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Drosophila melanogaster heavyweight (hwt), transcript variant A,


LOCUS       NM_001272555            9201 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001272555
VERSION     NM_001272555.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 9201)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9201)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9201)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 9201)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 9201)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 9201)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 9201)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 9201)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 9201)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 9201)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 9201)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 9201)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 9201)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 9201)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 9201)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 9201)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 9201)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 9201)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 9201)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 9201)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 9201)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 9201)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 9201)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001272555.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9201
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..9201
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /old_locus_tag="Dmel_CG11146"
                     /old_locus_tag="Dmel_CG15729"
                     /old_locus_tag="Dmel_CG32653"
                     /old_locus_tag="Dmel_CG42251"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="heavyweight"
                     /map="11A12-11B1"
                     /db_xref="FLYBASE:FBgn0264542"
                     /db_xref="GeneID:32202"
     CDS             1550..6856
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /old_locus_tag="Dmel_CG11146"
                     /old_locus_tag="Dmel_CG15729"
                     /old_locus_tag="Dmel_CG32653"
                     /old_locus_tag="Dmel_CG42251"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="CG43921 gene product from transcript CG43921-RA;
                     CG43921-PA; hwt-PA"
                     /codon_start=1
                     /product="heavyweight, isoform A"
                     /protein_id="NP_001259484.1"
                     /db_xref="FLYBASE:FBpp0305357"
                     /db_xref="GeneID:32202"
                     /db_xref="FLYBASE:FBgn0264542"
                     /translation="MERMWRKVNHSLRNTSKSQAQQAAGGDGIIGGPATGATAATPQS
