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Drosophila melanogaster enhanced adult sensory threshold (east),


LOCUS       NM_001297869            7954 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant G, mRNA.
ACCESSION   NM_001297869
VERSION     NM_001297869.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7954)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7954)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7954)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7954)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7954)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7954)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7954)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7954)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7954)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7954)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7954)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7954)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7954)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7954)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7954)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7954)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7954)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7954)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7954)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7954)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 7954)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7954)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 7954)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7954
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7954
                     /gene="east"
                     /locus_tag="Dmel_CG4399"
                     /gene_synonym="anon-WO03040301.224; CG4399; Dmel\CG4399;
                     East; EAST; EG:133E12.4; l(1)G0014; l(1)G0500; su(w[sp])"
                     /note="enhanced adult sensory threshold"
                     /map="2C2-2C4"
                     /db_xref="FLYBASE:FBgn0261954"
                     /db_xref="GeneID:46006"
     CDS             846..7766
                     /gene="east"
                     /locus_tag="Dmel_CG4399"
                     /gene_synonym="anon-WO03040301.224; CG4399; Dmel\CG4399;
                     East; EAST; EG:133E12.4; l(1)G0014; l(1)G0500; su(w[sp])"
                     /note="CG4399 gene product from transcript CG4399-RG;
                     CG4399-PG; east-PG; enhanced adult salt tolerance;
                     suppressor of white-spotted"
                     /codon_start=1
                     /product="enhanced adult sensory threshold, isoform G"
                     /protein_id="NP_001284798.1"
                     /db_xref="FLYBASE:FBpp0310126"
                     /db_xref="GeneID:46006"
                     /db_xref="FLYBASE:FBgn0261954"
                     /translation="MSSRKVPGGSGGADESTAAAAPLDDNANASVEIPDSSEEPAMGV
                     GEEMSIISKTRTSTLSVEPAKEPTVTAELEGEKELESNPVSKTPRSTPTPTLTPAVTP
                     TASDGVAAKSVRVTRHSSPLLLIISPTTSRREVGDGELDTEEPTGSGGQRKSSVERSL
                     APVIRGRKSIKDLKEAKEVKSEEPPAAASESRAASGVTPGQVKEQHVADGNEMESLPI
