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Drosophila melanogaster bifocal (bif), transcript variant E, mRNA.


LOCUS       NM_001272527            8842 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_001272527
VERSION     NM_001272527.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 8842)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8842)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8842)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 8842)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 8842)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 8842)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 8842)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 8842)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 8842)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 8842)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 8842)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 8842)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 8842)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 8842)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 8842)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 8842)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 8842)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 8842)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 8842)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 8842)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 8842)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 8842)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 8842)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001272527.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8842
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..8842
                     /gene="bif"
                     /locus_tag="Dmel_CG1822"
                     /gene_synonym="Bif; bif CES; CG1822; Dmel\CG1822"
                     /note="bifocal"
                     /map="10D4-10D5"
                     /db_xref="FLYBASE:FBgn0014133"
                     /db_xref="GeneID:32119"
     CDS             330..3653
                     /gene="bif"
                     /locus_tag="Dmel_CG1822"
                     /gene_synonym="Bif; bif CES; CG1822; Dmel\CG1822"
                     /note="CG1822 gene product from transcript CG1822-RE;
                     CG1822-PE; bif-PE; bifocal"
                     /codon_start=1
                     /product="bifocal, isoform E"
                     /protein_id="NP_001259456.1"
                     /db_xref="FLYBASE:FBpp0306540"
                     /db_xref="GeneID:32119"
                     /db_xref="FLYBASE:FBgn0014133"
                     /translation="MESQKRPSLDLHTDVPAGLAAGGSGLGAAAEMSPTSGFLPDMPQ
                     WKKDLIQRRKTNVARTQAASITSPTDGSCGALAEANAAPGAIADFTEPATISSTSQKR
                     NMIGSEEKSEKSSISNTNSDSTGGHHSVVAVSLSPDAAATTNVTVTPIPKQRSSLLNT
                     RSQEREMVRYILSESGERDGELESGEQPAGVVSNSRCGEVETGTIGSPSSSANQNPNP
                     NHLKTKCKPGQSVAEGKPSAKETIVDNSKSCSKTKSISDKLQSNKFIIQQQQQQQQQQ
