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LOCUS NM_001272567 12156 bp mRNA linear INV 26-DEC-2023 (Pde9), mRNA. ACCESSION NM_001272567 VERSION NM_001272567.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 12156) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 12156) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 12156) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 12156) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 12156) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 12156) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 12156) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 12156) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 12156) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 12156) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 12156) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 12156) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 12156) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 12156) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 12156) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 12156) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 12156) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 12156) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 12156) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 12156) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 12156) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 12156) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 12156) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_001272567.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..12156 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..12156 /gene="Pde9" /locus_tag="Dmel_CG42276" /old_locus_tag="Dmel_CG32648" /old_locus_tag="Dmel_CG3754" /gene_synonym="CG1627; CG32648; CG3754; CG3761; CG3765; CG42276; Dmel\CG42276; PDE9" /note="Phosphodiesterase 9" /map="11C2-11D1" /db_xref="FLYBASE:FBgn0259171" /db_xref="GeneID:32233" CDS 1384..5964 /gene="Pde9" /locus_tag="Dmel_CG42276" /old_locus_tag="Dmel_CG32648" /old_locus_tag="Dmel_CG3754" /gene_synonym="CG1627; CG32648; CG3754; CG3761; CG3765; CG42276; Dmel\CG42276; PDE9" /EC_number="3.1.4.-" /EC_number="3.1.4.17" /EC_number="3.1.4.35" /note="CG42276 gene product from transcript CG42276-RF; CG42276-PF; Pde9-PF" /codon_start=1 /product="phosphodiesterase 9, isoform F" /protein_id="NP_001259496.1" /db_xref="FLYBASE:FBpp0305705" /db_xref="GeneID:32233" /db_xref="FLYBASE:FBgn0259171" /translation="MYQDSGCSSSSSRRGSSSAAAATSTAATAAETAAAAAATTTSSS DEETLETLTIITTTITDSDIHATTTTTTVIASGTATTAAAAATTATLATLATLASNSD IEDSSPVESEDSEECEYIEIDCQTTAQEGTSPSGGSSSSGNAVLLQRSSNNLQQQQQQ QQQQQQHLQLQLQQADERLLRKIGYIASRVRCLSKYYGDFRLVNPYSARRQRRQLQEI LLRHSIFDPGKEHQRAIVLAAATAAIAGPLAAIDCVCGSSSISLEAVSSRSRSSELED DHHEQDQVQEEQEQEQHQGDTEDNEEEQEHPSEKPERTDIEEEPPPAIAVTTTTTATV RRKSSSSSTISGTATVSGSVSVSASASQSFCSNNINLLEELLIQFYEEQDHRSNLTVI RHHHHQQHQQHQQQQRITNNNNNNNNCNSIQNNNNMSNPAATAAATATPSVEQPATSG TTNIHLQPTSLPDGSDNPRRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGSC GAAGEHLLAANSIANRATIILSKSCSNVDGDATATAATALSSTVGGGIGGIGGSIKMR ASATDIETNALNGARDAIVASNNGNNGNNGNNGNNEYSILQLNNTIIQCHFNDDDFRA LVKDLKRKVEYTERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRA ALRLPAFDSYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEVPFH NFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTE LALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARH NEILTQFMEITPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFA QSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELIIIPVR IALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGTIDSNAAMVSTPGGASDKLSLDKG QGNSQGSGGGGGGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISVKSRRSIPSQK SASRTSVDEPGGMASELHDLPEGSESGDSETATEVDVAEKTSKFKVDTEGSSNRSKSS HSTSRKSSREKRPSMIGELCSSGGGQRIRNSYGNIHGYHSNRCHFGNNRAVSLDQYSS AGNNRRLSDGLPQVISDSNVFYGRHNRSSTETTVAVGNPQDTNANTNHPVGCQLKELL ARTEADSDGEGDGNGREDKKIPLVIPSMPQLATSSNGNISPTLVVTEQILPSNGSTRS SASSGRGGSGVPGGSGGSGMPGPSAGSGSSWKSRLRQFSDYFSFSFDKSNKRFGSTRS SPCPGSNSSSGRTNNNANGLGENQDGLGAGGGIKPGMCCTTITNSSGSTVKGETRGGT AGAGGGALTTMTTGNDAHQRHRAYSLDVPGMMRYSSNDSSRHPSNNTLQSAGGGAGLT TGLEVTAQRVPPSLSVEMGLASGSSSEAGPKI" misc_feature 3598..4284 /gene="Pde9" /locus_tag="Dmel_CG42276" /old_locus_tag="Dmel_CG32648" /old_locus_tag="Dmel_CG3754" /gene_synonym="CG1627; CG32648; CG3754; CG3761; CG3765; CG42276; Dmel\CG42276; PDE9" /note="3'5'-cyclic nucleotide phosphodiesterase; Region: PDEase_I; pfam00233" /db_xref="CDD:459723" ORIGIN 1 ctgcgcgcgc ggattacggt taattttcag ttggtttaca aactttacaa acggcgtacg 61 cttatcgcga tcgcttttaa tcaacaaacc gaattagttg ccaaaataac gggaatgaca 121 caggaaatgt gctgccggtg ctcaaatgct agcttaattg agtgaaaaag tgcaagtgat 181 cgaactgcaa cggttacaaa aaaaacggtt gtttttctct ttatttttgt tttataaact 241 aagaaatcgt tctataaatt gcatttattt gaatatctgt aagcccgcgt ttatctcaaa 301 tgtacttgtg cgcgccacct gttttttaat taatatttta ctacaatcgg cgtgataaaa 361 agtgtatgaa attcgttatt ttttttattt ttttggtttt tgttgagagt gcaagatcgt 421 gcagcttgtg cgtgtgtgtg cgttcagtgt gcttgtgagg aagttatagt ttaatgttgg 481 ttagcttcaa ttgtcgagca acagagaaaa aaagaaataa ataaataaaa cagcagcagc 541 aacaacaacg atgtgatgct gattgatgtc acacacacca cgaaggaaaa aaaaataaaa 601 aataaataaa ttatcacctt gaaggggttt atcaattttg ccagcacata aagatgttat 661 cttggaaaac cgtttagaga tttgccagcg ctcacaaacg gaaacggaag tgacgcccga 721 aaggaaaagg gggaagagga agtggtagcg caggacaaac ggctgaataa