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Drosophila melanogaster split discs (spdi), transcript variant F,


LOCUS       NM_001297819            4448 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001297819
VERSION     NM_001297819.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4448)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4448)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4448)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4448)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4448)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4448)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4448)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4448)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4448)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4448)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4448)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4448)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4448)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4448)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4448)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4448)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4448)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4448)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4448)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4448)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4448)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4448)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4448)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4448
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4448
                     /gene="spdi"
                     /locus_tag="Dmel_CG13366"
                     /gene_synonym="AAD55419; CG13366; Dmel\CG13366;
                     EG:118B3.2"
                     /note="split discs"
                     /map="1B10-1B12"
                     /db_xref="FLYBASE:FBgn0025633"
                     /db_xref="GeneID:31004"
     CDS             461..3745
                     /gene="spdi"
                     /locus_tag="Dmel_CG13366"
                     /gene_synonym="AAD55419; CG13366; Dmel\CG13366;
                     EG:118B3.2"
                     /note="CG13366 gene product from transcript CG13366-RF;
                     CG13366-PF; spdi-PF; SPECC1L-ortholog; SPECC1L ortholog"
                     /codon_start=1
                     /product="split discs, isoform F"
                     /protein_id="NP_001284748.1"
                     /db_xref="FLYBASE:FBpp0308520"
                     /db_xref="GeneID:31004"
                     /db_xref="FLYBASE:FBgn0025633"
                     /translation="MIKLKSLFRRGQGNSSSHSSNSSHKQQQNSSNNNRQKSQSSTSL
                     NTAHEQQQQHSITAATTKFYAHQETASYERGVDVGDEGALLLTNQQQEQRRQQQQLLQ
                     QPQSNTLPQKKSKLKGQKQPKLLPVQQPHSNAPEPHDPQQPLMTSLAAVPQASATGSS
                     SNSNINNNNALAALQDGGAAAAAAADFYQQLAAAATATATATSANGSNTSADSPVSSF
                     PAAAAAVAVAAVAASSYQQQQQQQQLLNNEQQQQQLLEANNKMQELHKQMERFRSEQM
                     QLETRITELLPYQSEVAKLKGDLVKMQSLQEKSQMEIGNLKYENESLRNRLRDVVNSP
                     LSDAEKHQIIQDSQRLHSSAPASIALPSTHDAHDGTPCLTPDWDKQSSSSEISVACLQ
                     DKIIQMEETHYSTNEELQATLQELADLQTQLTDTQTENERLAEEKDVLFQSLCRQTEK
                     LNESRTQISTLQELLLRDTKQPAPEVSASEREQKLLDLIKTSQEEREAVLLKQEELGA
                     ELAEMKQAREAGQLELQRQRERIALLDSQLDAANAERRQGEAQFSQAMEEISQRAIEI
                     SRLSTLLENARSKIEELEADLSRGDKTDLSEVLDVARKEKDALEERVAELQDQCSRSQ
                     AELRRLRDQLSGLTEECKVVKNNAKCAVSHLEYRLEQLQRDKDKIAGEWQALEERVAE
                     LQVQCKCHQEDKAQLQSLLAETQRHLGDVQLKLGEAECRLDQETQLRRKEAEEWQQFQ
