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Drosophila melanogaster ubiquitin specific protease 16/45,


LOCUS       NM_001297961            4454 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant F (Usp16-45), mRNA.
ACCESSION   NM_001297961
VERSION     NM_001297961.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4454)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4454)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4454)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4454)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4454)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4454)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4454)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4454)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4454)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4454)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4454)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4454)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4454)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4454)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4454)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4454)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4454)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4454)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4454)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4454)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4454)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4454)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4454)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4454
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4454
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Ubiquitin specific protease 16/45"
                     /map="4F10-4F10"
                     /db_xref="FLYBASE:FBgn0029763"
                     /db_xref="GeneID:31458"
     CDS             202..3582
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /EC_number="3.4.19.12"
                     /note="CG4165 gene product from transcript CG4165-RF;
                     CG4165-PF; Usp16-45-PF"
                     /codon_start=1
                     /product="ubiquitin specific protease 16/45, isoform F"
                     /protein_id="NP_001284890.1"
                     /db_xref="FLYBASE:FBpp0309404"
                     /db_xref="GeneID:31458"
                     /db_xref="FLYBASE:FBgn0029763"
                     /translation="MVKKRQADSRDHDCSTDSGNEDLHHRKGLGSPGQSDGATPTTAS
                     CQHIKKAVDAARLRRLLKSTGLLYECSQCQKLGKTAGSAAGAGASEGAVGPGGNPVTF
                     EFDNTLWLCLKCGSQLCGRARHKHALEHYQTPHSDSHALAMNTRSFDIWCYECDMKIC
                     SNLRKNLLECVELVKKLAQKPPTSTVTPSTPTISYIEEKLKAALEHLTPIVPMTGGSF
                     DDSSSRGSLAAAGGGGGVGSSRNRQVAIPMPPPEPSSGLSTSDSLTSVPGMAKRIDQY
                     SATTNGNTGNKRLLTLETPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQTPFLLSVL
                     KELSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSSWGGLTAALANALEELQAGGSVF
                     TPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQDV
                     NSVSEEMRQKCKIYGNQAGDRILRPEQVFRGFLVSTLTCQDCHNVSSRHEYFLDMSLP
                     VAVEKPQPPQRRKPSPELSLTSSSSSVTPSTGQPTINTKFTDGSVNFTASSPSFFLHA
                     HEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGNDSGNGNELAESVDQDDAS
                     LASLGAGDGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDNLVEDTAAPSTNNVPS
                     STASLTAPSKTYMDSNGNAQPPGEKRDDTPEHMDKDSLEEDENDSGIATSPAPTATNS
