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Drosophila melanogaster PAICS bifunctional enzyme (Paics),


LOCUS       NM_001272564            2547 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant B, mRNA.
ACCESSION   NM_001272564
VERSION     NM_001272564.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 2547)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2547)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2547)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 2547)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 2547)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 2547)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 2547)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 2547)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 2547)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 2547)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 2547)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 2547)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 2547)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 2547)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 2547)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 2547)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 2547)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 2547)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 2547)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 2547)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 2547)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 2547)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 2547)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2547
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..2547
                     /gene="Paics"
                     /locus_tag="Dmel_CG3989"
                     /gene_synonym="ade5; Ade5; AIRc-SAICARs; CG3989;
                     Dmel\CG3989"
                     /note="PAICS bifunctional enzyme"
                     /map="11B16-11B16"
                     /db_xref="FLYBASE:FBgn0020513"
                     /db_xref="GeneID:32228"
     CDS             245..1531
                     /gene="Paics"
                     /locus_tag="Dmel_CG3989"
                     /gene_synonym="ade5; Ade5; AIRc-SAICARs; CG3989;
                     Dmel\CG3989"
                     /EC_number="4.1.1.21"
                     /EC_number="6.3.2.6"
                     /note="CG3989 gene product from transcript CG3989-RB;
                     CG3989-PB; Paics-PB; AIR-carboxylase-SAICAR synthetase;
                     ade5"
                     /codon_start=1
                     /product="PAICS bifunctional enzyme, isoform B"
                     /protein_id="NP_001259493.1"
                     /db_xref="FLYBASE:FBpp0305933"
                     /db_xref="GeneID:32228"
                     /db_xref="FLYBASE:FBgn0020513"
                     /translation="MSTTTTASKGYKLGKVIIEGKTKQVYDLPEQPGLCLLLSKDRIT
                     AGDGVKAHDLAGKAEISNTTNGQVFRLLNEAGIRTAYVKQCGAKAFIARKCQMIPIEW
                     VTRRLATGSFLKRNVGVPEGYRFSPPKQETFFKDDANHDPQWSEEQIVSAKFELNGLV
                     IGQDEVDIMRRTTLLVFEILERAWQTKNCALIDMKVEFGICDDGNIVLADIIDSDSWR
                     LWPAGDKRLMVDKQVYRNLASVTASDLDTVKRNFIWVAEQLADIVPKKDHLVVILMGS
                     ASDISHSEKIATSCRSLGLNVELRVSSAHKGPEETLRIVREYESVMSNLIFVAVAGRS
                     NGLGPVVSGSTNYPVINCPPVKSDNMQVDVWSSLNLPSGLGCATVLYPEAAALHAATI
                     LGLGNFMVWSKLRVKALNNFITLKKADKELRGVRNA"
     misc_feature    275..1021
                     /gene="Paics"
                     /locus_tag="Dmel_CG3989"
                     /gene_synonym="ade5; Ade5; AIRc-SAICARs; CG3989;
                     Dmel\CG3989"
                     /note="Ade5_like
                     5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide
                     (SAICAR) synthase; Region: SAICAR_synt_Ade5; cd01416"
                     /db_xref="CDD:133471"
     misc_feature    order(293..298,302..307,311..313,317..322,347..349,
                     353..355,482..484,521..523,527..529,533..535,647..649,
                     833..835,869..874)
                     /gene="Paics"
                     /locus_tag="Dmel_CG3989"
                     /gene_synonym="ade5; Ade5; AIRc-SAICARs; CG3989;
                     Dmel\CG3989"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:133471"
     misc_feature    order(296..298,302..313,317..319,347..349,383..385,
