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Drosophila melanogaster adenosine deaminase acting on RNA,


LOCUS       NM_001297862            6823 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant N (Adar), mRNA.
ACCESSION   NM_001297862
VERSION     NM_001297862.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6823)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6823)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6823)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6823)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6823)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6823)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6823)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6823)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6823)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6823)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6823)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6823)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6823)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6823)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6823)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6823)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6823)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6823)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6823)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6823)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6823)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6823)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6823)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6823
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6823
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="Adenosine deaminase acting on RNA"
                     /map="2B9-2B9"
                     /db_xref="FLYBASE:FBgn0026086"
                     /db_xref="GeneID:31130"
     CDS             503..2512
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /EC_number="3.5.4.37"
                     /EC_number="3.5.4.4"
                     /note="CG12598 gene product from transcript CG12598-RN;
                     CG12598-PN; Adar-PN; hypoxia, anoxia, sensitive 2;
                     adenosine deaminase acting on rna; hypnos-2; adenosine
                     deaminases acting on RNA"
                     /codon_start=1
                     /product="adenosine deaminase acting on RNA, isoform N"
                     /protein_id="NP_001284791.1"
                     /db_xref="FLYBASE:FBpp0308381"
                     /db_xref="GeneID:31130"
                     /db_xref="FLYBASE:FBgn0026086"
                     /translation="MLNSANNNSPQHPVSAPSDINMNGYNRKLPQKRGYEMPKYSDPK
                     KKMCKERIPQPKNTVAMLNELRHGLIYKLESQTGPVHAPLFTISVEVDGQKYLGQGRS
                     KKVARIEAAATALRSFIQFKDGAVLSPLKPAGNLDFTSDEHLENGIENLSSSKMFEII
                     QTMLTEKLSNPTSLEQPTFCMSQNVSKSAITVDGQKKVPDKGPVMLLYELFNDVNFEC
                     INIDGAQNNCRFKMTVTINEKKFDGTGPSKKTAKNAAAKAALASLCNISYSPMVVPQK
                     NVPLPIDDKSSSMELPQIHADTIGRLVLEKFMEVIKGQEAYSRRKVLAGIVMTENMNF
                     CEAKVISVSTGTKCVSGEHMSVNGAVLNDSHAEIVSRRCLLKYLYAQLDLQCNQATAY
                     QSIFVRNTDGQYPYKLKSGVHFHLYINTAPCGDARIFSPHENDTGVDKHPNRKARGQL
