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LOCUS NM_001272478 3883 bp mRNA linear INV 26-DEC-2023 ACCESSION NM_001272478 VERSION NM_001272478.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 3883) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 3883) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 3883) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 3883) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 3883) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 3883) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 3883) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 3883) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 3883) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 3883) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 3883) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 3883) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 3883) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 3883) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 3883) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 3883) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 3883) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 3883) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 3883) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 3883) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 3883) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 3883) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 3883) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..3883 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..3883 /gene="flw" /locus_tag="Dmel_CG2096" /gene_synonym="anon-WO03040301.120; CG15305; CG2096; Dmel\CG2096; DmPp1-9C; FLW; FLW/PP1B; l(1)G0172; PP-1; PP-1c; PP1; PP1 9C; PP1 b9C; PP1 beta9c; Pp1-9C; PP19C; PP1beta; Pp1beta-9C; PP1beta-9C; Pp1beta9C; PP1beta9C; PP1B_DROME; PP1c; PP1cbeta; XE55" /note="flapwing" /map="9B14-9C1" /db_xref="FLYBASE:FBgn0000711" /db_xref="GeneID:44289" CDS 553..1545 /gene="flw" /locus_tag="Dmel_CG2096" /gene_synonym="anon-WO03040301.120; CG15305; CG2096; Dmel\CG2096; DmPp1-9C; FLW; FLW/PP1B; l(1)G0172; PP-1; PP-1c; PP1; PP1 9C; PP1 b9C; PP1 beta9c; Pp1-9C; PP19C; PP1beta; Pp1beta-9C; PP1beta-9C; Pp1beta9C; PP1beta9C; PP1B_DROME; PP1c; PP1cbeta; XE55" /EC_number="3.-.-.-" /EC_number="3.1.3.16" /note="CG2096 gene product from transcript CG2096-RC; CG2096-PC; flw-PC; flap wing; protein phosphatase 1; flapwing; PP1beta9C; protein phosphatase 1beta at 9C" /codon_start=1 /product="flapwing, isoform C" /protein_id="NP_001259407.1" /db_xref="FLYBASE:FBpp0305497" /db_xref="GeneID:44289" /db_xref="FLYBASE:FBgn0000711" /translation="MGDFDLNVDSLIQRLLEMRSCRTGKQVQMTEAEVRGLCLKSREI FLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLET ICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPV AAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKDVQGWGEN DRGVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFD NAGGMMTVDDTLMCSFQILKPSEKKAKYLYSGMNSSRPTTPQRSAPMLATNKKK" misc_feature 571..1443 /gene="flw" /locus_tag="Dmel_CG2096" /gene_synonym="anon-WO03040301.120; CG15305; CG2096; Dmel\CG2096; DmPp1-9C; FLW; FLW/PP1B; l(1)G0172; PP-1; PP-1c; PP1; PP1 9C; PP1 b9C; PP1 beta9c; Pp1-9C; PP19C; PP1beta; Pp1beta-9C; PP1beta-9C; Pp1beta9C; PP1beta9C; PP1B_DROME; PP1c; PP1cbeta; XE55" /note="PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain; Region: MPP_PP1_PPKL; cd07414" /db_xref="CDD:277359" misc_feature order(739..741,745..747,823..825,835..837,919..924, 934..939,949..951,1066..1068,1132..1140,1165..1167, 1207..1215,1291..1293,1363..1377) /gene="flw" /locus_tag="Dmel_CG2096" /gene_synonym="anon-WO03040301.120; CG15305; CG2096; Dmel\CG2096; DmPp1-9C; FLW; FLW/PP1B; l(1)G0172; PP-1; PP-1c; PP1; PP1 9C; PP1 b9C; PP1 beta9c; Pp1-9C; PP19C; PP1beta; Pp1beta-9C; PP1beta-9C; Pp1beta9C; PP1beta9C; PP1B_DROME; PP1c; PP1cbeta; XE55" /note="active site" /db_xref="CDD:277359" misc_feature order(739..741,745..747,823..825,919..921,1066..1068, 1291..1293) /gene="flw" /locus_tag="Dmel_CG2096" /gene_synonym="anon-WO03040301.120; CG15305; CG2096; Dmel\CG2096; DmPp1-9C; FLW; FLW/PP1B; l(1)G0172; PP-1; PP-1c; PP1; PP1 9C; PP1 b9C; PP1 beta9c; Pp1-9C; PP19C; PP1beta; Pp1beta-9C; PP1beta-9C; Pp1beta9C; PP1beta9C; PP1B_DROME; PP1c; PP1cbeta; XE55" /note="metal binding site [ion binding]; metal-binding site" /db_xref="CDD:277359" misc_feature order(835..837,934..939,949..951,1132..1140,1165..1167, 1207..1215,1363..1377) /gene="flw" /locus_tag="Dmel_CG2096" /gene_synonym="anon-WO03040301.120; CG15305; CG2096; Dmel\CG2096; DmPp1-9C; FLW; FLW/PP1B; l(1)G0172; PP-1; PP-1c; PP1; PP1 9C; PP1 b9C; PP1 beta9c; Pp1-9C; PP19C; PP1beta; Pp1beta-9C; PP1beta-9C; Pp1beta9C; PP1beta9C; PP1B_DROME; PP1c; PP1cbeta; XE55" /note="natural toxin binding site [chemical binding]; other site" /db_xref="CDD:277359" misc_feature order(1084..1086,1090..1092,1141..1143,1156..1158, 1195..1197,1222..1224,1246..1251,1255..1263,1267..1275, 1318..1320,1330..1332,1411..1416,1420..1422,1426..1428, 1432..1434) /gene="flw" /locus_tag="Dmel_CG2096" /gene_synonym="anon-WO03040301.120; CG15305; CG2096; Dmel\CG2096; DmPp1-9C; FLW; FLW/PP1B; l(1)G0172; PP-1; PP-1c; PP1; PP1 9C; PP1 b9C; PP1 beta9c; Pp1-9C; PP19C; PP1beta; Pp1beta-9C; PP1beta-9C; Pp1beta9C; PP1beta9C; PP1B_DROME; PP1c; PP1cbeta; XE55" /note="MYPT1 binding site [polypeptide binding]; other site" /db_xref="CDD:277359" ORIGIN 1 aacggtcata ctcagctagc tgtccgacga gttttgttat tggcggagaa aagattacgc 61 tggtttataa attctcagtt aagccgattt ctcagctcct ctccccctgc agagatctaa 121 cacatctata tagatatata tattttatat attccttgat cgatttgcga tcccgaaagt 181 cgatcagccg tgcgtctata tatttttttt tctgttcttg cccctcgtgc aacatcagtg 241 aacatcagcg gcccaccgta caaaatctca ataagaaaaa aagagagcat aaagtgaaat 301 tgccttttgc ggcaagtaag aaaacgacca aaaaagagaa aagaatataa cgactatttg 361 aattaaacaa agtttattgt ttacaatagc atacaataca agtttataag ctaacgggcg 421 tcgctgtgcg tgtgtgtgtg cttgtgtgtg cgtgcgtgta gttgttgcgc caaaaattcc 481 aatcggaatt ctggaacagc tggccacaac aacaaaacgc ggccaataga agaacaattt 541 agctgctgaa aaatgggcga cttcgatctg aatgtggaca gcttgataca gcggctgctg 601 gagatgcgca gctgccgaac gggcaaacag gtccagatga cggaggcgga ggtgcgtggc 661 ctctgtctca agtcgcgcga gatcttcttg caacagccca tcctgctgga actggaggca 721 ccgctgatca tctgcggcga catccacggc cagtacacag acctgttgcg cctgttcgag 781 tacggcggat tccctccggc tgccaactac ttgttcctcg gcgactacgt cgatcggggc 841 aagcagtccc tggagaccat ctgtctgctg ctggcctaca agatcaaata tccggagaac 901 ttcttcttgt tgcgcggcaa ccacgagtgc gccagtatta ataggattta cggcttctac 961 gatgagtgca agcgccgata caatgtcaaa ctgtggaaga ctttcacaga ttgcttcaac 1021 tgtctgccgg tagccgccat tattgacgaa aagatcttct