                     QQQQQLSPTKVTVKPTMVAMQEMKKTTKQNGQHRHLAGKIGSVAGGDVDPQHPPTNPI
                     PDSLDTGEDLSYGPGIVSKLRCRYLSLALRESRQQSSKQRLQRSTSLNTLLDRDDDEV
                     EVEEPEMTNSQVRAKSTPPPILGAKPTPKPSSQHQRPVSLGANGAGSAVNPPSNSDQA
                     QTGAVANGGAGSGQRSRHFKRGNEVMKRARSVEALLCEKSPWNSQRISTAGAAAAAAP
                     SPPAPKATAAAPSPVTSPTCVTIEDKIHNARERLHSGTDTAPPKRLTSIIDDTERPPP
                     DLVKQTLKMFEASANRRPRAAHRSNGVGGVASKVANYKSIIKDQKQPSSAAATPPPTG
                     MGFASSTPLRHVHPDIIPRQVDSPVSALSVMMRRMELQEPETPERETRDAEATPQSEA
                     LSETERNDRDEGDGEVDDDNHNNNDDDHDDGDDGSDNNEQRDKMGAAAAGDKPKPPAE
                     SAAGGAQRSFAASTENAHVASGSSSSTSASVRKLSNNNDSSSGPAVTKQIGVIRPLFN
                     SQGAGSTPLTSREIEKNRINEMKKSTATDAGGSVSGSGTVAGAGSGTSPTTSLDSVIN
                     TKEAASSETDASASPLWTLRKLRNQSQTAGGGSGPSSSLHSTENTSMVFNFSKSTKEV
                     PDYIESDVVIYRRKRELPKPNEPGFVLLGDLSVETSTDTDYDDYSMCPPSPCDVEFEN
                     ANIVIDGKSSIRQKPKESSFRVQFNDTLTSTFEYPSEASMTIEDPPYADPFGHVSKHH
                     QMLLAEQMHLLQHQEQLELEQMHQLGLAPEQHHHVTVDEIIELPTSTAGHGHGIGLGH
                     RSGAAGGGGTMLGNLPLGK"
ORIGIN      
        1 aacaatcgat aagcagtatt tgtgtattgg aaacgcggct taacttaatg cagatttttc
       61 cgctgattcg gctgcgaaag atgcactttt aaggcgcagc gagtgcaccc acgccccgag
      121 ttcgagtgca gttgcagtcg ggaaagcttg acaagtgcgc ggagcaagga gagcgacgag
      181 ttcgttgagc tacagcgaaa cggaaaagtg taaaagcggg gtaaacaggc gcagcggagc
      241 ggatgataaa cggaactcgg gatcggaaaa ttggaagcaa aaccaaccac cgattataaa
      301 aaatagtcag catcttaaaa acggggataa tggagtcaca gaagcggcct tcgttggact
      361 tacacacgga tgtgccagca ggattagcag ctggaggatc tggcctggga gctgcagctg
      421 agatgtcgcc cacttccggt ttcctgccgg acatgccgca gtggaagaag gacctcatcc
      481 agcgccggaa aacgaacgtg gcccgcaccc aggcggcgtc catcacctcg cccaccgatg
      541 gcagttgtgg ggctttggca gaagccaacg cagctccagg tgcaattgca gatttcacag
      601 aaccggcgac aatcagtagc actagtcaaa agagaaacat gatcggttca gaggaaaagt
      661 ctgagaaatc ttctatttcc aataccaatt ccgattccac tggaggtcat cactctgttg
      721 ttgccgtctc cctttcgccc gatgcggcag caacaacaaa tgtaacagta acaccaatac
      781 caaagcagcg atcgagttta ctcaacacaa gaagtcagga gagggagatg gtgcgatata
      841 ttctaagcga gagtggagaa cgggatggag agcttgagag cggcgaacag ccggctggtg
      901 tggtgagtaa cagccggtgc ggtgaagttg aaactggcac aattggatcg ccgtcgtcgt
      961 cagcaaatca aaatccaaac ccaaatcatt taaaaacgaa atgcaaaccg ggacagagcg
     1021 ttgctgaggg caagccttca gctaaagaga ccatcgtcga taacagcaaa agctgcagca
     1081 aaaccaagag tatttccgat aaattgcaga gcaacaagtt tataattcaa cagcagcagc
     1141 aacaacaaca acaacagcag caacaacagc aactgtcgcc cacaaaggta acggtaaaac
     1201 cgacaatggt cgccatgcaa gagatgaaga agacaaccaa acaaaatggc cagcaccgac
     1261 atctagcggg caaaattggc agcgtagcag gaggcgatgt ggatccacaa catccaccga
     1321 cgaatcccat accagattca ttggacaccg gtgaggatct gagctacgga cccggaattg
     1381 tgtccaagct gcgatgccgc tacttgagcc tggcccttcg cgagtcccgc cagcagagca
     1441 gcaaacaacg cctccaacgc tccaccagtc tgaacaccct gctcgaccgc gacgatgacg
