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Drosophila melanogaster frizzled 3 (fz3), transcript variant C,


LOCUS       NM_001297831            3250 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001297831
VERSION     NM_001297831.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3250)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3250)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3250)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3250)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3250)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3250)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3250)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3250)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3250)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3250)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3250)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3250)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3250)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3250)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3250)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3250)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3250)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3250)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3250)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3250)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3250)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3250)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3250)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3250
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3250
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="frizzled 3"
                     /map="1C4-1C4"
                     /db_xref="FLYBASE:FBgn0027343"
                     /db_xref="GeneID:31023"
     CDS             285..2030
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="CG16785 gene product from transcript CG16785-RC;
                     CG16785-PC; fz3-PC; Dfrizzled-3; dFrizzled3; frizzled 3;
                     frizzled3"
                     /codon_start=1
                     /product="frizzled 3, isoform C"
                     /protein_id="NP_001284760.1"
                     /db_xref="FLYBASE:FBpp0311620"
                     /db_xref="GeneID:31023"
                     /db_xref="FLYBASE:FBgn0027343"
                     /translation="MYAASILILHLTWAVATIAANGAGHNGPVASGAGPNGLQCQPIA
                     VSACQGLGYNMTALPNLAGHTNQLEAELQIAKLVPLIESGCSRRARFLLCSSLFPLCT
                     PDVPRPVAACKLLCETVRGECMENAPPELMELWPSFLNCDGLPQPEKHELCMQIPQEV
                     AVPGGSPSGPPTTGSPGVEDHPQTYRFWKSGASPTSDLAGVLCPQNFSGSPFNPEECV
                     PQCQRDAFHTSSQKKTSETLILGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCL
                     CYNLFSVCYLERIVFHNQARMHDVELQWRLMRPGCLLTPPCLASYITTSYLSLCAASW
                     WLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLEKVRPSELTGMC
                     YAPGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTLAHHRFGQIRKRFVLFSLLY
                     FAPTTAGVVAALCERYADSVPSCSTPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWV
                     WSRKTCESYRNRLGASGTPTSSLMNQSKAAGALPKKHLYTSGKSMLPTGGITPLYAGI
                     SFHNVPVYNPNQSRV"
     misc_feature    393..761
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="CRD_domain cysteine-rich domain, also known as Fz
                     (frizzled) domain; Region: CRD_FZ; cl02447"
                     /db_xref="CDD:470581"
     misc_feature    order(423..425,429..434,441..449)
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="putative Wnt binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:143549"
     misc_feature    957..1850
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="class F insect frizzled subfamily 3, member of
                     7-transmembrane G protein-coupled receptors; Region:
                     7tmF_FZD3_insect; cd15031"
                     /db_xref="CDD:320159"
     misc_feature    order(960..962,987..989,1137..1139,1440..1442,1455..1457,
                     1461..1463,1470..1475,1503..1505,1722..1727,1737..1739,
                     1752..1754,1761..1766)
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320159"
     misc_feature    984..1061
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320159"
     misc_feature    1086..1151
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320159"
     misc_feature    1236..1316