                     TDTISSAGGFGDGQLVVAVQGLASGGIGASITASGGSNATGRRLASSGGGGGCNKSLS
                     QHVLQTRTASSERRRRRRRKSRPRRGGGMGVTSCVGDPGGDNMSSSGGFYTLKEHQHY
                     RPSHHHGGGVSVGVGGGSSRRLFATSAPSGTVMMYPNPQRGTALAPSVGSGTGHANTA
                     GLGGGGGGGAGGAGGGATGSGTGGQPDISLRQRAVAKLRMFNFHLNWDLHMTHCKPCG
                     PRLSGSGGNIITRRLCRNRRREDNELYRSNSFKFERFERKECLEELSNTLQKQIAICD
                     DYSLPVDFVKKRPSSFDPCLAEAIPANPEHWIAPSPQTEFLPFGEAQQALQLQPAAAA
                     ATAAATTSAAAAANATAAAPQLPPPLPVPVATLPNQAATAAAAATAAILATHQQQQQQ
                     QHQHLSNNNNNGGSTHGQQHTHSNNNNTLPVGAQQQQQQQHQQQRATLQHPPLPNSNI
                     KQASVKLIEGYSDPKDTRNHKKVYHKKAKKRSTTGHKRHQQQQQQQQPHQQQLQQQQQ
                     QTLPTPRSAQQQQQLQQKLQQRHSTYNNNNGNSRKDKRNSQYNSDSSAPKSSDDEADI
                     DEEVEQQPLPVPQAPVQSASQPAAGLNSPDSISDDLVRPLPPQLQRSPRKLTVAPAEH
                     NKRQPSPYYYSDLLKSRDKDKDKDKDKDKDKDKDKDKDKDKDKERDKDREDFKLKCRQ
                     STASEPPQQTQTQLGGYRKSSSLDVPPAEEQPEAESHEEEDPRTGQDSQSTPKRYSFT
                     EEGVHIIRCETPSTSTSEESDCSECLKRREWHARALALVRKTCNVQPRNQNPTGSELQ
                     LQLQHCDAGEGELLKCCPPPPAPAENQSQVQPMPPHRLLGPAAVCGACITSAPASSLA
                     GGRGSELGDDLEEEYFRPRSIFYVHPHGVHECIECAQPAQPATVPAPTLSNPSLDIYG
                     DDEDEVDGDEDEDEEDDSEDIMGSRRRQIYETAFDCKIAKSDDDLDEVDRITNCSVLL
                     QLSNGNGGDISKVTGSSKTRAECKRAKNSKNQALQEQTGEAHVQVHHVEAELGKLQLS
                     QVDQQNQNQNQSQNQQHGVSATGSGASASSTQQLPVRGYTPSPPSTAPLPMKFPGKHD
                     RYLNMNSIRSAPNLPAANPAHPRLRDLRLPIQSMRHQCGGSSNDNSLTDSAYVNPPST
                     NSNSNAASASASASVSATGSAAPRRPRSFVLESGRVLELRRSAQGHQGGQSTHHHHHH
                     HHHAPGSRRNRHGQSQGQTTGGGHNYSSTESIATSSSGGSMESLRSSTSEGNRSTSSS
                     ESRHSSSLSSHSSESGSGGSGGSGGSSVAYPLRPAPLLLHSKLHILSPISDKSSQEPA
                     SASASEQSQQPSQQLAPMASQEDDSTTSGAPAGNQVQVNASLKQPRSNRGAPNKALLQ
                     LADELLGSDSGISLHSREDGKPQALALQRLTLPKLQLIGAEGTTTSATASGAGGSSAT
                     GGSSGAGGSGSGSVVASGSTGIQQDLRDLPFDMPKLRRRKTLQQEAACTSGSATSVDL
                     GELPFDMPKLRRRLRANQAEINNLLMHSTESSGISQASSSHSMRDDQKMSSKLDTALF
                     RQNLTLNLNESRQATKQFGSLDLRGLNSNKELNMNLSQGYVTAVDLIDVTIPLERQGW
                     YHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFMHMRIQRNETGQYI
                     LGQFSRPFETVPEMIRHFCLNRLPVRGAEHMCLIEPVIAQLL"
     misc_feature    6545..6838
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /old_locus_tag="Dmel_CG11146"
                     /old_locus_tag="Dmel_CG15729"
                     /old_locus_tag="Dmel_CG32653"
                     /old_locus_tag="Dmel_CG42251"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="Src homology 2 domain found in SH2
                     domain-containing adapter proteins B, D, E, and F (SHB,
                     SHD, SHE, SHF); Region: SH2_SHB_SHD_SHE_SHF_like; cd09945"
                     /db_xref="CDD:198198"
