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Drosophila melanogaster polyhomeotic proximal (ph-p), transcript


LOCUS       NM_001297873            5695 bp    mRNA    linear   INV 26-DEC-2023
            variant C, mRNA.
ACCESSION   NM_001297873
VERSION     NM_001297873.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5695)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5695)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5695)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5695)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5695)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5695)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5695)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5695)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5695)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5695)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5695)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5695)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5695)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5695)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5695)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5695)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5695)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5695)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5695)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5695)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5695)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5695)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5695)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5695
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5695
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="polyhomeotic proximal"
                     /map="2D2-2D3"
                     /db_xref="FLYBASE:FBgn0004861"
                     /db_xref="GeneID:31181"
     CDS             1056..5096
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="CG18412 gene product from transcript CG18412-RC;
                     CG18412-PC; ph-p-PC; polyhomeotic; polyhomeotic proxima;
                     Polyhomeotic-proximal; polyhomeotic proximal; ph-proximal"
                     /codon_start=1
                     /product="polyhomeotic proximal, isoform C"
                     /protein_id="NP_001284802.1"
                     /db_xref="FLYBASE:FBpp0310186"
                     /db_xref="GeneID:31181"
                     /db_xref="FLYBASE:FBgn0004861"
                     /translation="MEVQQQLQLQQQLSEANGGGAASAGAGGAASPANSQQSQQQQHS
                     TAISTMSPMQLAAATGGVGGDWTQGRTVQLMQPSTSFLYPQMIVSGNLLHPGGLGQQP
                     IQVITAGKPFQGNGPQMLTTTTQNAKQMIGGQAGFAGGNYATCIPTNHNQSPQTVLFS
                     PMNVISPQQQQNLLQSMAAAAQQQQLTQQQQQFNQQQQQQLTQQQQQLTAALAKVGVD
                     AQGKLAQKVVQKVTTTSSAVQAATGPGSTGSTQTQQVQQVQQQQQQTTQTTQQCVQVS
                     QSTLPVGVGGQSVQTAQLLNAGQAQQMQIPWFLQNAAGLQPFGPNQIILRNQPDGTQG
                     MFIQQQPATQTLQTQQNQIIQCNVTQTPTKARTQLDALAPKQQQQQQQVGTTNQTQQQ
                     QLAVATAQLQQQQQQLTAAALQRPGAPVMPHNGTQVRPASSVSTQTAQNQSLLKAKMR
