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LOCUS NM_001297914 4355 bp mRNA linear INV 26-DEC-2023 variant N, mRNA. ACCESSION NM_001297914 VERSION NM_001297914.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 4355) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 4355) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 4355) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 4355) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 4355) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 4355) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 4355) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 4355) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 4355) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 4355) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 4355) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 4355) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 4355) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 4355) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 4355) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 4355) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 4355) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 4355) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 4355) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 4355) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 4355) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 4355) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 4355) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..4355 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..4355 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Tousled-like kinase" /map="3E6-3F1" /db_xref="FLYBASE:FBgn0283657" /db_xref="GeneID:318206" CDS 395..4123 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /EC_number="2.7.11.1" /note="CG34412 gene product from transcript CG34412-RN; CG34412-PN; Tlk-PN; BEST:GH17330; tousled-like kinase; tousled like kinase" /codon_start=1 /product="Tousled-like kinase, isoform N" /protein_id="NP_001284843.1" /db_xref="FLYBASE:FBpp0311479" /db_xref="GeneID:318206" /db_xref="FLYBASE:FBgn0283657" /translation="MSPGAHLQMSPQNTSSLSQHHPHQQQQLQPPQQQQQHFPNHHSA QQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHLHKHPHQLQLHQQQQQQLHQQQQQH FHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDMLSGGAATPGAAAAAIQQQHPAFAP TLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSVLTVGKPRTPAERKRKRKMPPCATS ADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMPKVNMSLNLGDRLGGSAGSGVGAGG AGSGGGGAGSGSGSGGGKSARLMLPVSDNKKINDYFNKQQTGVGVGVPGGAGGNTAGL RGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGSAGGSAGNQVQVQTSSAYALYPPAS PQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHVVVGLGGHPLSLA SIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLGVVGMVGVGVGVG VGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLHELQEREAEHESGKVKLDEMTR LSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQ FVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGRKRNN NSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAG AIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSG GVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNA LKKEDADLQLEMEKLERERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGF SEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYD VFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVI HYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPE CFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFS NKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQ QQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS" misc_feature <2000..>2410 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Family of unknown function (DUF5401); Region: DUF5401; pfam17380" /db_xref="CDD:375164" misc_feature 3134..3937 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; Region: STKc_TLK; cd13990" /db_xref="CDD:270892" misc_feature order(3143..3145,3182..3184,3188..3190,3296..3298, 3347..3358,3368..3370,3374..3376,3491..3493,3497..3499, 3503..3508,3512..3514,3554..3556,3563..3565,3632..3643) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="active site" /db_xref="CDD:270892" misc_feature order(3368..3370,3374..3376,3491..3493,3497..3499, 3503..3505,3563..3565,3632..3643) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270892" misc_feature order(3551..3589,3602..3643) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="activation loop (A-loop); other site" /db_xref="CDD:270892" ORIGIN 1 cagtcgcaat tcaaacgcca tcaaaatcaa aacggcgccc agctatcaac aacattttca 61 tcatcaaaat cttcaccacc accaacaaca acatcaacaa caacaacaac aacaacatat 121 aacgcaagtg caacaacaac aacaacaaca acagcaactt ttggtattgc cacagcagca 181 gcaacagcaa catttgcgag tgtgcaacaa tcaaatcaat aacaacaata acagcagtaa 241 tagctgccaa aacagctatc