     misc_feature    order(6572..6574,6626..6628,6689..6691,6695..6697)
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198198"
     misc_feature    order(6692..6694,6779..6781)
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198198"
ORIGIN      
        1 acagtggctc cgttatttgt gcgtgcgcgt tgccaataaa cgggcagcgg cttctgctca
       61 gctctcgtgt gatacaaaaa tgtggattcc tgtggattcc gattgattgt ttatcgttaa
      121 ccgttggccg attcggcagt gtgtcttttc ccaaatttta accgacaaca acaatcgaaa
      181 tgacaacaac aacaacaatg catagttcct gctgagtagc ttttctgtat aatcgaatga
      241 gtgtcccttt gtgtatttga acgagatcca aggtaaacca agatgaaagt caatcaagca
      301 ataacaacag caaccgcaac aacaactaat cactgccacc taaaaacaat aagctaacaa
      361 caataacagc aaaaacagcc gcaccgaaga ggagaaagac cggaagaaaa agcagaacac
      421 gaaaggagtg tggcaaacaa gaaactagaa aatgtcccaa ccctcgtagc tagctgaaat
      481 ttcccaatag gaaaatggat acccgcagaa actgataaat atggttggaa acaacataaa
      541 aggaacaaca aataaaacaa caactaagaa gaactccaca tgaaatcaac ccataggtaa
      601 aaacaactat ctacatcaac aggggaatga acgactatca acaactgcca agaagattca
      661 acaacgataa tttacaccaa ctaacaaaat aagtttacaa aaaccaataa aggaaattca
      721 aattgttcca caacaacttt aaatgaaatc aatatcttat atcaaacata actattaaat
      781 agaaagaact ttaacaacga aaaggttaac aactagctgt tttgaaaata aataccaaaa
      841 acttcctagc aatggctaaa actcttcaaa aacatgtggt aattgaaata aactatataa
      901 attaatcaat aataaaaaaa gtgcttgcca atatcaaaaa ctttaaatct ttaggattaa
      961 tacatagtaa tggtaaacac cgactaaact cgcacaaaat ttaaactaac gtaacgtttt
     1021 agcaaaaaca cttcttatta tcgaaaaggc ttacatttaa ataaatgttg tggattatgc
     1081 aaatgaaagt atcttagatc tacggcttcc atacatttaa agcattacta aacaaactgg
     1141 taaaaaacca aaatatttgc taatcatttc acattaaatc acatatttac aacaattaaa
     1201 gtatttaaaa ataccaaaat actaacggaa tctgtattga gcagcaagag atattcaacc
     1261 acaaatcaca acaaggacgc acaccaatac tcaacaatga accaacaaag gaaattaagc
     1321 agctggaacg catttggcat taactgaaaa aattctcata tatctttaat taaccaaaaa
     1381 ttaaataaat atataaaaaa aaactattta ttggggtaaa gcgaaaagag taatggaaac
     1441 tgtaataagc taacaaatat actcgtatgc aacaatcact ttcaacaata tacccctcat
     1501 caagaaaaca ttatcgaatc gccgcaagga atcaagcgga tttttcaaga tggagcgcat
     1561 gtggcgaaaa gtaaaccaca gtttgcgcaa caccagcaag tcgcaagcac agcaagcagc
     1621 aggtggcgat ggaatcatcg gtggcccagc cacaggagcc actgcagcca cgcctcaatc
     1681 caccgacacg attagttcgg ctggcggttt cggcgatggc cagctggtgg tcgctgtcca
     1741 gggattagcc agcggaggca ttggtgcttc catcactgcc agtggtggca gcaatgccac
     1801 cggacgacga ctggccagca gcggtggagg tggcggttgt aacaaatccc ttagccaaca
     1861 tgtcctgcaa acacgtaccg cttcctcgga acgccgcagg cgacgccgtc ggaaaagtcg
     1921 cccacgacgt ggcggtggaa tgggtgtcac cagttgcgtc ggcgatcctg gtggcgacaa
     1981 tatgtcttcc tcgggcggct tttatacact gaaagagcac cagcactatc gtcccagtca
     2041 ccatcatggc gggggcgttt ctgtcggcgt tggcggtggc tcatcccgtc gtcttttcgc
     2101 cacttcggcg cccagcggca cagtgatgat gtatccgaat ccccagcgcg gcacggcact