                     ADLLMTVRVANDFKTEALSAREQLVLDNKTQKEKIRLLEQQLEKLTKQQMQQSETPQS
                     VLSTVQREMEMATRRSKLSFSRQDSRLSVKTLIESIENNKAQGKADESESHYSSTSSL
                     NSGTPDLGTTPIIFPPSSDWHESIRLPVLQSTNLHVNVGNEVGAGQGTNTSSGSGGDL
                     ASTTKATLPLRDQQQLAITSTQSQVQNVSQPSTPATPSSAGSSSSGGLPFGNVSKSFI
                     SGERKDPLNMLAKNGGSKRNALLKWCQNKTVGYRNIDITNFSSSWNDGLAFCAILHSY
                     LPDRIPYDQLTPANKRRNFSLAFAAAESVGIGTTLNINDMCQIERPDWMQVMSYVTAV
                     YKYFET"
     misc_feature    <1229..>2995
                     /gene="spdi"
                     /locus_tag="Dmel_CG13366"
                     /gene_synonym="AAD55419; CG13366; Dmel\CG13366;
                     EG:118B3.2"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <1961..>2842
                     /gene="spdi"
                     /locus_tag="Dmel_CG13366"
                     /gene_synonym="AAD55419; CG13366; Dmel\CG13366;
                     EG:118B3.2"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    3404..3739
                     /gene="spdi"
                     /locus_tag="Dmel_CG13366"
                     /gene_synonym="AAD55419; CG13366; Dmel\CG13366;
                     EG:118B3.2"
                     /note="calponin homology (CH) domain found in the cytospin
                     family; Region: CH_CYTS; cd21199"
                     /db_xref="CDD:409048"
     misc_feature    order(3428..3430,3440..3442,3590..3592,3596..3601,
                     3608..3613,3617..3619,3641..3667,3689..3691,3695..3700,
                     3704..3709,3716..3721,3728..3730)
                     /gene="spdi"
                     /locus_tag="Dmel_CG13366"
                     /gene_synonym="AAD55419; CG13366; Dmel\CG13366;
                     EG:118B3.2"
                     /note="putative actin binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:409048"
ORIGIN      
        1 cttgttgttg tcgggaatca gcagaaaaac cgaaacgcgc gtcgctttgt cgccagttgt
       61 tcgcttattt ggtgtcgtgc gtggctcacc tcgttttgag aactttacct ttatttttgt
      121 ttactgtttc ccaccgtagt atgtgctgca tttaatgttt atgacaaatt agcaatgagc
      181 aacaaagtta ttcgctcagt atgtacgtgt acgtgtaaaa gtgtgcgggt attgtttgag
      241 caacgtattg gtgtgcgtgt gaagttggcc tttcgttttg ttggcgtgtt gcagtttttt
      301 ttacgagacg caacgaacga taaaagatca aattaaacaa gctaacctgc aattagtacg
      361 caagccacaa taaatgatgg ttgctattaa ataagtttaa aagcaagtat atggttgatg
      421 gttcacgttt tgcaacgagc aaggaaagac tggcagcaag atgatcaaac tgaaatcctt
      481 gttccgcaga ggacagggca actccagctc ccattcctcc aactcgtcac acaagcagca
      541 gcagaactcc tccaacaaca atcggcagaa gtcgcaatcg agcacttcat tgaataccgc
      601 ccacgagcag cagcagcagc acagcatcac cgcagcaact acaaagttct acgcccacca
      661 ggagacggcc agttacgaaa ggggcgtgga tgtgggggac gagggggcgc tactgctgac
      721 taaccagcag caggagcaga gacgccagca gcagcaacta ctgcagcagc cccaaagcaa
      781 caccttgcct caaaaaaagt ccaagctcaa gggacaaaag cagcccaagc tgttgccagt
      841 gcagcagcca cacagcaatg cacctgagcc acatgatcca cagcaaccac tgatgacttc
      901 cctggcagca gtgccgcagg cttcagcgac tgggagctcc agcaatagca acatcaataa
      961 caacaacgca ttggccgcac tacaagatgg tggcgctgct gccgccgctg ctgcagattt
     1021 ctaccagcaa ctagcagcag cagcaacggc cactgcaaca gcaacgtcgg cgaacggcag
     1081 caacaccagt gctgatagtc cggtcagctc ttttcccgca gcagcagctg ccgttgctgt
     1141 tgccgctgtg gcagcaagca gctaccagca acagcagcag caacagcaac tcctcaacaa
     1201 cgaacagcag caacagcaac tcctagaggc taacaataaa atgcaggagc tgcacaaaca
     1261 gatggagaga ttcagaagcg agcaaatgca actggagaca cgcatcacgg agctgttgcc
     1321 ataccaaagc gaggtggcca agctgaaggg cgatctggtt aagatgcaga gtctacagga
     1381 aaagtcccag atggaaatcg gcaatttgaa atacgagaat gaatctctgc gcaatcgact
     1441 gcgggacgta gtaaactcac cgctgtcgga tgcggagaag caccagatca ttcaagactc
