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LOCUS NM_001297875 6939 bp mRNA linear INV 26-DEC-2023 C, mRNA. ACCESSION NM_001297875 VERSION NM_001297875.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 6939) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 6939) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 6939) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 6939) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 6939) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 6939) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 6939) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 6939) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 6939) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 6939) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 6939) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 6939) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 6939) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 6939) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 6939) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 6939) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 6939) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 6939) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 6939) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 6939) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 6939) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 6939) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 6939) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..6939 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..6939 /gene="wapl" /locus_tag="Dmel_CG3707" /gene_synonym="C204; CG3707; Dmel\CG3707; EG:87B1.2; l(1)2Dd; l(1)2Df; l(1)C204; l(1)N2; l(1)N5[72]; l74; N2; pasc; RNA D; RNAD; wap; Wapl; WAPL" /note="wings apart-like" /map="2D4-2D5" /db_xref="FLYBASE:FBgn0004655" /db_xref="GeneID:31187" CDS 773..5998 /gene="wapl" /locus_tag="Dmel_CG3707" /gene_synonym="C204; CG3707; Dmel\CG3707; EG:87B1.2; l(1)2Dd; l(1)2Df; l(1)C204; l(1)N2; l(1)N5[72]; l74; N2; pasc; RNA D; RNAD; wap; Wapl; WAPL" /note="CG3707 gene product from transcript CG3707-RC; CG3707-PC; wapl-PC; parallel sister chromatids protein; wings-apart-like" /codon_start=1 /product="wings apart-like, isoform C" /protein_id="NP_001284804.1" /db_xref="FLYBASE:FBpp0310572" /db_xref="GeneID:31187" /db_xref="FLYBASE:FBgn0004655" /translation="MSRWGKNIVVPLDSLCKEKENTNRPTVARSVGTVGKWGKMGFTS TRTYTLPAIHPMAAAAAAAAAAASPSQSPASTQDHDPNDLSVSVPEPPKPKKFFKSRN TAPPEVIAQIIQQLPHCGAGASPMRDHFSSAGAGAGGLTPTSGAQEAGGVKLKPGKGA