                     RTKIESGEGTIPVKSSDGIQTWDGVLQGQRLLTMSCSDKIARWNIVGIQGSLLSSIIE
                     PVYLHSIVLGSLLHPEHMYRAVCGRIEKSIQGLPPPYHLNKPRLALVTSAEPRNQAKA
                     PNFGINWTIGDTELEVVNSLTGRTIGGQVSRITKQAFFVKYGFLMANLPGILVRKVTT
                     DYGQTKANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEFGLAE"
     misc_feature    668..856
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="first double-stranded RNA binding motif of STRBP,
                     ILF3, RED1, RED2 and similar proteins; Region:
                     DSRM_STRBP_RED-like_rpt1; cd19865"
                     /db_xref="CDD:380694"
     misc_feature    order(668..670,677..682,689..694,698..700,740..745,
                     749..751,755..757,806..814,821..823)
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380694"
     misc_feature    1103..>1243
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="double-stranded RNA binding motif (DSRM)
                     superfamily; Region: DSRM_SF; cl00054"
                     /db_xref="CDD:444671"
     misc_feature    1382..2497
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="tRNA-specific and double-stranded RNA adenosine
                     deaminase (RNA-specific editase); Region: ADEAMc;
                     smart00552"
                     /db_xref="CDD:214718"
ORIGIN      
        1 tattgtgata actgctcaca tcgctagatt ccgagcaaca aaaaagcgac gaagggtcat
       61 tgttattttt tctaatgcaa tgtaatgcag caaatgtgca gatttgaaca agtgtaacgc
      121 gatttatgtt taatccgcat cgaggaacca aatcgaagta aacgcgcggc cagagaaaag
      181 agcagcaccg caccgaagat aaaacaaaca agcattgatt tgtttgtccg gccatgtcag
      241 tgtgtgtgtc acaagggctt gcaagtgtgt gcgtgtgtcc gtgcgtgtac gtgggtgctt
      301 ttttttttct cccgagtgcc gccaagtgaa atatgcaatt gcacgccact gcagttgcag
      361 ccacacaaat cctatcctaa tcgacgaaac agcgaagcga ggaggctaga atcggctgcc
      421 caacgaagag agcagaaccg ttaacaaatg acactctgcc gatacagcga agtaaaaatc
      481 aataattaga gcaaaaagag tcatgttaaa cagcgctaat aacaattctc cccagcaccc
      541 ggtgagtgca ccatccgata tcaacatgaa tggctataac cgaaaattgc cacaaaaacg
      601 tggctatgag atgccaaaat actctgatcc aaaaaagaaa atgtgcaagg agcgcattcc
      661 ccagccgaag aacacggtgg ccatgctgaa tgagctaaga catggactga tttacaaatt
      721 ggagtcacag actggtccgg tacacgcacc tctattcacg atatccgtgg aggtcgatgg
      781 acagaaatac ttgggccagg gccgtagtaa aaaagttgca cgcatcgaag cagcagcaac
      841 tgcactgcgc agctttatac agtttaagga tggagcagtt ctgtcgcctc tgaagccggc
      901 gggcaacttg gactttacca gcgatgaaca tcttgaaaat ggtattgaaa atttgtccag
      961 ttcaaaaatg tttgagatca ttcagacgat gttgactgaa aagctatcca accctacctc
     1021 gcttgaacaa cccacgtttt gcatgagtca gaatgtcagc aaaagtgcta ttactgttga
     1081 cggtcagaag aaggttccag ataagggtcc tgtcatgctc ctctacgaat tatttaatga
     1141 cgttaatttc gaatgcatta atattgacgg cgcccagaac aattgtcgct tcaaaatgac
     1201 cgtcacaatc aacgaaaaga agttcgatgg aacaggtcct tccaaaaaga cggcgaaaaa
     1261 tgcggcagct aaggcggcac ttgcttcgtt atgcaatatt tcctacagtc caatggtggt
     1321 gccacagaag aacgtacccc tgccaatcga cgacaagtcg tcatcgatgg agttgcctca
     1381 gatacacgcg gatacgattg gtcggttggt cttagaaaag ttcatggaag taatcaaggg
     1441 ccaggaggct tactcgcgtc gaaaggtatt agcgggcatt gtaatgactg aaaacatgaa
     1501 tttttgtgaa gccaaagtta tttcagtttc gacgggcacc aagtgtgtca gcggtgagca
