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LOCUS NM_001272572 5689 bp mRNA linear INV 26-DEC-2023 mRNA. ACCESSION NM_001272572 VERSION NM_001272572.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 5689) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 5689) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 5689) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 5689) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 5689) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 5689) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 5689) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 5689) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 5689) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 5689) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 5689) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 5689) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 5689) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 5689) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 5689) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 5689) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 5689) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 5689) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 5689) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 5689) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 5689) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 5689) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 5689) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_001272572.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..5689 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..5689 /gene="hep" /locus_tag="Dmel_CG4353" /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7" /note="hemipterous" /map="11D10-11D10" /db_xref="FLYBASE:FBgn0010303" /db_xref="GeneID:32256" CDS 659..2137 /gene="hep" /locus_tag="Dmel_CG4353" /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7" /EC_number="2.7.12.2" /note="CG4353 gene product from transcript CG4353-RE; CG4353-PE; hep-PE; hemipterus; Mitogen-activated protein kinase kinase 7; hempiterous; JNK kinase; hemipterous; JNK-Kinase" /codon_start=1 /product="hemipterous, isoform E" /protein_id="NP_001259501.1" /db_xref="FLYBASE:FBpp0303423" /db_xref="GeneID:32256" /db_xref="FLYBASE:FBgn0010303" /translation="MSTIEFETIGSRLQSLEAKLQAQNESHDQIVLSGARGPVVSGSV PSARVPPLATSASAATSATHAPSLGAGSVSGSGISIAQRPAPPVPHATPFGSASASSS SSSASAFASAAPATGTFGGTYTPPTTRVSRATPTLPMLSSGPGGGLNRTRPVILPLPT PPHPPVSETDMKLKIIMEQTGKLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLS SNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELM SMCFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNI KLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATA RSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPEL LAQPFIRIYESAKVDVPNWFQSIKDNRLRANGDPTLQRLPNS" misc_feature 1199..2086 /gene="hep" /locus_tag="Dmel_CG4353" /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7" /note="Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7; Region: PKc_MKK7; cd06618" /db_xref="CDD:270791" misc_feature order(1265..1279,1289..1291,1328..1330,1334..1336, 1427..1429,1475..1486,1490..1495,1502..1504,1616..1618, 1622..1633,1637..1639,1667..1672,1679..1681,1718..1729, 1733..1735,1820..1822,1847..1849) /gene="hep" /locus_tag="Dmel_CG4353" /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7" /note="active site" /db_xref="CDD:270791" misc_feature order(1265..1279,1283..1285,1289..1291,1328..1330, 1334..1336,1427..1429,1475..1486,1490..1495,1499..1504, 