SSAERKRKSPKKKAATTSASTPSTPGAFYGASDRDGDGLSDPASEQPEQPSSASGKQK QKKPKEEKKLKPEAPPSRVLGRARKAVNYREVDEDERYPTPTKDLIIPKAGRQPAEVA ATATLAAASSEAFISSTFGSPGSEPSLPPPTSAPSASASTSSQLPSASGSASNPPSAS RTPEHPPIVLRISKGTSRLVSTDSEEPPSSSPAHQNQLNQLSVTEEEPAERSGDETVP ASTPKITVKPLRPPTAADSVDGSSAAVGGASAGDSFEERKSQSLEPNEDEEEEEEEED EEEEPPEINYCTVKISPDKPPKERLKLIIKTDVIRNAIAKAAAAAESRSEKKSRSKKH KHKQLLAAGSGAAPASGATPAEINSEFKTPSPHLALSEANSQQAQHTPSHLHQLHQLH PQRGSAVISPTTRSDHDFDSQSSVLGSISSKGNSTPQLLAQAVQEDSCVIRSRGSSVI TSDLETSQHSSLVAPPSDIESRLESMMMTIDGAGTGAASAVPETPLQEDILAVLRGEV PRLNGNTDPEPTEEEDQQQQPKRATRGRGRKANNNVDVTPPATETRTRGRAKGADATT AAISPPTGKRNTRGTRGSRKAEQEVDMEVDETAMTTVPANEEQLEQATLPPRRGRNAA ARANNNNLASVNNNINKIAANLSAKAEASRLAEGGVAGGAARSYGRKRKNQQVTQVLQ QEPVPEEQETPDAEEEQPTPAKIPHTDHREHSPDHDPDPDPDELSNNSNNSSLQHDGS SSSPPPRDFKFKDKFKRTLTLDTQGAANAGAGGAAAAAPPESSGEQRGAVKLVISKKK GSIFKSRALVPSDQAEQATVAKRHLYKHSWDAALEANGGGTNSDASNASASGVGVAGA KDHLHHLAAGKSDGDFGDSPSSNNNGSSSACSSASTLRGDSPALGKISRLAGKQGVPA TSTSSDAFDLDLEPIAGELDLERSAAGASAGGTGATTGGGGATGGGGPVRVDRKTKDY YPVVRNVKTAHQIQEIGEYQEMDDDVEYILDALQPHNPPATRCLSALQLAAKCMMPAF RMHVRAHGVVTKFFKALSDANKDLSLGLCTSAIMYILSQEGLNMDLDRDSLELMINLL EADGVGGSTETGHPDRAGYDRNKQKVRELCEEIKAQGKGTHLNVDSLTVGTLAMETLL SLTSKRAGEWFKEDLRKLGGLEHIIKTISDFCRPVIACDTEIDWQPTLLDNMQTVARC LRVLENVTQHNETNQRYMLTSGQGKAVETLCQLYRLCSRQIMLHPSDGGGSNKEHPGV AMRELLVPVLKVLINLTHTFNEAQPSLGAELLGQRGDVVETSFRLLLLSANYIPDQCV FELSILVLTLLINLCMHTVPNRAALMQAAAPAEYVADNPPAQGSVSALQALLEYFYKC EELARLVEKNTDAFLESNEKGKKKQEEVEETVNNLVQRAGHHMEHTLKGSYAAILVGN LIADNELYESVVRRQLRGNSFKEIIGVLEKYHTFMNLTSSLEAAFVAHMKSTKRIIDN FKKRDYIYEHSDEHDNPLPLNLETTAQVLAVGADASHAATSSTTVGSGSAPSSTSATG TTRAPRVYKTYSSHR" misc_feature 977..>2080 /gene="wapl" /locus_tag="Dmel_CG3707" /gene_synonym="C204; CG3707; Dmel\CG3707; EG:87B1.2; l(1)2Dd; l(1)2Df; l(1)C204; l(1)N2; l(1)N5[72]; l74; N2; pasc; RNA D; RNAD; wap; Wapl; WAPL" /note="transcriptional regulator ICP4; Provisional; Region: PHA03307" /db_xref="CDD:223039" misc_feature 4226..5317 /gene="wapl" /locus_tag="Dmel_CG3707" /gene_synonym="C204; CG3707; Dmel\CG3707; EG:87B1.2; l(1)2Dd; l(1)2Df; l(1)C204; l(1)N2; l(1)N5[72]; l74; N2; pasc; RNA D; RNAD; wap; Wapl; WAPL" /note="Wings apart-like protein regulation of heterochromatin; Region: WAPL; pfam07814" /db_xref="CDD:462278" ORIGIN 1 aatcgttagc ccagctctaa aatagtgttt ctcttctctc gtgtagaaaa acagagaaat 61 taaacttttt cgcgcatttc gccattgcaa aaattgaaat tcgcgatcgc gttcgtttac 121 cctgcaaatt gcacaactac gcgctctcga ttggcgccga tttagcggag aatcgcgaaa 181 tcaaagaaat attcgcagca agaagaagaa cggaacggcc agtataatcg tattgttgtt 241 tgtgttggtg ttagttgtgt gtgtgtttgt gggtgttgtt gttgctgctg ctactgcttc 301 tgggatgatg ctgtaaagta aaagtggtgg