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Drosophila melanogaster polyhomeotic proximal (ph-p), transcript


LOCUS       NM_001297874            6048 bp    mRNA    linear   INV 26-DEC-2023
            variant D, mRNA.
ACCESSION   NM_001297874
VERSION     NM_001297874.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6048)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6048)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6048)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6048)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6048)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6048)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6048)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6048)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6048)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6048)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6048)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6048)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6048)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6048)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6048)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6048)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6048)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6048)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6048)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6048)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6048)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6048)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6048)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6048
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6048
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="polyhomeotic proximal"
                     /map="2D2-2D3"
                     /db_xref="FLYBASE:FBgn0004861"
                     /db_xref="GeneID:31181"
     CDS             1409..5449
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="CG18412 gene product from transcript CG18412-RD;
                     CG18412-PD; ph-p-PD; polyhomeotic; polyhomeotic proxima;
                     Polyhomeotic-proximal; polyhomeotic proximal; ph-proximal"
                     /codon_start=1
                     /product="polyhomeotic proximal, isoform D"
                     /protein_id="NP_001284803.1"
                     /db_xref="FLYBASE:FBpp0311667"
                     /db_xref="GeneID:31181"
                     /db_xref="FLYBASE:FBgn0004861"
                     /translation="MEVQQQLQLQQQLSEANGGGAASAGAGGAASPANSQQSQQQQHS
                     TAISTMSPMQLAAATGGVGGDWTQGRTVQLMQPSTSFLYPQMIVSGNLLHPGGLGQQP
                     IQVITAGKPFQGNGPQMLTTTTQNAKQMIGGQAGFAGGNYATCIPTNHNQSPQTVLFS
                     PMNVISPQQQQNLLQSMAAAAQQQQLTQQQQQFNQQQQQQLTQQQQQLTAALAKVGVD
                     AQGKLAQKVVQKVTTTSSAVQAATGPGSTGSTQTQQVQQVQQQQQQTTQTTQQCVQVS
                     QSTLPVGVGGQSVQTAQLLNAGQAQQMQIPWFLQNAAGLQPFGPNQIILRNQPDGTQG
                     MFIQQQPATQTLQTQQNQIIQCNVTQTPTKARTQLDALAPKQQQQQQQVGTTNQTQQQ
                     QLAVATAQLQQQQQQLTAAALQRPGAPVMPHNGTQVRPASSVSTQTAQNQSLLKAKMR
                     NKQQPVRPALATLKTEIGQVAGQNKVVGHLTTVQQQQQATNLQQVVNAAGNKMVVMST