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320159"
     misc_feature    1365..1415
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320159"
     misc_feature    1494..1568
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320159"
     misc_feature    1626..1709
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320159"
     misc_feature    1731..1808
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320159"
ORIGIN      
        1 gatacctggc tgctctatcg ataaactgcc gctccaccta tcggccacct catagcgtag
       61 cattcgttga gtgtcggtgg ttcagtttgt tggaaacagt gaagagtagt ggtcgcgttt
      121 cgcagttctt ggagtggaga ctttccaaac cggagaaata cgtaaaccac tgagagtcgc
      181 acagtaatat aaacacaaac atttttttta cgtgccgcga gtgacgtttg aacagaaacc
      241 ctggagtggc aaacatgacc tcctgaaacc cactaagcat cgcaatgtat gccgcctcga
      301 tcctgatcct gcacctgact tgggccgtgg ccacgatcgc ggccaacggt gccggccata
      361 atggcccggt ggcatccgga gcagggccta acggattgca gtgccagccc atcgccgtgt
      421 ccgcctgcca aggcctcggc tacaacatga ccgcactgcc caacctggca ggtcacacca
      481 atcagctgga ggctgagctc cagattgcca aactggtgcc actaatagaa tccggctgct
      541 cgcgtcgcgc ccgctttttg ctctgctcgt ctctgtttcc gctgtgcacg ccggatgtgc
      601 cacgccccgt tgccgcctgc aaattgctgt gcgagactgt taggggcgag tgtatggaaa
      661 acgctccgcc ggaactgatg gagctgtggc cttcgttcct taactgcgac ggactgccgc
      721 agccggagaa gcacgagttg tgcatgcaga ttccacagga ggtggctgtg ccaggcggga
      781 gtccaagtgg tccgcccacc actggttcac ctggcgtcga agatcacccg cagacgtacc
      841 gcttttggaa aagcggagca tctcccacct ctgacttggc tggcgtcttg tgcccgcaaa
      901 actttagcgg cagtcccttt aatccggagg agtgcgtgcc ccagtgtcag cgggacgcct
      961 tccacacgag ctctcagaag aagacgtctg agaccctcat tctaggcctc tcggccgtct
     1021 gcttcgtcct gacactgttc gccttggtga ccttctgggc ggagcccacc aggtttggct
     1081 accccgagag accagtgctc ttcctgtgcc tgtgctacaa cctcttcagc gtgtgctatc
     1141 tggagcgaat cgtgttccac aatcaagcaa ggatgcatga cgtcgagctg caatggcggc
     1201 tgatgcgacc gggttgcttg ctgacgcccc cttgcctggc ctcctacata accacctcct
     1261 atttaagcct gtgtgcagcc agctggtggc tgatatttgc cctgtgcttc tacctgtcct
     1321 cccacaaaaa gtggtccagc gaggcgctgg aaaagaggtc cgggctgttc cacgttctgg
     1381 cctgggtgcc accgctggcg ccccccattg ccgccctgct gctggagaag gtgcgtccga
     1441 gtgagctgac tgggatgtgc tacgcaccgg gatttgtgga gctgccagca ctggtcctgc
     1501 tcctgcttgg gctgtacttc accctgagag cctccaggtc tctgctctcc ctgcagcaac
     1561 agttgcagcc caccctggcc caccaccgat tcgggcagat ccggaagcgc tttgtgctct
     1621 tctccctgct gtacttcgca cccacgaccg ccggcgtcgt ggcggctctt tgcgagcggt
     1681 acgcggattc agtgcccagc tgctccacac ccgatgactg cctctcaccc actccgctca
     1741 gtgcctggcc agcgttggtc cggatcttct tccagctggt gggcggaacg ttgacagggt
     1801 tgtgggtgtg gtcgcgcaaa acctgcgaga gctacagaaa tcggctgggt gccagcggca
     1861 cacccacctc atccctgatg aatcaaagca aggcggccgg ggctttgccc aaaaagcatt
     1921 tgtatacgag tgggaaatcc atgctgccca cggggggaat cactcctcta tatgctggta
     1981 ttagttttca caatgtgccc gtctacaacc ccaaccaatc gagagtttag gggatctttt
     2041 agcccacatg gggggctcta gaaaaatctc gaactctact attgtacata taacatatac
     2101 atacatcata gaaggctttg agccgcggtg agagaacatg atcgaacata cgcctagttt
     2161 ttaagcccga aaaggagaaa ctgaaatgtg ttaatagctt tatagatcgc gctcccccaa
     2221 gtacccatca cctccagttt ttattagtag ttctctagct agtcctaagc ctgtaaatag
     2281 taaaacgttt tattcatagt agaatgaatt gtaaataaat tatatgaatc aaaaatgaat
     2341 gtcgttcaaa gtgggctcca aatgcattag gaactcaaga taagcaagat aaccactgcg
     2401 cgttctcacg gcatctccgt cagccacaag gctcaacact tcgcaagccc catttactat
     2461 atgtgggtta atgatgcaaa agttgtcgct gcaatgagct aagggatgga tggtgggtag
     2521 gaattccgac ggatcgctta attgcaacaa aatggctaat ttagttatgc tattgtctgc
     2581 gctccgagcc gtggcaatta gaaggaaaat gcttaatgac agatctcgac gttggttgcc
     2641 atcggttgcc gactggttat gctccgccgc acctccacct gtggctctgc gtattctttc
     2701 ccctgtatat gtttgtacat tttgcggaca ctccaactct ttcgtatgcc attcaagtac
     2761 cacctgtatt cggaccaagc gaaatatggt ggacctaaaa ttatcaaaca tggtggtcat
     2821 gtttataaat gagtaaatta cctaaaaact aagattgttt tttttactta gatgggatgt
     2881 gacaccctaa cacccgattc tttagcacag acactttccc tgctctctgg atgtttgggc
     2941 tgcgtcagaa cacgggtaat tggtatcaac cgaggcacaa ttaatttgat tgaagctgcc
     3001 acaccgcatg ccgctccaac gaacaacgaa tccatcctac aaattgccgg ccgtcgtggc
     3061 aggcaacaag ccgaaacact gcggcaacat cggcacaata gcaacagcaa ctgtgcagca
     3121 agcgtgcaat taactcttgt gcgccaagat caaagcgatt aatgcggccc caagttccca
     3181 gacgaaggga cggaggccag ggcatttgga gcagcgaagg gcaaggaacg gaaaccaaga
     3241 cagagacgag