tgcaaattaa 781 aacacaataa aatgtaaaac acaaatgaca acggagaaca cgagctgcaa aaggctaaag 841 gagctaaaaa caaaaacaaa aaaaaaaaaa tagcaaaagg cgaatcggtt gacatgccaa 901 aaaaaaatgc gagtggcggc aacttttcca ctgaattgat ttgattttca gtcaggagta 961 cagccggaat acggagcgta tgcgcgatac gtatacgcga tatttagggc gccgggggag 1021 cggcggaaat ttgcataact ttgctggcgt ggcataaaca tcaaaaaaca aattgcaagt 1081 aacaaaggga agcaatggtc ataaaaacgg cgccagcctc gtaaaaaata cgttacaaaa 1141 aaaaaaaaaa gaataagttc tcgcaaaacc cccgctcttt aagtgaaaat taatttatgc 1201 agcaaatcaa atacggatag ggaagaaata taaaagtaat cgctggccgt aacaattaag 1261 acagccgtgg gcagtgagga aaagtcggga aaagctgggt gaacgctgga aaaatcaagt 1321 gcagcagcag ccgaaaaagg aaacacagag tcgaagaaac cggttagcaa gggttgctta 1381 taaatgtacc aagacagcgg ctgcagcagc agtagcagtc gacgcggcag cagcagtgca 1441 gcagcagcaa catctacagc agcaactgca gcagaaactg cagcagcagc agcagcaaca 1501 acaaccagca gcagcgacga ggaaacactc gagactctga cgattataac gaccaccatc 1561 accgatagcg atatccatgc gaccacaaca actacgacgg ttatagccag cggtacggcg 1621 acaacagcgg cagcggcagc gacaacagca acacttgcca cacttgcaac actcgccagc 1681 aacagcgaca tcgaggacag cagtccggtg gagagcgagg atagcgagga gtgcgagtat 1741 atcgagatcg attgccagac gaccgcccag gaaggcactt cgccaagtgg cggcagcagc 1801 agcagcggca atgcggtctt gctgcaacgc agcagcaata acctccagca gcagcagcag 1861 caacaacagc agcagcaaca acatttgcaa ctgcagctgc agcaggcgga cgagcgattg 1921 ttgcgcaaaa tcggctatat tgcatcgcgt gtgcgctgcc tgtccaagta ctacggtgac 1981 ttccgcctgg tgaatccgta cagtgcccgc cggcagaggc gccaattgca ggagatcctg 2041 ctgcggcact cgatcttcga tcctggcaag gagcaccagc gggcgattgt cttggccgcg 2101 gcaacagcgg caattgccgg tcctctggcg gccatcgatt gcgtctgcgg cagcagtagc 2161 atcagtttag aggcagtcag cagcagaagt cgcagcagtg agctggagga cgatcatcac 2221 gagcaggatc aggtgcagga ggagcaggag caggagcagc atcaggggga taccgaggat 2281 aacgaagagg agcaagagca tccgagtgaa aagccagaga gaacagacat tgaggaggag 2341 ccaccgccgg cgattgcagt gaccaccacc acaacggcca ccgtgcgccg gaagtcctcg 2401 agcagttcca caatcagtgg cacggccacc gtttccggtt ccgtttcggt atcggcctcc 2461 gcctctcaat ccttttgctc caacaacatc aatctgctcg aggagctgct cattcagttc 2521 tacgaggagc aggatcatcg cagcaaccta acggtgatcc gacatcatca tcatcagcag 2581 caccagcagc accagcagca gcaaagaatc accaacaata ataacaacaa taacaattgc 2641 aacagcatac agaacaacaa caacatgtcg aatcctgcgg ctacagcggc agcaacagca 2701 acgccatcag tggaacaacc ggcaacatcg ggcaccacca acatccactt gcaacccacc 2761 tccctgcccg atggcagcga taatccgcgc cgccgccggg ccagcgattg ctcagcggtg 2821 caggccgctc tccagaatca gctgcactgc atcacgctga agaacaacaa ttgcggcaag 2881 gcgatgccct tccatcgcgg cagttgcggc gccgccggtg agcatctgtt ggccgccaat 2941 tcgatagcta atcgtgccac cattattttg agtaaatcat gcagcaatgt ggatggtgat 3001 gccactgcca cagcggcaac ggcactaagt tcaacggttg gcggcggcat cggtggcatt 