     1561 tatgagtgtg aacggagctg tcctaaatga ttcccatgct gaaatagtct ccaggcgttg
     1621 tcttctcaaa tatttatatg cacagctgga ccttcagtgc aatcaggcca cagcatatca
     1681 gtcgattttc gtgaggaata ctgatgggca atacccttat aaactaaaat ccggggtaca
     1741 tttccatttg tatataaata cagcaccttg tggggatgca cggatattta gtcctcacga
     1801 aaacgacact ggtgttgata aacatccaaa tagaaaagct cgtggccagc tgcgcaccaa
     1861 aatcgagtcc ggtgagggga cgattccagt gaaaagcagt gatggtatcc agacgtggga
     1921 tggcgtattg cagggccaac gcctgctaac aatgtcgtgc tcggataaaa ttgcccgttg
     1981 gaacatcgtg ggcatccaag gctcactatt gtcttccata attgaaccgg tgtacctgca
     2041 ttcgattgtg ctgggaagcc tgttgcatcc ggagcacatg taccgcgcag tttgcggccg
     2101 aattgagaag tccattcaag gcctgccacc gccgtaccat ctgaacaagc cgcgcctggc
     2161 actagtcact tcggccgagc cgcggaatca ggccaaggct cccaacttcg ggatcaattg
     2221 gaccattggg gacaccgagc tggaagtggt gaactcgcta accggtcgaa ccattggcgg
     2281 ccaggtgtct cgcatcacaa agcaggcgtt tttcgttaag tatggatttc taatggcaaa
     2341 cttgcccggt attttagtcc gcaaagtaac cactgactat gggcaaacca aagctaacgt
     2401 taaggactat cagatcgcaa agctagaatt gttctctgca ttcaagcgag aagaccttgg
     2461 cagctggctg aagaaaccca ttgaacaaga cgagttcggt cttgccgaat gactgcactc
     2521 agcactatta tataatttta aaaaagacaa cagcaacggc aagcaattaa tagaattaga
     2581 cgacatagat tttatgacaa attctgatat agaatgcaaa ttatattggg tgcaagcaca
     2641 tcgctatgat ataccacttc atatgattga caacctgcca actttgcgta cccattgcaa
     2701 tagcaagcac aaagatgctt atgctcgaaa tataaagaac agctctagaa tatttataga
     2761 atagaatgta gtttttatgc tggaactgag taaaggagta ttatggcgtt tttttttgaa
     2821 tcaattcatt tttaaattgg ctaaagcaat ttctttatca tttaagtttg tgacttgttt
     2881 tgttatttga atgaatgcga tgcgttgcga tgtcgtcgta accacactgt cgaaactttc
     2941 aagtgagttg tgtctttcgt tttccgtatt ttatatggta aatatggtaa tatggaatgt
     3001 tacgaaacag ttaaaagata tatataaaac caaaaaccaa caagtacact caatgaataa
     3061 caataatcca aacagaaatc tagaattcgt tctcttatcg attaagcaat gtattttgtt
     3121 aagtaatgtt atttgcaacg acataataat tataataata ataaagtcac gcttaatata
     3181 agcataagaa cattttaggt gaatctgcgt taatttcgcg tacttttctt cagatcagat
     3241 ataaacctaa gctttaatcg attttcaatg aataaaactg tgttcttggt tgaaaaacat
     3301 tatatctatg taacaacatt ttatcaatta aattacgtag atttctttgc atattagttg
     3361 atacaaatca catgcaagcg aaagcagata agaataaaaa tacatatatt agttaccaat
     3421 tttgtagcat gctgataaag gcatttgaac tacctaacta agtcttatca tgaagcttgt
     3481 atcgctattt cgtatattgt agaaatacat actatattag ttgtggttac ttgtacatca
     3541 taataccttc tcttaaattt acttccgccc tgagttcttc cggttgttcg ttcaatttga
     3601 aatgacaatt gttaatggtc aaatcaataa ctactcttcc aacgtcgatt gacgtattcc
     3661 aatttaaaac aaggcgattt ggctcctctt ttattgtgta cttgaaaatg ctacgacgaa
     3721 tgatctagtc aaatgtggta acctaataaa gccatagtct cctaccattc agttatgtga
     3781 aataaatatt acgtcgaagt tgcatagaaa acgaaaatga aaaggactgc atgacattag
     3841 agcagcacag catattttgt tgcagttgca gtttgtccga atcgtcttaa tctcactcac
     3901 gacctcgaaa aggtttgagt accgacttct tgcgatataa tttttcattt aaagccgtaa
     3961 aatttcttta agtactaaaa ttcaaccgct taattcgtcc aatgccgttt ataattaaca
     4021 agctacttcg aagtttaatt tcctttgact ttctcacagt ccacttaatg atacttttag
     4081 tagtaattta catgattgct tcgcaacttg tatccttcac taccgagtga acctgatggg
     4141 ctgattgtgt tttaaaaatg aaaaagaatt aattgttaac tttttcagca cggcacgaag
