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Drosophila melanogaster histone deacetylase 4, transcript variant H


LOCUS       NM_001272579            6510 bp    mRNA    linear   INV 26-DEC-2023
            (HDAC4), mRNA.
ACCESSION   NM_001272579
VERSION     NM_001272579.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6510)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6510)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6510)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6510)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6510)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6510)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6510)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6510)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6510)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6510)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6510)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6510)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6510)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6510)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6510)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6510)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6510)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6510)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6510)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6510)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6510)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6510)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6510)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001272579.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6510
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6510
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Histone deacetylase 4"
                     /map="11E8-11E9"
                     /db_xref="FLYBASE:FBgn0041210"
                     /db_xref="GeneID:32278"
     CDS             872..4417
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /EC_number="3.5.1.98"
                     /note="CG1770 gene product from transcript CG1770-RH;
                     CG1770-PH; HDAC4-PH; histone deacetylase 4"
                     /codon_start=1
                     /product="histone deacetylase 4, isoform H"
                     /protein_id="NP_001259508.1"
                     /db_xref="FLYBASE:FBpp0305524"
                     /db_xref="GeneID:32278"
                     /db_xref="FLYBASE:FBgn0041210"
                     /translation="MELEHKLQLEHKYQFAVNSHGAFQELRNESMVTAAAAAVAQEQH
                     RQQLHQQQQQHQQQQQQQQHQQQQQQQQARGRDGMKLKQNCSANASPEVKQILNCFIL
                     SRKSQAAASNGTTTTSPYRNRGVVKSSSGESLPAGTVTSAHPYKIPQPPPSLLKYESD
                     FPLRKTASEPNLLKIRLKQSVIERKARIGGPAGARRHERLLQAAQRRQQKNSVLTNCN
                     STPDSGPNSPPSAAALAVGVVGSRGSPTSAPIQEENEEGSQYQPGQRSSINDLPLFSS
                     PSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGCGQP
                     GYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVRSASATSTSSSQASLVGDVAPPQ
                     AHAASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGS
                     HAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLG
                     HPMLTGAVQLNVVQTHYENSEAERQAYEHQVVNQKVRQTVLTRSGAAAAAAAAAGVSV
                     VREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLPEALAAAAAAAAYRA
                     PHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLMRPLSRTLSSPLVP
                     LGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQLRNHQPS
                     ASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRL
                     RARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTW
                     NEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAI
                     AAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGP
                     TECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDA
                     ATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALL
                     GDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHD
                     ESETINAMAGLSMQSMHRTLSRDDSEEPMDQDETK"
     misc_feature    3116..4240
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Histone deacetylases, class IIa; Region:
                     HDAC_classIIa; cd11681"
                     /db_xref="CDD:212544"
     misc_feature    order(3557..3562,3584..3589,3674..3676,3680..3682,
                     3956..3958,4076..4078)
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="active site"
                     /db_xref="CDD:212544"
ORIGIN      
        1 agatatcgat gtggttccag ctctaatagt cgtggatttc ggaacattaa tttgtatttt
       61 ttgcgtcgcg tcgccccaga aagtccaatc caacagcaaa tcgcgcgttt tccaaagaac
      121 aacaaccccg aaaaattcga aaataataat tttcttgttt tttttttctg ttttcctgcg
      181 gcaaaaattc caattttttt cgtaacatct aaacaacaac aacaaaaaaa gtgcgtgcgc
      241 gtgcagaagc gaaaaaaacc gaataaattg tgggcgaatc aacaagcaaa agagaatgag
      301 cgatgatgag gagaagaggc aaaaaaagca gaggcagttg tcgtagtact agtaccaaaa
      361 agaaactgcg aaaactgcta aagtgacaaa aacaacaaca gcaagtaacg aaagagaaaa
      421 gcaaaagaag gtaaaaagaa tgaaggcgaa taaaaaataa gcgcaaaaat atacgtctac
      481 aaaaaagcag cagcaacaac tacacaaaaa ttaacttaaa aaagtcgtga attcatcgtt
      541 cagtatatat atatatatat gtatatatat atataaatca acacacacac atacgaagag
      601 tgagagcgag agagcgtgcg ttatttattt tatattttcg ttaatcattt ttcgcatttt
      661 gtgaaacaag ttggaaaagc gacaatacaa aatacagcaa caacaatagc agcagtaagc
      721 agtttgcacc acttggaaga ggttccgccc tcccccaatt ccatatgcaa aatgtctagt
      781 cccgacgata gaataccaat acacgctcaa gaagagccag gagctgcaaa agcagcggct
      841 tatcaactcg tttcaggagc aatcgaagca aatggaattg gagcataaac ttcaattgga
      901 gcacaagtat caatttgcgg tgaattcaca tggcgctttc caggaattgc gaaacgagag
      961 catggtgaca gccgccgctg ctgcggtggc tcaggagcaa catcgccaac agttgcatca
     1021 acagcagcag caacatcagc agcagcagca gcagcagcaa catcaacagc agcagcagca
     1081 gcaacaggca cgcggcaggg atggcatgaa actcaagcag aactgtagtg ccaatgccag
     1141 tcccgaggtc aaacagattc tcaactgctt catcctgagc agaaagtccc aggcggcggc
     1201 atcgaatggc acaacgacaa cgtcgcccta caggaatcgc ggcgtggtga agagctcctc
     1261 gggcgaatcc ctcccagctg gaaccgtgac cagtgcgcat ccgtacaaaa tacctcagcc
     1321 gccaccctca ctgctcaaat atgaatctga ttttccgctg aggaagacag catccgaacc
