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Drosophila melanogaster phosphodiesterase 9, transcript variant E


LOCUS       NM_001272566            6444 bp    mRNA    linear   INV 26-DEC-2023
            (Pde9), mRNA.
ACCESSION   NM_001272566
VERSION     NM_001272566.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6444)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6444)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6444)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6444)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6444)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6444)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6444)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6444)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6444)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6444)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6444)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6444)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6444)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6444)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6444)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6444)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6444)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6444)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6444)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6444)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6444)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6444)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6444)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6444
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6444
                     /gene="Pde9"
                     /locus_tag="Dmel_CG42276"
                     /old_locus_tag="Dmel_CG32648"
                     /old_locus_tag="Dmel_CG3754"
                     /gene_synonym="CG1627; CG32648; CG3754; CG3761; CG3765;
                     CG42276; Dmel\CG42276; PDE9"
                     /note="Phosphodiesterase 9"
                     /map="11C2-11D1"
                     /db_xref="FLYBASE:FBgn0259171"
                     /db_xref="GeneID:32233"
     CDS             1249..5829
                     /gene="Pde9"
                     /locus_tag="Dmel_CG42276"
                     /old_locus_tag="Dmel_CG32648"
                     /old_locus_tag="Dmel_CG3754"
                     /gene_synonym="CG1627; CG32648; CG3754; CG3761; CG3765;
                     CG42276; Dmel\CG42276; PDE9"
                     /EC_number="3.1.4.-"
                     /EC_number="3.1.4.17"
                     /EC_number="3.1.4.35"
                     /note="CG42276 gene product from transcript CG42276-RE;
                     CG42276-PE; Pde9-PE"
                     /codon_start=1
                     /product="phosphodiesterase 9, isoform E"
                     /protein_id="NP_001259495.1"
                     /db_xref="FLYBASE:FBpp0305704"
                     /db_xref="GeneID:32233"
                     /db_xref="FLYBASE:FBgn0259171"
                     /translation="MYQDSGCSSSSSRRGSSSAAAATSTAATAAETAAAAAATTTSSS
                     DEETLETLTIITTTITDSDIHATTTTTTVIASGTATTAAAAATTATLATLATLASNSD
                     IEDSSPVESEDSEECEYIEIDCQTTAQEGTSPSGGSSSSGNAVLLQRSSNNLQQQQQQ
                     QQQQQQHLQLQLQQADERLLRKIGYIASRVRCLSKYYGDFRLVNPYSARRQRRQLQEI
                     LLRHSIFDPGKEHQRAIVLAAATAAIAGPLAAIDCVCGSSSISLEAVSSRSRSSELED