                     NKQQPVRPALATLKTEIGQVAGQNKVVGHLTTVQQQQQATNLQQVVNAAGNKMVVMST
                     TGTPITLQNGQTLHAATAAGVDKQQQQLQLFQKQQILQQQQMLQQQIAAIQMQQQQAA
                     VQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQAQQQQREQQQQVAQAQAQHQQALA
                     NATQQILQVAPNQFITSHQQQQQQQLHNQLIQQQLQQQAQAQVQAQVQAQAQQQQQQR
                     EQQQNIIQQIVVQQSGATSQQTSQQQQHHQSGQLQLSSVPFSVSSSTTPAGIATSSAL
                     QAALSASGAIFQTAKPGTCSSSSPTSSVVTITNQSSTPLVTSSTVASIQQAQTQSAQV
                     HQHQQLISATIAGGTQQQPQGPPSLTPTTNPILAMTSMMNATVGHLSTAPPVTVSVTS
                     TAVTSSPGQLVLLSTASSGGGGSIPATPTKETPSKGPTATLVPIGSPKTPVSGKDTCT
                     TPKSSTPATVSASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPPSST
                     TPNSVSGKEEPKLATCGSLTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGT
                     FITSCTSTTTTTTSSISNGSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRYAD
                     KDVSDEPPKKKATMQEDIKLSGIASAPGSDMVACEQCGKMEHKAKLKRKRYCSPGCSR
                     QAKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQTEATPKLSESFPIL
                     GASTEVPPMSLPVQAAISAPSPLAMPLGSPLSVALPTLAPLSVVTSGAAPKSSEVNGT
                     DRPPISSWSVDDVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKEKHLVNAMGMKLGP
                     ALKIVAKVESIKEVPPPGEAKDPGAQ"
     misc_feature    3369..>4022
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     misc_feature    4848..5054
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="SAM domain of Ph (polyhomeotic) proteins of
                     Polycomb group; Region: SAM_Ph1,2,3; cd09577"
                     /db_xref="CDD:188976"
     misc_feature    order(4902..4907,5007..5012,5019..5024,5031..5033)
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="oligomer interface EH [polypeptide binding]; other
                     site"
                     /db_xref="CDD:188976"
     misc_feature    order(4935..4949,4953..4958,4965..4970,4980..4982,
                     4995..4997)
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="oligomer interface ML [polypeptide binding]; other
                     site"
                     /db_xref="CDD:188976"
ORIGIN      
        1 cgtcgctggc gacgtaggca gtgcagttaa aacaagtact tagtgctgtg actgtggctt
       61 aattttatgt aagatcgcgt gcacaggtgc ttagtcgtta cactgagaaa aagaaaagtg
      121 cctgcagcca gcggggagaa gttgaagtgg agtgactgtg agtggagcaa aaagagaaga
      181 aactgaggac taaaaagaaa gcgccatgcc gactataaca aaaacaacca cgagtgtctc
      241 cgccgccgcc gaaaacaaaa acaaaacgcc taagccgacg catgcatacc tataatttat
      301 tataaatatt gtttttattt tgaataatgg atcgtcgtgc attgaagttt atgcaaaaaa
      361 gagcggacac agaaagcgat acgaccacac ccgtgagcac cacagcatcc caggggattt
      421 cagcatcagc gattctagca ggaggcactc ttcccttgaa ggacaactcg aacatccgcg
      481 agaagcccct ccaccataac tacaaccaca ataacaacaa cagctcccag cactcacact
      541 cgcaccagca gcagcaacaa cagcaggtgg gtggcaagca gctcgagcgg ccactaaagt
      601 gcctggaaac gctcgcccag aaggcgggaa tcaccttcga cgagaaatac gatgtggcca
      661 gccccccgca tcccggcatt gcccagcagc aggcgacttc aggaacaggc ccagcaacgg