aatatagtta taacaataat aataacaaca ccaacgccaa 301 caacaacagc aatcagcagc tgcaacaaca aattgtgaat aacaacaaca atctcgagga 361 cgatgtgtat tatttatttt ataaagattt ttatatgtcc cccggcgccc atttgcagat 421 gtccccgcag aacacttcgt ccctaagtca acaccatcca catcaacagc aacagttaca 481 acccccacag cagcaacaac agcatttccc taaccatcac agcgcccagc aacagtcgca 541 gcagcagcag caacaggagc aacagaatcc ccagcagcag gcgcaacagc agcagcagat 601 actcccacat caacatttgc agcacctgca caagcatccg catcagctgc aactgcatca 661 gcagcagcaa caacaactcc accagcaaca gcagcaacac ttccaccagc agtcgctgca 721 agggctgcat cagggtagca gcaatccgga ttcgaatatg agcactggct cctcgcatag 781 cgagaaggat gtcaatgata tgctgagtgg cggtgcagca acgccaggag ctgcagcagc 841 agcgattcaa cagcaacatc ccgcctttgc gcccacactg ggaatgcagc aaccaccgcc 901 gcccccacct caacactcca ataatggagg cgagatgggc tacttgtcgg caggcacgac 961 cacgacgacg tcggtgttaa cggtaggcaa gcctcggacg ccagcggagc ggaaacggaa 1021 gcgaaaaatg cctccatgtg ccactagtgc ggatgaggcg gggagtggcg gtggctctgg 1081 cggagcagga gcaaccgttg ttaacaacag cagcctgaag ggcaaatcat tggcctttcg 1141 tgatatgccc aaggtaaaca tgagcctgaa tctgggcgat cgtctgggag gatctgcagg 1201 aagcggagta ggagccggtg gcgccggaag cgggggaggt ggcgctggtt ccggttctgg 1261 aagcggtggc ggcaaaagcg cccgcctgat gctgccagtc agcgacaaca agaagatcaa 1321 cgactatttc aataagcagc aaacgggcgt gggcgtcggt gtgccaggtg gtgcgggagg 1381 caataccgct ggccttcgag gatcacatac gggaggtggc agcaagtcac cctcatccgc 1441 ccagcagcag caaacggcgg cacagcagca gggaagcggt gttgcgacgg gaggcagtgc 1501 aggcggttcc gctggcaacc aggtgcaagt gcaaacgagc agcgcttacg ccctttaccc 1561 accagctagt ccccaaaccc agacgtcaca gcaacagcag cagcagcaac cgggatcaga 1621 ctttcactat gtcaactcca gcaaggcgca gcaacaacag cagcgtcaac agcaacagac 1681 ttccaatcaa atggttcctc cacacgtggt cgttggcctt ggtggtcatc cactgagcct 1741 cgcgtccatt cagcagcaga cgcccttatc ccagcagcaa cagcagcaac aacagcagca 1801 gcaacagcag caactgggac caccgaccac atcgacggcc tccgtcgtgc caacgcatcc 1861 gcatcaactc ggatccctgg gagttgttgg gatggtcggt gtgggtgttg gcgtgggcgt 1921 tggagtaaat gtgggtgtgg gaccaccact gccaccacca ccgccgatgg ccatgccagc 1981 ggccattatc acttatagta aggccactca aacggaggtg tcgctgcatg aattgcagga 2041 gcgcgaagcg gagcacgaat cgggcaaggt gaagctagac gagatgacac ggctgtccga 2101 tgaacaaaag tcccaaattg ttggcaacca gaagacgatt gaccagcaca agtgccacat 2161 agccaagtgt attgatgtgg tcaagaagct gttgaaggag aagagcagca tcgagaagaa 2221 ggaggcgcga cagaagtgca tgcagaatcg cctcaggctc ggacagtttg ttacccaacg 2281 agtgggcgcc acattccagg agaactggac ggacggctat gcgttccagg agctgagtcg 2341 gcggcaagaa gaaataaccg ctgagcgtga agagatagat cggcagaaaa agcagctgat 2401 gaaaaagcgt ccggcggagt ccggacgcaa gcgcaacaac aacagtaacc agaacaacca 2461 gcagcagcag caacagcaac accagcaaca gcagcagcaa caaaattcca actcgaacga 2521 ttccacgcag ctgacgagcg gagttgttac cggtccaggc agtgatcgtg tgagcgtaag 2581 cgtcgacagc ggattgggtg gcaataatgc gggcgcgatc ggtggcggaa ccgttggtgg 2641 tggcgttgga ggtggtggtg ttggaggcgg tggtgtcgga ggcggcggtg gacgtggact 2701 ttctcgcagc aattcgacgc aggccaatca ggctcaattg ctgcacaacg gcggtggtgg 2761 ttcgggcggc aatgtcggca actcgggcgg cgttggcgac cgcttgtcag atcgaggagg 2821 aggaggtggc ggcatcggcg gaaacgatag cggcagctgc tcggactcgg gcactttcct 2881 gaagccagac cccgtatcgg gtgcctacac agcgcaggag tattacgagt acgatgagat 2941 cctcaagttg cgacaaaatg ccctcaaaaa ggaggacgcc gacctgcagc tggagatgga 3001 gaagctggag cgggagcgca atctgcacat ccgagagctc aagcggattc ttaacgagga 3061 tcagtcccgc tttaacaatc atcccgtgct gaatgatcgc tatcttctgt tgatgctcct 3121 gggcaagggc ggcttctcag aggtccacaa ggccttcgac ctgaaggagc aacgctatgt 3181 cgcatgtaag gtgcaccaat taaacaagga ttggaaggag gataagaaag ctaattatat 3241 caaacacgct ttgcgggaat acaacattca caaggcactg gatcatccgc gggtcgtcaa 3301 gctatacgat gtcttcgaga tcgatgcgaa ttccttttgc acagtgctcg aatactgtga 3361 tggccacgat ctggacttct atttgaagca acataagact atacccgagc gtgaagcgcg 3421 ctcgataata atgcaggttg tatctgcact caagtatcta aatgagatta agcctccagt 3481 tatccactac gatctgaagc ccggcaacat tctgcttacc gagggcaacg tctgcggcga 3541 gattaagatc accgacttcg gtctgtcaaa ggtgatggac gacgagaatt acaatcccga 3601 tcacggcatg gatctgacct ctcagggggc gggaacctac tggtatctgc cacccgagtg 3661 ctttgtcgtg ggcaaaaatc cgccgaaaat ctcctccaaa gtggacgtat ggagtgtggg 3721 tgttatcttc taccagtgtc tgtacggcaa aaagcccttc ggtcacaatc agtcgcaggc 3781 cacgattctc gaggagaata cgatcctgaa ggccaccgaa gtgcagttct ccaacaagcc 3841 aaccgtttct aacgaggcca agagtttcat tcggggatgc ttggcctatc gcaaggagga 3901 tcgcatggat gtgttcgcac tggccaggca cgagtacatt cagccaccga taccgaaaca 3961 tgggcgcggt tcgctcaatc agcaacagca ggcgcaacaa cagcagcagc aacaacagca 4021 acagcagcag caacagtcgt cgacgtcaca ggccaattct acaggccaga catctttctc 4081 tgcccacatg tttggcaata tgaatcagtc gagttcgtcc tagctgccaa ccaagcgcaa 4141 ttcgaactca taattcgccg ccgccgcagt agcagcagct acattagctg ccagtagtca 4201 acagcaactt caacaccagc aacagcaact ccaaatccag caataccagc agaatcagca 4261 acttcatttg caaaacagca gtagcaatta tgcggccacg cttctagatg cagcggcctt 4321 ttgctacgaa accgtgatgg atgcagccca cttcc