                     DHHEQDQVQEEQEQEQHQGDTEDNEEEQEHPSEKPERTDIEEEPPPAIAVTTTTTATV
                     RRKSSSSSTISGTATVSGSVSVSASASQSFCSNNINLLEELLIQFYEEQDHRSNLTVI
                     RHHHHQQHQQHQQQQRITNNNNNNNNCNSIQNNNNMSNPAATAAATATPSVEQPATSG
                     TTNIHLQPTSLPDGSDNPRRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGSC
                     GAAGEHLLAANSIANRATIILSKSCSNVDGDATATAATALSSTVGGGIGGIGGSIKMR
                     ASATDIETNALNGARDAIVASNNGNNGNNGNNGNNEYSILQLNNTIIQCHFNDDDFRA
                     LVKDLKRKVEYTERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRA
                     ALRLPAFDSYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEVPFH
                     NFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTE
                     LALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARH
                     NEILTQFMEITPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFA
                     QSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELIIIPVR
                     IALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGTIDSNAAMVSTPGGASDKLSLDKG
                     QGNSQGSGGGGGGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISVKSRRSIPSQK
                     SASRTSVDEPGGMASELHDLPEGSESGDSETATEVDVAEKTSKFKVDTEGSSNRSKSS
                     HSTSRKSSREKRPSMIGELCSSGGGQRIRNSYGNIHGYHSNRCHFGNNRAVSLDQYSS
                     AGNNRRLSDGLPQVISDSNVFYGRHNRSSTETTVAVGNPQDTNANTNHPVGCQLKELL
                     ARTEADSDGEGDGNGREDKKIPLVIPSMPQLATSSNGNISPTLVVTEQILPSNGSTRS
                     SASSGRGGSGVPGGSGGSGMPGPSAGSGSSWKSRLRQFSDYFSFSFDKSNKRFGSTRS
                     SPCPGSNSSSGRTNNNANGLGENQDGLGAGGGIKPGMCCTTITNSSGSTVKGETRGGT
                     AGAGGGALTTMTTGNDAHQRHRAYSLDVPGMMRYSSNDSSRHPSNNTLQSAGGGAGLT
                     TGLEVTAQRVPPSLSVEMGLASGSSSEAGPKI"
     misc_feature    3463..4149
                     /gene="Pde9"
                     /locus_tag="Dmel_CG42276"
                     /old_locus_tag="Dmel_CG32648"
                     /old_locus_tag="Dmel_CG3754"
                     /gene_synonym="CG1627; CG32648; CG3754; CG3761; CG3765;
                     CG42276; Dmel\CG42276; PDE9"
                     /note="3'5'-cyclic nucleotide phosphodiesterase; Region:
                     PDEase_I; pfam00233"
                     /db_xref="CDD:459723"
ORIGIN      
        1 agcttttgaa ctcagtcagt tcaaatttac cagcggattt gtgcggatta caaaaactat
       61 tcacacgcac acacgcgcgc atctcacata tatcagtctc tcacacaaat acgagccatc
      121 aaacatacac acacctaccg acacattaac aaaggagcgg actgaaggtc cttaaacgaa
      181 aggaaacaaa acaaagcgtc ggcaagcaaa aaaaaaataa ataaataaat aaagaataaa
      241 taaaaaatat attgtaggaa atagaaaata atattgtctg gcaatcgtga ttgaaatcgc
      301 agtcatatcg gatatttcaa ttgttcaatt tttttgcgaa ttattttctg gtgctaccac
      361 agtgcgtatg tgtaatatct gagcgaagag tgctaaaaca aaaagtgtgc gagaccagcg
      421 ccattatcat cggccggaag gcgggcgcaa aagacagatc attattcgca tcgaaatcgg
      481 aatcgaaatc tgcacgagaa tcatcgatca gaatcagtcg tctagttgac aaaaataaaa
      541 ccagatttgc cagcgctcac aaacggaaac ggaagtgacg cccgaaagga aaagggggaa
      601 gaggaagtgg tagcgcagga caaacggctg aataatgcaa attaaaacac aataaaatgt
      661 aaaacacaaa tgacaacgga gaacacgagc tgcaaaaggc taaaggagct aaaaacaaaa
      721 acaaaaaaaa aaaaatagca aaaggcgaat cggttgacat gccaaaaaaa aatgcgagtg
      781 gcggcaactt ttccactgaa ttgatttgat tttcagtcag gagtacagcc ggaatacgga
      841 gcgtatgcgc gatacgtata cgcgatattt agggcgccgg gggagcggcg gaaatttgca