     1501 gcagcggctg cacagttcag cgcccgcttc aatagccctg cccagtacac acgatgcgca
     1561 tgatggcaca ccctgcctca ctcccgactg ggataaacag tcatcctcca gcgagatctc
     1621 tgtagcctgc ctgcaagaca agatcattca aatggaggag acacactact ccactaacga
     1681 ggagctacag gctacgttgc aggagctggc ggacttgcaa acccagctga cggatacgca
     1741 gacggagaac gagcgtctgg ccgaggagaa ggatgtgctc ttccagtcgc tatgccgaca
     1801 gacggaaaag ctaaatgaat cgcgtacgca gatcagcacg ctgcaagagc tgttacttcg
     1861 ggataccaaa cagcctgcac ccgaagtaag tgcttcggag agggagcaga agcttctgga
     1921 cctgatcaag acatcacagg aggagcgcga ggcagttttg ctcaagcagg aggaactggg
     1981 agctgagctg gcggaaatga aacaggcccg ggaagctggc caactggaac tgcagcgcca
     2041 gagggaacga attgccctcc tggattctca gttggatgca gcaaacgcag agcggcggca
     2101 aggagaggct caattttcgc aggccatgga agagatttcg cagagggcca tcgaaatcag
     2161 tcgattgagc actcttctgg agaatgcgcg ctcaaaaatc gaggagctag aagcagattt
     2221 gtccagagga gacaagacag acctgagcga agtgctggat gtggccagaa aggagaagga
     2281 tgccctagaa gagcgtgtgg ctgagttaca agatcagtgc tctcgcagcc aagctgagct
     2341 gagaagacta cgtgatcagc tatccgggct aactgaggaa tgcaaagtag ttaagaataa
     2401 cgccaagtgt gcggtctccc accttgaata ccgcttagag cagctccaac gtgacaagga
     2461 caaaatagct ggcgaatggc aggccctaga ggaacgcgtg gccgaactgc aggttcagtg
     2521 caaatgccat caggaagaca aggcccagtt gcaatctctg ctagctgaaa ctcagcgcca
     2581 tctgggcgac gttcaactga agctgggtga ggcagagtgt agactcgacc aggagacgca
     2641 gctgcggcgc aaggaggccg aggagtggca gcagttccag gccgaccttc tcatgactgt
     2701 gcgagtggcc aacgacttta agactgaggc gctcagcgcc cgggagcagc tagttctcga
     2761 caacaagacg cagaaagaaa agatcagact gttggagcag cagcttgaaa aacttaccaa
     2821 acagcaaatg caacagtcgg agactccgca gtccgtgctg tccacagttc agcgtgagat
     2881 ggagatggcc acacgacgca gcaagcttag cttcagccga caggattcgc ggctctccgt
     2941 caaaacgctc attgagagta ttgagaataa caaagcgcag ggcaaagccg acgagtcgga
     3001 atcccactac agctcgacgt ccagcctaaa cagcgggact cctgacctgg gcactacgcc
     3061 catcatcttt cctccctcca gtgactggca tgagagcatt cggttgcctg tgctgcagag
     3121 caccaacttg cacgtaaacg tcggcaacga agttggtgcc ggacagggaa ccaatacttc
     3181 atctggcagc ggaggagatt tagctagcac taccaaagcc actttgccgc tgcgcgatca
     3241 acaacagctt gcgataacat ctacccaaag ccaggtacag aacgtctccc aaccttctac
     3301 gccggccacg cccagcagcg cgggcagcag cagtagcggc gggttgccat ttggtaacgt
     3361 ctcaaagtca tttatcagcg gcgaacgcaa ggacccgctt aacatgctgg ccaagaacgg
     3421 gggttcgaag cgcaacgcct tgttgaagtg gtgccaaaac aaaacagtgg gctaccgtaa
     3481 catcgacatc accaacttca gctcgtcgtg gaacgatggg ttagcttttt gtgctatctt
     3541 acactcgtat ttgccggatc gcattccgta cgatcagctg actcccgcca acaagcggcg
     3601 caacttttcg ctggcatttg cggctgccga gtccgtggga atcggcacaa cactgaatat
     3661 caatgatatg tgtcagatcg aacgaccgga ctggatgcag gtgatgtcct atgtgacggc
     3721 agtctacaaa tactttgaga cctagacgag ggaatttaag gaccatctgc tgccctccac
     3781 ttgagctctt ttgtgcagta ttcgtggggt tccctttgct ttcaatatat gtttgttctt
     3841 tcgcatacat atttctttgg tgttgtgtat attcagttca cgaaggagag caatctaatg
     3901 ttttctccaa ttcctctagc ttgtacactt ttttcctgta aagcctcttc tgctttagtg
     3961 cgtctgattc catatccttg cccatgtata atggtcgtcc gatgcagcgc cccatattca
     4021 gacatcgcta cttttaaata tcattgtttt tgggttttaa agaaaaagcc tagtattaag
     4081 tataagcaaa agttacattt tttttatgaa gcttcaaagt ttgttggacc gatcatacca
     4141 aggacaacga tgactatccc agcctgttcc cactgtacat gggtgtttat ataggtgttt
     4201 ttttttattg cgtggtacag attttatttt aatgcgtaaa tcgacgattg agctggacga
     4261 tgattagctt gacgacgaaa cattactata cagataataa ggagatggac tagctttagc
     4321 gtatatataa ctatttattt caactaattc aaaacactaa tttaaacata aacaaaatgt
     4381 atttttaaac gattaattct acgatctatc ataaagaaca atatgctgca aaaggcagta
     4441 agtcaagt