                     485..487,518..529,533..535,545..547,551..553,557..559,
                     569..577,641..643,647..649,665..667,821..829,833..835,
                     872..874,887..898)
                     /gene="Paics"
                     /locus_tag="Dmel_CG3989"
                     /gene_synonym="ade5; Ade5; AIRc-SAICARs; CG3989;
                     Dmel\CG3989"
                     /note="active site"
                     /db_xref="CDD:133471"
     misc_feature    order(383..385,545..547,551..553,557..559,569..577,
                     641..643,665..667,821..829,887..898)
                     /gene="Paics"
                     /locus_tag="Dmel_CG3989"
                     /gene_synonym="ade5; Ade5; AIRc-SAICARs; CG3989;
                     Dmel\CG3989"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:133471"
     misc_feature    1052..1513
                     /gene="Paics"
                     /locus_tag="Dmel_CG3989"
                     /gene_synonym="ade5; Ade5; AIRc-SAICARs; CG3989;
                     Dmel\CG3989"
                     /note="phosphoribosylaminoimidazole carboxylase, PurE
                     protein; Region: purE; TIGR01162"
                     /db_xref="CDD:273474"
ORIGIN      
        1 acgctcagtt gctttggagc gattctttga tgcagacgaa catcggagtt tgcggattgt
       61 aataatagag ccaagcggag agagcgaaaa agacagagag agagatagag agcgagagcg
      121 agagggaagg caccagcgaa tatcgagcat aaagcaaagc ccgcaacacg tgaaacagcc
      181 agcagccaat tgatttcaat ttcgattctt aaagtgaagt gaccaacaac gtgcgattaa
      241 cgagatgtcc accaccacaa cagcatccaa gggctataag ctcggcaagg tcatcatcga
      301 gggcaaaacc aaacaggtgt acgatctgcc agagcagcca ggactttgcc tgctcctcag
      361 caaggatcgc atcaccgccg gcgatggtgt caaagcacat gatctggccg gcaaggcgga
      421 gatctccaat accaccaacg gtcaggtctt ccggctgctc aacgaggcag gcattcgcac
      481 cgcctatgtg aagcagtgcg gcgccaaggc cttcatcgcc cgcaagtgcc agatgatacc
      541 cattgagtgg gtgacccgtc gcctggccac cggttcgttc ctcaagcgca atgtcggcgt
      601 gcccgagggc tacaggttct cgccgcccaa acaggagacg ttcttcaagg atgatgccaa
      661 ccacgatccc cagtggagcg aggagcaaat tgtctccgcc aagttcgagc taaatggcct
      721 ggtgatcggc caagatgagg tggacattat gcgtagaacc acactgctgg tcttcgagat
      781 tctcgagagg gcatggcaga ccaagaattg cgccctgatc gacatgaaag tggagttcgg
      841 tatctgcgac gatggcaaca tagttctggc cgatatcatt gattccgatt cgtggcgctt
      901 gtggccagcg ggtgacaagc gtttgatggt cgacaagcag gtgtatcgca atctggcatc
      961 ggtgacggcc agcgatttgg ataccgtaaa gaggaacttc atttgggtgg ccgaacaact
     1021 ggctgatatt gtgcccaaga aggatcacct ggttgtcatt ctgatgggca gtgcttccga
     1081 tatatcgcac agcgagaaga tagccaccag ctgtcgatcc ctcggcctta atgtggaact
     1141 tcgcgtgagt tcggcccaca agggaccgga ggaaacgttg cgcattgtcc gcgaatatga
     1201 atcggtgatg agcaacttga tctttgtggc cgtcgccggg cgatccaatg gactgggtcc
     1261 agtcgtttcc ggcagcacca actatccggt aatcaattgt ccgcccgtca aatcggacaa
     1321 catgcaggtg gacgtgtggt ccagcttgaa tctgccatcg gggctgggct gtgccacagt
     1381 tctctatcca gaggcagctg ctctgcatgc ggccaccatt ctggggctgg gcaacttcat
     1441 ggtctggtcg aaattgcgtg tcaaggcgct caacaacttt atcactctca agaaggccga
     1501 caaggagttg cgcggcgtgc gaaatgctta gttgctggtt atcatagctt atggtgggag
     1561 atatcagcat tggatatcaa ccaggaggcc atatatagag aatccttccc tgatcattgc
     1621 cgttcggcga tcatccaggg atcccataaa ggtcatcatc agatcacata ctttgttaat
     1681 tcttctttct cctatttttt tttttttgaa accaaacatt tttttattag tattaggaaa
     1741 gcatgacttc aacttgttgt accacgttct tgacaggtta cgaactcgaa ataacaaaaa
     1801 ataaaaatta cattttaaat gttacgcact ttgagctgaa ttttttataa atataaaaga
     1861 aatatagcat ggattacacg taaatgtgat tgaatgtttc tccatttttg gagtaaaaac
     1921 attccctttc ttggacgcaa ctttaaaaat aattgtctga gtatggaatg ccatatctcg
     1981 tcgagctcgt aattaaattt ccaattcaac tgtgtccaaa aattgtattt ctattttttt
     2041 gccatttttt gtaaatttac cttaccaaaa tatgcaaaaa ttggtcaaaa aataaatttt
     2101 tctaaatcct tgaaaaggtg atagggattg ttagcattgg taattagctg ctcaaaacag
     2161 ttattctttt gactttgtgt tgattttgag caacgtttag aagaaatctg cattcgttcc
     2221 ctagccaatt tttaaattga tttagtttga atttagaacc gacaataagt ttttttttgt
     2281 ttatttttgc caatttttag ttcaaactaa ttagtagcat acttttgggc tgagacgatg
     2341 acgatttgaa tgactaaact gttgcacttt ttaaacgtga ttcttggctc tattaaacaa
     2401 aacaaaaaac gggaattagc catgtgtata gtttatatat taaaatagca tctagaatgc
     2461 taaaaaaaat gtattaaaaa ccacgtttgg agaaaagaga aattgtagat aaatttccaa
     2521 aaaatgtaaa taaaagagtt atttatc