      901 taactttgct ggcgtggcat aaacatcaaa aaacaaattg caagtaacaa agggaagcaa
      961 tggtcataaa aacggcgcca gcctcgtaaa aaatacgtta caaaaaaaaa aaaaagaata
     1021 agttctcgca aaacccccgc tctttaagtg aaaattaatt tatgcagcaa atcaaatacg
     1081 gatagggaag aaatataaaa gtaatcgctg gccgtaacaa ttaagacagc cgtgggcagt
     1141 gaggaaaagt cgggaaaagc tgggtgaacg ctggaaaaat caagtgcagc agcagccgaa
     1201 aaaggaaaca cagagtcgaa gaaaccggtt agcaagggtt gcttataaat gtaccaagac
     1261 agcggctgca gcagcagtag cagtcgacgc ggcagcagca gtgcagcagc agcaacatct
     1321 acagcagcaa ctgcagcaga aactgcagca gcagcagcag caacaacaac cagcagcagc
     1381 gacgaggaaa cactcgagac tctgacgatt ataacgacca ccatcaccga tagcgatatc
     1441 catgcgacca caacaactac gacggttata gccagcggta cggcgacaac agcggcagcg
     1501 gcagcgacaa cagcaacact tgccacactt gcaacactcg ccagcaacag cgacatcgag
     1561 gacagcagtc cggtggagag cgaggatagc gaggagtgcg agtatatcga gatcgattgc
     1621 cagacgaccg cccaggaagg cacttcgcca agtggcggca gcagcagcag cggcaatgcg
     1681 gtcttgctgc aacgcagcag caataacctc cagcagcagc agcagcaaca acagcagcag
     1741 caacaacatt tgcaactgca gctgcagcag gcggacgagc gattgttgcg caaaatcggc
     1801 tatattgcat cgcgtgtgcg ctgcctgtcc aagtactacg gtgacttccg cctggtgaat
     1861 ccgtacagtg cccgccggca gaggcgccaa ttgcaggaga tcctgctgcg gcactcgatc
     1921 ttcgatcctg gcaaggagca ccagcgggcg attgtcttgg ccgcggcaac agcggcaatt
     1981 gccggtcctc tggcggccat cgattgcgtc tgcggcagca gtagcatcag tttagaggca
     2041 gtcagcagca gaagtcgcag cagtgagctg gaggacgatc atcacgagca ggatcaggtg
     2101 caggaggagc aggagcagga gcagcatcag ggggataccg aggataacga agaggagcaa
     2161 gagcatccga gtgaaaagcc agagagaaca gacattgagg aggagccacc gccggcgatt
     2221 gcagtgacca ccaccacaac ggccaccgtg cgccggaagt cctcgagcag ttccacaatc
     2281 agtggcacgg ccaccgtttc cggttccgtt tcggtatcgg cctccgcctc tcaatccttt
     2341 tgctccaaca acatcaatct gctcgaggag ctgctcattc agttctacga ggagcaggat
     2401 catcgcagca acctaacggt gatccgacat catcatcatc agcagcacca gcagcaccag
     2461 cagcagcaaa gaatcaccaa caataataac aacaataaca attgcaacag catacagaac
     2521 aacaacaaca tgtcgaatcc tgcggctaca gcggcagcaa cagcaacgcc atcagtggaa
     2581 caaccggcaa catcgggcac caccaacatc cacttgcaac ccacctccct gcccgatggc
     2641 agcgataatc cgcgccgccg ccgggccagc gattgctcag cggtgcaggc cgctctccag
     2701 aatcagctgc actgcatcac gctgaagaac aacaattgcg gcaaggcgat gcccttccat
     2761 cgcggcagtt gcggcgccgc cggtgagcat ctgttggccg ccaattcgat agctaatcgt
     2821 gccaccatta ttttgagtaa atcatgcagc aatgtggatg gtgatgccac tgccacagcg
     2881 gcaacggcac taagttcaac ggttggcggc ggcatcggtg gcattggtgg cagtataaaa
     2941 atgcgtgcca gtgccacaga tatcgagacg aatgcattga acggtgcccg ggatgccatt
     3001 gttgcatcga ataacggtaa taacggcaat aacggaaata acgggaacaa cgagtacagc
     3061 atcctgcagc tgaacaacac gatcatccag tgccacttca acgacgatga ctttcgcgcc
     3121 ctggtcaagg acctcaagcg caaggtcgag tacacggagc gcatgaactg gctatgtctc
     3181 tccaaacgac cgctgggccc gccgcatcgt aaaagcagtc taccaaagca tcaggaggtg
     3241 aagcgtcgct tcctggaaat ttgtgatacg accttctcgg aggaggtgag ggccgcccta
     3301 cgcctgccgg ccttcgattc ctacgagtgg agcgatgccg atgtcatcca tctcatgcag
     3361 accatgttcg tcgagctggg attcattgag aagttcagca ttccggtgga cacgctgcgc
     3421 gagtggctct atgaggtcta caagcactac aacgaggtgc ccttccacaa ctttcggcac
     3481 tgcttctgcg ttgcccagat gatgtatgcc ataacgcgcc aggcgaactt gctgagtcgc
     3541 ctgggcgacc tagagtgtct gatcctgttg gtgtcctgca tttgccacga cctcgaccat
     3601 cctggctaca ataatatcta ccagatcaat gcccgcaccg agctggcact cagatataat