     1501 aggtggaagt ggaggagccc gaaatgacca acagccaggt gcgtgccaaa tcaacaccgc
     1561 caccgatatt gggggcaaaa ccgacaccga aacccagcag ccagcatcag cgtcccgtca
     1621 gtctgggcgc caatggagct ggatcagctg ttaacccgcc ctcgaactcg gatcaggccc
     1681 aaacgggcgc cgttgccaac ggaggcgcag gatctggcca acgttcgcgt cactttaagc
     1741 gcggcaacga ggtgatgaag cgggcacgtt ccgtggaggc tctgctctgc gagaaatcgc
     1801 catggaacag ccagagaatc agcactgccg gcgcagctgc agcagcagca ccttcaccac
     1861 ctgctcccaa ggccacagcc gctgctccct cacctgttac atcgcccacc tgcgttacca
     1921 tcgaggacaa gatccacaat gcccgcgaac gactgcacag cgggacggat acggcgccac
     1981 ccaagcgtct gacctccatc atcgatgaca ccgagcggcc gccaccggat ctggtcaagc
     2041 agacgctcaa gatgtttgag gcgagtgcta atcgacgacc gcgcgcagcc catcgttcca
     2101 atggtgttgg cggagtggcc agcaaggtgg ccaactacaa atcgatcatt aaggatcaga
     2161 agcaaccatc atcagcagcg gcgacgccac cgccgaccgg catgggtttt gcctcctcaa
     2221 cgccgctaag gcatgtccat ccggatatta taccccgtca ggtggattcg cccgtatcgg
     2281 cgttgagtgt aatgatgcgt cgcatggagc tgcaggagcc cgagacgccg gaaagggaga
     2341 cacgggacgc ggaggccaca ccgcagagcg aggcgctaag tgagactgag cgaaatgatc
     2401 gcgatgaagg cgatggcgaa gtcgatgacg acaaccacaa caacaacgac gacgatcacg
     2461 acgacggcga cgacggcagc gacaacaatg agcaacgcga taaaatgggc gcggcggcgg
     2521 caggcgataa gcctaagccc ccagcggaat cggcagcggg aggcgcccaa cgatcattcg
     2581 ctgcctcgac ggagaacgcg catgtagcca gcggtagtag cagcagtacc agtgccagtg
     2641 tacggaagct cagcaacaac aacgactcca gcagcggacc agcggtgacc aaacagatcg
     2701 gtgtcatccg tccgctattc aatagccagg gagccgggag cacgccgcta acgagtcgcg
     2761 agatcgaaaa gaatcgcatc aatgagatga agaagtcgac ggccacagat gccggtggtt
     2821 cggtatccgg atccggaacg gttgctggtg ctggatcagg aacctcgccc accactagtc
     2881 tcgacagcgt gataaacacc aaggaagcgg ccagcagcga aacggatgcc agtgcctcgc
     2941 cactgtggac attgcgcaag ctgaggaatc agagccagac ggccggcgga ggatcgggtc
     3001 ccagttcgag ccttcattcc acagagaaca cctcgatggt gttcaacttt tccaagagca
     3061 ccaaggaagt gcccgactac atcgaaagcg acgttgtgat ttacaggcgc aagcgggagc
     3121 tgccaaagcc aaatgaacct ggcttcgtgc tcctgggcga tctctccgtg gagacgtcga
     3181 cggacacgga ctacgacgac tactccatgt gcccgccatc gccgtgcgat gtggagtttg
     3241 agaatgccaa cattgtgatc gacggcaagt ccagcatacg ccagaaaccc aaagagtctt
     3301 cgttccgcgt gcagttcaac gacacgctga cgtcgacgtt tgaatacccc tccgaggcat
     3361 cgatgaccat cgaggatccg ccgtacgccg atccctttgg ccatgtgagc aaacaccatc
     3421 agatgctgct cgccgagcag atgcatctgt tgcagcacca ggagcagctg gagctggagc
     3481 agatgcacca gctggggctg gcgccggagc agcaccatca tgtgaccgtc gacgagatca
     3541 tcgagctgcc cacatcgacg gcgggacatg gacatggcat cggacttgga cacaggtcgg
     3601 gggcggcggg gggcggtggc acgatgctgg ggaatttacc gttgggtaag taatatctgt
     3661 tccaccgagt ccatccaagc gtgcattgta ttattattat tattattatt attattatta
     3721 ttattgttgt tgctgtacgc tgtacgagat gtatgttgtg tgttgttgta tgtggcatgc
     3781 agcagcgaat gatgatggaa tggctttttg tctttgtctc tctctgcgct ctctattatc
     3841 gtctctatct ctctctctgt ctgcctgatt gcctgcatcc aagcctctct atctatccat
     3901 ctctatctat acccgtctct atctctgtca cttgccttgt ccttactctt gacttaccat