3061 ggtggcagta taaaaatgcg tgccagtgcc acagatatcg agacgaatgc attgaacggt 3121 gcccgggatg ccattgttgc atcgaataac ggtaataacg gcaataacgg aaataacggg 3181 aacaacgagt acagcatcct gcagctgaac aacacgatca tccagtgcca cttcaacgac 3241 gatgactttc gcgccctggt caaggacctc aagcgcaagg tcgagtacac ggagcgcatg 3301 aactggctat gtctctccaa acgaccgctg ggcccgccgc atcgtaaaag cagtctacca 3361 aagcatcagg aggtgaagcg tcgcttcctg gaaatttgtg atacgacctt ctcggaggag 3421 gtgagggccg ccctacgcct gccggccttc gattcctacg agtggagcga tgccgatgtc 3481 atccatctca tgcagaccat gttcgtcgag ctgggattca ttgagaagtt cagcattccg 3541 gtggacacgc tgcgcgagtg gctctatgag gtctacaagc actacaacga ggtgcccttc 3601 cacaactttc ggcactgctt ctgcgttgcc cagatgatgt atgccataac gcgccaggcg 3661 aacttgctga gtcgcctggg cgacctagag tgtctgatcc tgttggtgtc ctgcatttgc 3721 cacgacctcg accatcctgg ctacaataat atctaccaga tcaatgcccg caccgagctg 3781 gcactcagat ataatgacat ctcaccgctg gagaatcacc attgttcgat agcgttccgc 3841 ctgctggaac atcccgaatg caatatattc aagaacttta gccgcgacac cttcaataac 3901 attcgcgagg gcatcatccg gtgcattttg gccacggaca tggcccgtca caatgaaatc 3961 ctcacgcagt ttatggagat aacgcccatc ttcgactata gcaatcgtgc ccacatcaat 4021 ttgctctgca tgatcctgat caaagtggcg gacatttcga acgaggcgcg acccatggac 4081 gtggccgagc cctggctgga ccgcctgctc caggagttct ttgcccagag cgcagccgag 4141 aagtccgagg gattgccggt gacgccgttc atggatccgg acaaggtcag caagccgggc 4201 tcgcaggtgc gcttcatcgg actcgttctc ctgccactat tcgaggctct aggcgaactg 4261 gtgccggagc taaccgagct catcatcata cccgtgcgca tcgccctaga gtactacagg 4321 cgcctcaacg atgcccagac aaaaacgcgc aaatcggtgg cggacagcaa tacgtccgca 4381 acctccgata gcaacagcgg caccatcgat tccaatgcgg cgatggtcag cacaccggga 4441 ggcgccagcg ataagctcag cttggacaag ggacagggca attcgcaggg ctccggcggc 4501 ggaggaggcg gaggaggagg aggaggtgcc ggtggtggga caggatctgg atgcggcagc 4561 aatgccgctg gtagcgtatc gccacaaatg ccacgctccg gatccgggat cagtgttaag 4621 tcgcgacgca gcattccatc gcaaaagtcc gcctcgagga cgtccgtgga tgagcccgga 4681 ggaatggcgt cggagctcca cgatttgccg gagggcagcg agagcggtga ttcggaaacg 4741 gccaccgaag ttgatgtggc cgagaagacg tccaagttca aggtggacac cgagggcagc 4801 agcaaccgga gcaagtcctc gcactcgacc tcccggaagt cctctcgcga gaagcgtccc 4861 tcgatgatcg gtgaactgtg cagcagtggc ggtggccagc gaatccggaa ctcgtacggc 4921 aacatccacg gctatcacag caatcgctgt cattttggca acaatcgggc ggttagcctg 4981 gatcagtata gtagtgccgg taacaatcgc cgcctctcgg acggactgcc gcaggtgatc 5041 tcggacagca atgttttcta cggccggcac aatcggagca gcacggagac cactgttgct 5101 gttggcaatc cgcaggatac caatgcgaat accaatcatc cggtcggatg tcagctgaaa 5161 gagctattgg cccgcaccga agcggactcg gatggtgagg gcgatggcaa tggcagagag 5221 gacaaaaaga ttccattggt cataccgtcg atgccgcagc tggccacatc atcgaacggt 5281 aacatatcgc cgacactggt ggtcaccgag caaatcctgc ccagcaacgg cagtacacgg 