     3661 gacatctcac cgctggagaa tcaccattgt tcgatagcgt tccgcctgct ggaacatccc
     3721 gaatgcaata tattcaagaa ctttagccgc gacaccttca ataacattcg cgagggcatc
     3781 atccggtgca ttttggccac ggacatggcc cgtcacaatg aaatcctcac gcagtttatg
     3841 gagataacgc ccatcttcga ctatagcaat cgtgcccaca tcaatttgct ctgcatgatc
     3901 ctgatcaaag tggcggacat ttcgaacgag gcgcgaccca tggacgtggc cgagccctgg
     3961 ctggaccgcc tgctccagga gttctttgcc cagagcgcag ccgagaagtc cgagggattg
     4021 ccggtgacgc cgttcatgga tccggacaag gtcagcaagc cgggctcgca ggtgcgcttc
     4081 atcggactcg ttctcctgcc actattcgag gctctaggcg aactggtgcc ggagctaacc
     4141 gagctcatca tcatacccgt gcgcatcgcc ctagagtact acaggcgcct caacgatgcc
     4201 cagacaaaaa cgcgcaaatc ggtggcggac agcaatacgt ccgcaacctc cgatagcaac
     4261 agcggcacca tcgattccaa tgcggcgatg gtcagcacac cgggaggcgc cagcgataag
     4321 ctcagcttgg acaagggaca gggcaattcg cagggctccg gcggcggagg aggcggagga
     4381 ggaggaggag gtgccggtgg tgggacagga tctggatgcg gcagcaatgc cgctggtagc
     4441 gtatcgccac aaatgccacg ctccggatcc gggatcagtg ttaagtcgcg acgcagcatt
     4501 ccatcgcaaa agtccgcctc gaggacgtcc gtggatgagc ccggaggaat ggcgtcggag
     4561 ctccacgatt tgccggaggg cagcgagagc ggtgattcgg aaacggccac cgaagttgat
     4621 gtggccgaga agacgtccaa gttcaaggtg gacaccgagg gcagcagcaa ccggagcaag
     4681 tcctcgcact cgacctcccg gaagtcctct cgcgagaagc gtccctcgat gatcggtgaa
     4741 ctgtgcagca gtggcggtgg ccagcgaatc cggaactcgt acggcaacat ccacggctat
     4801 cacagcaatc gctgtcattt tggcaacaat cgggcggtta gcctggatca gtatagtagt
     4861 gccggtaaca atcgccgcct ctcggacgga ctgccgcagg tgatctcgga cagcaatgtt
     4921 ttctacggcc ggcacaatcg gagcagcacg gagaccactg ttgctgttgg caatccgcag
     4981 gataccaatg cgaataccaa tcatccggtc ggatgtcagc tgaaagagct attggcccgc
     5041 accgaagcgg actcggatgg tgagggcgat ggcaatggca gagaggacaa aaagattcca
     5101 ttggtcatac cgtcgatgcc gcagctggcc acatcatcga acggtaacat atcgccgaca
     5161 ctggtggtca ccgagcaaat cctgcccagc aacggcagta cacggagcag cgccagcagt
     5221 ggccgtggcg gctccggcgt acctggagga tcgggtggct ctgggatgcc tggaccatcg
     5281 gccggttctg gtagttcatg gaaatcgaga ctgcgccagt tctccgatta ctttagcttc
     5341 agctttgata agagcaacaa gcgctttggc agcacacgta gtagtccgtg tcccggttcc
     5401 aattccagtt cgggacggac caataacaat gccaatggat tgggtgaaaa tcaggacgga
     5461 ttgggagcag gaggcggtat aaagccgggc atgtgctgca ccaccatcac caatagctca
     5521 ggatccacgg taaaaggcga gacgagagga ggtaccgccg gtgcaggcgg cggtgctctg
     5581 accaccatga ccaccggaaa tgatgcccat caacgccatc gcgcctatag cctggatgtg
     5641 cccggcatga tgagatactc ctccaacgac agcagtcgcc atcccagcaa caatacgctt
     5701 cagagtgcgg gtggcggtgc tggtttgacc accggattag aggtcactgc ccaacgagtg
     5761 ccgcccagtt tgagcgttga aatgggcctg gccagcggct catcatcaga ggcgggccca
     5821 aagatttgac aacaggggag caccaggcag gatgcggtag ccattagcaa gggctacgac
     5881 ggggccgttg agcaacagga ggaggaggag gaggaggagg atgagcagga ggacgatgac
     5941 gaggatgagg gacgcgagga gcaccgccag ctgcagcggc atcagcagca gccggacgct
     6001 tcgtccagct gcgaggtgtc ctccatgtcg atgaccgtgt ggtcggcgat tggtcagcgt
     6061 ttgaacgccc tcgtctgcca ttgctgcgaa cgcaaattac cggaaccaga aaatgtctaa
     6121 gtgggtggaa agtagggcca ggtttaaccc agaacccatc gccacccatt taagatgcaa
     6181 tcaaatgccc ccatcccctg tcctcatttt tagcagctgg gggattcctt ggctttcaca
     6241 gtcattgact tttgcctggt agcttaggtt tacgtttaac tcctagcaaa ttacattagg
     6301 tttccactga ttttactctc ttgttttgtt tttttttttt tttttaatta ttattttata
     6361 tttttatctt gttacctttt aagtattttt atttatgtac atgcgcatac acacacacac
     6421 aaatatatat atatatatac atct