881 ccgacaacgg cggtctaaaa caggctttca gggcctacaa gaaatgggag accttacatg
     2941 ggcgggagca gcagctgccc ggcctgaaca tgacccacga tcagctgttc tttctcaact
     3001 acgcccaaat ctggtgcgga tccatgcggc cggaggacgc tctgaccaag atccgctccg
     3061 cggtccactc gcccggattc gttcgtgtcc tgggaccact ttcgaattct cgcgactttg
     3121 ccagcgccta caaatgccca ctgggcagca ccatgaatcc ggcggaaaag tgcagcgtgt
     3181 ggtagtccgc cgcggccgtc gatgtttttt ttttatatat ttatatcgca tactatatag
     3241 tatttacata tcgatataca ccatacgagt actgtagatc acctgcggca acagcaaacc
     3301 aacctaccaa ccaggacgat aagattgacg accagccaat ctgggctgtt ccaatttttt
     3361 gtgtatttcc tcgttttact ttccgttcat tatggcgctg caatgcatat gtactttata
     3421 cctggctata tagaattata gtgtgtttgt agttgtacac gagtgcgcta tccgagtagc
     3481 ccacaaaatg ccccggatcc gcacttttca cacacctcct taccgacatt atattcgtga
     3541 ataaagaaca agtacgg