5341 agcagcgcca gcagtggccg tggcggctcc ggcgtacctg gaggatcggg tggctctggg 5401 atgcctggac catcggccgg ttctggtagt tcatggaaat cgagactgcg ccagttctcc 5461 gattacttta gcttcagctt tgataagagc aacaagcgct ttggcagcac acgtagtagt 5521 ccgtgtcccg gttccaattc cagttcggga cggaccaata acaatgccaa tggattgggt 5581 gaaaatcagg acggattggg agcaggaggc ggtataaagc cgggcatgtg ctgcaccacc 5641 atcaccaata gctcaggatc cacggtaaaa ggcgagacga gaggaggtac cgccggtgca 5701 ggcggcggtg ctctgaccac catgaccacc ggaaatgatg cccatcaacg ccatcgcgcc 5761 tatagcctgg atgtgcccgg catgatgaga tactcctcca acgacagcag tcgccatccc 5821 agcaacaata cgcttcagag tgcgggtggc ggtgctggtt tgaccaccgg attagaggtc 5881 actgcccaac gagtgccgcc cagtttgagc gttgaaatgg gcctggccag cggctcatca 5941 tcagaggcgg gcccaaagat ttgacaacag gggagcacca ggcaggatgc ggtagccatt 6001 agcaagggct acgacggggc cgttgagcaa caggaggagg aggaggagga ggaggatgag 6061 caggaggacg atgacgagga tgagggacgc gaggagcacc gccagctgca gcggcatcag 6121 cagcagccgg acgcttcgtc cagctgcgag gtgtcctcca tgtcgatgac cgtgtggtcg 6181 gcgattggtc agcgtttgaa cgccctcgtc tgccattgct gcgaacgcaa attaccggaa 6241 ccagaaaatg tctaagtggg tggaaagtag ggccaggttt aacccagaac ccatcgccac 6301 ccatttaaga tgcaatcaaa tgcccccatc ccctgtcctc atttttagca gctgggggat 6361 tccttggctt tcacagtcat tgacttttgc ctggtagctt aggtttacgt ttaactccta 6421 gcaaattaca ttaggtttcc actgatttta ctctcttgtt ttgttttttt tttttttttt 6481 aattattatt ttatattttt atcttgttac cttttaagta tttttattta tgtacatgcg 6541 catacacaca cacacaaata tatatatata tatacatcta ttattattga acgaagttgc 6601 tgttgtgggt agaaaaacta cgagctgcaa gtacctacct gaaatgcctc gatcagcaaa 6661 gcgaggtaaa tgcattaacg acattgccaa cgataatagt tcactaccaa gttagcatgg 6721 caatggaaga gaactaactt tgttagctcc tttgattcag atgaatactg ttttttttct 6781 tttttgctgg gaatttctcg ttaatagctg catggcagca tcaattttcc gtgccagtga 6841 attctcagaa ggagaggatt cggattccag gatttcagac accaaaaaaa aaaaaaagtt 6901 tgaggccttc agttttgctt ccatgcgaaa ttcacgtcta attacgcaaa acaaatttcg 6961 cccattgaaa tgcatggtac atagggtata tggctacatc gatgtatgca acaggcatgg 7021 tcgctggatt tatccgatgt atgtagattc agtcccagtc gactaattcc atttgcttgt 7081 agctcgttgc ctgtttctcc cgctttttgc ccaatttttt gtgttcgttt ggttcgattt 7141 ttgcacgtgg gatgaaagtc gctgcattgg gatgcccgca ggagcaatgt ccatggccaa 7201 acgattggat tgggcagccg cagctgttga tgttgctgct gctgctgctg ttgctgttgc 7261 tgttgcagtt ggctctgctg ctgctgctgc tgctgcgggg gcattggtgt tgctgatgac 7321 gctgatggca gcactcaatt agaaggcact gtgggagatg tcgttctttc gattatgcac 7381 gattttccgg ctgcaactct cagctgctaa atacgtttct aaaaatgaga gtcctttggg 7441 agttggtggg ccagcagaaa aaaagaaaac aaatatcaat ttgcattcga taatggaaac 7501 acgattgagg ccaactgcat tcacatatcg cagaaaaatg cagaaaatat gaaaaaccca 7561 agttaattat aatcaatgta aatttctgta tgtaattatg ttacatatac acactcacac 