                     TGTPITLQNGQTLHAATAAGVDKQQQQLQLFQKQQILQQQQMLQQQIAAIQMQQQQAA
                     VQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQAQQQQREQQQQVAQAQAQHQQALA
                     NATQQILQVAPNQFITSHQQQQQQQLHNQLIQQQLQQQAQAQVQAQVQAQAQQQQQQR
                     EQQQNIIQQIVVQQSGATSQQTSQQQQHHQSGQLQLSSVPFSVSSSTTPAGIATSSAL
                     QAALSASGAIFQTAKPGTCSSSSPTSSVVTITNQSSTPLVTSSTVASIQQAQTQSAQV
                     HQHQQLISATIAGGTQQQPQGPPSLTPTTNPILAMTSMMNATVGHLSTAPPVTVSVTS
                     TAVTSSPGQLVLLSTASSGGGGSIPATPTKETPSKGPTATLVPIGSPKTPVSGKDTCT
                     TPKSSTPATVSASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPPSST
                     TPNSVSGKEEPKLATCGSLTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGT
                     FITSCTSTTTTTTSSISNGSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRYAD
                     KDVSDEPPKKKATMQEDIKLSGIASAPGSDMVACEQCGKMEHKAKLKRKRYCSPGCSR
                     QAKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQTEATPKLSESFPIL
                     GASTEVPPMSLPVQAAISAPSPLAMPLGSPLSVALPTLAPLSVVTSGAAPKSSEVNGT
                     DRPPISSWSVDDVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKEKHLVNAMGMKLGP
                     ALKIVAKVESIKEVPPPGEAKDPGAQ"
     misc_feature    3722..>4375
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     misc_feature    5201..5407
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="SAM domain of Ph (polyhomeotic) proteins of
                     Polycomb group; Region: SAM_Ph1,2,3; cd09577"
                     /db_xref="CDD:188976"
     misc_feature    order(5255..5260,5360..5365,5372..5377,5384..5386)
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="oligomer interface EH [polypeptide binding]; other
                     site"
                     /db_xref="CDD:188976"
     misc_feature    order(5288..5302,5306..5311,5318..5323,5333..5335,
                     5348..5350)
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="oligomer interface ML [polypeptide binding]; other
                     site"
                     /db_xref="CDD:188976"
ORIGIN      
        1 cggcgaagga ggaggtcaca actaatagaa aaaaagctcc gaaaaaacaa gcatacacac
       61 acatcgaatg agaacaacca aagcaaggca gagagcgaga gagagagagc aaaagcactt
      121 aaaaagccta aaaataatat ggcggcagca aaaaagaaaa ggaaacgaga cgagacaagc
      181 caacaaaaag ctaatcggaa tgaaaacatt tgtggggctc agcgacgttg ttgttggatg
      241 aggtgggaag agtaagaaga agaccaacaa gagcccaaag caacgcacac atactacaaa
      301 tggtgcatgc acacacgcac gggctggcac aaaatgaaaa atgaaatgac aaagacaggc
      361 acagtgggtc atgagtggtg gatatttgaa acattaataa acttaaaact taataaatca
      421 actcaatacg tatgtctatt atataattct attttactaa acgttttcat tttacttatc
      481 gtaacattgt ttatatgtat aaaaagtttg gaaaaattgc tgttctaaaa aattgaccca
      541 ctgtactctt ggttctcaaa ctgcaactgt aaagcaatcc aataataatg gatcgcttac
      601 cactgttcaa tggggtggag agaataagat ttcgctctgc ctctgcgcat acgctatcct
      661 ccccttctca accgacacac ccgtgtgtta ctgacaagca caactaataa taagagcgga
      721 cacagaaagc gatacgacca cacccgtgag caccacagca tcccagggga tttcagcatc
      781 agcgattcta gcaggaggca ctcttccctt gaaggacaac tcgaacatcc gcgagaagcc
      841 cctccaccat aactacaacc acaataacaa caacagctcc cagcactcac actcgcacca
