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Drosophila melanogaster alpha-Mannosidase class I a (alpha-Man-Ia),


LOCUS       NM_001272473            3156 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant P, mRNA.
ACCESSION   NM_001272473
VERSION     NM_001272473.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3156)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3156)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3156)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3156)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3156)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3156)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3156)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3156)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3156)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3156)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3156)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3156)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3156)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3156)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3156)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3156)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3156)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3156)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3156)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3156)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3156)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3156)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3156)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001272473.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3156
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3156
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /note="alpha-Mannosidase class I a"
                     /map="9B5-9B7"
                     /db_xref="FLYBASE:FBgn0259170"
                     /db_xref="GeneID:31957"
     CDS             287..2218
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /EC_number="3.2.1.113"
                     /note="CG42275 gene product from transcript CG42275-RP;
                     CG42275-PP; alpha-Man-Ia-PP; alpha mannosidase I;
                     alpha-D-mannosidase; alpha 1,2 mannosidase; mannosidase 1;
                     alpha-1,2-mannosidase I; alpha1,2-,mannosidase;
                     alpha-mannosidase"
                     /codon_start=1
                     /product="alpha-Mannosidase class I a, isoform P"
                     /protein_id="NP_001259402.1"
                     /db_xref="FLYBASE:FBpp0304147"
                     /db_xref="GeneID:31957"
                     /db_xref="FLYBASE:FBgn0259170"
                     /translation="MCPKTSKTTPLLLIGGICFVIVLVGITGITLINNINLSNIIRLN
                     EKVASDSVSNNENQIKELNYVNNHPRNVYLKLNASSRDDEDDEQMQKEQEQLELPKIS
                     AVIGGSKPKVEDNQVKESSEVISPSTSTFSMRSSAGELTSTSAPLSSIVSVTAPPMPF
                     GGVKYNQSSGLIDYEKRNQVVKMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYD
                     LGATIVDGLDTLYIMGLEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLY
                     AFTGDPLYKEKAQHVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFG
                     TLHLEFAYLSDITGNPLYRERVQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLG
                     ALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLAILDKMVRTSPGGLTYVSDLKFDRL
                     EHKMDHLACFSGGLFALGAATRQNDYTDKYMEVGKGITNTCHESYIRAPTQLGPEAFR
                     FSEAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAH
                     GYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVFNTEAHPLPIK
                     GANAYYRQAPVTLPVSNAS"
     misc_feature    809..2155
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /note="Cyclases involved in the biosynthesis of
                     lantibiotics, and similar proteins; Region: LanC_like;
                     cl04955"