     1381 gaacctgctg aagatccggc tgaagcagag cgtcatcgag cgcaaggccc gcatcggagg
     1441 accggcggga gcccggcgcc acgaacgact cctccaggcg gcgcagcgta ggcagcaaaa
     1501 gaactcggtt ctcacaaact gcaacagtac accggattct ggacccaatt caccgccctc
     1561 ggcagctgcg ttggcggtgg gcgtggtcgg tagccgtgga tcaccgacaa gtgcacccat
     1621 tcaggaggaa aacgaggagg gcagccaata tcagccgggc cagaggagca gcatcaacga
     1681 tttgccattg ttcagttcac catcgctgcc gaatatttcg ctcgggcgac cgcatttacc
     1741 caactcggcg caggcgcatg cccaggtgaa tgcccaggtt gctgcccagg ctcaggcaca
     1801 ggcccaggca caggcacagg cgcatgccat gttcgcggca ctggctgccg cccagggtgg
     1861 ctgcggacag ccgggctact ataatccact gggcatggca ttcgttggcc ggcaaccagc
     1921 accgctggcc atgattccgg ccacggggat agcaccgcag caaccgtcgc cggtggtgcg
     1981 cagtgcatcg gccacttcga catcgtcgtc gcaggcctcg ctggtgggcg atgtggcgcc
     2041 accgcaggct catgccgcct ccaccattct gccctcgtca tcgtcctaca tgcagcaact
     2101 gggcagtgtg gccggttcgg gtgttaatct ccatgccgcc gccgttgctg cagcggcagc
     2161 agcagcagcc gccgccggtt cactgccacc gaccaatagc catggtcacg gacacggttc
     2221 ccacgcacat ccacatccac atgcccatgg acacgggcat ggccatggcc atggtatcta
     2281 cgctggccac cagcacaatg tgcccataac ggacgcccag gtggcgcagg tgcatctgca
     2341 caaacagggc catcggccgc tgggacgaac gcagtcggca ccactgcccc ttggacatcc
     2401 gatgctaacc ggagctgtgc aactgaatgt ggtccaaacg cactacgaga atagtgaggc
     2461 ggagcgccag gcgtacgagc accaggtggt gaaccagaaa gtccgccaga ccgtcctgac
     2521 tcgcagcgga gctgctgcag cagccgctgc tgccgccggc gtgagcgtgg tgcgtgaggc
     2581 acagttgaag gaggaggatg acgactcggc cgccgaggtg atggacctca cagataagaa
     2641 aaaaccgccg aagacggtgc taaccagcac gatagccacc agtacgtccc agaatctgcc
     2701 cgaagctttg gcggcggcgg cggcggcagc cgcctaccgt gccccgcaca acgcgtccag
     2761 taactccgcc tccgccacaa agtccggtat taagctgcgg gaccaggagt atttgcaaca
     2821 gcagcgggag caactattgc tccttcagca ggaggaggaa ctggcgaaga gcctaatgcg
     2881 tccgctatcg cgaacgctta gcagtccgct ggtgccgctg gggccacatg gtcttagtca
     2941 gattcccgac actggacaac agccggcacc gatagccaca tcctcgtcgg ccgatcatat
     3001 accgcccgtt aacctctcgc tgccgcatcg ccagcaccgc cagctaatga gcacactata
     3061 cgccagccaa ttgcgtaacc accagccatc ggcgagtggt tcaccgccgc acaaggtcac
     3121 caccggtttg gcctacgatc cgcttatgct gaagcattcg tgtatttgcg gagacaatgc
     3181 ccagcatccg gagcacagtg gtcgactgca gagcgtgtgg gcacggttaa atgaaacgga
     3241 tctggtgaag cgttgcgatc gcctgcgcgc tcgcaaggcg acacaggagg agctgcagac
     3301 tgtgcacacc gaagcgcatg ccatgctctt cggttcgaat cagtgccagc tcagcaggcc
     3361 caagttggaa aacacgttgt cggccagctt tgtgcgtttg tcgtgcggcg gcttgggtgt
     3421 ggatctggat accacgtgga atgagcacca tacggcaacc gctgcacgaa tggcagccgg
     3481 ttgtgttatc gatttggcac tgaagacggc caagggtgac ctgcggaatg gctttgccgt
     3541 tgtccggccg ccgggccatc atgcggaggc caatttggcc atgggctttt gtttcttcaa
     3601 ttcgatagcc attgcggcca agctgctgcg tcagcggatg cccgaggtgc ggcgcatcct
     3661 gatcgtcgat tgggatgtgc atcacggcaa tggcacacag caagcattct accaaagtcc
     3721 cgacattcta tatctttcca tacatcgaca cgatgacggt aacttctttc ccggcacagg
     3781 tggacccaca gagtgcggct ccggtgctgg tctcggcttt aacgtgaaca tctcatggtc
     3841 tggggcactt aatccgccac tgggcgacgc cgagtatatc gctgcattcc gtaccgttgt
     3901 gatgcccatc gcgcggagct ttaatccgga cattgtgctg gtatcctccg gcttcgatgc
