Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

Drosophila melanogaster histone deacetylase 4, transcript variant J


LOCUS       NM_001272581            6248 bp    mRNA    linear   INV 26-DEC-2023
            (HDAC4), mRNA.
ACCESSION   NM_001272581
VERSION     NM_001272581.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6248)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6248)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6248)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6248)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6248)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6248)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6248)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6248)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6248)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6248)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6248)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6248)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6248)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6248)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6248)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6248)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6248)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6248)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6248)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6248)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6248)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6248)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6248)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001272581.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6248
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6248
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Histone deacetylase 4"
                     /map="11E8-11E9"
                     /db_xref="FLYBASE:FBgn0041210"
                     /db_xref="GeneID:32278"
     CDS             538..4155
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /EC_number="3.5.1.98"
                     /note="CG1770 gene product from transcript CG1770-RJ;
                     CG1770-PJ; HDAC4-PJ; histone deacetylase 4"
                     /codon_start=1
                     /product="histone deacetylase 4, isoform J"
                     /protein_id="NP_001259510.1"
                     /db_xref="FLYBASE:FBpp0305526"
                     /db_xref="GeneID:32278"
                     /db_xref="FLYBASE:FBgn0041210"
                     /translation="MELKKSQELQKQRLINSFQEQSKQMELEHKLQLEHKYQFAVNSH
                     GAFQELRNESMVTAAAAAVAQEQHRQQLHQQQQQHQQQQQQQQHQQQQQQQQARGRDG
                     MKLKQNCSANASPEVKQILNCFILSRKSQAAASNGTTTTSPYRNRGVVKSSSGESLPA
                     GTVTSAHPYKIPQPPPSLLKYESDFPLRKTASEPNLLKIRLKQSVIERKARIGGPAGA
                     RRHERLLQAAQRRQQKNSVLTNCNSTPDSGPNSPPSAAALAVGVVGSRGSPTSAPIQE
                     ENEEGSQYQPGQRSSINDLPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQ
                     AQAQAQAHAMFAALAAAQGGCGQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPV
                     VRSASATSTSSSQASLVGDVAPPQAHAASTILPSSSSYMQQLGSVAGSGVNLHAAAVA
                     AAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQV
                     AQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQAYEHQVVNQ
                     KVRQTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTST
                     IATSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLL
                     QQEEELAKSLMRPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLS
                     LPHRQHRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPE
                     HSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKL
                     ENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAV
                     VRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQ
                     SPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAF
                     RTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVV
                     LALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTH
                     WPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDET
                     K"
     misc_feature    544..>687
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Glutamine-rich N-terminal helical domain of various