caaaagcact aagcccgtgg tgcgacgcaa 361 aaaacacgct gcagttagcg gccaggcgga aaatgataag agtgatggtg gcttgagccc 421 cgagtaatcg ctaaaatatc gagcacacag ttcgtgcaaa tcaaattgcg ccaataagca 481 aaagcaaacg caaacatcgt ttgttttatt gcattccacg cacacacaca cctatatata 541 tgcacacgca cgcagtcgca tacatatgcg ctgcagcagc aacagagatt tttttatttg 601 accacactca ctcacacacg caaccacatg catccacgca gcaaacggat aacaacaaaa 661 acaaagagag cagccaaatg tttcgcctga gtgaccacat caccaaggat tagagtcagc 721 aacacggagt tagaggatac cagaagcagc aaaggaacca ccgctagcga agatgtcgcg 781 ctggggcaag aacatcgtgg tgccgctgga ctcactctgc aaggagaagg agaacaccaa 841 ccggcccact gtcgcccgtt ccgtgggcac cgttggcaag tggggcaaga tgggcttcac 901 ctccacgcgc acctacaccc tgcccgccat ccatcctatg gctgcggcag cggcggctgc 961 tgcagcagcc gccagtccct cccagagtcc cgcctccacg caggatcacg atcccaacga 1021 cctgtccgtt tcggttccgg agccgccgaa gccgaaaaag ttcttcaaat cgaggaatac 1081 agctccgccg gaggtcatag ctcagatcat tcagcagcta ccgcactgtg gagccggcgc 1141 atcacccatg cgagaccatt tctcgtcggc gggtgcgggt gctggtggtc tcacgcctac 1201 ttccggtgcc caggaggcgg gcggagtgaa gctgaagccg ggcaagggcg ccagttccgc 1261 agagcggaag cgcaaatcgc cgaaaaagaa ggcagcaaca acgtcagcct ccacgccctc 1321 gacgcctggt gcgttctacg gcgcctccga tcgagatggc gatgggctaa gcgatcccgc 1381 ctcagagcag ccggagcaac cgtccagtgc ctcgggcaag cagaagcaga agaagccgaa 1441 ggaggagaag aagctgaagc cagaggcgcc gccttcgcgg gtactgggac gcgcccgcaa 1501 ggctgtcaac taccgcgaag tggacgagga cgagcgctat cccacgccca ccaaggatct 1561 gatcattccc aaagcggggc gccaaccggc tgaagtggcg gctacggcaa cacttgccgc 1621 cgcttcgtcg gaagccttca tcagttccac gtttggcagc cctggatcgg agccgtcgtt 1681 acccccgcct acgtcagcgc caagtgcatc tgcgtccacc tcgtcccaac tgccctccgc 1741 atcaggcagc gcgtcaaatc ctcccagcgc ctcccgcacg ccagaacatc ctcctatcgt 1801 gctacgcatc tccaagggca cttcgcggtt ggtcagcacg gatagcgagg agccgccgag 1861 cagctcgccc gctcaccaga accaactgaa tcaactttcg gtcacggagg aggagccagc 1921 ggagcggtcc ggagacgaaa cagttcctgc aagtacgcca aaaatcacag tgaagccact 1981 gaggccgccc acagcagcag attccgtcga tggatcatct gcggcagttg gaggagcatc 2041 agcaggcgat tctttcgagg aacgcaagtc ccagtcacta gaacccaacg aggacgagga 2101 ggaggaagaa gaggaggagg acgaggagga ggaaccgccg gagatcaact actgcacggt 2161 aaagatatcc ccggacaaac cgccgaagga gcggctcaaa ctgatcatca agacggacgt 2221 gatccgcaac gccatcgcca aagccgcagc agcagccgag tcccgcagtg aaaagaagtc 2281 gaggagcaaa aagcacaagc acaagcagct gcttgccgcg ggatctggtg ccgctccagc 2341 ttctggagcc acccccgccg agatcaactc cgaattcaag acaccctcac ctcatttggc 2401 tctcagcgag gccaatagtc aacaagcaca gcatacacca tctcatctac atcaactgca 2461 ccagctgcat ccgcagcgag gctccgcggt catatcacca accactcgat ccgatcacga 2521 cttcgactcg cagtcctcgg