     3961 ggccaccggc catccggcac cgctgggtgg ctaccatgtc tctccggcct gctttgggtt
     4021 catgacccgc gaactccttc agttggccaa cggcaaagtg gtgctggccc tcgagggcgg
     4081 ctacgatctg gccgccatct gtgattccgc ccaggagtgt gtgcgggcgc tgctcggcga
     4141 tcccgctgct cccattgcca aggccgagct ggagcgcccg ccttgccaga atgccatcaa
     4201 tacgctccag aagacgatag ccatacagca aacgcattgg ccctgcgtga ggatgctgga
     4261 gcacacggtt ggcttgtctg cgctggagac gctcaaggtg gagcacgacg agtccgagac
     4321 gatcaacgcc atggctggcc tctcgatgca gtcgatgcac agaactctat cccgcgatga
     4381 ttccgaggag ccgatggatc aggatgaaac caaatagaag gcgatgcaga cgtatattgc
     4441 ggaagaggag gcggtgggcg tggcgaggtt tttgtggacc tggtagagtg ggaatggcag
     4501 gagggggcgt ggccgcaagc tgctcaatgc acatttagtt atttgttgta gttgaattga
     4561 ttgttgttgc tgttgttgtt gtggcgctcg cttgcaattg ttgtcgttgt cattgatcgt
     4621 ctatagccac atctatctct ctcactcgat cgattatagc atcccaattc cccgccccgc
     4681 caaaaaaaac aaaaagaaga gaaacatcga aaatataggg gaacatgtct aaaagaagca
     4741 gaacagggcc taaagttcaa aatggtggct gtgcctccaa aagaagaaat aattataata
     4801 attagaaaag aatcctttca aaaaaaaagg agattttata tgaatatata tatatatgaa
     4861 tatatatgta gcttaagctc agaatttagt tgtagaagtc atcgagattt tttttttttg
     4921 ttttaaggtg agagcagagg tattttaacg cacacacaaa cacacgcaac tcaatgtatc
     4981 ttattattat tatttaagta agtgtgtcaa aaggatatag aaccactaac gtactggtga
     5041 acatcatcag taagctataa agataatgtt taaagaggtc gggtgcaaga agcatgtgtt
     5101 tttttttata aggtaaggtt caacctcaaa gttcccaagt ctagacccca ccacgcccac
     5161 ttatccgcca tcgcttacag agatcgagtg gggagttgat tacatgttat gtagaatgct
     5221 ttagttgata ataagatatg agaaaaaaaa aacttaacaa ctaactagtt ggatgaaaag
     5281 cgaaaaaact gagaaatctt tttgtacaat ttatagttta gtgcaagttt caagtacaac
     5341 atgctattat ttaaagaatt ctatatatat acatatatat atatatatat acaaaaaaaa
     5401 tatatattgt gcaataaatg tgagaaaatg aaaatcgcca cacaaaacag aaactaaaac
     5461 gaataagaga aaatttgttg ttaaatgttg ccgagatctt atatacgtat gtatacctaa
     5521 taactgttac aataataacc ctttatatat ataactatat aaatgcacat gtgtattcac
     5581 catgtgtgta acgataacga tgttcaacaa atgtctgaaa tgaagtaaaa ctattattat
     5641 atgtaaataa aacacaaaaa acaaagagaa caattttaat aaaaaaaaag caacaataaa
     5701 atacaaaatc aaagaaaata tccacgctca cacacacaca tacacacaca aacatatata
     5761 cgtcctgggc aggacccgag aggcgtgaat cgggaaaaat tctgaaataa ccgttcaatc
     5821 gctaaccgtt aactgtaaaa ccgctgtaac tgtatttgta ctcgtgtacc tttagctgtc
     5881 tatagccgtc tctctctaac tcgctaccta actgtaaagg agcacctcaa taacgaaaga
     5941 agaaggagca acagacaagg atcaaaaata tatagcaagt gaaaaggatg atggaaagaa
     6001 ggaggaggag gaggagaaac aagaaaaata agcacaacga gagatggacc gattggctcc
     6061 aactggatga aacaattgtt aacaaaacga aacagaaact aaaaactatc cttaaaaaaa
     6121 aatgaaatca caaatgtaac tattaatcta agcgaagcat atgcccttgc catttttatt
     6181 ttcttattat tcacctgttt tctcttttca atacagcaga ttttttgaaa aacatacttt
     6241 tgaacataag ctgtttcgta tgcaagccac gtaattgctg ttacttagga atatatatat
     6301 acgaattttt cttgggttcc aaaagcgtta caatacgctc tgtgttaaat ctgtgctttt
     6361 attttaattt tctatttata atttggcaaa ttggcgatct ccccttacct tacctttttt
     6421 tatctttcct gaatttgttt tttttttacc aaaacacgaa ttatgaagag gattctacta
     6481 acaagatgaa atattattgt tgcgcactgc