1622..1624,1628..1633,1637..1639,1670..1672) /gene="hep" /locus_tag="Dmel_CG4353" /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:270791" misc_feature order(1274..1279,1616..1618,1622..1630,1679..1681, 1718..1729,1733..1735,1820..1822,1847..1849) /gene="hep" /locus_tag="Dmel_CG4353" /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270791" misc_feature 1667..1735 /gene="hep" /locus_tag="Dmel_CG4353" /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7" /note="activation loop (A-loop); other site" /db_xref="CDD:270791" ORIGIN 1 ggctgatgca tcgatgtttt tttacatcac tattgtacac gcgatttagg cagcaaaaac 61 gtacaaaagc gagtgatcaa attgtgccag tgataccgcc gcccgcggtc gcgaaacgaa 121 tcgattgcag aagtgcgaca aacagcgccg cgaaaggaaa acaaccgatg aaatattctc 181 ccaaaaaagg aggaaaaaat cgcaagttgt tgttgccgtt gctgctgaaa aagaaagaga 241 gagagggcgc tgcgtgtatg cctgtgtgtg tgcgtgtgtg ggggtgagga tgtctctctc 301 taatgcacag tgactgtgtt ttcctttttt cgattttgtt tttgtgcccc cccttggcaa 361 acaacaaaag tccaagcaat cctttatttt tgcaagtgta aagtttacag tgtatgtgtg 421 ccgccgaaca acaacaacat cagcgacaaa acaaacaggg cgcacagcaa aacaattcac 481 acacacacgc accctccccc gcctgcgcgc gcttgtgtgt gtgtgagaga gagggagtga 541 gtgagaggaa aatcgaagaa gtgctggcca aaaaacggcg aaaaaaattt aataaatacc 601 aaaatccaac gatactagca actaactata aaaaatcgaa ccaaatcgac tcgatataat 661 gtccaccatt gagttcgaaa cgatcggcag tcggctgcaa tccttggagg caaagctcca 721 ggcgcagaat gagtcccacg accagatcgt cctctccggt gcgcgcggcc ctgtcgtttc 781 cggttccgtt ccatctgccc gcgtcccgcc cctggcgaca tccgcatccg cagccacatc 841 cgccacccac gcaccttcct tgggcgcagg ttccgtttcc ggatcgggta tcagcatagc 901 ccagcgtcca gcacctccag ttcctcatgc gacgcccttc ggcagcgcca gcgcctcgtc 961 atcatcctca tccgcatccg catttgcatc cgcagcaccg gcgacgggca ccttcggtgg 1021 aacatacacc ccgccgacaa ctagagtgtc gcgagccacg cccacactgc ccatgctttc 1081 tagtggtccc ggtggtggac tgaatcgtac gcggccggtg atacttccgc tgcccacgcc 1141 gccacatcct ccagtttcgg aaacggacat gaagctgaag atcatcatgg agcagaccgg 1201 caagctgaac atcaacgggc ggcagtatcc gacggacatc aatgacctca agcacctggg 1261 cgacctgggc aatgggacta gcggcaatgt ggtgaagatg atgcacctgt ccagcaacac 1321 gatcatcgcc gtgaagcaga tgcgacgcac tggcaacgcg gaggagaaca aacgcatcct 1381 gatggatctg gatgttgtgc tcaaatcgca cgactgcaag tacattgtca agtgccttgg 1441 ctgcttcgtt cgcgatccgg atgtgtggat ctgcatggag ctgatgtcca tgtgctttga 1501 caagctgctc aagctgtcca agaagccggt gccggaacag atcctgggca aggtcacagt 1561 ggcgacggtc aacgcattgt cctacttgaa ggacaagcac ggagtcatcc atcgagatgt 1621 gaagccctcg aacattctga tcgatgagcg cgggaacatc aagctctgtg atttcgggat 1681 cagcggacgc ctggtggact ccaaggccaa cactcgatcc gccggctgtg cagcttatat 1741 ggcgccggag cgcatcgacc ccaagaaacc aaagtacgac attcgcgcag atgtgtggtc 1801 actgggcata acgctggtgg agctggccac agcgcgatcc ccgtacgagg gatgcaacac 1861 ggacttcgag gtgctcacca aggtgcttga ctcggagccg ccgtgtttgc catacggcga 1921 gggttacaac tttagtcagc agttccgcga tttcgtcatc aagtgcctca caaagaacca 1981 tcaggatcga cccaagtatc cggagctttt ggcccagccc ttcatccgga tttatgaatc 2041 agccaaagta gatgtgccca attggtttca gagcatcaag gataaccgac tgcgcgccaa 2101 tggcgatcca acgctccaga ggttacctaa ttcctaatac catttcttaa acaataatga 2161 caaacaatga agaaatccaa taaacataat ctaacaaaaa ataaaagcaa acgaaaaaga 2221 agaagacaaa ctataaacaa aaaccaaaca ttaaaaacta tcgacataaa ctgaaaaaca 2281 aaacaaaagc attcaagtaa accttgcaac catcaactct atatacagat atataaacct 2341 aaaaatatat ttacctatat ataatgataa tgccaaccaa acataactac tcaaaaaaaa 2401 aaaaaaaaaa cgataaaaac tcctcccaat taaaaaagta aaattcagaa agtgttattt 2461 tggaaagcca tcatgagcaa agattcttta attctgcgcg gccatctttc gctttcgctc 2521 cctttggcat ttacctgtgt ttcccacctg tcgcttacac aaaagaacac acaactcaca 2581 cgcaaaactc actcatcaac ttgtatatat acaaaacaca cacatcgatc