                     /db_xref="CDD:471159"
ORIGIN      
        1 gaatttgaag acatgcatac ttacgctaca agacgacaac tcgcaatata aaaacaaata
       61 aaaacaaaca aaaagcccga aactattagc cataacacac agagaggagc aacaaatttg
      121 tatcgttata aataaaatgt gtcacgaaaa tgtgaaccct gaaatatata gtggacttcc
      181 ccccgagcga accaattgag tcaagaaacg gttagcttaa atcaaaagaa atatgacaac
      241 ataatttcca atcaaaacta aagtgcatgc aaatcaaaaa gtgaaaatgt gtccgaaaac
      301 gtcgaaaacc acgccgctcc tgctgattgg cggaatttgc tttgtgatcg ttctggtcgg
      361 gattaccggc ataacgctga tcaacaacat caatttgtcg aacatcattc gactgaacga
      421 gaaggtagcc agcgatagtg ttagcaacaa tgagaatcag atcaaagagt tgaactatgt
      481 gaacaatcat ccgcgaaatg tgtatctcaa gttgaatgcc agcagcaggg atgacgagga
      541 tgatgagcaa atgcaaaaag agcaggagca gttggagcta cccaagatat ctgctgttat
      601 tggtggcagt aagccaaaag tcgaggataa tcaagtgaag gagtcgtcgg aagtcatttc
      661 cccatctaca tcaactttct ccatgcgctc gtctgccgga gaattaacct caacctctgc
      721 acccttgtcc tcaattgtat ccgtgaccgc tccacctatg cccttcggcg gggtcaagta
      781 caaccaatcc agcggtttga ttgattacga aaaacgtaac caagtcgtca agatgatgga
      841 acatgcgtgg cacaattaca aattgtatgc gtggggcaaa aacgagctgc gtccgctttc
      901 gcagcgaccc cattcggcca gtatttttgg atcatacgat ctgggtgcta caatcgtcga
      961 cggtctggat accctgtaca ttatgggact ggagaaggaa tatcgcgagg gtcgcgattg
     1021 gatcgagcga aaattctcac tggacaatat cagcgcagag ttgagtgttt tcgaaacgaa
     1081 cattcgtttt gttggcggca tgctgacgct gtacgccttt acgggcgatc cactgtacaa
     1141 ggagaaggcc cagcacgttg ccgacaagct gctgcccgcc ttccaaacac caacgggtat
     1201 tccctacgcg ctggtcaaca ccaagaccgg tgtggccaag aactacggct gggcatccgg
     1261 cggcagttct atcctatccg aatttggcac actgcatctg gaatttgcct atctgagcga
     1321 cattaccggg aatccactgt atcgggaacg agtccagacc attcgccaag tgctcaagga
     1381 gatcgagaaa ccaaagggcc tctatcccaa cttccttaat cccaagacag gcaaatgggg
     1441 gcaacttcac atgtcattgg gcgctctggg cgacagctac tacgagtact tgctgaaggc
     1501 ctggctgcaa tccggccaaa cggatgagga agcccgcgag atgttcgacg aggcaatgct
     1561 ggccattctg gataagatgg tccgcacaag tcccggcgga ctgacatacg tctctgatct
     1621 caagttcgac aggctggagc ataagatgga ccatttggct tgcttctcgg gtggcctctt
     1681 cgctttggga gcggctacac gtcaaaatga ctatacggac aagtacatgg aggtgggcaa
     1741 gggcattacg aatacctgcc acgagagcta catcagagca cccactcagc tgggacccga
     1801 ggcctttaga ttcagcgaag ctgtggaggc gcgagcactg agatcgcagg agaagtacta
     1861 cattctacgg ccagagactt tcgagagcta ctttgtgctg tggcgactca cgcacgacca
     1921 gaaataccgc gactggggct gggaggcggt cctcgccctg gagaagcact gccgcacggc
     1981 gcacggatat tgtggcctgc gcaacgtcta ccagcaggag ccgcaaaagg acgacgttca
     2041 gcaaagcttc ttcctcgccg aaacgcttaa gtacctgtac ttgctgttct cggacgattc
     2101 ggtgctgccg ctggacgaat gggtgttcaa cacggaggcc catccgctgc cgatcaaggg
     2161 tgcgaatgcg tactatagac aggcgcccgt aacgcttccg gtttcgaacg catcgtaaac
     2221 gggcgccatg ttgcgccgct ggctattcgg cctgtcccta gcaatgcacc ttacttagct
     2281 cgcgatattt ggatatctac acatgtgtgt accagatcgt aacatttttt tttttttttg
     2341 ttttgtttaa gttattagtt agattacgtg aggatgacaa ctgcgtacga aagatattgt
     2401 atgtttacaa tcaatccagg cacacacaca cacacactcg agaaactgtc aatgtaacat
     2461 atttataaag cttgcacata tataggaacg taaacttaaa cggatatatc gtagtttagt
     2521 tcttaactgt ttgcacaagt ttctccaagt ctctcttctt gatttatctt atggaattaa
     2581 tagcaatcca aatagttgac agaggtggat ggtgggaaga cctcaatttc catttaaatg
     2641 cgaatgacgt agacgtaggc aaaaactctt gatattaatt atgatatgat atataatatg
     2701 atatacgtgt aaatgtaaaa ctcaggtgtt cttattatga ttttccttgc gctcacacaa
     2761 ggcacttttt caactaaacc agctacgtaa ctatctctac aagcattcta tacgcaattc
     2821 tcgatctgcg actatatctc tgtgtggatt tatggccact tggcgggcat ttcgttagat
     2881 ctactctgct aatttccaat tcgaatcttt gaccacttta ttttgtatat aatttctact
     2941 gactttcctc gcaaaatgaa ggcagaagaa aatcgaattg atatttatac aaatatattc
     3001 ttacacaata ttgtttactt tgtagcctaa atatttaaat ataaatctaa tatagagtct
     3061 agcttactgt atgtgacgaa agaaatgtaa cgcaaattac cttaaatcga gaacatcaag
     3121 cgaaaagaac gcaaatgaat atatataaag taaaat