     3961 caaccagcgt tgtgttcttg agttttgttt gtttgtttac catcattaat acccactcat
     4021 ccatcacaca tcgtcgcgat ctcgtttttt ttttttaaca ctttcgtttg ccttgggcgg
     4081 atcgcgaata tacaatagca attgagaaac cccaaagaca actcaagaca cttgtttagc
     4141 aatgaacgta gaaaggtagt gccaatgagc agcagggaaa tatacataat gtaaatcagc
     4201 tggataacca tccttacaat gctacttata aaatgtgatg atgtgaagga atttacatgc
     4261 accatcttat gctcatttta atatttacac tgttccaagt aaaatgtttc caaattaaag
     4321 aaatcaatgt aaagttctcg tataaaactg atttaaacta gagtttatag gactacgacg
     4381 aacccagttc ggaactgggt gacccgcaag cccacatccc atgcctggct aaactctcgg
     4441 gtatataaca acgaaggttt ctgcacttta cagatgctga taatagagcc acagagcatc
     4501 ttgtctccgt atccgtttct gagcccgctc caaactccgc tccagcctcc gtctccgctt
     4561 cagtctccgc ctcaactttc gtaaccgtct cagatcccaa atgtcgtagc gccaggacct
     4621 cgggcaacgg cggctgctgg ccgtggccga agttccgtac ggtccttggt gctcagtttc
     4681 gccggctgac caggcgcatc aggtgggtgc agccatcagc tagcagcagc cccttccaat
     4741 gccccgttta ccgatccccg attcacctgc tcttctatat acatacgcta tgtcacagct
     4801 ctcaacgaac caaaagctaa acccaagcca ccgagttctc caaatagcaa accatcgtgc
     4861 tacggtcttt tctggctgaa aggctttcaa tttcgcctca cgcatatttg cagattaccc
     4921 aagtttaggg aggggtatta tcttgccaca gtcgccacaa cagcagtcaa cgcagcagca
     4981 ggagcagcca gaacctgcaa tagccacatc ggcaacagtg gcaggattag cagtggcaat
     5041 ggcaaccgaa gtggaaatcg agccaccact accagcacca ccagtcacag tcgccaagcg
     5101 cccgcagctc ccggcgaagc cagcacagca gcagcaacaa caggcggcgc gtagggccag
     5161 gccatcggtg ctgcttaagc cgcagtacgc ctgcttcctt cagcacgacg atgatgcacc
     5221 caaatcccag ccaactgctg ctggacgacc gcgcaaggca gcctcgtttt cattgggcaa
     5281 tcaacggcaa tcgaaggagc agcagcaaca tcatcatcat taccagccac agcatcagca
     5341 gagtaaatat gaacgcaacg attgcagtag gagtcggggc agttgcgaga gtccagctcc
     5401 agaacaccag cagcgacgtc gtcggcctag tctgccgtcg tcgctggctt tgtccaatgc
     5461 cagctcggcc ctgctccagg cacgcattcc aggcaccacg ctctactatg tctgatggcc
     5521 acccgatatg aaaagcatta gactccaaac tccagataac cagatatcca gataaccaga
     5581 tactccaact ccgaaccgat ttgaaaccgc cagcgaaacg taggcattgc ccaagcttta
     5641 ctatatgttt acaactaggc taaagaacac ccatcatccc ttggatacct cttggtgacc
     5701 ccgttccgct cccaaaaaaa aaaaaaaaca aaaatatata ttggtttgat ggccgctaaa
     5761 ctgtaaagtg taaccctgtg catatccgac tcactccaaa acaaataact caatgcggaa
     5821 accaggaaca ccaaacccga acacaccaat cacaacacac acaagaaaac aaacactggg
     5881 gcaaccggac actcgaaaca cacgtttaat cgattcatag atgcgattca cgatgcttcc
     5941 cgatgtcgat gcactgccgc cgttaatcgt ttatgcgatg ctctggataa caatcaacag
     6001 taattcgcga attagcgagc gaagaatacg cgaaggatga tggattttag aactaaccta
     6061 aatgatggat aatgctggtg tccccatgtt tcactaaaac caaaccatgt tcctatgact
     6121 gctgcttgat aatgccctgc tcccccgtct gtattcatta tccacaacct taggtataag
     6181 atgctccata gtctttagca accattatat gatagtttac ctagtaaatc gtatgccaat
     6241 catcagattg aactgtacta tgcccaccca gcccatgtgg aagttaaaga ttattgtaga
     6301 aaactattta ggtcacctat aaatgttggc aacgcctaag aattaagcta actactcagc
     6361 tagagatcgc agaaaccgaa acaattgcga taattgataa ctaagtgttc atggcaaatt