      721 gatcaggctc agtcaccccc acaagccatc ggcacggaac tccgcccacg ggccgcaggc
      781 aaacccacac cccaagcact ccgaacaggc ccagtgctcc cagcacaccc aacactaact
      841 gcaactcaat tgcccgccac accagcctca cgctggagaa ggcgcagaat cccggccagc
      901 aggtggccgc caccaccacg gtgccactgc agatatcccc tgagcagctg cagcagttct
      961 atgcgagcaa tccctacgcc attcaggtga agcaagagtt tcccacgcac acgaccagtg
     1021 gcagtggaac tgaactaaag catgcaacca acattatgga agttcagcag cagttgcagc
     1081 tgcagcagca gctgtcggaa gccaacggtg gaggagcagc ctcggccgga gccggaggag
     1141 cagctagtcc ggccaactcg cagcaaagcc agcaacagca gcactccaca gccatcagca
     1201 ccatgtcgcc gatgcaattg gcagcggcca ctggaggagt tggcggggat tggacacagg
     1261 gaaggacggt gcagctaatg caaccctcca ccagtttcct gtatccccaa atgattgtgt
     1321 cgggaaatct gttgcatcca ggaggcctcg gtcagcagcc aatccaggtg atcaccgccg
     1381 gcaagccatt ccaaggcaac ggcccccaga tgcttaccac cacgactcaa aacgccaagc
     1441 aaatgatcgg tggccaagcg ggattcgctg gcggaaatta cgcgacctgc attcccacaa
     1501 accacaatca atcgccccag acggtgctct tctcaccgat gaacgtcatt tcgccacagc
     1561 agcaacagaa cctgctgcaa tcaatggccg ctgcagctca gcagcagcaa ctcacccaac
     1621 agcagcaaca gtttaaccag cagcaacaac agcagcttac tcagcagcaa cagcagttga
     1681 cagctgctct ggccaaggtg ggagtggatg cgcagggcaa gctggcccag aaagtggttc
     1741 agaaagtgac taccaccagt agcgcggtcc aggcggcgac gggtcctgga tctactgggt
     1801 caacacagac ccagcaggtg cagcaggttc agcaacagca gcagcagacc acccaaacca
     1861 ctcagcagtg cgtgcaggtt tcacagtcga ctttgccagt cggtgtgggt ggacagtctg
     1921 ttcagactgc ccaacttctg aacgctggcc aagcgcaaca aatgcagatt ccctggttct
     1981 tacagaatgc tgcaggactg cagccgtttg ggccaaacca gatcatcctg cgaaaccagc
     2041 cagacggaac ccaaggcatg ttcattcaac agcaaccggc gacgcagact ttgcagaccc
     2101 agcaaaacca gattattcaa tgcaacgtga cgcagacgcc cactaaggca cgcactcaac
     2161 tggatgcact tgctcccaag cagcaacagc agcagcagca ggttggcact accaaccaga
     2221 cgcagcagca gcaactagcg gtggctactg cccagttgca gcaacagcag cagcaactca
     2281 ctgcagcagc tctgcagcga ccaggagccc ctgtcatgcc ccacaatgga actcaagtgc
     2341 gtccggccag ttccgtatcc acacagactg cccagaacca gagcctgctg aaggccaaaa
     2401 tgcgcaacaa gcagcagccg gtgcgccccg ctttagccac attgaaaacc gaaatcggtc
     2461 aagtcgcagg acaaaataag gtagtaggcc acctgaccac cgtgcagcag cagcaacagg
     2521 cgacgaatct ccagcaggtg gttaatgcgg cgggcaacaa aatggttgtg atgagcacaa
     2581 cgggcactcc gatcaccctg cagaatggac agacccttca tgcagccact gcggcaggag
     2641 tcgacaagca gcaacagcag ctacaactgt ttcagaaaca gcaaatcctg caacaacaac
     2701 aaatgttgca acagcagatt gctgccattc aaatgcagca gcagcaagcg gctgttcagg
     2761 cccagcaaca acagcagcaa caggtctctc agcagcagca ggttaacgcc cagcaacagc
     2821 aagcggtggc gcaacaacaa caggcagtcg cgcaggctca gcaacagcag agggagcaac
     2881 agcagcaagt tgcccaagcc caggcgcagc atcaacaggc tctcgcgaat gccactcagc
     2941 aaatccttca ggtggcgcca aatcaattca tcacgtccca ccagcaacag cagcagcagc
     3001 aacttcacaa ccaactgata cagcagcagc tacagcaaca ggcgcaggca caagttcaag
     3061 cccaagtgca ggctcaagcg caacagcaac aacagcagcg agagcagcag cagaatatta
     3121 tccagcagat tgtggtgcaa cagtctggag cgacttctca acagacttcc cagcagcaac
