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Drosophila melanogaster no circadian temperature entrainment


LOCUS       NM_001272480            9940 bp    mRNA    linear   INV 26-DEC-2023
            (nocte), transcript variant D, mRNA.
ACCESSION   NM_001272480
VERSION     NM_001272480.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 9940)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9940)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9940)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 9940)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 9940)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 9940)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 9940)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 9940)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 9940)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 9940)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 9940)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 9940)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 9940)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 9940)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 9940)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 9940)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 9940)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 9940)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 9940)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 9940)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 9940)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 9940)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 9940)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9940
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..9940
                     /gene="nocte"
                     /locus_tag="Dmel_CG17255"
                     /gene_synonym="CG17255; Dmel\CG17255"
                     /note="no circadian temperature entrainment"
                     /map="9C5-9D1"
                     /db_xref="FLYBASE:FBgn0261710"
                     /db_xref="GeneID:31976"
     CDS             435..7352
                     /gene="nocte"
                     /locus_tag="Dmel_CG17255"
                     /gene_synonym="CG17255; Dmel\CG17255"
                     /note="CG17255 gene product from transcript CG17255-RD;
                     CG17255-PD; nocte-PD"
                     /codon_start=1
                     /product="no circadian temperature entrainment, isoform D"
                     /protein_id="NP_001259409.1"
                     /db_xref="FLYBASE:FBpp0305169"
                     /db_xref="GeneID:31976"
                     /db_xref="FLYBASE:FBgn0261710"
                     /translation="MSTLGGSRGERNAKPKFTALDINRMYKNSRGESSEPSAQKNQVP
                     RKHGMQILGKVPSARRPPANLPSLKAETHTSSNNNLLVSVEGATSGGAGAGGAAGSGA
                     AGTNTSHNNTTAHSGSSGTSGGAGSGGGGTASSSAGGHLSQQLTHSQHQHNNNVALGP
                     NAGKFVNSNNGSSNNNAGSSGSGNKNFKLINNSVGSSGGGGQGGSGGGGSSGVGGGSG
                     SGSGGHSVNSPKTWSAITTGHERGSGGQNYGRQQQQVVPHYQSPQFQYEFPTLDGTVG