                     TDKKDHKDTKDKGDERETDQEEEKEKSADTEIIADTEKTSEKQKYTEKDKAADKDGGK
                     EKDIDANKDIDKEKEKVKEVLPPVVPIAPVTPTCNRVTRKSHAQEQAINTRVTRNRRQ
                     SSTVGANSTASLVAASSSVTEQPPPSRGRRKKPVVVAPPLEPAVKRKRSQDVEADSDA
                     NNSTKYSKVEVVKSEEAEAPEEDSSAVPIKQESVDGNEVSSISPTVTPTPTPAPTPAP
                     VPGSRRGRGRPQNRNSSSPATTTRATRLSKAGSPVILTPVAQEPAPPKRRRVGSSTRK
                     TVSASSLAPSSQGGAGDEDSKDSMASSMDDLLMAAADIKQEKLTPDFDDSLMPEGLPS
                     TSGASSANGHSCTEPLTVDTEINVKPADSKVKPKESPVVAVEESPSQSETQSAKVSAH
                     AGKAPSLSPDMISEGVSAVSVRKFYKKPEFLENNLGIEKDPELGEIVQTVSNNDTETD
                     VEMAVDGEVNQPSTPKSQDKKKEEQEKNQKSGLKAAKKAPAKLEPKAEDISEILTDVP
                     VDISTEAVEIIEEAEEDTCSNSSIKPGELRLDESNDEPELLLEDALIVNGDENETPDQ
                     PEEKEDQVEFFHTGEYDDFEHEIMVELAKEGVLDASGNALSQQKVELEHPEDVTLHES
                     KNDIEAEESVERKPLKDPSVADEMEDMNEESYIDIKDQTNQLLVEHLAEEAMEADCGP
                     EDNKENLSTSASSTAADGLDIQLAIKEDDDEEKPLAVIADEQKPGLLLTNDMKVDEKP
                     NGKQESVCDEHVQLVPNLRQEQEIHLQNLGLLTHQAAEHRRKCLLEAQARQAQMQLQQ
                     HHHHQHKRQGARGGGSATHVESSGTLKTVIKLNRSSNGGVSGSGGLPTGTVIHGGCGS
                     SSASSTSSSSVGSATRKSSGTLGSGAGAGAGVRRQSLKMTFQKGRARGHGAADRSADQ
                     YGAHAEDSYYTIQNENEDSSHSESQGQTDHGFYQMVKKDEKEKILIPEKASSFKFHPG
                     RLCEDQCYYCSGKFGLYDTPCHVGQIKSVERQQKILAISLSFADEEKLTVDNCLCDAC
                     FRHVDRRANVPSYKKRLSASGHLEMGSAAGSALEKQFAGDSGVITESGGEAGSTAAVA
                     VQQRSCGVKDCVEAARHSLRRKCIRKRVKKYQLSLEIPAGSSNVGLCEAHYNTVIQFS
                     GCVLCKRRLGKNHMYNITTDTIRLEKALSEMGIPVQLGMGTAVCKLCRYFANLLIKPP
                     DSTKAQKAEFVKNYRKRLLKVHNLQDGSHELSEADEEEAPNATETERPTSDGHEDPEM
                     PMVADYDGPTDSNSSSSSTAALDTSKQMSKLQAILQQNVGADAAGAAGTGTVAASPGG
                     SGSGADISNVLRGNPNISMRELFHGEEELGVQFKVPFGCSSSQRTPEGWTRVQTFLQY
                     DEPTRRLWEELQKPYGNQSSFLRHLILLEKYYRNGDLVLAPHASSNATVYTETVRQRL
                     NSFDHGHCGGLNIAGSPSSSGSGKRSGVPQPTGASVLATALTTPLTSHSSSSASISSE
                     QHSSVDPVIPLVDLNDDDEGEDGAGGAGERESTNRQQDVILECLRTASVDKLTKQLSS
                     NAVTIIARPKDKSQLSCNSGSSTSISSSSSAISSPEEVAVTKVTAVAPVQSKDAPPLA
                     PASSGVSNSRSILKTNLLGMNKAVELVPLTTAPHAYKPTGCHKPEKQQKILDVANKQP
                     GSQGEPVPSSALLGLQSKLKPPTHQQQVSGSGAGTSGSQKPSNVAQLLSSPPELISLH
                     RRQTSGAAAGSSSFLQGKRLQLPRSGAGPSGAGTGTGAGAAGSRSAGGPPPPNVVILP
                     DALTPQERHESKSWKPTLIPLEDQHKVPNKSHALYQTADGRRLPALVQVQSGGKPYLI
                     SIFDYNRMCILRREKLMRDQLLKSNAKPKPQNQQQQQGQTHQQQQNSAASAAAFSNMV
                     KLAQQHTARQQLQQLQQKPQQQQQLPTLQPGGVRLARLPQKLLMPPLTNPQIGSQAPN
                     LQPLLSSTLDNSNNCWLWKNFPDPNQYLLNGNGGGAGSSSSKLPHLTAKPATATSSSG
                     AANKSAGSLFTLKQQQHQQKLIDNAIMSKIPKSLTVIPQQMGGNTGGDMGGSSSSGKD
                     "
ORIGIN      
        1 attctctttc acttcctttt cgcctgcttt gttgctgtcg tcgctgtgac agttatgcta
       61 gttgttagtg tgcgtgtcgt gtccgtgtga gttttccgcg tttcttcgcc ggtgcgaact
      121 gcaatctgaa atctcgcact cgcgctaaaa tggcgcatgt cagaatcgaa attaaaatca
      181 taagccaaaa gctactctga tcgtcaggcc acgaagaagc ggagaaagaa gatgaagaag
