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Drosophila melanogaster multiple edematous wings (mew), transcript


LOCUS       NM_001272576            4350 bp    mRNA    linear   INV 26-DEC-2023
            variant D, mRNA.
ACCESSION   NM_001272576
VERSION     NM_001272576.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4350)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4350)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4350)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4350)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4350)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4350)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4350)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4350)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4350)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4350)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4350)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4350)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4350)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4350)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4350)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4350)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4350)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4350)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4350)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4350)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4350)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4350)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4350)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001272576.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4350
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4350
                     /gene="mew"
                     /locus_tag="Dmel_CG1771"
                     /gene_synonym="alpha integrin; alpha-PS1; alpha1Int;
                     alphaPS1; alpha[[PS1]]; aPS1; CG1771; CT5254; Dmel\CG1771;
                     Integrin alpha PS1; ItgaPS1; l(1)G0429; l(1)G0443; Mew;
                     PS1; PS1alpha; PSalpha1"
                     /note="multiple edematous wings"
                     /map="11E3-11E8"
                     /db_xref="FLYBASE:FBgn0004456"
                     /db_xref="GeneID:32275"
     CDS             713..3889
                     /gene="mew"
                     /locus_tag="Dmel_CG1771"
                     /gene_synonym="alpha integrin; alpha-PS1; alpha1Int;
                     alphaPS1; alpha[[PS1]]; aPS1; CG1771; CT5254; Dmel\CG1771;
                     Integrin alpha PS1; ItgaPS1; l(1)G0429; l(1)G0443; Mew;
                     PS1; PS1alpha; PSalpha1"
                     /note="CG1771 gene product from transcript CG1771-RD;
                     CG1771-PD; mew-PD; alpha1 integrin; multiple edematous
                     wings; alphaPS integrin; PS1-Integrin; alphaPS1 integrin;
                     integrin alphaPS1; integrin alpha PS1; integrin alphaPS1
                     subunit; integrin PSII alpha subunit; PS I alpha;
                     alpha-PS1-integrin; Position-specific-1 antigen;
                     alpha[[PS1]] subunit of integrin; PS1 integrin;
                     Position-specific-antigen-1alpha; alpha integrin; alpha1
                     integrin subunit"
                     /codon_start=1
                     /product="multiple edematous wings, isoform D"
                     /protein_id="NP_001259505.1"
                     /db_xref="FLYBASE:FBpp0302768"
                     /db_xref="GeneID:32275"
                     /db_xref="FLYBASE:FBgn0004456"
                     /translation="MTQRFDDCEQVITDGRRTNGAYEINKHFDSEILSPPGNDEIKED
                     QWMGVTVRSNPLQANGSGGKVIVCAHRYMYIVRENRYGQGLCYLLTNDLQFEEVHEPC
                     KGRPVQRQHEDYGLCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKT
                     TYYSDHSDLNSPVDKYSYLGMSVTGGRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPI
                     PVHSILDGEQFGSSFGYELATADINGDHRPDLIVAAPLYFTKTEGGAVYVYQNIQDTL
                     PMKYTLKLTGPLESRFGLALANIGDLNKDNCEDLAVGAPYEGNGVVYIYLGSSQGLNS
                     KPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLAR
                     PIISIQTSVQRKELHNMDPNTPGCLDDPASNLTCFTFRACCSIEPYDEKNKELRLAYS