      901 gcagcagcaa caacagcagg tgggtggcaa gcagctcgag cggccactaa agtgcctgga
      961 aacgctcgcc cagaaggcgg gaatcacctt cgacgagaaa tacgatgtgg ccagcccccc
     1021 gcatcccggc attgcccagc agcaggcgac ttcaggaaca ggcccagcaa cgggatcagg
     1081 ctcagtcacc cccacaagcc atcggcacgg aactccgccc acgggccgca ggcaaaccca
     1141 caccccaagc actccgaaca ggcccagtgc tcccagcaca cccaacacta actgcaactc
     1201 aattgcccgc cacaccagcc tcacgctgga gaaggcgcag aatcccggcc agcaggtggc
     1261 cgccaccacc acggtgccac tgcagatatc ccctgagcag ctgcagcagt tctatgcgag
     1321 caatccctac gccattcagg tgaagcaaga gtttcccacg cacacgacca gtggcagtgg
     1381 aactgaacta aagcatgcaa ccaacattat ggaagttcag cagcagttgc agctgcagca
     1441 gcagctgtcg gaagccaacg gtggaggagc agcctcggcc ggagccggag gagcagctag
     1501 tccggccaac tcgcagcaaa gccagcaaca gcagcactcc acagccatca gcaccatgtc
     1561 gccgatgcaa ttggcagcgg ccactggagg agttggcggg gattggacac agggaaggac
     1621 ggtgcagcta atgcaaccct ccaccagttt cctgtatccc caaatgattg tgtcgggaaa
     1681 tctgttgcat ccaggaggcc tcggtcagca gccaatccag gtgatcaccg ccggcaagcc
     1741 attccaaggc aacggccccc agatgcttac caccacgact caaaacgcca agcaaatgat
     1801 cggtggccaa gcgggattcg ctggcggaaa ttacgcgacc tgcattccca caaaccacaa
     1861 tcaatcgccc cagacggtgc tcttctcacc gatgaacgtc atttcgccac agcagcaaca
     1921 gaacctgctg caatcaatgg ccgctgcagc tcagcagcag caactcaccc aacagcagca
     1981 acagtttaac cagcagcaac aacagcagct tactcagcag caacagcagt tgacagctgc
     2041 tctggccaag gtgggagtgg atgcgcaggg caagctggcc cagaaagtgg ttcagaaagt
     2101 gactaccacc agtagcgcgg tccaggcggc gacgggtcct ggatctactg ggtcaacaca
     2161 gacccagcag gtgcagcagg ttcagcaaca gcagcagcag accacccaaa ccactcagca
     2221 gtgcgtgcag gtttcacagt cgactttgcc agtcggtgtg ggtggacagt ctgttcagac
     2281 tgcccaactt ctgaacgctg gccaagcgca acaaatgcag attccctggt tcttacagaa
     2341 tgctgcagga ctgcagccgt ttgggccaaa ccagatcatc ctgcgaaacc agccagacgg
     2401 aacccaaggc atgttcattc aacagcaacc ggcgacgcag actttgcaga cccagcaaaa
     2461 ccagattatt caatgcaacg tgacgcagac gcccactaag gcacgcactc aactggatgc
     2521 acttgctccc aagcagcaac agcagcagca gcaggttggc actaccaacc agacgcagca
     2581 gcagcaacta gcggtggcta ctgcccagtt gcagcaacag cagcagcaac tcactgcagc
     2641 agctctgcag cgaccaggag cccctgtcat gccccacaat ggaactcaag tgcgtccggc
     2701 cagttccgta tccacacaga ctgcccagaa ccagagcctg ctgaaggcca aaatgcgcaa
     2761 caagcagcag ccggtgcgcc ccgctttagc cacattgaaa accgaaatcg gtcaagtcgc
     2821 aggacaaaat aaggtagtag gccacctgac caccgtgcag cagcagcaac aggcgacgaa
     2881 tctccagcag gtggttaatg cggcgggcaa caaaatggtt gtgatgagca caacgggcac
     2941 tccgatcacc ctgcagaatg gacagaccct tcatgcagcc actgcggcag gagtcgacaa
     3001 gcagcaacag cagctacaac tgtttcagaa acagcaaatc ctgcaacaac aacaaatgtt
     3061 gcaacagcag attgctgcca ttcaaatgca gcagcagcaa gcggctgttc aggcccagca
     3121 acaacagcag caacaggtct ctcagcagca gcaggttaac gcccagcaac agcaagcggt
     3181 ggcgcaacaa caacaggcag tcgcgcaggc tcagcaacag cagagggagc aacagcagca
     3241 agttgcccaa gcccaggcgc agcatcaaca ggctctcgcg aatgccactc agcaaatcct
     3301 tcaggtggcg ccaaatcaat tcatcacgtc ccaccagcaa cagcagcagc agcaacttca
     3361 caaccaactg atacagcagc agctacagca acaggcgcag gcacaagttc aagcccaagt
     3421 gcaggctcaa gcgcaacagc aacaacagca gcgagagcag cagcagaata ttatccagca