     2161 agcaccatct gtgggatctg gaaccgggca cgcaaacact gcgggcttag gaggaggagg
     2221 aggaggagga gccggaggtg ctggaggtgg agcgactgga tccggaactg gaggacagcc
     2281 ggacatttca ctgagacagc gggcggtggc caagttgcgc atgttcaact tccatctcaa
     2341 ctgggatctg cacatgacgc actgcaagcc ctgcggtccc cgtttgagtg gcagtggtgg
     2401 caacataatc acccgaaggc tgtgccgcaa tcgtcggcgg gaggacaacg aactgtaccg
     2461 ctccaatagc ttcaagttcg agcgattcga gcgcaaggag tgcctggagg agctgtccaa
     2521 cacgttgcag aagcagattg ccatctgtga tgattacagc ctgcccgtag actttgttaa
     2581 aaaacgaccg tccagctttg atccgtgcct ggcggaggcg ataccagcga atcccgagca
     2641 ttggatagca cccagtccgc aaaccgagtt tctgccattt ggtgaagccc aacaagcgtt
     2701 gcagctacaa ccagcagcag cagcagcaac agcagcagca acaacatctg cagcagcagc
     2761 ggcaaacgca acagcagcag ctcctcaact accgccaccg ctgcccgttc ccgtggcaac
     2821 attgcccaat caggcggcga cggcagcagc agcagcaaca gctgcgattt tggccactca
     2881 ccagcaacag cagcagcagc agcatcagca tttgagcaac aacaacaaca acggcggcag
     2941 cacacacggc caacagcata cgcacagcaa caataacaac acattgccag taggggcaca
     3001 gcagcagcaa cagcagcagc atcaacaaca acgtgcaaca ttgcaacatc caccgctgcc
     3061 caacagcaac atcaagcagg catcggtgaa attaatcgaa ggatattcag atccaaagga
     3121 tacgcgcaat cacaaaaagg tctatcacaa aaaggccaag aaacgctcga ctactggcca
     3181 caagcggcat cagcaacagc agcagcaaca gcagccgcat cagcagcaat tgcagcagca
     3241 gcaacagcaa acgttgccaa cgcctagaag tgcgcagcag caacagcaac tgcagcaaaa
     3301 gttacagcag cggcattcca cctacaacaa caacaacggc aactcaagaa aggataaacg
     3361 caacagtcaa tacaattcag actcctcggc tccgaaatcc tccgacgacg aggcggacat
     3421 cgacgaagag gttgagcagc aaccgctgcc cgtgccacaa gcacctgtcc agagtgcttc
     3481 acaaccagcg gccggactca actcgccgga ttccatatcc gatgacctgg tgcgtccgct
     3541 tccaccgcaa ctgcagcgca gtccgcgcaa actgaccgtc gctccggcgg agcacaacaa
     3601 gcgccagccc tcgccctact actactccga tctgctcaag agtcgtgaca aggacaagga
     3661 taaagacaag gacaaggaca aagacaagga caaggataaa gacaaggaca aggacaagga
     3721 caaggaacgg gacaaggaca gggaggactt taagctcaag tgtcgccagt cgacggccag
     3781 tgaaccgccg cagcaaaccc agacacagtt gggtggctac cggaagagct ccagcttgga
     3841 tgtgccgccg gcggaggagc agccggaagc agagagtcac gaagaggagg atccccggac
     3901 gggacaggac tctcaatcca cgcccaagcg ttacagtttc accgaggagg gtgtacacat
     3961 cattcgctgc gagacgccca gcaccagtac ttccgaggaa tccgattgca gtgagtgcct
     4021 caagcgacgc gagtggcacg ctcgtgcctt agccttagtc cgcaagacct gcaacgttca
     4081 gccaaggaat cagaatccca ctggcagcga gcttcagctg cagttgcagc attgcgacgc
     4141 cggcgagggc gaactgctta agtgctgtcc accgccaccg gctccagcgg agaaccagtc
     4201 tcaggtccag ccgatgccac cgcaccgcct gctgggacca gcagccgtgt gcggagcctg
     4261 catcacatcc gctcctgcct cctccttggc cggcggacgg ggcagcgagc tcggcgatga
     4321 tctggaagag gagtacttcc ggccgcgcag catcttctat gtgcatccac atggcgtcca
     4381 cgagtgcatc gagtgcgccc agccagccca gcctgcgact gttccagcgc caacgctgag
     4441 caatccatcg ctcgatatct acggcgacga cgaggacgaa gtggacggtg acgaggacga