     3181 agcaccacca atccgggcaa ctacagctaa gtagcgtgcc cttctcagtt tcttcgtcaa
     3241 cgacgccagc cggaatagct acctctagtg ctctgcaggc agccctctcc gcctctggcg
     3301 ccatctttca gacagctaag ccgggtactt gcagttcctc ctcccccaca agcagtgtgg
     3361 tcacaattac caaccagagc agcactcctt tggtcaccag cagtacggtg gccagtatac
     3421 agcaggctca gacgcaatct gctcaggtcc accaacatca gcagctaatc agcgccacaa
     3481 ttgccggagg gactcaacaa cagccacagg gaccgccatc acttacaccc accacaaatc
     3541 caattttggc catgacctcg atgatgaatg ctacagtggg tcacctttcc actgctccgc
     3601 ctgtaactgt ttctgtgaca agcaccgctg ttacttcgtc gccgggtcag ctggttctct
     3661 taagcacggc tagtagcggt ggaggaggta gcataccagc cacgcccacc aaagagacac
     3721 cttcgaaagg gcccaccgca accctggtgc ccattggttc gcccaagact cctgtatcag
     3781 gaaaggacac ctgcactacc cccaaatcat ctactcctgc cactgtcagc gcatccgtag
     3841 aggccagtag ttccacaggc gaagccctgt ccaatggaga tgcctcagat aggtcttcca
     3901 cgccgtcaaa gggcgctacc actcccacca gcaagcaaag caatgcagca gtgcagccac
     3961 cgagtagcac cactcccaac agtgtcagtg ggaaagaaga gccgaagctg gcaacctgcg
     4021 gcagtttaac gtccgcaaca tcaacttcaa ccacgacaac gatcaccaat gggattggag
     4081 tagccagaac gacagccagc acggctgtct caaccgctag cacaaccact accagttctg
     4141 gcacctttat cacaagttgc accagcacaa ccacaaccac cacgtcgagt atcagtaatg
     4201 gatcgaagga tctccccaag gcgatgatta agccgaacgt cttaactcac gtcatcgatg
     4261 gcttcatcat ccaggaggcc aacgagccat ttcccgtcac cagacagcga tatgcagaca
     4321 aagacgtcag cgatgagccg ccaaagaaaa aggcaaccat gcaggaggac atcaagctaa
     4381 gtggaatagc atcagctcca ggctcggata tggttgcttg cgagcagtgt ggaaagatgg
     4441 agcacaaagc aaagctgaaa cggaagcgct actgttcgcc aggatgctcg aggcaggcaa
     4501 agaacggcat cggtggagtt ggatcaggag agacgaacgg cctggggaca ggtggtatag
     4561 ttggggtgga cgccatggca ttggtggaca ggctggatga agccatggct gaggagaaga
     4621 tgcagacaga ggccacccca aagctttcag aatcgtttcc tattttggga gcctcaacag
     4681 aagtacctcc aatgtcactg ccagtccaag cggcgatttc tgcgccctcg cctcttgcaa
     4741 tgcctctagg atcgccattg tcagttgcac ttccaactct tgcaccactg tctgtagtca
     4801 cttctggcgc ggcgcccaag tcttcggaag tgaatggaac agatcgtccg ccaatcagca
     4861 gctggagtgt ggacgatgtc agcaacttca ttcgagaact gcctggttgt caggactacg
     4921 tggacgactt tatacagcag gagatcgacg gccaagcgct tctgttgctc aaggagaagc
     4981 atttggtgaa cgctatgggc atgaagctgg gtccagctct taaaattgtg gccaaggtgg
     5041 agtccattaa ggaggtcccg ccacctggcg aggccaagga tccaggagcg cagtagggca
     5101 gctagagcac gaaaagccga aaaagatgat ctcctaaccg agcagtggac ctggttcaac
     5161 caagtctgtc gtgccaggtg attctgattc aatcgggcag gcgaaaagga cgcgaatcca
     5221 tttgcaaaat attattagca tcaggccatc aggtcttaaa cccattgact ttgtacatac
     5281 tcccaagatc acttataagc atattcattt ataaattaaa ctaacagtca acagtcaaaa
     5341 acgaatggaa ttacttaaac taaggaaaag ctatgaatta attgccagcc aagtaaatga
     5401 ataaagtaca ttttataaat aagcataagt ttatagtcta agtagcatat taataactcc
     5461 caacgtcatg gatagtttgt acaagtattt taatcttagg aatcaaatgt agcactatga
     5521 ttgttctaac aactaagaat tttaagccta tgaataataa ttgatatcta aatgtgaatt
     5581 tgaacttttt actaaataat atttgaatgc ctagacctaa gctttttttt caagattttt
     5641 tttttgcaat tgctgaagaa attaaaatgg cactgaatag tgtttaataa atgtg