     3481 gattgtggtg caacagtctg gagcgacttc tcaacagact tcccagcagc aacagcacca
     3541 ccaatccggg caactacagc taagtagcgt gcccttctca gtttcttcgt caacgacgcc
     3601 agccggaata gctacctcta gtgctctgca ggcagccctc tccgcctctg gcgccatctt
     3661 tcagacagct aagccgggta cttgcagttc ctcctccccc acaagcagtg tggtcacaat
     3721 taccaaccag agcagcactc ctttggtcac cagcagtacg gtggccagta tacagcaggc
     3781 tcagacgcaa tctgctcagg tccaccaaca tcagcagcta atcagcgcca caattgccgg
     3841 agggactcaa caacagccac agggaccgcc atcacttaca cccaccacaa atccaatttt
     3901 ggccatgacc tcgatgatga atgctacagt gggtcacctt tccactgctc cgcctgtaac
     3961 tgtttctgtg acaagcaccg ctgttacttc gtcgccgggt cagctggttc tcttaagcac
     4021 ggctagtagc ggtggaggag gtagcatacc agccacgccc accaaagaga caccttcgaa
     4081 agggcccacc gcaaccctgg tgcccattgg ttcgcccaag actcctgtat caggaaagga
     4141 cacctgcact acccccaaat catctactcc tgccactgtc agcgcatccg tagaggccag
     4201 tagttccaca ggcgaagccc tgtccaatgg agatgcctca gataggtctt ccacgccgtc
     4261 aaagggcgct accactccca ccagcaagca aagcaatgca gcagtgcagc caccgagtag
     4321 caccactccc aacagtgtca gtgggaaaga agagccgaag ctggcaacct gcggcagttt
     4381 aacgtccgca acatcaactt caaccacgac aacgatcacc aatgggattg gagtagccag
     4441 aacgacagcc agcacggctg tctcaaccgc tagcacaacc actaccagtt ctggcacctt
     4501 tatcacaagt tgcaccagca caaccacaac caccacgtcg agtatcagta atggatcgaa
     4561 ggatctcccc aaggcgatga ttaagccgaa cgtcttaact cacgtcatcg atggcttcat
     4621 catccaggag gccaacgagc catttcccgt caccagacag cgatatgcag acaaagacgt
     4681 cagcgatgag ccgccaaaga aaaaggcaac catgcaggag gacatcaagc taagtggaat
     4741 agcatcagct ccaggctcgg atatggttgc ttgcgagcag tgtggaaaga tggagcacaa
     4801 agcaaagctg aaacggaagc gctactgttc gccaggatgc tcgaggcagg caaagaacgg
     4861 catcggtgga gttggatcag gagagacgaa cggcctgggg acaggtggta tagttggggt
     4921 ggacgccatg gcattggtgg acaggctgga tgaagccatg gctgaggaga agatgcagac
     4981 agaggccacc ccaaagcttt cagaatcgtt tcctattttg ggagcctcaa cagaagtacc
     5041 tccaatgtca ctgccagtcc aagcggcgat ttctgcgccc tcgcctcttg caatgcctct
     5101 aggatcgcca ttgtcagttg cacttccaac tcttgcacca ctgtctgtag tcacttctgg
     5161 cgcggcgccc aagtcttcgg aagtgaatgg aacagatcgt ccgccaatca gcagctggag
     5221 tgtggacgat gtcagcaact tcattcgaga actgcctggt tgtcaggact acgtggacga
     5281 ctttatacag caggagatcg acggccaagc gcttctgttg ctcaaggaga agcatttggt
     5341 gaacgctatg ggcatgaagc tgggtccagc tcttaaaatt gtggccaagg tggagtccat
     5401 taaggaggtc ccgccacctg gcgaggccaa ggatccagga gcgcagtagg gcagctagag
     5461 cacgaaaagc cgaaaaagat gatctcctaa ccgagcagtg gacctggttc aaccaagtct
     5521 gtcgtgccag gtgattctga ttcaatcggg caggcgaaaa ggacgcgaat ccatttgcaa
     5581 aatattatta gcatcaggcc atcaggtctt aaacccattg actttgtaca tactcccaag
     5641 atcacttata agcatattca tttataaatt aaactaacag tcaacagtca aaaacgaatg
     5701 gaattactta aactaaggaa aagctatgaa ttaattgcca gccaagtaaa tgaataaagt
     5761 acattttata aataagcata agtttatagt ctaagtagca tattaataac tcccaacgtc
     5821 atggatagtt tgtacaagta ttttaatctt aggaatcaaa tgtagcacta tgattgttct
     5881 aacaactaag aattttaagc ctatgaataa taattgatat ctaaatgtga atttgaactt
     5941 tttactaaat aatatttgaa tgcctagacc taagcttttt tttcaagatt ttttttttgc
     6001 aattgctgaa gaaattaaaa tggcactgaa tagtgtttaa taaatgtg