                     SGAGGGSGAGVGSGSGAGKSHYQNQVHHAGHQNHHQHQQHHQQHQQHHHQQQQHHRDY
                     HHGHGRQYGHHSHRDYRDGSDDVGGGSADLGELSLRPQNDTAAWLQQQEKAAKVAAAA
                     AADQGLNLQGPGHHQMGGNGGAGGGSGGAVPLPILSLMPSFMRSGAPMPASGATAASI
                     LAGGSLDTSALPNAPYQNGILGARSASPAVVGSGSFRAATAIPKRPPTSSSPPQSGLG
                     IGGSPTPPQSQQQANGGAGGAGRKDKDYVVEPEVAQMQRPIIREEDLERLNAIAKDDS
                     WTKQDDIDFTKKLAFSDDESTPEEHQGQGKQHSSAQLQAQGSSSSTDQRKLSASTTSW
                     QRGKESTDRDQPSEGIQDQQQQLQQQQQQQEVRQQNGHRGSSGNVGAPVAGGIALDAS
                     VYERVKQRKEEEERREMERKQAAAKKLQELEMKMNSKKAAAAALAGAEGGVSSASVPL
                     SNEVPPTSAPLGNASEDEGGGQGGGGGLNRRPRGSISSLGSGVTPTGGAGGGGGGVSS
                     SSSAGGDYGQKNFLTHFQSNLPPRFQRQQQQQQQQLPRLEKSASASSAFDSNSRYLQK
                     GGVSGGGGGVSGGAQANAGQGRSISGGYVQRGASVGGSSGYGRNRHDSSSAREDQDLD
                     QQRFTRGQDYRQAQALPRSISENSHRKTSVSSAGDDVLGGSCSSWAEQTDAEQKVHHR
                     HREESFSSSHSHDSAVQIKILQRPARQPSLSEESSTQQKQLPASPQQQKTLTTDPMPT
                     QILRRSVDIDKSGDERAEDKSALESDDKAKSAGKVEEDKSGNKRVSPRSGAACGGRGG
                     RGYAGSSGGSSVGSGSSYRGQRNASDWGSSRGSGGAGGRRYYGSGGEQSEHSEDVDEE
                     CYSSGGGGAARRSPKESGNGAPNSGASANKAGFSPRGEPSRRGRGGLSSGGGASASCY
                     RRQPVGTGSAGGSGSGGSGRSYGRLGYEEYGKQQRTSESETDLDKTKQNQLALSAGLH
                     KPSKDDKDLPALGGEEKDKTAALAPAHNTALLAKDELQKDAAGRLPLPPGLAAPGSAV
                     GSVTATSSSVVVPGAADKKKIESCAVVGGEKVTGSKLPAIGEKTSLGAVGSGPSTSLL
                     LDAGAPVNTIIFENSTYKQQAAAASVVTKPGTLSVSSSGATMTVDSLSSALSQMSFGG
                     KATAAGSGDDSQDMKLGFSFGDDPTTPLKVVDNIDKTASQQQQQQQQQHSQQQQQQQQ
                     QQNNSTADLNMKIASVKKVWESATPMSDGPSPAQVQQQQQQQPQQQQQSQVQVAAQQQ
                     QQQVVGPQQAGDDGSGHMSAASFVAAVAASQHQQQHQQMPHYAVSAVHMQSHHHQQQQ
                     QQQQAAVAAAQAQHHQQQQAQAHHQHHALSSPGPVPGSHGHGYSHGSPFDAGSLEQQF
                     QQEDYPSPQQQQQAHQKTKQLQQQQHLGMSPPPSQQQQQQHSQQQQQAQHQQQQQQAH
                     QQQQQQQQPSFYQASPQFGVGGIPTIPSPPAVVYNSSQMPPPSQGGNLYAPFHSLDHS
                     SRSPAYSAAAAAHSYPNPYAAAAAAAAAAAAGGGPFNVNVNAYAMQTPHGGSLPPTAP
                     TPDMYSNLSSQFRLGGGPGPGPGPFGQPSSQQLSNPSNHAAVAIISSSSNSMMSSGAA
                     KPPQSQQTIGAIGSKSAGSGGGPGPGPGPYATTQTYMNLYAAPPPQHPGQGGPPPGAH
                     QLQSNSFYSNSAPGGPSGPQFYGGPPPQGNGGAQSYGLATAAGMYGGHQGGPPGSNGP
                     PGPPQSQHTMGTFNTPFMNSQLLTAASINQYRGGPTPGAAYLKGNQGQTHMQDSMGRQ
                     LKSPLSADMSLGLAKQVQSQPSPPHHKNYGANQVLQQQQQQSQQQQQQQQRQVGGGNG
                     PSMNALGGRGSGAVGSGSGNGGGGGGGAGGSQVGGNGGGNGVGSVGQSGGGGQGRYPT
                     PIQRPNNYPQHPQQQQQQQQQQQQQREQAAAAAVAAQRAQNMRQVTGAGGGVAGSAGG
                     GGSQTPVGPAGGNGGPGGAGGGGGAGGAAGSGPGKPYYANNASGAAVAANRGEWHAN"
     misc_feature    435..923
                     /gene="nocte"
                     /locus_tag="Dmel_CG17255"
                     /gene_synonym="CG17255; Dmel\CG17255"
                     /note="BAT2 N-terminus; Region: BAT2_N; pfam07001"
                     /db_xref="CDD:462063"
ORIGIN      
        1 tgagaagtgg tagaggaaga actcgaggaa gaagaattag cggcaaactt tatgttggac