      241 gaggaccagc aagcggcaac agcagaagca ggatacctaa ccaatttgag gattattcaa
      301 catctcatcg actcttcagc ttctcttctc agccttgccc agttgctgct tcttccgact
      361 ctgctcttct ctcctctaca cgccactcgt ctcctctgct cttttctcgt tttgctttcc
      421 tcgcattctc gcagctccca gctgctgcca aaacttgttt tcagcagcga tagaaaagag
      481 gggcaatgga gctggacagt ggctggcaag gagaagaggg ggtttctgga aaccgcaaaa
      541 gcatgtttaa tgttctagtc gcgttactgg actccgaatc ggaatcgagt gaacggatcg
      601 gatcggattg tcctggggat tgaatgagct aaaaggggct aagagagcgg cttactttcg
      661 gccagatatt cttcacatca cagtcaacca atgggaccaa atcactgcga ctcgaactgg
      721 acacaatcag catcggatcg cagggaacaa caggaggtgg tggagcagca gcgccagaag
      781 gcgtcggggg agcggccatc ataggagcag caacgtcggc agcagctgcc cagggcccct
      841 cgagaatgtc tagccggaag gtgccaggag gctctggagg agctgacgaa tccacagcag
      901 cagctgcccc cctggatgat aatgccaatg ccagtgtgga gattccagac agcagcgagg
      961 agccagcaat gggcgtcggc gaagagatgt ctatcataag caaaacacgc acctcaactt
     1021 tgtcagtgga gcccgctaag gagccaacag taacagcaga gctggaaggc gaaaaagagc
     1081 tggaatcgaa tccagtctcc aaaactccta ggtccacgcc tacgccaacc cttacgccag
     1141 ccgtcacgcc taccgccagt gatggagtgg cggccaagag cgtgagggtt acccggcact
     1201 cgtcgccact gcttctgatc atctcgccca cgacaagtag acgtgaggtc ggcgacggag
     1261 agctagacac cgaggaacca acgggatcgg gtggccaaag aaagagctcc gtggagcgat
     1321 ctttggcgcc cgttatacgc ggacgaaagt ccatcaagga tctgaaagaa gccaaagaag
     1381 tcaagtccga ggagccgcct gccgcagcat cagagtcacg agctgcaagt ggagtgacgc
     1441 ctggccaggt caaggaacag catgtcgcgg atggcaacga aatggaatcc ttgccaatca
     1501 cagacaagaa agaccacaaa gacacaaaag acaagggaga tgagcgggaa accgatcagg
     1561 aggaagagaa ggaaaaatca gctgatacag aaataattgc agatacagaa aaaacttcgg
     1621 agaaacaaaa gtatacagag aaggacaaag ctgccgataa agatggagga aaagaaaaag
     1681 atattgatgc aaataaggat atagataagg agaaggaaaa ggtcaaggaa gtacttccgc
     1741 cagtggtgcc tatagcacca gtgacaccca cttgtaaccg tgtcacacgt aaatcacatg
     1801 cccaggagca ggcgattaac acgcgggtca ctcgcaatcg tcgccagtcc tctacagttg
     1861 gagccaactc caccgcgtct ttggtagctg catcctcctc agtaacagag caaccccctc
     1921 catctcgcgg tcgacggaag aagccagtgg tggtggctcc tcccttggag cctgcggtaa
     1981 aacggaagcg atcgcaagat gttgaagccg actcagacgc caacaacagc acgaaataca
     2041 gcaaggtgga agtggtaaag tctgaggaag ctgaggcacc agaggaggac tccagtgccg
     2101 tgcccattaa gcaggaatct gttgatggca acgaggtcag ttctatttct ccaacagtca
     2161 cgcccacacc cacacctgcg ccaacaccag ctccagtccc gggcagtcga cggggtcgtg
     2221 ggcgcccgca gaacaggaac tcctcttcgc ctgcaaccac aacgcgggca acgcggctaa
     2281 gcaaggcggg atcaccggtt atcctgacgc cagtagccca ggaaccggcg ccaccgaaac
     2341 ggcggcgagt cggctccagc acacggaaga ctgtctcggc cagctcgctg gcacccagct
     2401 cgcagggcgg cgccggggat gaggactcca aggacagtat ggcctcgtcc atggacgacc
     2461 tgctgatggc cgcagcagat atcaagcagg agaagctgac gcccgatttc gacgatagtt
     2521 tgatgccaga aggcctgccc tctacttctg gtgcgtcgag tgccaatggt cattcctgca
     2581 ccgaaccgct tactgtggac acggaaatta atgttaagcc cgctgattcc aaagtaaaac
     2641 caaaggagtc accggtggta gcagtcgagg aatctccatc acaatccgaa acgcaatctg
     2701 caaaggtgtc agcgcatgcg gggaaggctc catctcttag tccagatatg ataagtgaag
     2761 gcgtgagcgc ggtcagtgtt cgaaagtttt ataagaagcc tgagttcctg gaaaacaatc