                     STSTSATGNNNSVAGSGLSGSSGALEDPLAPASLVTAGLSEKGASVIRQVSVGAEQGA
                     SNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSYSDWSTTIAPRYQCEDG
                     ECSVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKAKSVNTNATKQLLVSSPPAV
                     LILHLKRFQLGPRCIFRKLTRPVSYPNLLDIAAFCGSKVKNLPNIDRKQKKLLYALYG
                     VVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKLEELLAKE
                     KAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEEAAN
                     VRAPPGKWYYVSDSRVQEVSEDTALKAQAYLLFYERIY"
     misc_feature    523..678
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Zn-finger in ubiquitin-hydrolases and other
                     protein; Region: zf-UBP; pfam02148"
                     /db_xref="CDD:460464"
     misc_feature    <1120..3171
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Ubiquitin C-terminal hydrolase [Posttranslational
                     modification, protein turnover, chaperones]; Region:
                     UBP12; COG5560"
                     /db_xref="CDD:227847"
     misc_feature    1120..>1737
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    <2746..3570
                     /gene="Usp16-45"
                     /locus_tag="Dmel_CG4165"
                     /gene_synonym="CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16;
                     Usp45; USP45"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19K; cd02667"
                     /db_xref="CDD:239132"
ORIGIN      
        1 cgcgggagtt gcgacccaaa taagcaacgg tcacacttgg tcacgtcgtt cacgttttct
       61 atttacgcat atacgaataa aaaaaagtgc ataaaagtgc tgtaaaacat atatgttgtg
      121 tgcttacgtg caacgcatat cgcagcgagt aaattcaaga gcgcgcccac aaggaggcca
      181 aggccaagca gctaccttgc catggtaaag aagcgtcagg cggacagtcg cgaccacgat
      241 tgctcaacgg attccggcaa tgaggatctg catcatcgaa aaggactcgg ctcgcccggt
      301 cagtcggatg gcgccacccc caccaccgcc agctgccagc acatcaagaa ggcggtggac
      361 gcggcccgac taaggcgtct actgaagtcc acgggtctac tctacgagtg cagccaatgt
      421 cagaagctgg gcaagacagc gggcagcgct gcgggagcgg gagcgagtga aggagctgtc
      481 ggtcctggcg gaaatccggt caccttcgaa tttgacaaca ccctgtggct gtgcctcaag
      541 tgcggcagcc agctgtgcgg gagggcacgc cacaagcacg ccttagaaca ctaccagaca
      601 cctcattcgg actcacatgc cctggccatg aatacgcgct ccttcgacat ctggtgctat
      661 gagtgcgaca tgaagatctg ctccaatctg cgcaaaaacc tgcttgagtg cgtggagctg
      721 gtcaagaaat tggcccagaa gccgcccact agcacggtta cgcccagtac gccaacgatt
      781 agctacatcg aggagaagct taaagccgcg ctggagcatc tcacaccaat agtgccaatg
      841 actggcggat catttgacga ctccagcagt agagggtctc tggcggcggc cggtggcggg
      901 ggcggggtcg gttcatctcg aaataggcag gtggccatac cgatgccacc accagagcct
      961 agctccggac tttcgacctc agactcgctg accagtgtgc cgggtatggc aaagagaatt
     1021 gaccagtact cggccaccac caatggcaac actgggaaca aacgactcct gaccctagag
     1081 acgccgcgca tcgaaaatga acgcctgccc cgcgtgcgag gattgaccaa cctgggcaat
     1141 acatgcttct ttaatgcggt gatgcagtgc ctcgcccaga cgccgttcct acttagcgta
     1201 ctgaaagaac tgtcggagcc cggagaagaa ttcatcttac ctggcggaac gttcaccata
     1261 aaggacaaag gtgacattga gctgccgatg atcaagggta ccctgtcctc ttggggtgga
     1321 ctcacggccg cgttagccaa tgcccttgag gaactgcagg ctggcggtag tgtatttacg
     1381 cccagaaaac tcttcgacag gctgtgcgta aagtgtcctc agtttacggg cggcgatcag
     1441 catgatgctc acgaactgct gcgccagcta ctggagagcg tgcggaacga ggacctaaag
     1501 cgctaccagc gtgtaattct gcagaacctc ggctacaagg atcaggatgt aaatagtgtg
     1561 tcagaggaga tgcgacaaaa gtgcaagatc tatggcaatc aagcaggaga ccgaattctg