     4501 ggacgaagag gacgactccg aggacatcat gggcagccgg cggcggcaga tctatgagac
     4561 ggccttcgac tgcaagatag ccaagtcgga tgacgatcta gatgaggtgg atcgcattac
     4621 caattgctcg gtcttgctgc agttgagtaa tggcaacggt ggtgacatca gcaaggtaac
     4681 cggctcttcg aagacgcggg ccgagtgcaa gcgagccaaa aactccaaaa atcaggctct
     4741 gcaagagcaa acgggcgagg cccatgtaca agtgcatcat gtggaggcgg agctgggcaa
     4801 gctgcagctg agtcaagtgg accagcagaa tcagaatcag aaccagagcc aaaaccagca
     4861 gcatggtgtg agtgctaccg gtagtggagc aagtgcatcc agcacgcagc agctgcccgt
     4921 gcggggatat accccatcgc cgccatcgac ggctccgctg ccgatgaaat ttcccggcaa
     4981 acatgatcgc tacctgaaca tgaacagcat caggagtgca cccaatctgc ccgccgccaa
     5041 tccagcgcat ccccgtctcc gggatctccg tctgcccatc cagtccatgc ggcatcagtg
     5101 cggcggcagc agcaatgaca acagtctcac cgacagcgcc tacgtgaatc cgccctcgac
     5161 caactcgaat tcgaatgcgg catcggcttc cgcctcggcc tccgtctcgg caaccggatc
     5221 agcagctcca cgccgaccgc gatcttttgt cctcgaatcg ggccgggtgc tagagctgcg
     5281 acgcagtgcc cagggccatc agggtggcca gtcgacccac catcaccatc atcatcatca
     5341 tcatgcgccg gggagcagaa gaaatcgcca tggccaaagc caggggcaaa cgaccggtgg
     5401 tggccacaac tacagcagca ccgagagcat tgccacctcg agcagtggcg gcagcatgga
     5461 atcgctgcgt tccagcacca gcgagggcaa tcgcagcacc tccagctccg agtcgcggca
     5521 ctccagttcg ctgagctctc acagctcgga gagcggcagc ggtggcagcg gcggtagcgg
     5581 aggctccagt gtggcctatc ccctgcgacc ggctcccctg ctgctacact ccaagctgca
     5641 catcctgagt cccatttccg acaagtcctc gcaggaaccg gcatcggcca gtgcctcgga
     5701 gcaatcacag cagccgtccc agcagctggc gccgatggcg tcgcaggaag acgattccac
     5761 aacgagtggc gcaccagcag ggaaccaagt ccaggtgaat gcctccttga agcagccgcg
     5821 tagcaatcgg ggtgcaccaa ataaggccct gctccagctg gccgatgagc tactgggttc
     5881 ggatagtggg atatcgctgc attcccggga ggatggaaaa ccgcaggcct tagcgctaca
     5941 gcgtttaacg ctgcccaagc tacagttgat tggtgctgaa ggaacaacaa cgtcggcaac
     6001 ggcctccgga gcaggaggta gctcagcaac gggtggcagt agcggcgctg gaggatcagg
     6061 atccggttcg gtagttgcca gcggatcgac tggcatacag caggatctgc gcgatttgcc
     6121 cttcgatatg cccaaactga ggcgacgcaa gacgctgcaa caggaggccg cctgcacatc
     6181 gggcagtgcc acgtccgtcg atctcggcga gctgcccttc gacatgccca agttgcgacg
     6241 acgcctgagg gccaaccagg cggagatcaa taacctgctg atgcacagca ccgaatccag
     6301 tggcatctcg caggcttcct ccagtcattc gatgcgcgac gaccaaaaga tgtccagcaa
     6361 gttggatacg gcactttttc ggcagaatct cactctaaac cttaatgaat cgcgacaggc
     6421 gaccaaacag tttggcagcc tggatctgcg tggtctcaat agcaacaagg agctaaacat
     6481 gaatctcagc cagggatatg tcactgctgt ggatctaatc gatgtgacaa ttccgctgga
     6541 gcggcagggt tggtaccatg gtgccataac gcgaattgag gcggagacca cactgcgtcc
     6601 gctgtccgag ggatccttcc tggtgcgcaa ctgcgagtcc acgaagcagg actattcgct
     6661 atccctcaag ggcgccaagg gctttatgca catgcgcatc cagcgcaacg agactggaca
     6721 gtacatcctt ggccagttta gtcgtccctt cgagacggta ccggagatga tccggcactt
     6781 ttgcctcaac cggctgccag tgcgcggtgc cgagcacatg tgtctgatcg agccggtcat