     2821 tgggcattga aaaggatccg gagctaggtg aaatcgttca gacggttagt aacaatgaca
     2881 cggaaacaga tgtggagatg gctgttgatg gcgaggtgaa tcaaccgtca actcccaagt
     2941 cgcaggataa aaagaaagag gagcaggaaa agaatcagaa atcagggcta aaggcagcaa
     3001 agaaggctcc tgctaagtta gaacctaaag ctgaagacat ttctgaaatt cttactgacg
     3061 ttcctgttga tatttcgact gaggcagtag aaattataga agaagcagag gaagacactt
     3121 gttcaaatag ctcaatcaaa ccaggtgagc tccgactgga cgagagcaac gatgaacctg
     3181 aactgcttct tgaagacgcc ctcatagtca atggtgatga gaatgagaca ccagatcaac
     3241 cggaggaaaa ggaggaccag gtggagttct tccatacagg agaatacgac gactttgagc
     3301 acgagattat ggtggagctg gcgaaggagg gggtgctaga tgccagcggc aatgcattaa
     3361 gtcagcaaaa ggtagaactt gagcatcccg aggatgtaac tctacacgaa tcaaaaaatg
     3421 acatagaagc cgaagaatcg gttgaacgta agcctcttaa ggacccgtcg gttgcggacg
     3481 aaatggagga catgaatgag gaatcctata ttgacattaa ggaccagaca aatcaactgt
     3541 tagttgaaca cttggcagaa gaggccatgg aagcggactg cggtcccgag gataacaagg
     3601 agaacttgtc cacgtctgct tcgagcaccg ctgccgatgg tctagatatt cagttggcca
     3661 tcaaggagga tgacgacgag gagaaaccgc ttgcagttat cgctgacgaa cagaagcctg
     3721 ggctgctgtt gaccaatgac atgaaagtgg atgagaaacc aaatggcaag caggaatcgg
     3781 tctgtgatga gcacgttcag ctggtgccaa accttcgtca agaacaggaa attcacttac
     3841 aaaatctggg cctactcacg caccaggccg ctgaacatag gcgcaagtgt ctgcttgagg
     3901 cacaggcccg ccaggcgcaa atgcagctcc agcaacatca ccaccatcag cacaagcgac
     3961 aaggagcgcg cggaggaggc agtgccactc atgtggaatc cagcggtact ttgaagacag
     4021 tcatcaagct gaacaggagc agcaacggag gagtaagcgg tagtggcggc ctgcctactg
     4081 gtacagttat ccatggaggc tgtggctcct cttcagcttc ttccacgtcc tcctcctcgg
     4141 tgggcagtgc cacacgtaag tcaagcggga ccttgggctc aggagcggga gcaggagctg
     4201 gcgttcgccg gcagtcgctt aagatgacat tccagaaggg tcgggctcgt ggtcacggtg
     4261 ctgcggatcg atccgccgat cagtatggcg cccacgccga ggactcctac tacaccattc
     4321 aaaacgagaa cgaagattcg tcccactcgg aaagtcaggg acagacggac cacggcttct
     4381 atcagatggt caaaaaggac gaaaaggaga agatcctcat tccggaaaag gcctcctcgt
     4441 ttaagtttca cccagggaga ctgtgcgaag accagtgcta ctactgtagc ggaaagtttg
     4501 gcctctatga caccccctgc catgttggac aaataaagtc cgtggagcgc cagcagaaga
     4561 tcctagccat ttccttatca tttgcagacg aggagaagct caccgtggat aactgcttgt
     4621 gcgacgcatg ttttcgacac gtggaccgcc gggcaaatgt gccatcctat aagaagcgtc
     4681 tttccgcttc aggtcacttg gagatggggt ctgcagcggg atctgcacta gagaaacagt
     4741 ttgctggcga cagcggcgtc attacggaat cgggtggcga agctggttct acggcagctg
     4801 tggccgtgca gcaacgatct tgtggcgtga aggactgcgt cgaagcggca cgacactcgc
     4861 tgcggcgcaa gtgcatacgc aagagagtaa agaagtatca gctcagcctg gagattcccg
     4921 caggctcgtc gaacgtgggg ctgtgtgagg cacattacaa tacggtcatc caattttccg
     4981 gctgcgttct ttgcaagcgt agattaggca agaaccatat gtacaacata accacggaca
     5041 caattcgact ggaaaaggcg ctgtccgaga tgggcatccc agttcagctt ggcatgggca
     5101 ctgcagtctg caagctgtgt cgctattttg ccaacctttt gataaagcca ccggatagca
     5161 ccaaggcaca aaaggcggaa ttcgtgaaga actacagaaa gaggctcctc aaggtgcata
     5221 atctgcagga tggcagtcat gagctgtccg aagcggatga agaagaggca cctaatgcaa
     5281 cggagacaga aaggccaacc tcagacggac acgaagatcc cgagatgccc atggtagcgg
     5341 actatgatgg acctaccgac tccaattcca gtagttcttc gactgcagcc ctggacacca