       61 ggtgaaaagc agaatcaaaa gatatcaatt tccgcgaagt taacagttaa ataaccaaca
      121 tacaggcggc caagtgtgcc agcagaccgc gaaacattcg aagtaaacaa attcaagcgt
      181 tttccattca gtttatcatc gctgcccaac aaacgaaact ccccgagtgt attgctgtgt
      241 gcgtgcgtgc tgtttaaacg cccaccagaa agactgaaac aaggagcttc ggcccaaaag
      301 cgatcccagc tccttaaact cattctcgtc aagaaccaca gccacatcct agcccatcct
      361 ccagcgcagc gggaagacga ggagcgcggc ggtggcgaga aggaagctaa cgctaatgag
      421 gatctattgg cagcatgagt acactggggg gaagtagggg agagcgaaat gccaagccca
      481 aattcacagc gttagatata aatcgcatgt acaagaatag ccgcggcgag tcaagtgaac
      541 catctgcaca aaagaatcaa gtgccacgta aacatggaat gcaaatcttg ggcaaagtgc
      601 cgtccgctag gcgaccacca gccaatttgc catccctgaa ggccgagacc cacaccagca
      661 gcaacaacaa tctcttagtc tcagtcgaag gagccacatc tggtggggcg ggcgcaggcg
      721 gagcagcggg atctggcgcg gcaggaacca acactagcca caacaacacc actgcccaca
      781 gcggaagttc aggaacgagc ggcggagcgg gatcaggcgg cggaggaact gcgtcttcat
      841 ctgctggtgg ccatctatcc cagcagctga ctcacagcca gcatcagcac aataataacg
      901 tcgctctcgg ccctaacgcc ggaaagtttg tcaacagcaa caacggcagc agcaacaaca
      961 acgccggcag ctcaggcagc ggcaacaaga acttcaaatt aatcaacaac tccgtgggca
     1021 gttccggcgg aggcggacaa ggagggtcgg gcggcggcgg atcgtcagga gtaggaggtg
     1081 gatcagggtc aggatcgggc ggacactcag tcaactcacc caagacatgg tctgcaatta
     1141 ccacaggaca cgagcggggc tcgggcggtc agaactatgg acgccagcaa cagcaggtgg
     1201 tcccccatta tcagagtcca cagttccagt acgaatttcc cacgctggac ggcacagttg
     1261 gcagcggcgc cggcggagga tcgggagcgg gtgtgggttc aggatctgga gcgggcaaga
     1321 gccattacca gaatcaggtg caccatgccg gccaccaaaa ccatcaccag catcagcagc
     1381 accaccagca gcatcaacag caccaccacc agcagcaaca gcaccatcgg gactaccacc
     1441 atggccacgg gcgccagtat ggacaccact cgcatcgcga ctacagagat ggcagcgacg
     1501 acgtcggcgg cgggtccgcg gatctgggcg agctcagcct tcggccacag aacgacacgg
     1561 ccgcctggtt gcagcagcag gagaaggcgg ccaaggtggc agcagctgcg gcagcggacc
     1621 agggcctcaa cctacagggc ccgggccacc atcagatggg cggtaatggc ggagcaggag
     1681 gagggtcggg cggagctgtg cccctgccca tactatcgct gatgccctcg ttcatgcgta
     1741 gcggagctcc gatgcccgcc agtggagcga cagcggccag catcttggcc ggcggatcgt
     1801 tggacacttc tgcgttgccc aacgctccct accagaacgg aatcctgggt gctcggtctg
     1861 cctcgccagc tgtggtgggc agtggaagct tcagggcggc cactgccatt cccaagcgac
     1921 caccgacctc ctcgtcgccc ccacaatctg gcctaggcat tggaggatca cccactcccc
     1981 cacaatccca gcagcaggcc aacggaggcg ctggcggagc cgggcgcaag gataaggact
     2041 acgtggtgga gccggaggtg gcccaaatgc agcgtcctat catacgcgaa gaggacttgg
     2101 agcgcctcaa cgccatcgcc aaggacgata gctggaccaa gcaggacgac attgacttca
     2161 cgaagaaact agcattctcg gacgatgagt ccactccgga agagcaccaa ggccagggca
     2221 agcagcacag ctccgcccaa ctgcaggcgc aaggatcctc ctcctcaacc gatcaacgaa
     2281 agctgtccgc ttccacaacc agttggcagc gcggcaagga gagcaccgat cgcgaccagc
     2341 catcggaagg cattcaggat cagcagcagc agcttcagca gcaacagcag cagcaagagg
     2401 ttcgccaaca gaatggccac cgcggtagct ctggcaacgt tggagcacca gtggccggtg
     2461 gaattgcctt ggatgccagc gtgtacgagc gagtaaagca gcgcaaggag gaggaagagc
