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LOCUS NM_001272580 6559 bp mRNA linear INV 26-DEC-2023 (HDAC4), mRNA. ACCESSION NM_001272580 VERSION NM_001272580.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 6559) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 6559) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 6559) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 6559) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 6559) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 6559) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 6559) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 6559) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 6559) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 6559) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 6559) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 6559) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 6559) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 6559) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 6559) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 6559) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 6559) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 6559) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 6559) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 6559) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 6559) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 6559) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 6559) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_001272580.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..6559 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..6559 /gene="HDAC4" /locus_tag="Dmel_CG1770" /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770; dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a" /note="Histone deacetylase 4" /map="11E8-11E9" /db_xref="FLYBASE:FBgn0041210" /db_xref="GeneID:32278" CDS 849..4466 /gene="HDAC4" /locus_tag="Dmel_CG1770" /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770; dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a" /EC_number="3.5.1.98" /note="CG1770 gene product from transcript CG1770-RI; CG1770-PI; HDAC4-PI; histone deacetylase 4" /codon_start=1 /product="histone deacetylase 4, isoform I" /protein_id="NP_001259509.1" /db_xref="FLYBASE:FBpp0305525" /db_xref="GeneID:32278" /db_xref="FLYBASE:FBgn0041210" /translation="MELKKSQELQKQRLINSFQEQSKQMELEHKLQLEHKYQFAVNSH GAFQELRNESMVTAAAAAVAQEQHRQQLHQQQQQHQQQQQQQQHQQQQQQQQARGRDG MKLKQNCSANASPEVKQILNCFILSRKSQAAASNGTTTTSPYRNRGVVKSSSGESLPA GTVTSAHPYKIPQPPPSLLKYESDFPLRKTASEPNLLKIRLKQSVIERKARIGGPAGA RRHERLLQAAQRRQQKNSVLTNCNSTPDSGPNSPPSAAALAVGVVGSRGSPTSAPIQE ENEEGSQYQPGQRSSINDLPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQ AQAQAQAHAMFAALAAAQGGCGQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPV VRSASATSTSSSQASLVGDVAPPQAHAASTILPSSSSYMQQLGSVAGSGVNLHAAAVA AAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQV AQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQAYEHQVVNQ KVRQTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTST IATSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLL QQEEELAKSLMRPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLS LPHRQHRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPE HSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKL ENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAV VRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQ SPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAF RTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVV LALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTH WPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDET K" misc_feature 855..>998 /gene="HDAC4" /locus_tag="Dmel_CG1770" /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770; dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a" /note="Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9); Region: ClassIIa_HDAC_Gln-rich-N; cl25407" /db_xref="CDD:421006" misc_feature order(858..860,870..872,879..881,891..893,900..902, 912..917,924..929,936..938,948..950) /gene="HDAC4" /locus_tag="Dmel_CG1770" /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770; dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a" /note="dimer interface A, D [polypeptide binding]; other site" /db_xref="CDD:197200" misc_feature 3165..4289 /gene="HDAC4" /locus_tag="Dmel_CG1770" /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770; dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a" /note="Histone deacetylases, class IIa; Region: HDAC_classIIa; cd11681" /db_xref="CDD:212544" misc_feature order(3606..3611,3633..3638,3723..3725,3729..3731, 4005..4007,4125..4127) /gene="HDAC4" /locus_tag="Dmel_CG1770" /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770; dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a" /note="active site" /db_xref="CDD:212544" ORIGIN 1 agatatcgat gtggttccag ctctaatagt cgtggatttc ggaacattaa tttgtatttt 61 ttgcgtcgcg tcgccccaga aagtccaatc caacagcaaa tcgcgcgttt tccaaagaac 121 aacaaccccg aaaaattcga aaataataat tttcttgttt tttttttctg ttttcctgcg 181 gcaaaaattc caattttttt cgtaacatct aaacaacaac aacaaaaaaa gtgcgtgcgc 241 gtgcagaagc gaaaaaaacc gaataaattg tgggcgaatc aacaagcaaa agagaatgag 301 cgatgatgag gagaagaggc aaaaaaagca gaggcagttg tcgtagtact agtaccaaaa 361 agaaactgcg aaaactgcta aagtgacaaa aacaacaaca gcaagtaacg aaagagaaaa 421 gcaaaagaag gtaaaaagaa tgaaggcgaa taaaaaataa gcgcaaaaat atacgtctac 481 aaaaaagcag cagcaacaac tacacaaaaa ttaacttaaa aaagtcgtga attcatcgtt 541 cagtatatat atatatatat gtatatatat atataaatca acacacacac atacgaagag 601 tgagagcgag agagcgtgcg ttatttattt tatattttcg ttaatcattt ttcgcatttt 661 gtgaaacaag ttggaaaagc gacaatacaa aatacagcaa caacaatagc agcagtaagc 721 agtttgcacc acttggaaga gatctgccat cagaagccgg aagcgatgag cgattgctgc 781 acataacgcc ggccactctg acattggact tcaagcccca tcccgccgtg gatatcgatc 841 agcagatcat ggagctcaag aagagccagg agctgcaaaa gcagcggctt atcaactcgt 901 ttcaggagca atcgaagcaa atggaattgg agcataaact tcaattggag cacaagtatc 961 aatttgcggt gaattcacat ggcgctttcc aggaattgcg aaacgagagc atggtgacag 1021 ccgccgctgc tgcggtggct caggagcaac atcgccaaca gttgcatcaa cagcagcagc 1081 aacatcagca gcagcagcag cagcagcaac atcaacagca gcagcagcag caacaggcac 1141 gcggcaggga tggcatgaaa ctcaagcaga actgtagtgc caatgccagt cccgaggtca 1201 