                     VEAETFDHLKKFSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTRDIQT
                     PVRFRLKYSLVEPPLADSALVRLNPILDQTQAHVDFEGTFQKDCGDDDLCESNLIIRV
                     EPNITESSGNEYTLILDETELEVRINVSNLADSAYEAQLFIAHQAGVSYVATKKPTNA
                     TCNSYNTTLVACSLGNPMLRDTTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPE
                     RPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGPMGMDDVG
                     SQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGE
                     CHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHR
                     DDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCV
                     RIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMD
                     HNNIEVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPT
                     DPTLSGNLEKMNEEKPFLAPSKNTHHVF"
     misc_feature    1397..1552
                     /gene="mew"
                     /locus_tag="Dmel_CG1771"
                     /gene_synonym="alpha integrin; alpha-PS1; alpha1Int;
                     alphaPS1; alpha[[PS1]]; aPS1; CG1771; CT5254; Dmel\CG1771;
                     Integrin alpha PS1; ItgaPS1; l(1)G0429; l(1)G0443; Mew;
                     PS1; PS1alpha; PSalpha1"
                     /note="Integrin alpha (beta-propellor repeats); Region:
                     Int_alpha; smart00191"
                     /db_xref="CDD:214549"
     misc_feature    1580..1732
                     /gene="mew"
                     /locus_tag="Dmel_CG1771"
                     /gene_synonym="alpha integrin; alpha-PS1; alpha1Int;
                     alphaPS1; alpha[[PS1]]; aPS1; CG1771; CT5254; Dmel\CG1771;
                     Integrin alpha PS1; ItgaPS1; l(1)G0429; l(1)G0443; Mew;
                     PS1; PS1alpha; PSalpha1"
                     /note="Integrin alpha (beta-propellor repeats); Region:
                     Int_alpha; smart00191"
                     /db_xref="CDD:214549"
     misc_feature    1784..1921
                     /gene="mew"
                     /locus_tag="Dmel_CG1771"
                     /gene_synonym="alpha integrin; alpha-PS1; alpha1Int;
                     alphaPS1; alpha[[PS1]]; aPS1; CG1771; CT5254; Dmel\CG1771;
                     Integrin alpha PS1; ItgaPS1; l(1)G0429; l(1)G0443; Mew;
                     PS1; PS1alpha; PSalpha1"
                     /note="Integrin alpha (beta-propellor repeats); Region:
                     Int_alpha; smart00191"
                     /db_xref="CDD:214549"
     misc_feature    1886..3466
                     /gene="mew"
                     /locus_tag="Dmel_CG1771"
                     /gene_synonym="alpha integrin; alpha-PS1; alpha1Int;
                     alphaPS1; alpha[[PS1]]; aPS1; CG1771; CT5254; Dmel\CG1771;
                     Integrin alpha PS1; ItgaPS1; l(1)G0429; l(1)G0443; Mew;
                     PS1; PS1alpha; PSalpha1"
                     /note="Integrin alpha; Region: Integrin_alpha2; pfam08441"
                     /db_xref="CDD:462478"
ORIGIN      
        1 cattttattt ttcgtttgcc cgtcgaagaa ggcgaagcga agagaaaata tctgccgctt
       61 cgaacgcacg ctatcaatgt ctaattcttt acgtaataat catttttttt tttgctgtgt
      121 gactgaaacg aagaaatata cgagcaaaag tgaaaaatac gtggactacc tgttgatcca
      181 aagatctcaa cggatttagt gtgtgtgtgt gtgtgtgcgt gcgtgttttt tttcggttca
      241 ttgttttgtt tgcaatagtg caaaggaaaa agtaatcact ttgccgtgtt cggtgcacgt
      301 gcacgaaata tttataaaat atatattaaa aaaaaaaaac ataaaattaa cgatgttgga
      361 gctaccgttt accaccatac ggcccaactg ccggctaaga cagaatcttg gtattctgat
      421 aatcctgcaa tgcgttctca cttgctacaa tttcaaccta gaacagcgat tgcccattgt
      481 gaagtacgga catccgcatt cgcatttcgg ctactcggtg gccacccaca ctattggcga
      541 ggccaatggg cccaacaaga ccaactggta tgtactgctt aacccattag ctgcagctgt
      601 gcttaattaa ggcacaaaat gttcggatat cacatttgtt ttagtgggag ctccattgga
      661 tcaaaatcga cagccgaaca ccacacactc tggcgccctc tggcggtgtc caatgacaca
      721 gcgtttcgat gactgcgaac aagtgatcac cgatggcagg cgaacgaacg gagcatatga
      781 gattaataag cacttcgaca gcgaaatcct ttcaccgccc ggcaatgacg aaatcaagga
      841 ggatcaatgg atgggcgtta cggtgcgttc gaatccccta caggccaacg gatccggcgg
      901 aaaggtaatc gtctgcgccc atcgctatat gtacatcgtc cgagagaatc gttatggaca