     2521 gtcgcgagat ggaacgcaag caggcggctg ctaagaagtt gcaagaactg gaaatgaaga
     2581 tgaatagcaa aaaggcagcg gctgcggctc tggctggagc cgagggcggc gtgtcctctg
     2641 cctcagtccc gttgagcaat gaggtgccac ccacgtccgc accgctaggc aatgccagcg
     2701 aagatgaggg cggaggccaa ggcggcggcg gagggttgaa tcgtcgaccc cggggaagca
     2761 tctctagctt gggaagcggc gtaacaccca cgggaggagc tggcggcggc ggcggaggag
     2821 tttcgtcatc ctcgtcagca ggcggcgact atggtcaaaa gaacttcctt acccatttcc
     2881 aatcaaattt accaccacgt ttccagcgcc agcaacagca acaacagcag cagctgccgc
     2941 gcttggagaa gagcgcctcg gcaagcagtg cattcgatag caattcccgc tacctccaga
     3001 agggaggagt aagcggagga ggcggtggtg taagtggagg agcgcaagcc aatgctggcc
     3061 agggtcgcag catctccggc ggttatgtgc agcgtggtgc aagtgtcgga ggaagcagcg
     3121 gatacggacg aaatcgtcac gacagcagca gtgctcggga ggatcaggat ctggatcagc
     3181 agcgtttcac ccgtggccag gactatcggc aggcacaagc tctgccgcgc agcatatctg
     3241 agaactcgca ccgtaagacc agcgtctcat cggctggcga cgatgtgctg ggtggctcgt
     3301 gctcctcatg ggcggagcaa acggatgccg agcagaaggt gcaccatcgg caccgcgagg
     3361 agagcttctc ctcgtcgcac agccatgact cggcagtgca aataaagatc ctgcaacgcc
     3421 cggcccgaca gccgagcctc agtgaggagt cctcgaccca gcagaaacag ctgcccgcct
     3481 cgccgcagca gcaaaagacg ctgacgacag atcccatgcc tacccagatt ctgcgacgca
     3541 gcgtggatat cgataagtcc ggtgatgagc gcgcggagga caagtctgca ttggaatctg
     3601 atgacaaggc gaagtcggct ggcaaggtgg aggaggacaa gagcggcaat aagcgggtaa
     3661 gtcccaggag cggagctgct tgcggaggtc gaggtggccg tggttatgcc ggcagctctg
     3721 gtggatcatc cgtcggatcg ggcagtagct accgcggcca gagaaatgcc agcgattggg
     3781 gaagcagtcg tggaagcggc ggcgccggcg gcaggcgcta ctacggcagc ggcggtgagc
     3841 aatcggagca ctccgaggat gtggacgagg agtgttacag cagtggagga ggcggagccg
     3901 ctcgtcgcag cccaaaggaa tcgggcaacg gtgcgcccaa ttccggtgcg tcggcaaaca
     3961 aggcaggatt ctcgccacgc ggcgaaccat ctagacgtgg tcgaggcggc ctctctagcg
     4021 gaggaggcgc ctctgcttct tgttaccgtc gacagcccgt gggcactgga tccgctggtg
     4081 gatctggttc gggcggatcg ggccgcagct atggcagact tggctacgag gaatatggca
     4141 agcaacagcg aacttccgag tcggagacgg acctagacaa gaccaagcag aaccagctgg
     4201 cactcagcgc cggcctgcac aaaccaagca aggatgacaa ggatttgcct gcgcttgggg
     4261 gcgaggagaa ggacaagact gccgccctgg cgcctgccca taacactgcc ctgctagcaa
     4321 aggatgaatt acagaaagat gcagcgggtc gcctgccgtt gcctcccggc ctcgcagcac
     4381 ctggctctgc agtgggatcc gttactgcca catcctcatc ggtcgtagtt cccggtgcag
     4441 cggacaagaa gaagattgaa tcctgcgccg ttgtcggcgg tgagaaggtg acgggtagca
     4501 agttgcccgc cattggggaa aagacttcgc tcggcgccgt tggctcgggt ccatcaacca
     4561 gtcttctact ggacgccggc gcacccgtca acacgattat atttgagaac tccacgtaca
     4621 agcagcaggc agctgccgct tccgtggtaa ccaaacccgg aacgctctcg gtgtcaagca
     4681 gtggcgccac catgaccgtg gacagcctgt ccagcgcact ctcccaaatg agtttcggcg
     4741 gcaaggcgac ggcggcgggc tctggcgatg attcgcagga tatgaaacta ggatttagct
     4801 tcggtgacga tcccaccaca cccctcaagg ttgtggataa catcgataaa acggccagtc
     4861 agcagcagca acagcagcag caacaacact ctcaacagca acaacaacag cagcagcagc
     4921 aaaacaattc gacggcggat cttaacatga agatagccag cgtaaagaag gtttgggagt