aacagattct caactgcttc atcctgagca gaaagtccca ggcggcggca tcgaatggca 1261 caacgacaac gtcgccctac aggaatcgcg gcgtggtgaa gagctcctcg ggcgaatccc 1321 tcccagctgg aaccgtgacc agtgcgcatc cgtacaaaat acctcagccg ccaccctcac 1381 tgctcaaata tgaatctgat tttccgctga ggaagacagc atccgaaccg aacctgctga 1441 agatccggct gaagcagagc gtcatcgagc gcaaggcccg catcggagga ccggcgggag 1501 cccggcgcca cgaacgactc ctccaggcgg cgcagcgtag gcagcaaaag aactcggttc 1561 tcacaaactg caacagtaca ccggattctg gacccaattc accgccctcg gcagctgcgt 1621 tggcggtggg cgtggtcggt agccgtggat caccgacaag tgcacccatt caggaggaaa 1681 acgaggaggg cagccaatat cagccgggcc agaggagcag catcaacgat ttgccattgt 1741 tcagttcacc atcgctgccg aatatttcgc tcgggcgacc gcatttaccc aactcggcgc 1801 aggcgcatgc ccaggtgaat gcccaggttg ctgcccaggc tcaggcacag gcccaggcac 1861 aggcacaggc gcatgccatg ttcgcggcac tggctgccgc ccagggtggc tgcggacagc 1921 cgggctacta taatccactg ggcatggcat tcgttggccg gcaaccagca ccgctggcca 1981 tgattccggc cacggggata gcaccgcagc aaccgtcgcc ggtggtgcgc agtgcatcgg 2041 ccacttcgac atcgtcgtcg caggcctcgc tggtgggcga tgtggcgcca ccgcaggctc 2101 atgccgcctc caccattctg ccctcgtcat cgtcctacat gcagcaactg ggcagtgtgg 2161 ccggttcggg tgttaatctc catgccgccg ccgttgctgc agcggcagca gcagcagccg 2221 ccgccggttc actgccaccg accaatagcc atggtcacgg acacggttcc cacgcacatc 2281 cacatccaca tgcccatgga cacgggcatg gccatggcca tggtatctac gctggccacc 2341 agcacaatgt gcccataacg gacgcccagg tggcgcaggt gcatctgcac aaacagggcc 2401 atcggccgct gggacgaacg cagtcggcac cactgcccct tggacatccg atgctaaccg 2461 gagctgtgca actgaatgtg gtccaaacgc actacgagaa tagtgaggcg gagcgccagg 2521 cgtacgagca ccaggtggtg aaccagaaag tccgccagac cgtcctgact cgcagcggag 2581 ctgctgcagc agccgctgct gccgccggcg tgagcgtggt gcgtgaggca cagttgaagg 2641 aggaggatga cgactcggcc gccgaggtga tggacctcac agataagaaa aaaccgccga 2701 agacggtgct aaccagcacg atagccacca gtacgtccca gaatctgccc gaagctttgg 2761 cggcggcggc ggcggcagcc gcctaccgtg ccccgcacaa cgcgtccagt aactccgcct 2821 ccgccacaaa gtccggtatt aagctgcggg accaggagta tttgcaacag cagcgggagc 2881 aactattgct ccttcagcag gaggaggaac tggcgaagag cctaatgcgt ccgctatcgc 2941 gaacgcttag cagtccgctg gtgccgctgg ggccacatgg tcttagtcag attcccgaca 3001 ctggacaaca gccggcaccg atagccacat cctcgtcggc cgatcatata ccgcccgtta 3061 acctctcgct gccgcatcgc cagcaccgcc agctaatgag cacactatac gccagccaat 3121 tgcgtaacca ccagccatcg gcgagtggtt caccgccgca caaggtcacc accggtttgg 3181 cctacgatcc gcttatgctg aagcattcgt gtatttgcgg agacaatgcc cagcatccgg 3241 agcacagtgg tcgactgcag agcgtgtggg cacggttaaa tgaaacggat ctggtgaagc 3301 gttgcgatcg cctgcgcgct cgcaaggcga cacaggagga gctgcagact gtgcacaccg 3361 aagcgcatgc catgctcttc ggttcgaatc agtgccagct cagcaggccc aagttggaaa 3421 acacgttgtc ggccagcttt gtgcgtttgt cgtgcggcgg cttgggtgtg gatctggata 3481 ccacgtggaa tgagcaccat acggcaaccg ctgcacgaat ggcagccggt tgtgttatcg 3541 atttggcact gaagacggcc aagggtgacc tgcggaatgg ctttgccgtt gtccggccgc 3601 cgggccatca tgcggaggcc aatttggcca tgggcttttg tttcttcaat tcgatagcca 3661 ttgcggccaa gctgctgcgt cagcggatgc ccgaggtgcg gcgcatcctg atcgtcgatt 3721 gggatgtgca tcacggcaat ggcacacagc aagcattcta ccaaagtccc gacattctat 3781 atctttccat acatcgacac gatgacggta acttctttcc cggcacaggt ggacccacag 3841 agtgcggctc cggtgctggt ctcggcttta acgtgaacat