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Drosophila melanogaster histone deacetylase 4, transcript variant G


LOCUS       NM_001272578            6876 bp    mRNA    linear   INV 26-DEC-2023
            (HDAC4), mRNA.
ACCESSION   NM_001272578
VERSION     NM_001272578.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6876)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6876)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6876)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6876)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6876)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6876)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6876)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6876)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6876)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6876)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6876)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6876)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6876)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6876)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6876)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6876)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6876)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6876)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6876)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6876)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6876)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6876)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6876)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001272578.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6876
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6876
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Histone deacetylase 4"
                     /map="11E8-11E9"
                     /db_xref="FLYBASE:FBgn0041210"
                     /db_xref="GeneID:32278"
     CDS             772..4581
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /EC_number="3.5.1.98"
                     /note="CG1770 gene product from transcript CG1770-RG;
                     CG1770-PG; HDAC4-PG; histone deacetylase 4"
                     /codon_start=1
                     /product="histone deacetylase 4, isoform G"
                     /protein_id="NP_001259507.1"
                     /db_xref="FLYBASE:FBpp0305523"
                     /db_xref="GeneID:32278"
                     /db_xref="FLYBASE:FBgn0041210"
                     /translation="MSSPDDRIPIHDLPSEAGSDERLLHITPATLTLDFKPHPAVDID
                     QQIMELKKSQELQKQRLINSFQEQSKQMELEHKLQLEHKYQKQPTNKRFSLELIVIIQ
                     FAVNSHGAFQELRNESMVTAAAAAVAQEQHRQQLHQQQQQHQQQQQQQQHQQQQQQQQ
                     ARGRDGMKLKQNCSANASPEVKQILNCFILSRKSQAAASNGTTTTSPYRNRGVVKSSS
                     GESLPAGTVTSAHPYKIPQPPPSLLKYESDFPLRKTASEPNLLKIRLKQSVIERKARI
                     GGPAGARRHERLLQAAQRRQQKNSVLTNCNSTPDSGPNSPPSAAALAVGVVGSRGSPT
                     SAPIQEENEEGSQYQPGQRSSINDLPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVA
                     AQAQAQAQAQAQAHAMFAALAAAQGGCGQPGYYNPLGMAFVGRQPAPLAMIPATGIAP
                     QQPSPVVRSASATSTSSSQASLVGDVAPPQAHAASTILPSSSSYMQQLGSVAGSGVNL
                     HAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVP
                     ITDAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQAYE
                     HQVVNQKVRQTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPK
                     TVLTSTIATSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQR
                     EQLLLLQQEEELAKSLMRPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHI
                     PPVNLSLPHRQHRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGD
                     NAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQ
                     LSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDL
                     RNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGT
                     QQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDA
                     EYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQL
                     ANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTI
                     AIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEP
                     MDQDETK"
     misc_feature    898..>1032
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Glutamine-rich N-terminal helical domain of various
                     Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9);
                     Region: ClassIIa_HDAC_Gln-rich-N; cl25407"
                     /db_xref="CDD:421006"
     misc_feature    order(910..912,922..924,934..936,943..945,955..957,
                     964..966,976..981,988..993,1000..1002,1018..1020)
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="dimer interface A, D [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197397"
     misc_feature    3280..4404
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Histone deacetylases, class IIa; Region:
                     HDAC_classIIa; cd11681"
                     /db_xref="CDD:212544"
     misc_feature    order(3721..3726,3748..3753,3838..3840,3844..3846,
                     4120..4122,4240..4242)
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="active site"
                     /db_xref="CDD:212544"
ORIGIN      
        1 agatatcgat gtggttccag ctctaatagt cgtggatttc ggaacattaa tttgtatttt
       61 ttgcgtcgcg tcgccccaga aagtccaatc caacagcaaa tcgcgcgttt tccaaagaac
      121 aacaaccccg aaaaattcga aaataataat tttcttgttt tttttttctg ttttcctgcg
      181 gcaaaaattc caattttttt cgtaacatct aaacaacaac aacaaaaaaa gtgcgtgcgc
      241 gtgcagaagc gaaaaaaacc gaataaattg tgggcgaatc aacaagcaaa agagaatgag
      301 cgatgatgag gagaagaggc aaaaaaagca gaggcagttg tcgtagtact agtaccaaaa
      361 agaaactgcg aaaactgcta aagtgacaaa aacaacaaca gcaagtaacg aaagagaaaa
      421 gcaaaagaag gtaaaaagaa tgaaggcgaa taaaaaataa gcgcaaaaat atacgtctac
      481 aaaaaagcag cagcaacaac tacacaaaaa ttaacttaaa aaagtcgtga attcatcgtt
      541 cagtatatat atatatatat gtatatatat atataaatca acacacacac atacgaagag
      601 tgagagcgag agagcgtgcg ttatttattt tatattttcg ttaatcattt ttcgcatttt
      661 gtgaaacaag ttggaaaagc gacaatacaa aatacagcaa caacaatagc agcagtaagc
      721 agtttgcacc acttggaaga ggttccgccc tcccccaatt ccatatgcaa aatgtctagt
      781 cccgacgata gaataccaat acacgatctg ccatcagaag ccggaagcga tgagcgattg
      841 ctgcacataa cgccggccac tctgacattg gacttcaagc cccatcccgc cgtggatatc
      901 gatcagcaga tcatggagct caagaagagc caggagctgc aaaagcagcg gcttatcaac
      961 tcgtttcagg agcaatcgaa gcaaatggaa ttggagcata aacttcaatt ggagcacaag
     1021 tatcaaaaac aaccaacaaa caaacgattc tctctcgaac ttattgtaat tattcagttt
     1081 gcggtgaatt cacatggcgc tttccaggaa ttgcgaaacg agagcatggt gacagccgcc
     1141 gctgctgcgg tggctcagga gcaacatcgc caacagttgc atcaacagca gcagcaacat
     1201 cagcagcagc agcagcagca gcaacatcaa cagcagcagc agcagcaaca ggcacgcggc