     4981 cagccacgcc catgtccgac ggcccatcgc cagcacaggt gcagcagcaa cagcaacagc
     5041 agccccaaca gcaacaacag tcccaggtgc aggtggcggc gcagcagcaa caacagcagg
     5101 tggtgggacc gcagcaggca ggtgacgacg gcagtggtca catgagcgcc gcctcctttg
     5161 tggcagccgt ggccgcctca cagcatcagc agcaacacca gcaaatgccg cactacgcgg
     5221 tgtcggcggt gcacatgcag agccaccacc accaacagca gcagcaacag cagcaggcag
     5281 cggtggcggc agcgcaggcg cagcaccacc agcagcaaca ggcacaggcg caccaccagc
     5341 accatgcact ttcctcgccg ggcccggtgc ccggtagtca tggccatggc tacagtcatg
     5401 gatcgccgtt cgacgctgga tcgttggagc aacagttcca gcaagaggat tatcccagtc
     5461 cacagcagca acagcaggcg caccagaaga ccaagcagtt gcagcagcag cagcatctgg
     5521 gcatgtcacc gccgcccagc cagcagcaac agcagcagca ctcgcaacag cagcagcaag
     5581 cacagcacca gcaacaacag cagcaggccc atcagcagca gcaacagcag cagcagcctt
     5641 cattctacca ggcgtcaccg cagttcggcg ttggaggcat tcccactatc cccagtccgc
     5701 cggccgtggt gtacaactcg tcgcagatgc cgccaccgtc gcaggggggt aatctgtacg
     5761 ctccattcca ttcgctcgat cattcgagcc gttcgcccgc ctactcggcg gcggcggccg
     5821 cccacagcta cccgaaccct tatgcggcag cagcagcggc ggcggcggca gcggccgctg
     5881 gcggaggtcc cttcaatgtc aacgtgaacg catatgcgat gcagactccg cacggcggca
     5941 gcctaccgcc cacagcgccc acaccggaca tgtactcgaa cctctcttcg cagtttcgat
     6001 tgggcggtgg tccgggtccc ggacccggtc cctttggcca gcccagctcg cagcagttaa
     6061 gcaatccgag caatcatgct gcggtggcta taatttcgtc aagcagcaac tccatgatgt
     6121 cgtcaggtgc ggccaaaccg ccgcagagcc agcagacaat cggtgccatt ggctccaagt
     6181 cggcaggtag cggtggcggt ccaggaccag gacctggtcc ctatgccacc acccagacgt
     6241 atatgaatct ttatgcggct ccaccgccgc aacatccagg acaaggtgga ccaccgccgg
     6301 gtgcccatca gctgcagtcg aacagtttct actcgaattc ggcgccaggc ggtccgagcg
     6361 gaccacagtt ctacggtggt ccgccgccgc agggcaatgg tggagcgcag agctatggac
     6421 tggccaccgc ggccggcatg tatggcggcc atcagggcgg accgcccggc tccaatgggc
     6481 cgccgggacc gccgcagtcg cagcacacga tgggcacgtt caacacgccg ttcatgaact
     6541 cgcagctgct gacggcggcc agcattaatc agtaccgcgg cggaccaacg cctggagcgg
     6601 cttatctcaa gggtaaccag ggccagacac acatgcaaga ctcgatgggt cgtcagctga
     6661 agagtccgct gagcgctgac atgagcctcg gtctggccaa gcaggtgcag tcgcagccca
     6721 gtccaccgca tcacaagaac tacggcgcga accaggtgct tcagcagcag cagcagcaat
     6781 ctcagcagca acagcagcag caacagcgcc aggtcggcgg cggcaatggt ccgagcatga
     6841 acgccttggg cggtcgcggc agtggagcgg tgggcagcgg cagcggcaac ggcggaggag
     6901 gaggaggagg agctggtggg tcccaagtgg gcggcaatgg cggcggtaac ggcgttggca
     6961 gcgtgggcca aagtggcggc ggcggccagg gacgctatcc cacgcccatt cagcggccca
     7021 acaactatcc gcagcatccg caacaacagc agcaacaaca gcagcaacag caacagcaga
     7081 gagagcaggc ggcagctgcc gccgtggcgg ctcagcgggc acagaatatg cgacaggtga
     7141 ccggtgccgg cggaggcgtg gccggaagtg caggtggcgg tggtagtcaa acaccagtgg
     7201 gaccggccgg cggcaatggt ggccccggtg gcgcaggagg aggcggtgga gctggcggtg
     7261 cagcaggatc aggacccgga aagccctact atgcgaataa cgctagcgga gcggccgttg
     7321 cggccaatcg aggtgagtgg catgcgaact gagtgccaga tggtcaccac ccatcgacca
     7381 gccgatccca gccacccacc ataacaaacc cggaataact atgtacgagt acgaaacaga