tgctgggcag catctcctcg aagggcaaca gcacgccgca 2581 actgttagcg caggctgtgc aggaggatag ttgtgtgatt cgcagcaggg gatctagtgt 2641 gatcaccagt gatctagaga cgagtcagca ctcctcgctg gtggctcccc cctcggacat 2701 tgagtcacga ctggagtcca tgatgatgac catcgacgga gcgggaacgg gagcagcatc 2761 tgcagtgccg gagacaccac tgcaggagga catactggct gtgctgcgag gggaagtgcc 2821 acggctaaat ggcaatacgg acccggagcc aaccgaggag gaggatcaac agcaacagcc 2881 gaagagggcc acgcgtggca ggggcagaaa ggccaataac aatgtggatg taaccccacc 2941 cgccacggag accagaaccc gaggtagggc caaaggagca gatgcgacca cggctgccat 3001 atcgccacca acgggcaaaa gaaacacgcg gggcacccgg ggctccagaa aggccgagca 3061 ggaagtcgac atggaagtgg acgaaacggc gatgacgacg gtgccagcga acgaggaaca 3121 gctggaacag gccacacttc caccgaggag aggtcgcaat gctgctgccc gagccaataa 3181 caataatttg gcaagcgtta acaataacat taataaaata gccgccaatt tgtcagccaa 3241 ggccgaggcc agccgactag cagaaggcgg agtcgcgggt ggagcggcac gaagctatgg 3301 tcggaaacga aagaaccagc aggtaacgca ggtgctacag caggagccag tgcccgaaga 3361 gcaggaaact cctgatgctg aggaggagca gcccacaccc gccaagattc cgcacacaga 3421 tcacagggaa cattcgccag accatgatcc ggatcctgat ccggatgaac tgtcgaacaa 3481 ctcaaacaac tcctcgttgc agcacgatgg gtcctcctcc tcgcccccac cccgcgattt 3541 caagtttaag gataagttta agcgaacatt gacactggac acacagggcg cggcgaacgc 3601 cggagcggga ggagcagcag cggcggcgcc acctgagtcc tctggcgaac agcggggcgc 3661 tgtcaagctg gtcatctcaa agaagaaagg cagcatcttc aaaagccgcg ctctggtgcc 3721 atccgatcaa gcggaacagg ctacagtggc caagcgacat ctgtacaagc acagttggga 3781 tgctgcgcta gaagcgaatg gcggtggaac caacagcgat gccagcaatg cctcggcatc 3841 tggcgtgggc gtcgctgggg cgaaggatca tctgcatcat ttagcggcgg gcaagtccga 3901 tggtgatttc ggtgacagtc cgtcgtcgaa caacaatggc tcctccagtg cgtgcagcag 3961 cgcatccacg ttgcgcggcg atagcccggc cctcggaaag atctcgcgac tggcgggaaa 4021 acagggagta cctgccacct ccactagttc cgatgccttt gacctggatt tggaaccaat 4081 tgccggagag cttgacctag agcgtagtgc agctggtgct tccgctggtg gaacaggggc 4141 aacgacaggc ggaggtggag cgacgggcgg tggcggcccc gttcgggtcg accgcaaaac 4201 taaggactac tatccagtgg tgcgtaacgt taagacggcc catcaaattc aggagatcgg 4261 cgagtaccag gaaatggacg acgacgtcga gtacatcctg gacgcacttc agccgcacaa 4321 tcccccggca acacggtgtc tctccgccct tcagctagcc gccaagtgta tgatgcccgc 4381 cttccggatg cacgtgcgtg cccatggggt ggtcaccaaa tttttcaagg cattatccga 4441 cgccaacaag gacctcagcc taggcctgtg cacctcggcc atcatgtaca ttctttccca 4501 ggagggcctc aacatggacc tggatcgcga ctccttggag ctgatgatca accttctgga 4561 ggcggacggc gtgggtggca gcacggagac tgggcacccg gatagagcgg gctacgaccg 4621 caacaagcag aaggtgcgcg agttgtgcga ggagatcaag gcgcagggca agggaacgca 4681 tctcaacgtt gattctctga ctgtgggcac gctggcaatg gaaacgctgc tatcgctaac 