     6841 cgcccagctg ctctagagag gctccaagaa ctcgaaggac accgggatgt ggccaatcgg
     6901 aggctttaga ggctccaggg gatggggaac caaaacagaa taacatatta atagcgtgta
     6961 gagaacgtag aaacctatgt gaacgatgtg tatgcactag ttatatatgc gagttagttg
     7021 taaaaggatg atggcaattt tttcatgttt tttttttttt gcctcgaact ttgtatgtcg
     7081 gtctactaaa gtacacacac acaaacacaa aactcactca ctaatacacg aactagttta
     7141 gcgtttaaag tacgtagcac attcagacaa taccagcaaa ttacaaaaac caaacaacaa
     7201 acgatattta tatagaaggc atatatacaa gcgagacgat atatacaaaa gcatatagat
     7261 acggataaca aaagcacttg acgacagttg ctaaaaacgt agcggtacat gatgatccca
     7321 aatgcggaca aagatggtac agattttaga tgtgtttaca ccgaaccgag catcagatta
     7381 ggagcaacta attgtagcat tgggcgccaa aagtaaaaac aaaaaaaact cttccattgg
     7441 ctaaagattt atggtagaac acatacaact cacttctagc gattatatgg tcgaaactta
     7501 tgcaactttt cgcagcacac acacacacac acacaaacac tcgcccacta gcaccgccca
     7561 gcatcgtccg attattcaga taattacgcc attatttata aatcctaatt cctttggcga
     7621 cggatgctag tgggcatcgc ttaaggcacg tttacactaa gaaaagtttt agcaagcaac
     7681 tctaaaaatt tgttgattaa ttttatgtta ccaaaacgaa gaaaaacgaa caaaaaatct
     7741 aaaatatgta tatctatatg tatgaaaact aactttagca agagcgatgt cacatttttt
     7801 tttttggtct tagctgtagg tcagaggtac gcgaaataga acgctcaaag cgcttttggt
     7861 taaaggatcg aaacgaatag gatcagatca gatcggatcg gatcagaagg aattggagga
     7921 ttgatcggat cggatcggat cgaatcgata gggatggtta gaaggggcaa ggatatagca
     7981 acgcatatga aatgtcagtt taagtgttag tttctaattg agcgaacgaa gggcagactc
     8041 tatatatata tacataaata tatatatata tattgaatgc tacaaaatga tatatactta
     8101 ctatttatat ttctatatat acatctatat atatatatat atatatatac atatatatat
     8161 atacgatatt aaagagcagt caatggtttt ttggttccag ttccgaaaga gaagcaagtg
     8221 tcaggatgca ggatgctaat taactaatta actaattatt gtttctggca gttttctgtt
     8281 ccaccttcgt accgccgagc aatacaactg atttccagta tcccaaaccc aaagttatgt
     8341 ttatatgtgt gtgccaaagt attattctag tcgtatgtat gtgaatcgaa tctccgtgtg
     8401 aatatcagcg cgttatattt ttttcgatat gttgattgtt gcctaatttc taatactcaa
     8461 gcaatccgaa gcagtgcaat atacgaatac gttttaaata tctcggttat gtatctatga
     8521 tttgactaat ttagctctaa gttacaaacg ccctgatttg tccatagtta agcgtatcgg
     8581 ttgatgataa caatctccat ttggcgaaag ctgcaccagt ttgtaaacgg cttttttgta
     8641 aatatacgga atataaatac aacacgacag atatgtacga tatatacaag tcgatatgat
     8701 tttagttgca atacacaact tttaagctaa gatttgaact tcacatagaa acagcaaatc
     8761 aacacataca ttaacgacgt acataacaat gtattttgag gcttccgtag cagtaacaga
     8821 aaaaaccaat caaccaaaca aactaccaaa caaaaaaaaa aatccaaacc aaaattccaa
     8881 gattatcgca gcactcgggc accgtttaca cctgccaacc atgaggtcgt agtgcaaatt
     8941 cgctgagtgt cgatcgcttc cgtttttgtt gtgtataaaa attgtacttt taggtctgcg
     9001 gacgatgatg aacaaccggc ttactctaac cgaaacttgt actccaaact agaggcgctc
     9061 tctatctacg gcaccctaat atctgattaa ttcaattagt acagagcgaa tacgtaacaa
     9121 gaacttaaca aacagaaacc gcaacaacaa caaacgaaag aaacgaaatg tattgaataa
     9181 aaataaatat gataaatttc c