     6421 ttggggtgta actaaacgtt taataaacga aaagtaaagc aactaaagct gcagacaaat
     6481 caaagaacct ttatgtagcg gctaatttcg acatgtgttc ggtgtaaacc aaacaaaaac
     6541 gaatcacaga acactagtta gtgactattt tcatttcagt tacgtactta agtatatata
     6601 tttgtgcacc cgtgtgagtt ggcgttagtt atgtgttatg tgcttatgta tgtttgcttt
     6661 gtttggctca gttcggtttg gtatgcagtt gtggggcatg tattgaattg caatttgcga
     6721 tttgaaattg tagccatgta gttacgctaa cctaccttct cgcccccgct gtttcacgcc
     6781 acccaaatgg tttttcattt caacaacaac cttttgttaa agtcaccgct gtcgctttgt
     6841 ttgtttgcta tttgtttact tctatttcta ttttttgttc ataccaattt ctttttgcag
     6901 atattattta aatgtaacag aatacataag caaagcgttg aaataatatc tattgtatac
     6961 caaaaccaaa aatatctatg ataacaaaca agcaaaggca attaaaccga tccgtaaact
     7021 gaataaccga ttaataactg cagccgctca acccgaaccg caataaataa ctatcaagta
     7081 aagaatagaa caacttaaca atgaaaaatg caatattcaa tatgcgaaat gacaaatgcc
     7141 taatgccaaa tgccaatcca aataacccaa taaccgattc aagtgcgaga acagaaatgc
     7201 cacacctcta acccagtgca cttgctctgt ctgctccgct gggcaatcaa actaatcgcc
     7261 aattcatatt attattaagg taactaaccc agattagaac agacactcga acacacgcac
     7321 acaccagcca ccaacaccac ttggcacatc ctagtcatat catcaacttc catcgctcat
     7381 ctccacttcc atttctttat ccactggtca tgtttcgttt tcatttgctt gaaaagatcc
     7441 aggcgagatc ctcctttatc cacaacaccg tcacctcatc tcgattatat atacatataa
     7501 atatatatat atatgttctg aaatatatat ttcccaactc ggagccacct tatttatcat
     7561 tgtactaacc ccaaatcctt ggaaggattt aaacccactt gaaataaaga tatacagtcg
     7621 attaatctcg ttctacacat aattgcaggc tccacggctc tgggcttcta cacgcccatg
     7681 aagggcacgg cgatggacaa cctattccag ctgggtgtca cccgatacgc cctgcccgag
     7741 agcagcagca gtgggagcag caatggcagc cacagtccag gcagcaacgg gagcagtcca
     7801 gccggagctg cgggcagccg gttgatgttc aacgggaatg gcagcattat gggcatcggc
     7861 gagggactga tcaaggaggg cgacttggcg gcaacggaag caggacctgg aactgcagat
     7921 ggagcaggtg cctccaagaa gggttcagct gtggacgagg atgattacca tctgacggcg
     7981 acgccgggcg ccgaagttgt gtacagcgag ggtacacaga aaacggattt gctatattag
     8041 gtcgtcctgc cagccaaaaa accggagcgt ctagctcttt ttctaccggt ttccaccaaa
     8101 ctccaaacct tccgagcata acaacctacc acatcctgat cgttccccta attgaaaagc
     8161 gtgcacttag gtgaaatatc aacttcggtt agacgcgaaa acagtaacga aggaaagaaa
     8221 aataaaaaca acaaggcaac gtaaaccaag tatggcaaga aatccataaa gatacgtata
     8281 taaatagata ttatttgtaa gtttgtaagc ctagagatcc gatgtgtatg tgtacaacag
     8341 caagcgtgtg tgtctgtctt ctttataaat atatatatat ggtttttttt ttttgataaa
     8401 ttaataatta tattattgta atgtatctac atacggcact gaatgaacaa ctttgctgct
     8461 gcaattgtat ttgtatttgt attgtgtatt ccatttacgg cattttgata gtaaatatac
     8521 aacaacaaca aatcaacgta tttccgactg catcccgaag gttactgaaa ccttaatcca
     8581 cgaagtacgc gacgagcggt tagtcccgcc cgagtattaa cttaatggat tctaacgatc
     8641 cgatcttgtg acccatcatc atcccttttc gcgacccttc caaaacgaaa atgaagaaca
     8701 ttctaagctc cgcttgccca ttcagcggaa gaaagcaaag gaaaatgtaa catttgcctc
     8761 ataattatta tatacattta gcgcttattg aatatttttt acaattgtat tccgtaaata
     8821 aatataaaat acatcaacat ct