gatcaccaac 2641 acacattcca aatgcgatta cagctcattt aaatgtctta gatatgttgc cattgcgccg 2701 tcaatctatt taaatgtacc ctacaaaccc atcacatccc ggatatcctg atgcttcctc 2761 aaaatccccg atatatgtcc cctaaatagc ccgatgtatc ccctccaaac acaaaccttc 2821 tttctgccac tggcgtacat ttgagtgtgc tctcattact ggtcatctag ccattaagaa 2881 tgcactaatc ttaaacgaat caatcgtcaa tttgcagggc aacggcgact ggaagtgcga 2941 tcggttctgg ggccggatct ctcgcaggat caggatcagg atccgcaggt ggagctgtaa 3001 aatatggtag ggcgacaacg tatgcggggc agagtcccac aaatccgcag aagacaataa 3061 aacccactca gataccgagt taccagcagc aacagtcgca gtttttcatg caatcagcca 3121 cacaactacc tcaaacaaca accacaacac cgacggcaac gacaaactgt ttcggcggca 3181 gcggaaacgg aaatggaaga ggaaacggca gcggcggaag cggaaatggt agcggaagca 3241 gcagcagtgc cagtcctcta tcgccaccaa gcgccggtat cggcgatctt aaccggcttt 3301 atcgcaaatc gccgttcatg cagcgaaaac tgagcaacgg atcccatcat ccgcactaca 3361 aatataacga cgagagcccc aagaaggagt ccatgtttag tagcatcggt caatcgattc 3421 tacgcaatct gacaacatcg cccttcagcc aaaagaaaca caattcaact gcaacaacaa 3481 taccactgcc gcacaacaac caaacattga tcacggatgc agcaacagca gcagcagcgg 3541 cggcaacagc aacaacaccg ccaaatattg cagctacagt gctcacgaca acgccaacga 3601 ccacgcccac ttggcgcctg ccaacggaaa attcccaagc ctacgacagc tgtgatagta 3661 gtagtaatgc gaccacgacg accttgaatt tgggcctctc ctcaccctcc ccctcgttgc 3721 cgcgcaagca attccccaca gaatcgccga ccctgcaact cacgagtcag cagcagcagc 3781 agccacagcg attgcagccg ggcaatcaga gccccatagt gctgcagcgc ttctaccacc 3841 agcagaatca gctgcgcgag aaggaggcgg ctgagcggta tcagcagcag cgccagcagc 3901 cgcccgttgg agtgaccagc acgaatccgt ttcacagcaa ctatgtgccg ccgccgccat 3961 caacgcactc cacctctagt cagtcctcca cgcagtcgac gtgttcgcaa atcgccatca 4021 atcccgccag catatcccca tcgtctggtt ccggaacggg aaacatggcg ggattgggaa 4081 tcggttcggc tccggcatcg ggattggggg cagctggtca ctttggagcg ggcggcactg 4141 gcgagcagct gcagtatcag ccgctgccca tcgccgccga ggcaacggga acgagtccca 4201 cgctccagtc tagatcaccg gaacagcagt cggattatgg aggaaacggc aacatggtgg 4261 ccagtaagct gagcaagctg tacgcacgcc gacaactttt gggccagagc tccagcagcg 4321 gagcgagcaa tagcagcctg gacggttgca gtcgggagca acacgatgca ggctggttca 4381 acactcttgc cggtgccatg aagcgacagt ttgccaccta tgttaaaacc caattgaatt 4441 ccacagccac gtcgccggtg gcgtccagca tggatcgaga ccaggagcca gtgcatccgc 4501 agccgccggc gtacaggagc gttgtgaata acggcagcgg tggcaagtct tactactatc 4561 gcaccttgtc ggcggccagc agcagtagca ataccagcca gagcacctcg cccacgacgg 4621 aaccgctgcc cggcggtggc accagtagct ttctgcgtcg ctatgcaagc agtggaccgg 4681 gaggtagcat cagcacgccg cccagtccgc atatcttggc gggattggat cgcaggcatc 4741 gaagtccaga tccgccgcca cgctacaatc gcggacagtc accgctattg ctgcgcaaga 4801 atctgctgga gctgagtggc cagccgcccg gctctccgct gctgcaccga agatacgttt 4861 cggcttcgcc gccgctgccg ccaccgcgtc gaggctctga aagcgtgccg ggatcaccgc 4921 agcatttccg cactcgcatc cactatacac ccgagcccca gagacgcatc taccgtacga 4981 tagatcaatg agtagcgctg caaatcatgg tcatgtgatg ctggtatggc ttcgacgacg 5041 atgccgccga cgctgctgtt cacgacgaca atcaggacga ggaggtggga ctattggagc 5101 ccatttccct gcccgtctcg tcagcagtcg gcgactcgct gtcgatgccg gcgtatgcag 5161 gtggcctggg caccaggttg tccggagccg aacggcgaat cggcgatcgt cggacgtgtt 5221 cggccagcgg atcgtattcc agcttgtata cggataagga cgaatggcca ggtggatcgt 5281 ccggtggggc atcgggtaca tcgacgacca gagctggata tccgtggaca tgtgattgat 5341 gacaaacgaa agtgttcaaa agtcttatac gtttaagtgc ttgagcctca gcgattcatc 5401 tgtatccgca tctgctagac acttcgtttc gttgcgcagc tccaattgta catagacata 5461 tatcttaagg gacctatata gacacatccg ataatagtgc aatagttgaa agcaattctg 5521 ttcgcccaac aaccgcgccc ccccctgtaa ccaagtctat actgttctat atatctctgt 5581 atctgtatct ccttcaatgg taactctgta atcaaaagtt tacactttac acaacgtaac 5641 ttatttaatc gtagctctaa aaagaaaatg aaacaaaata gctaaatcg