     1261 agggatggca tgaaactcaa gcagaactgt agtgccaatg ccagtcccga ggtcaaacag
     1321 attctcaact gcttcatcct gagcagaaag tcccaggcgg cggcatcgaa tggcacaacg
     1381 acaacgtcgc cctacaggaa tcgcggcgtg gtgaagagct cctcgggcga atccctccca
     1441 gctggaaccg tgaccagtgc gcatccgtac aaaatacctc agccgccacc ctcactgctc
     1501 aaatatgaat ctgattttcc gctgaggaag acagcatccg aaccgaacct gctgaagatc
     1561 cggctgaagc agagcgtcat cgagcgcaag gcccgcatcg gaggaccggc gggagcccgg
     1621 cgccacgaac gactcctcca ggcggcgcag cgtaggcagc aaaagaactc ggttctcaca
     1681 aactgcaaca gtacaccgga ttctggaccc aattcaccgc cctcggcagc tgcgttggcg
     1741 gtgggcgtgg tcggtagccg tggatcaccg acaagtgcac ccattcagga ggaaaacgag
     1801 gagggcagcc aatatcagcc gggccagagg agcagcatca acgatttgcc attgttcagt
     1861 tcaccatcgc tgccgaatat ttcgctcggg cgaccgcatt tacccaactc ggcgcaggcg
     1921 catgcccagg tgaatgccca ggttgctgcc caggctcagg cacaggccca ggcacaggca
     1981 caggcgcatg ccatgttcgc ggcactggct gccgcccagg gtggctgcgg acagccgggc
     2041 tactataatc cactgggcat ggcattcgtt ggccggcaac cagcaccgct ggccatgatt
     2101 ccggccacgg ggatagcacc gcagcaaccg tcgccggtgg tgcgcagtgc atcggccact
     2161 tcgacatcgt cgtcgcaggc ctcgctggtg ggcgatgtgg cgccaccgca ggctcatgcc
     2221 gcctccacca ttctgccctc gtcatcgtcc tacatgcagc aactgggcag tgtggccggt
     2281 tcgggtgtta atctccatgc cgccgccgtt gctgcagcgg cagcagcagc agccgccgcc
     2341 ggttcactgc caccgaccaa tagccatggt cacggacacg gttcccacgc acatccacat
     2401 ccacatgccc atggacacgg gcatggccat ggccatggta tctacgctgg ccaccagcac
     2461 aatgtgccca taacggacgc ccaggtggcg caggtgcatc tgcacaaaca gggccatcgg
     2521 ccgctgggac gaacgcagtc ggcaccactg ccccttggac atccgatgct aaccggagct
     2581 gtgcaactga atgtggtcca aacgcactac gagaatagtg aggcggagcg ccaggcgtac
     2641 gagcaccagg tggtgaacca gaaagtccgc cagaccgtcc tgactcgcag cggagctgct
     2701 gcagcagccg ctgctgccgc cggcgtgagc gtggtgcgtg aggcacagtt gaaggaggag
     2761 gatgacgact cggccgccga ggtgatggac ctcacagata agaaaaaacc gccgaagacg
     2821 gtgctaacca gcacgatagc caccagtacg tcccagaatc tgcccgaagc tttggcggcg
     2881 gcggcggcgg cagccgccta ccgtgccccg cacaacgcgt ccagtaactc cgcctccgcc
     2941 acaaagtccg gtattaagct gcgggaccag gagtatttgc aacagcagcg ggagcaacta
     3001 ttgctccttc agcaggagga ggaactggcg aagagcctaa tgcgtccgct atcgcgaacg
     3061 cttagcagtc cgctggtgcc gctggggcca catggtctta gtcagattcc cgacactgga
     3121 caacagccgg caccgatagc cacatcctcg tcggccgatc atataccgcc cgttaacctc
     3181 tcgctgccgc atcgccagca ccgccagcta atgagcacac tatacgccag ccaattgcgt
     3241 aaccaccagc catcggcgag tggttcaccg ccgcacaagg tcaccaccgg tttggcctac
     3301 gatccgctta tgctgaagca ttcgtgtatt tgcggagaca atgcccagca tccggagcac
     3361 agtggtcgac tgcagagcgt gtgggcacgg ttaaatgaaa cggatctggt gaagcgttgc
     3421 gatcgcctgc gcgctcgcaa ggcgacacag gaggagctgc agactgtgca caccgaagcg
     3481 catgccatgc tcttcggttc gaatcagtgc cagctcagca ggcccaagtt ggaaaacacg
     3541 ttgtcggcca gctttgtgcg tttgtcgtgc ggcggcttgg gtgtggatct ggataccacg
     3601 tggaatgagc accatacggc aaccgctgca cgaatggcag ccggttgtgt tatcgatttg
     3661 gcactgaaga cggccaaggg tgacctgcgg aatggctttg ccgttgtccg gccgccgggc
     3721 catcatgcgg aggccaattt ggccatgggc ttttgtttct tcaattcgat agccattgcg
     3781 gccaagctgc tgcgtcagcg gatgcccgag gtgcggcgca tcctgatcgt cgattgggat
     3841 gtgcatcacg gcaatggcac acagcaagca ttctaccaaa gtcccgacat tctatatctt
     3901 tccatacatc gacacgatga cggtaacttc tttcccggca caggtggacc cacagagtgc
     3961 ggctccggtg ctggtctcgg ctttaacgtg aacatctcat ggtctggggc acttaatccg
     4021 ccactgggcg acgccgagta tatcgctgca ttccgtaccg ttgtgatgcc catcgcgcgg