                     Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9);
                     Region: ClassIIa_HDAC_Gln-rich-N; cl25407"
                     /db_xref="CDD:421006"
     misc_feature    order(547..549,559..561,568..570,580..582,589..591,
                     601..606,613..618,625..627,637..639)
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="dimer interface A, D [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197200"
     misc_feature    2854..3978
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Histone deacetylases, class IIa; Region:
                     HDAC_classIIa; cd11681"
                     /db_xref="CDD:212544"
     misc_feature    order(3295..3300,3322..3327,3412..3414,3418..3420,
                     3694..3696,3814..3816)
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="active site"
                     /db_xref="CDD:212544"
ORIGIN      
        1 agatatcgat gtggttccag ctctaatagt cgtggatttc ggaacattaa tttgtatttt
       61 ttgcgtcgcg tcgccccaga aagtccaatc caacagcaaa tcgcgcgttt tccaaagaac
      121 aacaaccccg aaaaattcga aaataataat tttcttgttt tttttttctg ttttcctgcg
      181 gcaaaaattc caattttttt cgtaacatct aaacaacaac aacaaaaaaa gtgcgtgcgc
      241 gtgcagaagc gaaaaaaacc gaataaattg tgggcgaatc aacaagcaaa agagaatgag
      301 cgatgatgag gagaagaggc aaaaaaagca gaggcagttg tcgtagtact agtaccaaaa
      361 agaaactgcg aaaactgcta aagtgacaaa aacaacaaca gcaagtaacg aaagagaaaa
      421 gcaaaagaag atctgccatc agaagccgga agcgatgagc gattgctgca cataacgccg
      481 gccactctga cattggactt caagccccat cccgccgtgg atatcgatca gcagatcatg
      541 gagctcaaga agagccagga gctgcaaaag cagcggctta tcaactcgtt tcaggagcaa
      601 tcgaagcaaa tggaattgga gcataaactt caattggagc acaagtatca atttgcggtg
      661 aattcacatg gcgctttcca ggaattgcga aacgagagca tggtgacagc cgccgctgct
      721 gcggtggctc aggagcaaca tcgccaacag ttgcatcaac agcagcagca acatcagcag
      781 cagcagcagc agcagcaaca tcaacagcag cagcagcagc aacaggcacg cggcagggat
      841 ggcatgaaac tcaagcagaa ctgtagtgcc aatgccagtc ccgaggtcaa acagattctc
      901 aactgcttca tcctgagcag aaagtcccag gcggcggcat cgaatggcac aacgacaacg
      961 tcgccctaca ggaatcgcgg cgtggtgaag agctcctcgg gcgaatccct cccagctgga
     1021 accgtgacca gtgcgcatcc gtacaaaata cctcagccgc caccctcact gctcaaatat
     1081 gaatctgatt ttccgctgag gaagacagca tccgaaccga acctgctgaa gatccggctg
     1141 aagcagagcg tcatcgagcg caaggcccgc atcggaggac cggcgggagc ccggcgccac
     1201 gaacgactcc tccaggcggc gcagcgtagg cagcaaaaga actcggttct cacaaactgc
     1261 aacagtacac cggattctgg acccaattca ccgccctcgg cagctgcgtt ggcggtgggc
     1321 gtggtcggta gccgtggatc accgacaagt gcacccattc aggaggaaaa cgaggagggc
     1381 agccaatatc agccgggcca gaggagcagc atcaacgatt tgccattgtt cagttcacca
     1441 tcgctgccga atatttcgct cgggcgaccg catttaccca actcggcgca ggcgcatgcc
     1501 caggtgaatg cccaggttgc tgcccaggct caggcacagg cccaggcaca ggcacaggcg
     1561 catgccatgt tcgcggcact ggctgccgcc cagggtggct gcggacagcc gggctactat
     1621 aatccactgg gcatggcatt cgttggccgg caaccagcac cgctggccat gattccggcc
     1681 acggggatag caccgcagca accgtcgccg gtggtgcgca gtgcatcggc cacttcgaca
     1741 tcgtcgtcgc aggcctcgct ggtgggcgat gtggcgccac cgcaggctca tgccgcctcc
     1801 accattctgc cctcgtcatc gtcctacatg cagcaactgg gcagtgtggc cggttcgggt
     1861 gttaatctcc atgccgccgc cgttgctgca gcggcagcag cagcagccgc cgccggttca
     1921 ctgccaccga ccaatagcca tggtcacgga cacggttccc acgcacatcc acatccacat
     1981 gcccatggac acgggcatgg ccatggccat ggtatctacg ctggccacca gcacaatgtg
     2041 cccataacgg acgcccaggt ggcgcaggtg catctgcaca aacagggcca tcggccgctg
     2101 ggacgaacgc agtcggcacc actgcccctt ggacatccga tgctaaccgg agctgtgcaa
     2161 ctgaatgtgg tccaaacgca ctacgagaat agtgaggcgg agcgccaggc gtacgagcac
     2221 caggtggtga accagaaagt ccgccagacc gtcctgactc gcagcggagc tgctgcagca
     2281 gccgctgctg ccgccggcgt gagcgtggtg cgtgaggcac agttgaagga ggaggatgac
     2341 gactcggccg ccgaggtgat ggacctcaca gataagaaaa aaccgccgaa gacggtgcta
     2401 accagcacga tagccaccag tacgtcccag aatctgcccg aagctttggc ggcggcggcg
     2461 gcggcagccg cctaccgtgc cccgcacaac gcgtccagta actccgcctc cgccacaaag
     2521 tccggtatta agctgcggga ccaggagtat ttgcaacagc agcgggagca actattgctc
     2581 cttcagcagg aggaggaact ggcgaagagc ctaatgcgtc cgctatcgcg aacgcttagc
     2641 agtccgctgg tgccgctggg gccacatggt cttagtcaga ttcccgacac tggacaacag
     2701 ccggcaccga tagccacatc ctcgtcggcc gatcatatac cgcccgttaa cctctcgctg