7621 acacacacag acgaatgcag agcaatgcaa aaatgatagc atactttgta gggcgagctg 7681 tgattggcga agacgaaact tgaattcaat tacgatatgg caacgcagag ataaatagaa 7741 aaagggcaga tttaattaaa tatgcactat gcaaaggcga gaccaagctg gtccttggat 7801 acagataaag ctatatacat atttactgaa acaattaaaa agagttgtat tttttttttt 7861 ttgaatgtgt gtaattaagt gagcacttat tgagcgttca attcgatgaa agtgttatga 7921 ggaatattta ttcggtgtac atttggatgt ctagtgaatc gcagctaata ctctttacta 7981 attgtgcatt gtaattgcaa gctgcagcat atatgtatgt acctagatgt gtacgtgtca 8041 ttttctctct aagttttgtg tacgtttgtt gtagtgcgta agtaatggag tactaaatat 8101 atatgtatat aacatacact tatatatata tatatatata tatatatata tatatacata 8161 tatatatata aaccagaacg catcagtgta tgcccggcta agtaattatc tgcgtgtgga 8221 tctccgctcg ttgtgtgttt tctgtagtta gactcgaaac tagcagccta attataagtt 8281 tatcgaatgt attcgtgtat gtaccttcca gtccccgcac ttcaaacagt tttctgttgg 8341 tggccctgca tagactgagc aggacattat atatatatac tacacatggc gcccgagcag 8401 ggactgcatg gcatgcaccc agcattaact agctaaatgg aaaatgaaaa caagttaaat 8461 cccttgacgg ctaactcgac tcctagatgt aagactctac ctaaacaaac cactcgaaat 8521 tagctaacac ttcaaattga tttgttgcct tatgatacta caactactac aactactact 8581 gtactgcatt acagctgtgt gagtggaaaa ctctccgcgc cggaaaactc cacttgaatt 8641 ggtcacagcg ttttatattg ttcatgccac caacttccct tgtttgaatg acaaaaacat 8701 aaagactaaa acttgaattt aaacaaaatc aacaacaaaa aaatatgaaa aagaaaaacc 8761 aaacaaaaga actttccaac aaaaccaact atacatatag atacaaatat atatatacat 8821 acataaatat ttatcttaaa gatactacaa ctacaaaaat cgtaaaaaag aactctaggt 8881 gttttacaaa tgcataaaac aaaaaaatat ataaatggca actaaaccaa aaacaaaaac 8941 caaatgtaag ccatttcaag cataactaaa ctagtttaga gcccaagcaa aaaagatcgc 9001 aaagcaagcc cagatgttgg ccaaaaccta atatggatga acaaatttga caggccgaaa 9061 atattaatgt ccttgcaatg gggatcgtca gggatcgtat caatgattga atcttttaag 9121 tcaattcaaa gtatttaaac aatgagaatc acaaaaaaaa aaatggctga cagttttaaa 9181 tgattgactt acttgctaaa ttgcatcaaa aaatatttca ataagtaaag acaataggtg 9241 aataaaacaa atatataata gatgtttact actttggatc atgttttcgc taagtctttt 9301 tttttaagtc cgactacaat tttgaaatca tctcaattaa taaattaaga attagatttt 9361 attaaattgt tttctatgtt gtcaaaataa tacaaaaagt acacaacaaa taatgcgaga 9421 aaaaaaaaaa aaattgattt gcctgtgagt gtatgacatt aggatatcaa aattctgtta 9481 tcgatacttt tgccaaaaat tgaacgattg acagctacac tagttatgta tataaaactc 9541 tgatcgaatc gctaatgagc attgcagggg cattcctatc gtatttcggc aatcacgtaa 9601 ctatttagcg tactttttgg cagtcaatta aatgcttccc ccttcccagt tggttaaatg 9661 atatatggga gagatacatc ggataagatc cgatagcgat agatagaaca agttccaaaa 9721 caaaaaacaa atgcttgttc tcggacctaa tcaaatattt agacaaggat atgagcaatt 9781 tggaccaact tgactaaacc cttacactta acccttgatt tcccgtacga aacccctgca 9841 gctacatatt tatgtataaa tgtatgtgca aaacgattac ggtagcgata tcgactacga 9901 