     5401 gcaaacaaat gtccaagctt caggccatcc tgcagcaaaa tgtgggagcg gatgcggcag
     5461 gagctgcggg aacaggaact gttgcagcaa gtcccggagg aagcggatct ggggcagata
     5521 tctctaacgt attgcgaggg aatccgaaca tttccatgcg cgaacttttc cacggcgagg
     5581 aagagctggg tgtgcagttc aaggtgccgt tcggatgcag cagcagccag cgtactccgg
     5641 agggctggac acgagtgcag actttcctac aatacgatga gccgacgcgc cgcctctggg
     5701 aggagttgca aaagccgtac ggaaatcaga gctcatttct gcgccacttg atactattag
     5761 agaagtacta ccgaaacgga gatctcgtcc tagcaccgca tgcttcctcc aatgccacgg
     5821 tttacacaga gactgttcgt cagcggctga attcgtttga tcacggtcac tgcggtggat
     5881 tgaacatcgc aggcagccct tcttcttcgg gttccggcaa gcgcagtgga gttcctcaac
     5941 ctacgggtgc cagtgtgctg gccaccgccc tcacaacacc cttgacaagc cattcatcct
     6001 cctctgcatc catttcctcc gaacagcatt cgtcggttga tcctgtcatt ccgctggtag
     6061 acctcaatga tgacgatgaa ggcgaagatg gggcaggagg agcgggcgaa agggagtcga
     6121 caaataggca gcaggacgta atcttggaat gccttagaac tgcctctgtg gacaagctga
     6181 ctaagcagct cagctcgaat gcggtgacga ttatcgcccg gcccaaagac aaatcgcagc
     6241 tctcctgcaa cagcggatcc tccacgtcca tttccagctc ctcgtccgct atttcctcgc
     6301 cggaggaagt ggccgtcact aaggttacag cagtcgcacc agtccagtcc aaggatgcac
     6361 cgccactggc gccagcaagt agcggtgtta gcaacagtcg tagtatcctt aaaaccaacc
     6421 tcttgggcat gaacaaggcc gtggaactcg tgcccttaac gactgccccc cacgcttaca
     6481 agccaactgg atgccataag cctgagaaac agcaaaagat tcttgacgtg gccaataagc
     6541 agcccggtag ccagggggaa ccggtaccat caagcgcctt gcttggcctg cagtcaaagc
     6601 taaagcctcc aacgcatcag cagcaggtca gcggatcagg agcgggaact agtggttctc
     6661 agaagccatc taatgtggcg caattgctta gctctccacc ggagctaatc agcttgcatc
     6721 gacggcagac cagcggagca gcagcggggt ccagcagctt ccttcagggc aagaggcttc
     6781 aacttccacg atctggagca gggccttcag gagcgggaac gggaacaggc gctggagcag
     6841 caggaagccg cagtgcgggt ggaccaccac cgcccaatgt ggtcatactg ccggacgcct
     6901 taacccccca ggagcgacac gagagcaaga gctggaagcc aacgctgata ccgctggagg
     6961 atcagcacaa ggtgccgaac aaatcacatg ctctttatca gaccgccgac ggtcgaaggt
     7021 tgcccgccct ggtgcaagtg cagtctggtg gcaagccata cctcatctct atcttcgact
     7081 ataaccgcat gtgcatcttg cgaagggaaa agctgatgcg ggaccagttg ctcaagagta
     7141 acgccaagcc aaagccgcag aaccagcaac agcagcaggg ccaaacgcac cagcagcagc
     7201 agaattccgc cgcatcggcg gctgccttct ccaacatggt gaagttggcc cagcaacaca
     7261 cggcgcgaca gcagcttcag cagctgcaac agaagccaca acagcagcaa caattgccca
     7321 ctttgcagcc aggtggggtg cgacttgccc ggctgccgca aaaactactg atgccaccac
     7381 tgactaatcc gcagattggc agtcaagcac ccaacttaca gccgttgctg tctagtacgc
     7441 tggataacag caacaactgc tggctgtgga aaaactttcc tgatcccaat cagtatctgc
     7501 taaatggaaa cggagggggt gccgggagct cctccagcaa gttgccacat ctcacggcca
     7561 aaccagccac ggcaactagt agctccggag cggccaacaa atcagcagga agcctattta
     7621 ccctcaagca gcagcagcac cagcagaaac tcatcgacaa cgctatcatg tcaaagatac
     7681 ccaaaagtct gacagtaata ccgcagcaga tgggtggtaa taccggtggc gatatggggg
     7741 gcagcagctc ctccggcaag gactgatgac ggcgaaggag ggcgccatgg ccattagccg
     7801 tagcgccgga ggtaacccgg cgaagtagta ggatcaacaa gcaggcgacg tgcagcttaa
     7861 gcggcgatct tcagaacaag aggtgaccag cggcggctcc atggatatca caaactccac
     7921 aattccatgg ctgcagtaga ataagtgata cact