     2761 ccgcatcgcc agcaccgcca gctaatgagc acactatacg ccagccaatt gcgtaaccac
     2821 cagccatcgg cgagtggttc accgccgcac aaggtcacca ccggtttggc ctacgatccg
     2881 cttatgctga agcattcgtg tatttgcgga gacaatgccc agcatccgga gcacagtggt
     2941 cgactgcaga gcgtgtgggc acggttaaat gaaacggatc tggtgaagcg ttgcgatcgc
     3001 ctgcgcgctc gcaaggcgac acaggaggag ctgcagactg tgcacaccga agcgcatgcc
     3061 atgctcttcg gttcgaatca gtgccagctc agcaggccca agttggaaaa cacgttgtcg
     3121 gccagctttg tgcgtttgtc gtgcggcggc ttgggtgtgg atctggatac cacgtggaat
     3181 gagcaccata cggcaaccgc tgcacgaatg gcagccggtt gtgttatcga tttggcactg
     3241 aagacggcca agggtgacct gcggaatggc tttgccgttg tccggccgcc gggccatcat
     3301 gcggaggcca atttggccat gggcttttgt ttcttcaatt cgatagccat tgcggccaag
     3361 ctgctgcgtc agcggatgcc cgaggtgcgg cgcatcctga tcgtcgattg ggatgtgcat
     3421 cacggcaatg gcacacagca agcattctac caaagtcccg acattctata tctttccata
     3481 catcgacacg atgacggtaa cttctttccc ggcacaggtg gacccacaga gtgcggctcc
     3541 ggtgctggtc tcggctttaa cgtgaacatc tcatggtctg gggcacttaa tccgccactg
     3601 ggcgacgccg agtatatcgc tgcattccgt accgttgtga tgcccatcgc gcggagcttt
     3661 aatccggaca ttgtgctggt atcctccggc ttcgatgcgg ccaccggcca tccggcaccg
     3721 ctgggtggct accatgtctc tccggcctgc tttgggttca tgacccgcga actccttcag
     3781 ttggccaacg gcaaagtggt gctggccctc gagggcggct acgatctggc cgccatctgt
     3841 gattccgccc aggagtgtgt gcgggcgctg ctcggcgatc ccgctgctcc cattgccaag
     3901 gccgagctgg agcgcccgcc ttgccagaat gccatcaata cgctccagaa gacgatagcc
     3961 atacagcaaa cgcattggcc ctgcgtgagg atgctggagc acacggttgg cttgtctgcg
     4021 ctggagacgc tcaaggtgga gcacgacgag tccgagacga tcaacgccat ggctggcctc
     4081 tcgatgcagt cgatgcacag aactctatcc cgcgatgatt ccgaggagcc gatggatcag
     4141 gatgaaacca aatagaaggc gatgcagacg tatattgcgg aagaggaggc ggtgggcgtg
     4201 gcgaggtttt tgtggacctg gtagagtggg aatggcagga gggggcgtgg ccgcaagctg
     4261 ctcaatgcac atttagttat ttgttgtagt tgaattgatt gttgttgctg ttgttgttgt
     4321 ggcgctcgct tgcaattgtt gtcgttgtca ttgatcgtct atagccacat ctatctctct
     4381 cactcgatcg attatagcat cccaattccc cgccccgcca aaaaaaacaa aaagaagaga
     4441 aacatcgaaa atatagggga acatgtctaa aagaagcaga acagggccta aagttcaaaa
     4501 tggtggctgt gcctccaaaa gaagaaataa ttataataat tagaaaagaa tcctttcaaa
     4561 aaaaaaggag attttatatg aatatatata tatatgaata tatatgtagc ttaagctcag
     4621 aatttagttg tagaagtcat cgagattttt tttttttgtt ttaaggtgag agcagaggta
     4681 ttttaacgca cacacaaaca cacgcaactc aatgtatctt attattatta tttaagtaag
     4741 tgtgtcaaaa ggatatagaa ccactaacgt actggtgaac atcatcagta agctataaag
     4801 ataatgttta aagaggtcgg gtgcaagaag catgtgtttt tttttataag gtaaggttca
     4861 acctcaaagt tcccaagtct agaccccacc acgcccactt atccgccatc gcttacagag
     4921 atcgagtggg gagttgatta catgttatgt agaatgcttt agttgataat aagatatgag
     4981 aaaaaaaaaa cttaacaact aactagttgg atgaaaagcg aaaaaactga gaaatctttt
     5041 tgtacaattt atagtttagt gcaagtttca agtacaacat gctattattt aaagaattct
     5101 atatatatac atatatatat atatatatac aaaaaaaata tatattgtgc aataaatgtg
     5161 agaaaatgaa aatcgccaca caaaacagaa actaaaacga ataagagaaa atttgttgtt
     5221 aaatgttgcc gagatcttat atacgtatgt atacctaata actgttacaa taataaccct
     5281 ttatatatat aactatataa atgcacatgt gtattcacca tgtgtgtaac gataacgatg
     5341 ttcaacaaat gtctgaaatg aagtaaaact attattatat gtaaataaaa cacaaaaaac
     5401 aaagagaaca attttaataa aaaaaaagca acaataaaat acaaaatcaa agaaaatatc
     5461 cacgctcaca cacacacata cacacacaaa catatatacg tcctgggcag gacccgagag
     5521 gcgtgaatcg ggaaaaattc tgaaataacc gttcaatcgc taaccgttaa ctgtaaaacc
     5581 gctgtaactg tatttgtact cgtgtacctt tagctgtcta tagccgtctc tctctaactc
     5641 gctacctaac tgtaaaggag cacctcaata acgaaagaag aaggagcaac agacaaggat
     5701 caaaaatata tagcaagtga aaaggatgat ggaaagaagg aggaggagga ggagaaacaa
     5761 gaaaaataag cacaacgaga gatggaccga ttggctccaa ctggatgaaa caattgttaa
     5821 caaaacgaaa cagaaactaa aaactatcct taaaaaaaaa tgaaatcaca aatgtaacta
     5881 ttaatctaag cgaagcatat gcccttgcca tttttatttt cttattattc acctgttttc
     5941 tcttttcaat acagcagatt ttttgaaaaa catacttttg aacataagct gtttcgtatg
     6001 caagccacgt aattgctgtt acttaggaat atatatatac gaatttttct tgggttccaa
     6061 aagcgttaca atacgctctg tgttaaatct gtgcttttat tttaattttc tatttataat
     6121 ttggcaaatt ggcgatctcc ccttacctta ccttttttta tctttcctga atttgttttt
     6181 tttttaccaa aacacgaatt atgaagagga ttctactaac aagatgaaat attattgttg
     6241 cgcactgc