taacgattca gtatatgtac aaaacatagc acacacacac agacacaccg acacggacat 9961 agatacaaat acaaaataca gaagtcttag tatgcagttc aacgtatgta acaatctcgt 10021 aggtcttaac cataactacc tgtcgactta tcgatcttta attgagatca acaatatcag 10081 cttaaaaaca aagagcggat tagaagagga cctatgcagg aacagtggga atggaacaag 10141 agaaaagcga ggaaacggaa aaggaaccgc atgcatctta ctttatactt ttctacgtga 10201 cttacaactc gagccggaga cgacaaacaa ctagaaaact aaaaataaac ttcctaaacg 10261 gtttccacaa aaacacaagc ctatccacac gccctaaaat ccacgcacac aaacgcagct 10321 ttgtcaatga gaaaattcct tctaagtgaa gtaaatcaaa ccgtttcaaa gttggtccta 10381 caatcagctt agtgtgacct ttcgcatcga cgatgtgacc aagtgtacat ctgattcaaa 10441 tgcgaacagc tttctgcctt gattgtaaaa aatttcttga ttatttcgaa ataatttgac 10501 cttagaactc attgacactg tctgtcggat attcaaatgt ccaggcaagg catccaacca 10561 ccgataatgg accacgccca gcaccagata gataacccgt aattaacccg aaccgaactg 10621 cttaaccctt gaaagccttg accgccatct aaacttggta aaaaaaaaaa aaaaacgtta 10681 ctgctacaaa acaaaaatgc aacttatata tgtgtaatta ctagtgaccc tcctgaacaa 10741 ctgacaaagc ctttactcca agaaaacaca cacaaaaaat acgaagacta caattttaat 10801 atacaaaaat aagcgaatcg agatctttaa tcgaaatttt aagaagaaag taagagagag 10861 agatccttga acagcattct tcggcaggcc gaagtttaga tgctctttca atgcccacac 10921 acacatatga actaagaaaa gatctattat atatacatat aagcctggcc gcttgctctt 10981 cagtgtactg gaacggttat tttttttttt ggtcacctcc catgttgcaa gactttttaa 11041 aagtgaaaag aacgagaaaa aggcagaagt actggagata cccttgctag atagcgaaaa 11101 cccgaaaaga tcctcaaaaa ctatcatttg caggggcatc aacaagttat atagtatatt 11161 ttcaaatttt atgtcaatga atagaaatgg atatatacat acacatatat atacacacac 11221 ataccaacta gaatcataaa tatatacata caaatagtta taatttgtaa gtaaaaaaaa 11281 acagagatca gatcgccagc aagccacata ccttaaatac aaaatactga agacacacaa 11341 cccaaaagta gttgaattct ttacgatgat cgagtaatag ggatcgggaa atattatctc 11401 agcagaagag caagatttgt gtgtaaatta aattaaattc aagaagtaaa agaaattcgc 11461 cacccacaga taatatccct caccactcaa tggcaattta aacagttcat gcaagagata 11521 gacatacaaa catacataca tacatatata tggaaacaaa ccaaagagca tgaggaaaac 11581 aaagtgctga gcaaattcga tgtgaagtaa tagttattat atatatatat atatatatat 11641 atatatatat atacatacac acctatatac aagcctaaaa agatttagat gtaaaaagct 11701 cttggcaccc cctaaataaa tgaatcaaat atcgctgagt cacccacaca gaaaagtcaa 11761 catgggtata caactaataa atcagctaag aagcgagaaa ttcaatgaaa cttttccgaa 11821 aatgcattta aatggtaaac aaatatttaa atgagataac tcaacttgta tttaacactt 11881 agttatgtcc aactcagatt aatggcatat aagacaacta caatacatac agaaaaaaaa 11941 taaacacaca gagacagaca gaccgagata gcaaaggact actcaaggac acaccaatac 12001 caatagaaga acctacgaga caaacacgaa cacacggaca cactcacaca cacacacaca 12061 cacaagtatt tttgtgtaaa agtataaaac agaaaatatg aactaatgaa tgaatatgaa 12121 atatattgaa ataaaatcat ttccaaacta cttatt