     1621 cgcccggaac aggtattccg tggctttctt gtgtcaacgc tcacctgcca ggattgtcac
     1681 aatgtttcct cgcggcacga gtacttcctg gacatgtcgc tgcccgtggc cgtagagaaa
     1741 cctcagccgc cgcagcgccg aaagccaagt ccggagctca gtcttacgtc cagcagctct
     1801 agcgtcaccc cgagcactgg ccagccgacg ataaacacca agtttacgga tggtagtgtc
     1861 aactttacag cctcatcccc gtccttcttc ctgcacgccc atgaggcggc atccctgggc
     1921 ccatccaagt cgcaggtgaa aaaggagaag gagcgacagc gtaaggcgaa gcgggcggcc
     1981 aagaagcgtc agaagtctag ccttaatctg aacggaaatg atagcggaaa tggcaatgaa
     2041 ttggccgagt ccgtagacca ggacgatgcc tcattggctt ccctgggtgc cggcgacggc
     2101 caggccaatg atggcctcga acagaccaac ggccagaccg aggattccac cacctccagc
     2161 gtgactactt cggagcactc cgacgccgat gttgaggaca atctggtgga ggatacagcc
     2221 gcgccgtcca ctaataatgt gccgagcagt acggcatcct tgacagctcc ctccaagacc
     2281 tacatggaca gcaatggcaa tgcccagccg ccgggggaga agcgcgacga tacgccggag
     2341 cacatggaca aggattcgct cgaagaggac gagaatgact cgggaatcgc caccagtcca
     2401 gcaccaactg ctaccaacag cagcaccagt accagtgcca cagggaacaa taactctgtt
     2461 gccggatcgg ggctgtccgg ttcatcgggc gctctggagg atcccttggc gccagccagc
     2521 ttggtcactg ccggactctc agagaagggc gcctcggtga tccgccaggt ctcggtggga
     2581 gctgagcagg gcgcatccaa tggcacagaa gacgcggatg gcgaagccaa ggcaatcgag
     2641 cagccagaga agactcctag ccaagctcaa gccatggctc aggcccaggc ccgtacgaag
     2701 cgagtgcgca cgcaaagcta ctcggactgg agcaccacga tagcgccgcg ctaccagtgc
     2761 gaggatggag agtgctccgt gcagtcgtgc ctcaataatt tcaccgctgt cgagctgatg
     2821 acgggacaga acaaggtggg atgcgatagc tgcacgcagc gcattaacgg cagtgatccg
     2881 aaggccaagt cggtgaacac caatgccacg aaacagctgc tggtctccag tccgccagcg
     2941 gtgctcatac tacacctgaa gcgttttcag ctgggaccgc gctgcatctt ccgcaagctg
     3001 acgcgcccgg ttagctatcc caatctgctg gacattgccg ccttttgtgg gtccaaggtc
     3061 aagaatctgc cgaacatcga tcgcaagcag aagaagctgt tgtacgcgct atatggcgta
     3121 gtggagcact cgggcggcat gtacggtggc cactatacgg cgtacgtgaa ggtgcgtcca
     3181 aaggtggcgc cgggcgacaa acgctggaag ttcctgccgc atggcagcaa ggcggaattg
     3241 gaccaggacg atgaccaact aaaaaaactg gaggagctgc ttgccaagga gaaggcgcgc
     3301 gagcagcacc tgaaggtgtt ggacgacagc gatgacttta gcaactccag cagcaactcg
     3361 tccacctccg acgagagcca gaccccagcc acgccactgg aggagcaaca gacgcagcag
     3421 gcgcagcagc cgcagcagcc gcagcagctg gaggaggctg ccaacgttcg tgcgccgcct
     3481 ggcaaatggt attacgtgtc cgactcgcgt gtccaggagg tcagcgagga tacggcgctg
     3541 aaggcgcagg cctatctgct tttctacgaa cgcatatact agggattagc tcgagcttta
     3601 agcggaactg aggatgcgag gcgtatggaa gaaaattttg gaatcctata tttgatacag
     3661 acagagtgcc ggagaaagag aaggcagata ctcacacatg ccaaatgcat ttggtttctc
     3721 ccactcaaaa ttaattgtac actttcgcta tttttattat tattattttt tttttttgga
     3781 acaagcttta gttagttaaa tgatgcaaag gagtagacac acgcactcat gttaaattgt
     3841 agttctcagg aggtttgcta ttatgtcctc gatttaattg tactattttt ttagtcatta
     3901 acaaaaagac actgaagaga aaattatgtt ttattagctg taagttcttt tgttaccaaa
     3961 attgcccatt atgacagaaa gttacttaaa catactcgag ttgggggtta aaaaaatgga
     4021 tcgaaaggaa aagacagacc gcagaatgga tagctaaaaa cggataagca caaatgaaat
     4081 ggaggcggtt aaccaagaga gaaactattt gcagatgttc ataagttata ataacgaata
     4141 caaatgaaat aaaaaaaaac cgattgctcg cttctgccaa tatatttaac tttgcagtaa
     4201 cataacatta tgtacacctt aattatatat aatatatata cactatatta cgggcccata
     4261 tacacatacc gcccacgtag atatgtattt acaagttcag ccgaaggagt aaatgtgttc
     4321 ttggacctac gtagcgaaag aattggcaac aggagagatt tatacaatag cgaagaataa
     4381 ataattatac acacagttta tcttatgatc taggcttaac tatcgtttaa tttatgataa
     4441 ctaatcaatc tatg