ctcatggtct ggggcactta 3901 atccgccact gggcgacgcc gagtatatcg ctgcattccg taccgttgtg atgcccatcg 3961 cgcggagctt taatccggac attgtgctgg tatcctccgg cttcgatgcg gccaccggcc 4021 atccggcacc gctgggtggc taccatgtct ctccggcctg ctttgggttc atgacccgcg 4081 aactccttca gttggccaac ggcaaagtgg tgctggccct cgagggcggc tacgatctgg 4141 ccgccatctg tgattccgcc caggagtgtg tgcgggcgct gctcggcgat cccgctgctc 4201 ccattgccaa ggccgagctg gagcgcccgc cttgccagaa tgccatcaat acgctccaga 4261 agacgatagc catacagcaa acgcattggc cctgcgtgag gatgctggag cacacggttg 4321 gcttgtctgc gctggagacg ctcaaggtgg agcacgacga gtccgagacg atcaacgcca 4381 tggctggcct ctcgatgcag tcgatgcaca gaactctatc ccgcgatgat tccgaggagc 4441 cgatggatca ggatgaaacc aaatagaagg cgatgcagac gtatattgcg gaagaggagg 4501 cggtgggcgt ggcgaggttt ttgtggacct ggtagagtgg gaatggcagg agggggcgtg 4561 gccgcaagct gctcaatgca catttagtta tttgttgtag ttgaattgat tgttgttgct 4621 gttgttgttg tggcgctcgc ttgcaattgt tgtcgttgtc attgatcgtc tatagccaca 4681 tctatctctc tcactcgatc gattatagca tcccaattcc ccgccccgcc aaaaaaaaca 4741 aaaagaagag aaacatcgaa aatatagggg aacatgtcta aaagaagcag aacagggcct 4801 aaagttcaaa atggtggctg tgcctccaaa agaagaaata attataataa ttagaaaaga 4861 atcctttcaa aaaaaaagga gattttatat gaatatatat atatatgaat atatatgtag 4921 cttaagctca gaatttagtt gtagaagtca tcgagatttt ttttttttgt tttaaggtga 4981 gagcagaggt attttaacgc acacacaaac acacgcaact caatgtatct tattattatt 5041 atttaagtaa gtgtgtcaaa aggatataga accactaacg tactggtgaa catcatcagt 5101 aagctataaa gataatgttt aaagaggtcg ggtgcaagaa gcatgtgttt ttttttataa 5161 ggtaaggttc aacctcaaag ttcccaagtc tagaccccac cacgcccact tatccgccat 5221 cgcttacaga gatcgagtgg ggagttgatt acatgttatg tagaatgctt tagttgataa 5281 taagatatga gaaaaaaaaa acttaacaac taactagttg gatgaaaagc gaaaaaactg 5341 agaaatcttt ttgtacaatt tatagtttag tgcaagtttc aagtacaaca tgctattatt 5401 taaagaattc tatatatata catatatata tatatatata caaaaaaaat atatattgtg 5461 caataaatgt gagaaaatga aaatcgccac acaaaacaga aactaaaacg aataagagaa 5521 aatttgttgt taaatgttgc cgagatctta tatacgtatg tatacctaat aactgttaca 5581 ataataaccc tttatatata taactatata aatgcacatg tgtattcacc atgtgtgtaa 5641 cgataacgat gttcaacaaa tgtctgaaat gaagtaaaac tattattata tgtaaataaa 5701 acacaaaaaa caaagagaac aattttaata aaaaaaaagc aacaataaaa tacaaaatca 5761 aagaaaatat ccacgctcac acacacacat acacacacaa acatatatac gtcctgggca 5821 ggacccgaga ggcgtgaatc gggaaaaatt ctgaaataac cgttcaatcg ctaaccgtta 5881 actgtaaaac cgctgtaact gtatttgtac tcgtgtacct ttagctgtct atagccgtct 5941 ctctctaact cgctacctaa ctgtaaagga gcacctcaat aacgaaagaa gaaggagcaa 6001 cagacaagga tcaaaaatat atagcaagtg aaaaggatga tggaaagaag gaggaggagg 6061 aggagaaaca agaaaaataa gcacaacgag agatggaccg attggctcca actggatgaa 6121 acaattgtta acaaaacgaa acagaaacta aaaactatcc ttaaaaaaaa atgaaatcac 6181 aaatgtaact attaatctaa gcgaagcata tgcccttgcc atttttattt tcttattatt 6241 cacctgtttt ctcttttcaa tacagcagat tttttgaaaa acatactttt gaacataagc 6301 tgtttcgtat gcaagccacg taattgctgt tacttaggaa tatatatata cgaatttttc 6361 ttgggttcca aaagcgttac aatacgctct gtgttaaatc tgtgctttta ttttaatttt 6421 ctatttataa tttggcaaat tggcgatctc cccttacctt accttttttt atctttcctg 6481 aatttgtttt ttttttacca aaacacgaat tatgaagagg attctactaa caagatgaaa 6541 tattattgtt gcgcactgc