      961 gggtctctgc tatctcctaa cgaacgatct gcaattcgaa gaggtccacg agccctgcaa
     1021 aggacgacct gtgcaaaggc aacacgaaga ttatggactg tgccaggcgg gcacatcggc
     1081 tgccctactg gacgatgaca ccatggtgtt gggttcccct ggaccgtaca catggcgcgg
     1141 atccatttgg gtgactcagg tgggcgggga gtacctgcag cgcgacaaga cgacctacta
     1201 cagtgatcat tcggacttga attcgccggt ggacaagtac agctatcttg gtatgtcggt
     1261 gaccggtggc agattctttg gtcacatgtc atatgcggct ggagctccac gatccgaggg
     1321 tcatggacag gtggtgattt tcgacaagtc caccgataat ccaataccgg tgcactcgat
     1381 cctggatggt gagcaattcg gttcgagttt tggctatgaa ctggcaaccg ccgatataaa
     1441 cggagatcac aggccggatt taatagtggc agctcctttg tacttcacaa aaacggaagg
     1501 tggagctgtg tatgtgtacc agaatatcca ggatacgttg cccatgaagt acacactcaa
     1561 gttgacggga cctctggaga gtcgtttcgg tctggcgttg gccaatatcg gagatctgaa
     1621 caaggataac tgcgaggatc tggccgtggg agcaccatac gagggcaacg gcgtagtcta
     1681 catctacttg ggctcgagtc agggcctgaa ttccaagccc gcccagaaga tccaggcctc
     1741 ggaactgggt ggaaccatac ccaatggtca accgattcgt acctttggca tctctatatc
     1801 cggcaacacg gacttggatg ataactccta tccggatgtg gtaatcggag cattcaactc
     1861 ctcggcagcc gtaatcctgc tggccagacc tatcatcagc attcagacga gtgtacagcg
     1921 caaggagctg cataacatgg atcccaatac gcccggctgt ttggacgatc cggccagtaa
     1981 tctaacatgt ttcacgttca gagcatgttg cagcattgaa ccgtacgatg agaagaacaa
     2041 ggaactccgg ttggcttata gcgtcgaagc ggaaaccttc gatcacctaa agaaattctc
     2101 tcgcgtcttc ttcttcgatc gggaaaataa gcggacgaat gtgctcagtc gcgtggtgag
     2161 agtgcatacg aatggaagga cagaatgcca ggcagtcacg ggctacatca aggccaatac
     2221 ccgggatatc cagactcccg tgcgtttccg cttgaagtac tcgctggtgg aacccccatt
     2281 ggcggattct gctttggtac gcctcaatcc gatattggat cagacccagg cgcatgtcga
     2341 tttcgagggc accttccaga aagactgtgg cgatgacgat ctctgtgaga gcaatctgat
     2401 tatccgggtg gagccgaaca tcactgagtc ctcaggcaac gaatacacac tgattctgga
     2461 tgaaacggaa ctggaggtcc gcatcaatgt tagcaatctg gcggattctg cttacgaagc
     2521 tcaactattc atcgcccatc aggcgggtgt ttcatatgtg gcaaccaaga agccgacgaa
     2581 tgccacgtgc aatagctaca ataccaccct ggttgcctgc agtcttggta atcccatgct
     2641 gcgcgacacc accacatttg tgaccatccg attccagccc aaaggattgg agccaagtga
     2701 gaagatcatg ctattccaca tattcgcaaa taccacctcc aagctggtgg gacccgaacg
     2761 tcccgagcgg gatcttcgcg tgaatgtggt gcgtcgggcg aagctcaact tccgaggttg
     2821 ggccataccc gagcagagtt tctacagtgg atcgagtgtg gctaattcgg ttgcaaatac
     2881 tgccgccacc gatatagaag gacatggtcc gatgggtatg gacgatgtgg gctcccaagt
     2941 tcatcacatg ttcaccattt tcaatgaggg accatccacg gcgccgaagg tacaaatggt
     3001 catccattgg ccatactcac tgtacagtga tccacagagc ggtcgaccgg ttcagtatct
     3061 actctatctg gagcaagtac ccactgtgga agttagccag ggcgaatgcc atgtggccaa
     3121 agaatatgtc aatccgctga atttggccag cggttctagg gaaaatccag cctacttgag
     3181 tgctcccgcc cagatgagaa tgttcccctc gcagtcgcgt cattcgttca acaagagctt
     3241 gatccactcg cagagaagct actactccag cagccaccgg gatgatcatt cggatgacac
     3301 tcaatcgaac cgcaatcgtg tccgtcgcag tttcctagaa cgggtgacgc gcctggagag
     3361 gttaatgtac gatcccgaga gtagcaatgc ggcgaatggc aagaagcagg acatcgtcga
     3421 gctggactgc aataagggcg cgaccaactg cgtgcgcatc gagtgtgaca tcctaaacat
     3481 gcccgctttg tccgaggccc aggtggtggt caaggcgcgc ctgtggaact cgacgctggt
     3541 cagtgagtat cctcgggtgg aaagggtcag gattttctcg acagccacgg ctcaaatacc
     3601 cgagagctat ggcgtcgagg tgatggatca caataacata gaggtggaga cgcgggccta
     3661 tccggagtta aggaaccaac agcgcgacac atcgataccg tggctgatta tcatcctggg
     3721 catcgttggt ggcctgctcc tccttgcgct ggtcacctat gtgctgtgga aggtaggctt
     3781 ctttaagcgc atccgaccca ccgatccgac gttaagcggc aatctggaga aaatgaacga
     3841 ggagaagccc ttcctggcgc catcaaagaa tacgcatcac gttttctaac aagagggcac
     3901 cgttggctgg gatttggtgc gccgtcggag gcgtcgacgt cgtctaaagc tgcgacttcc
     3961 tgttaccgct cagccacgac atggttggcg aaaaactacg gataagtcca ttaacaacaa
     4021 taataacaac aatcacaaca acaacagcag caacagtaga aacgacagcg atgtggacgt
     4081 actttcgctg acaccaccgc cgccccctct tagcatcttt agctggggaa acgatggcta
     4141 ttaccaagcc agcgcagcct ggtggggtca ccacatgtga tcaaatgggt caccgtggat
     4201 caagtgggtc atgtgggttg tggttcaatg tgccatttca cttacttaat acaaatgggt
     4261 taagttcagt tcggtggatg cgatcggatg gaattgatag cccggattcc gtcactggaa
     4321 tcagctaaat ataaattcaa gttcaatcct