     4201 taggcaattg agttttaagc tattgaattt ggaagcgtag cttatgggaa atttgctgat
     4261 gctgaataca aatataatag gaaaaccatc agggcttttt aaatgtgaaa ttatatttta
     4321 agtggagagg acattattta taattttcaa tagtggtatt cttcaaatta cgtcgatagc
     4381 aaaaatttaa ttatagattt cctttaagtt caaagtgata catgtacacc attttttttc
     4441 ctgcgcatgc taaaaatata ttggcatatt atttgtgaaa aagaaaaaaa aacttgcgag
     4501 tttttctcca ttacttgatt aaataataat atgacgatat aattgactta agtaatattt
     4561 gcaaaaatac cgcgtatgat ggataaacca aagttgatct tatataaaat actgtgatac
     4621 taaattttac tagtacttcc agcatagctg cattttatcc attcttaaat attctatgat
     4681 aagcagcagc agataataat caatgactat ataggaaaac aaaaattttt aaatggcatg
     4741 caccatgctt gtctacatta gattttcaaa taagaaattt tacaaactag attaatacgt
     4801 atggaatggt gggtataaca ttgggactcc tcaaatatca tttttaattg caaaataaaa
     4861 caataggctc tcgaatgcag cgtacacagg aaaacttcag tcaactaatt tctattgcga
     4921 aaagatacac taaattaaac cctataaaac gtaggctagt cgtcaagtcg gtatattcaa
     4981 gaaccagcta ataaacgttc aacacgtatt agaataccta gctaagaaca cacaatgata
     5041 actatgagaa ttttttaaat atacttagtt ggaagaagat cagacatata caatagtatg
     5101 ctagtcgagt cctctactct tgttatggaa tggttttaac cattcaccta ctaagttggt
     5161 ttgcctatcg gttcgcattc acattatttc ataatataat tgaaaccagt ttgggaataa
     5221 atagaaatag acatagacat agtaaatatc acagtttgaa atggatattg tacttggaag
     5281 ttggaagttg gacttacatg aataagtata caaaacaaaa ggttgctcaa attgcaaaac
     5341 acttggaaag tatttctaca tcttccaaac aaaaagcagt cctcagaaac acacttagat
     5401 gctatagaac tataaaacat gccgggtttt actatatatc ccgctaaacc agtgataaga
     5461 agccgcgttc tagaccaaac ccatatacca actaccatat agcatgaaga cactaatcaa
     5521 gctgcataca tatgtacgag ctaaaggcag caatccaaca cagattatat taccacttgc
     5581 aattgtatta atagttagaa catttgatgt tttgggagtt caaggactgt atgcaatcaa
     5641 ttatctaaga cacaacatgc taaacatatt gcagatccgg caggatgcca agattgaatc
     5701 tgttttacgt gctcctgaga tcaagaatca ttcattactg acattctggg ctaaacgcgt
     5761 tagaaaaaga gaccaaaaaa acaatcataa tttgggctta tctactaggc attgcttaca
     5821 catatttcac taagtttacg aaacggatat taaactacca aagaaataaa cagtataatc
     5881 gtggtaaatt tacatttaca ttacatcgag ccaaaaacac cttattacaa aacatcaaat
     5941 attttttgat tccaccgaaa cttgcaattt tgatggaaaa gtgggtttgg gaatttagca
     6001 atgcggacat ccaaatatag atggcttttc tttagtttac gaacaagccc gtatttacca
     6061 ggaaatcaat atatgcataa cttaatatat agaaatacac acttatacgt aaaactttgt
     6121 tcttgaaaaa gattagtgca tatatccaaa agatttaagc aaataataaa cacttaatat
     6181 ctaaatacac agaacaaact ttaataagaa ctaggtttac acttcctaca cttaaacttc
     6241 gcttgtccac gtttcaagaa attcgcttgg ataacgaatc aataaaattc caaaatagta
     6301 acagtctagt ctgcgaatta caaattctat ttgcaattta agaaatattc ttttaaacac
     6361 taaaacactg aatacttgca agaacgtaga aatcaattgc atgcatccaa aattgctcgt
     6421 ttagttataa aagaaatccg tatgtaccag gaattctgta tatgcgtggc ttaatacata
     6481 taaaatacat acacacttat acgtaaagct ttgttcaaaa cttgatcaaa atttagtgca
     6541 aatagccagg cgattcaaat ggaataatag cgagcaagaa agagcattgt taacagctac
     6601 cataaacatt taagtcggca aaaaccaatg tatcaataac ttaaactttt aaaatagatt
     6661 ttacgatggc ctttttgttt tataatcgac tgtcagccaa taaaatgatc cccacgtcat
     6721 tgaagacgaa acttaaaccc tataagccta tgaatattta cacaatcgtt cggtctccaa
     6781 ctaatgtaaa tgaaatttaa taaattacca ataatatata gag