     7441 aacacaatga tgcaaattga taacgaagga ggatggccaa gagaatgagc aacagctgga
     7501 ggaatgtatt gcatccaaaa cgagaatatg aacgtaaaca gagcaagtca ggagtaaaac
     7561 tatatatgtg gaatataatc aagttaccga gcgagacaca ggcatccgaa taataagccc
     7621 acaaaatatg tgaaaggggc gatgcgagta gaatagtgct atagctgttt gggggaatcc
     7681 ccgtcacaat cgcaaaatgg caactcagct aaatcaccgt agcgaggagg aaattaattt
     7741 aaatcgcaat ttgaaagtaa gaaaaaagtt aagacgaaag ttaagaatca acaggaaacg
     7801 agtaaggaat acctaaatgc aagaagaaat atttaacaaa aatgaacaga atacaacacc
     7861 atgccacacc acaacacaca cacacacaca catgcataca tttacatata catacataca
     7921 tacagaatag cagattgtat tttttgtcaa acaaatttac ataataatat attactttta
     7981 tatacttatg attttttgta gtagtctttc tcctttaaac aaatcaagaa aaacaaaacg
     8041 aacctttggc actgcgtatg ctttaatttc tttatatata aatattgttt actttttttg
     8101 caaccaacaa aaaattaact aataattcta atttatgatt atgctacaat atacattata
     8161 tataccatct atctatccta tctatctata ttgatatcca tatttctgtg tagacagcga
     8221 ataagagaga gacagacaaa cagagagaaa gagacagaca tagacggtca aaaagagagg
     8281 gagagagaaa gagaacgaac ggataaggac gaaaaataga gtttgtttaa gctaagcgca
     8341 aagttaagtt caaacagaaa acaaatccat cgaaatttct ttctttttaa cgacaacaac
     8401 aactaatgca acaattagac acgacacttg cgtaagaaat tgtactcggc ggactctata
     8461 ttgttatagt catgtgaaac taaaccctga tcctaaccta aactaaaact aaaaaagggg
     8521 gcgacaattt gaaaatagtg ttcagcgcaa tcgcacacgg gtggcaacgc cgccgcatcc
     8581 ctcgcagcca gcgctgccac ctcggccgct gtcggcgata attagttaat cgattatcat
     8641 taacccgcca gttctgctgc aatttgaaaa tcacgaaaaa tgacgtttat gctcaacgta
     8701 gaatgctaat ggtgggcagg tgaggaggca acatgaaatt taaacgattt atataaatgt
     8761 gtaattcatt atgtaactgt aacttaacat ggatatgata tgtatggcat atagtacaca
     8821 aaaaaaaaag aagaacacag gcaaccacac ataaatattt atatatgtat ttagtctcta
     8881 tataaatata tatatatata tatttatata tatacatata tatagatgca aaatccaagc
     8941 gaaaaaaaaa acaaaaacac tccagcaaac atttttaagg aaaagcaaaa aaactcacaa
     9001 atatatctca gtaaccttaa ttaaaacgat tatactcgga tcgaaacccc gcggagtggg
     9061 acacggatct ctaaacacca cgaaagccaa tggtcgcaag gacatccctg ccacattccg
     9121 caggactatg cgtagtagaa ttaataatta aacaatgcaa ataaaaataa aatgaaaagc
     9181 atgagcaagg cacttttcgc taggcttctg aaaagcaaac cgaaataaaa aacagaaaac
     9241 tatatagcga tattaattag tccacacaca cacacacaca tgaactctct cccacacatg
     9301 cgccccagcc aggcccacat ataaaaaacc caaaatattt gggacgtttg ctatgccagg
     9361 caatgtttag ttattaacaa aaccaaatgc aaaagcaaag gaaaacaaac tgaaatcgaa
     9421 agcaaacaca aattaatgaa aatgatgagt aaagtaacaa aacaagcttg ctatcacaca
     9481 atacatgtaa aaggtatatt atatagcata ttgataaatg atataaacat taatttatac
     9541 ctatatttta aatgcatcat ctggtttttc gtgtccacca aaacaaggat agcaaacagc
     9601 ataagcatga taacgattac gataacgata gcgacgacgt ttaggccgga aacggaacga
     9661 agaggaagtg tagacgatgg tggagagaat aggagaagag aagtgaagag tacttggcat
     9721 ataaatgcat acaaatatat gtaaaccatt tttacattca attcattcaa attaattttt
     9781 agtaatactg aattttcgat aaaccgggcc agcaaacgct acgcccaccg ccccgccccc
     9841 ctcaaaaaag tccctaccca cgaaaatgag gaaatttaaa gcaagtttga aatgaaataa
     9901 aaactttaaa taaaatatta aaaacagaaa accaaaaagg