4741 atccaagcgc gcgggcgagt ggtttaaaga ggatctgcgc aagctgggtg gcctggagca 4801 cattatcaag accatctcgg acttctgcag accggtgatt gcctgcgaca cggagattga 4861 ctggcagccg acgctgctgg ataacatgca aacggtggcg cgttgtctgc gagtcctcga 4921 aaacgtgacg cagcacaatg agacgaacca gcgctacatg ctcacctctg gccagggaaa 4981 agcagtggag acgctttgcc aactgtaccg tctttgcagc cgacaaataa tgctgcatcc 5041 ttcggatggt ggtggcagca acaaggagca tccgggtgtg gctatgcgcg agctgctggt 5101 gccggtgctc aaggtactga tcaacctgac gcacacgttc aacgaggcgc agccatcgtt 5161 gggagccgag ctgctaggtc aaaggggcga tgtggtggag acgagcttcc gattgctgct 5221 gctctcggcc aactacattc ccgaccaatg tgtctttgag ctaagcatac tggttcttac 5281 actgctaatc aatttgtgca tgcatactgt gcccaaccgg gctgctctaa tgcaagctgc 5341 cgctccggca gagtacgtag cggataatcc accagcgcag ggatctgtga gtgcactgca 5401 agctctgctt gagtacttct acaagtgcga ggagctggct agattggtgg aaaagaacac 5461 ggacgccttc ctcgagagca acgagaaggg aaagaagaaa caagaagaag tggaggagac 5521 agtcaacaat cttgtgcaac gagccggcca ccacatggag cacacgctaa agggaagtta 5581 tgcggccatc ctggtgggaa atctgatagc ggacaacgag ttgtacgagt cggtggtgcg 5641 ccgccagctg cgaggaaata gctttaagga gattattgga gtgctggaga agtaccacac 5701 attcatgaac cttacatcca gcttggaggc agcctttgtg gcgcatatga agtccacgaa 5761 gcgcatcatc gacaacttta agaagcgcga ctacatctac gagcactcgg atgagcacga 5821 caaccccctg cctctgaatc tggaaacgac ggcgcaagtc ttggccgtgg gagcggacgc 5881 gtcgcatgct gctacaagct cgaccacggt cggctctggc tccgcaccct catccacatc 5941 ggccacagga acgacgaggg cgccgcgggt ctataaaacg tacagcagcc acaggtaatc 6001 ggacctggga tctgaatcgg aatcgaagag ccatcgcaat tgtcgttaac cacaccgaaa 6061 gcctgccacc aaaataaaat tctgttgttt gtgattatgt aatttgttta tgtgttgata 6121 taacaatcac tacatgtatg tgtatagcct gtaatgcacc tagtttcagt cagctatata 6181 tatatagata tatatatata tagaagtata tagctaagag cgataggata caatgcgatc 6241 tgtttttgcg tttgtattaa cccaaagtga tagcgaattc ctgagcatgg tctgcgtttt 6301 aactaaagaa aatgattaag attgacgaaa cgaaagcgac accccgaaca acacaaagat 6361 ccaaatcccc actaatatga gtacgttata tagtcataag caatattagc agctaaatgt 6421 cggcttaccc tcgaaagcac acacccatgt aaatattctt taatcagcga ttttatcgga 6481 cgcgtcttag gtttatttcg aatgtgtttt ttttttacct attcatactt tatatattaa 6541 accttttttt tattgattgt aaaacaagcg ctcttagcaa aaacgctgca gcagaaagag 6601 cgagagcgat agacatgtgt aaagagagag ttagagagga aaattctaga ttagatgtgg 6661 gaaataaagt tattttattg cctaaacgta agctaaagaa actctactta taaaactaac 6721 actgataaat aaatatatat atgtatatgg atatatgtgt acgtttacaa ccactaaaaa 6781 tgtcattttt aggctacaaa agtcagattt aaaaagcaag cgcgcgtgca agaaagaaac 6841 aatttcggga acaaaatata tatatttatt ttgtgttttc aacgagtaca taatatattg 6901 ttcttgcgga aaaaacaaac agaattaaaa ctaaaattg