gctgccacgg cggcctcagt 1081 cccgatcttc agggcatgga gcagatccgt cgcctaatgc gacccacaga tgtgccggat 1141 accgggttac tgtgcgatct tctgtggagt gatcccgaca aggatgttca gggttggggc 1201 gagaatgatc gcggtgtgag cttcaccttc ggtgtggatg tggtctccaa gtttttgaac 1261 cgccacgagc tggacttgat ctgccgtgca catcaggttg tggaggatgg ctatgagttc 1321 tttgcgcgtc ggcaactggt cacgttgttc tcggcgccca attactgtgg agagttcgac 1381 aatgccggcg gaatgatgac cgtggacgac acgctgatgt gctcattcca gatcctgaaa 1441 ccatccgaga agaaggccaa gtatctgtac agcggaatga actcgtcgcg acccacaaca 1501 ccgcagcgca gcgccccaat gcttgcgacc aacaagaaga aataatatat ccatccgctt 1561 ccatttcctt aaaggttcaa caaacaacag aaataaactt ttacatagat acacacatat 1621 atacatataa atataacgaa acgatagaaa aggagagcgt taggcgatag tagagaaagg 1681 gcaaatgata aattaaatgt gtgagctatt aaagcaagca aaatcgaagt gcatgaatat 1741 caacatctat gtgaatccgt cattatctgt tatctgatgt gtcatctgta tccaacttga 1801 ttaccttatc cgtgtacctg ctagttgcag cagcaacatc aggagcaaca acaccagcag 1861 cagcagcagc agaaacatca gtgaaacact cagaggccca tagttaagtc gattcctgca 1921 tttgatgatt atctgttgaa tggaaattgt gacaacgtcc ccgtaacagc agctcccaga 1981 tccaaaactc ccgaaacatg cagataaata aatacattaa aagtacagcg atgttaagca 2041 atgaatttat atataggctt attaatgtaa actatatact atatacttat atattcataa 2101 ctacaaaaga gaaacgaaaa caaacctaaa caaaaaaaaa aaaaaaaaaa aaaaagggaa 2161 gcaaagtatc tggccattgt gcgactcctt tggggctcgc acagtggagc aaaccacatg 2221 gactagctat cactttactt ttccttttgg ccgtgcgccg agcttacaaa attcgctgca 2281 aattgttcga tttttggttc tcttcctatc gactaagtgc gcattacaaa tttgtctaac 2341 aaaatattaa gaaaaatcaa aaaataagaa agaaaattat aataattata ataatgaacg 2401 caaacgaaat gtaacgaaaa cctatattgt aagcttaaaa cagttcaact ctgtgtgtgt 2461 attttattta ttatgtatct ataaatataa atatatgttc tttttgtcat tgtttaatta 2521 atttattgct tacattgtat ttataaaacg caaaacaatt aatccctaac aactattttt 2581 tgtcattata ctcggtttaa gtgtcaaaat actgttaacg tgttaatggg catttaacga 2641 ttggggcttg tttttcattg cctaaacttt aactagaaaa actccaacct aacttaattt 2701 gcctcacaca caaaaatgaa aatgataaat aaataaaaga gtataaaatt aacgaatttt 2761 gaaagcatta cttcgagttc ttgaaacacc aatttttgtg catatttagt ttataaataa 2821 gaaacggaat tcgttaggaa tcgatagaat cggcgaacaa gtgaatgaga atatatatga 2881 aaatatataa gtatatacag aaggaacgaa agaaaaacta attttttaat cgtcgtaact 2941 tattagatta tagtgccttt tttgcctccc caaatgaaaa ttcacaaacg ataacgagca 3001 tgtaaactaa caaatggttt atatatacag atcatttaca catatacata tacagctaac 3061 gaatgctaat tatggagtaa agagtactgc gtttattttg taacaattaa agaaaccaca 3121 actgatctaa tagagtatta taattaatcc cacttcattt tagagagaat ctaaattcat 3181 ttaaaaattg ttattcctcc gacaaatgta agcatagttt gtagtaggtt tcaattgatt 3241 tgagctaact ggcaaaacac tttccatact taaacgaaat tagaagcttt aaaatgatag 3301 ggatatcatt tgttgatgtt ccccgtactc aaataaagtg atttcttatt gtttcgtcaa 3361 gagtacgttg tggttttaaa tcaatacgca tcgaaaaaga atgctggcgg caaacaagtc 3421 aattaattgc attacgagta aaccgatata gaaatgattg aaaatgtgag aaaaactaaa 3481 actgtggaga gatctagcat tttagctttg agctgttgtt ttaacactaa ctatttgttg 3541 ttattcccga ttattagcaa tcacaattcc caattatcag catcagtttc gtgtgtgtga 3601 ggtatacata tgtgtgtgtg tgtgtgtgtg tgtgtgtgag ctgcattcgc atactagttt 3661 tcatattaat acacacacat gcaaacatac gagaacttat atatatgtaa atatatatat 3721 atatgaacaa tgaaataaat aaaggtaacg aaatatacaa agtactacag tgagaaaccc 3781 atgcgaagaa gtgtagagag agaaaaagca atacgaaaaa acaaaacgta taacagatac 3841 atatatttat tattaaaaat caaataaaaa ttaattaaaa ctt