     4081 agctttaatc cggacattgt gctggtatcc tccggcttcg atgcggccac cggccatccg
     4141 gcaccgctgg gtggctacca tgtctctccg gcctgctttg ggttcatgac ccgcgaactc
     4201 cttcagttgg ccaacggcaa agtggtgctg gccctcgagg gcggctacga tctggccgcc
     4261 atctgtgatt ccgcccagga gtgtgtgcgg gcgctgctcg gcgatcccgc tgctcccatt
     4321 gccaaggccg agctggagcg cccgccttgc cagaatgcca tcaatacgct ccagaagacg
     4381 atagccatac agcaaacgca ttggccctgc gtgaggatgc tggagcacac ggttggcttg
     4441 tctgcgctgg agacgctcaa ggtggagcac gacgagtccg agacgatcaa cgccatggct
     4501 ggcctctcga tgcagtcgat gcacagaact ctatcccgcg atgattccga ggagccgatg
     4561 gatcaggatg aaaccaaata gaaggcgatg cagacgtata ttgcggaaga ggaggcggtg
     4621 ggcgtggcga ggtttttgtg gacctggtag agtgggaatg gcaggagggg gcgtggccgc
     4681 aagctgctca atgcacattt agttatttgt tgtagttgaa ttgattgttg ttgctgttgt
     4741 tgttgtggcg ctcgcttgca attgttgtcg ttgtcattga tcgtctatag ccacatctat
     4801 ctctctcact cgatcgatta tagcatccca attccccgcc ccgccaaaaa aaacaaaaag
     4861 aagagaaaca tcgaaaatat aggggaacat gtctaaaaga agcagaacag ggcctaaagt
     4921 tcaaaatggt ggctgtgcct ccaaaagaag aaataattat aataattaga aaagaatcct
     4981 ttcaaaaaaa aaggagattt tatatgaata tatatatata tgaatatata tgtagcttaa
     5041 gctcagaatt tagttgtaga agtcatcgag attttttttt tttgttttaa ggtgagagca
     5101 gaggtatttt aacgcacaca caaacacacg caactcaatg tatcttatta ttattattta
     5161 agtaagtgtg tcaaaaggat atagaaccac taacgtactg gtgaacatca tcagtaagct
     5221 ataaagataa tgtttaaaga ggtcgggtgc aagaagcatg tgtttttttt tataaggtaa
     5281 ggttcaacct caaagttccc aagtctagac cccaccacgc ccacttatcc gccatcgctt
     5341 acagagatcg agtggggagt tgattacatg ttatgtagaa tgctttagtt gataataaga
     5401 tatgagaaaa aaaaaactta acaactaact agttggatga aaagcgaaaa aactgagaaa
     5461 tctttttgta caatttatag tttagtgcaa gtttcaagta caacatgcta ttatttaaag
     5521 aattctatat atatacatat atatatatat atatacaaaa aaaatatata ttgtgcaata
     5581 aatgtgagaa aatgaaaatc gccacacaaa acagaaacta aaacgaataa gagaaaattt
     5641 gttgttaaat gttgccgaga tcttatatac gtatgtatac ctaataactg ttacaataat
     5701 aaccctttat atatataact atataaatgc acatgtgtat tcaccatgtg tgtaacgata
     5761 acgatgttca acaaatgtct gaaatgaagt aaaactatta ttatatgtaa ataaaacaca
     5821 aaaaacaaag agaacaattt taataaaaaa aaagcaacaa taaaatacaa aatcaaagaa
     5881 aatatccacg ctcacacaca cacatacaca cacaaacata tatacgtcct gggcaggacc
     5941 cgagaggcgt gaatcgggaa aaattctgaa ataaccgttc aatcgctaac cgttaactgt
     6001 aaaaccgctg taactgtatt tgtactcgtg tacctttagc tgtctatagc cgtctctctc
     6061 taactcgcta cctaactgta aaggagcacc tcaataacga aagaagaagg agcaacagac
     6121 aaggatcaaa aatatatagc aagtgaaaag gatgatggaa agaaggagga ggaggaggag
     6181 aaacaagaaa aataagcaca acgagagatg gaccgattgg ctccaactgg atgaaacaat
     6241 tgttaacaaa acgaaacaga aactaaaaac tatccttaaa aaaaaatgaa atcacaaatg
     6301 taactattaa tctaagcgaa gcatatgccc ttgccatttt tattttctta ttattcacct
     6361 gttttctctt ttcaatacag cagatttttt gaaaaacata cttttgaaca taagctgttt
     6421 cgtatgcaag ccacgtaatt gctgttactt aggaatatat atatacgaat ttttcttggg
     6481 ttccaaaagc gttacaatac gctctgtgtt aaatctgtgc ttttatttta attttctatt
     6541 tataatttgg caaattggcg atctcccctt accttacctt tttttatctt tcctgaattt
     6601 gttttttttt taccaaaaca cgaattatga agaggattct actaacaaga tgaaatatta
     6661 ttgttgcgca ctgcaaaaaa aaggaaaaaa taatgaataa ttccgtaagc tgagaaatag
     6721 ttaaataacg gttttagcaa aataaaaacg aaatcaaata tttatatttt gtttattgtt
     6781 gcacaaataa gtccaaggaa cgagaaacaa gaaacaatta agagtaatat tgtgtgtcgc
     6841 tttttctaaa cgaaataaaa caaagaaatc gtcaag