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Drosophila melanogaster hyperkinetic, transcript variant K (Hk),


LOCUS       NM_001272470            8450 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001272470
VERSION     NM_001272470.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 8450)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8450)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8450)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 8450)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 8450)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 8450)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 8450)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 8450)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 8450)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 8450)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 8450)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 8450)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 8450)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 8450)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 8450)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 8450)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 8450)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 8450)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 8450)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 8450)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 8450)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 8450)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 8450)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001272470.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8450
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..8450
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="Hyperkinetic"
                     /map="9B4-9B5"
                     /db_xref="FLYBASE:FBgn0263220"
                     /db_xref="GeneID:31955"
     CDS             707..2353
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="CG43388 gene product from transcript CG43388-RK;
                     CG43388-PK; Hk-PK; kvbeta channel subunit; hyperk;
                     hyperkinetic"
                     /codon_start=1
                     /product="hyperkinetic, isoform K"
                     /protein_id="NP_001259399.1"
                     /db_xref="FLYBASE:FBpp0303754"
                     /db_xref="GeneID:31955"
                     /db_xref="FLYBASE:FBgn0263220"
                     /translation="MSMALCNLNGDGSAAQSTSQSQSQSPAATAAAAPLLPHSHSHTL
                     QPESTPLLLGHEQSGSAAPEGSGGGDVTDGAVTSIEMPTVVADDAGVPPLPLPLPQST
                     PQPLLMALPANLNFITGPTTQQLMIGNGAMGVIPSTNDSNNNNNNNNNVDNTSDESNP
                     VTIYRCRAPIASLDCMEEFSGRSISLGSNPALPLRHGSTPTPGLRYKNLGKSGLRISN
                     VGLGTWPVFSPGVSDDQAEAILKLAIESGINLFDISEAHSETEIGKILQRAGWKRTAY
                     VITTKVYWSTKSEERGLSRKHIIECVRASLQRLQLQYIDIVIIHKADPMCPMEVVRAM
                     SYVIQQGWAMYWGTARWSQVEIMEAYTNCRQFNCITPIVEQSEYHMFCREKCELYLPE
                     MYNKIGVGLMAWGPLSMALSDTQNGDKLFLPKGSFKTKSFSWTEDEINRNAALSPQGS
                     WGKDRIDEGRRHCDRLRDLAALAEKLGCSPTQLSIAWSLKHEPVQCLLLGATSAEQLH
                     QSLQSLQLLPRLSSSVMLELERILENKPVRPPMISTLALR"
     misc_feature    1316..2314
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="AKR6B family of aldo-keto reductase (AKR); Region:
                     AKR_AKR6B1; cd19142"
                     /db_xref="CDD:381368"
     misc_feature    order(1370..1378,1460..1462,1475..1477,1547..1549,
                     1664..1666,1751..1756,1829..1831,1916..1933,1943..1945,
                     1949..1951,2147..2149,2198..2212,2222..2224,2231..2236)
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="putative active site [active]"
                     /db_xref="CDD:381368"
     misc_feature    order(1460..1462,1475..1477,1547..1549,1664..1666)
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="catalytic tetrad [active]"
                     /db_xref="CDD:381368"
ORIGIN      
        1 ttattcgact ggactttgcc ttaaaagtat gctttttaga aaacaaaatc ccatgtgatt
       61 tgtagtccag tctaagtgta agatacaaca aaaatcaacc aaaacaaatg cagaagtgaa
      121 attgaaatat ctgaacttga aactttgaaa ttatgataaa ctttcaaagt aatcatatca
      181 ttcaaaatag taaatatgcg aaagcaaaaa aaaacttaaa taaccttaaa gatgaacata
      241 taattttaga aaacctacaa aaaaaataaa aaaatttgaa acctaatagg tgttgaaaat
      301 actacgtaaa agaaaaccaa actataaact cttaacttca aaaataaata ttaatattta
      361 acaagtagct gaatcaatag cagacatttt aaatgtcaaa gcaaacttca attagaattg
      421 caataaaaaa accacacaaa tataaataaa accttgctgc tattaaaatt gaaatcaaat
      481 gcctaaataa ataatagaag aaattccaat caacacgcag tagctaaata aatatgaagt
      541 gcgtgcaaac ctaggataaa caatggcgtc caatagtatc taaaaaaata tatatatata
      601 tatatagaaa acgtaggaag caaaataaca acacaagtga aagtaaactt tgataaatat
      661 taaaattgag ttaaatcata acaaaagcag tggaactaca agcacaatgt ctatggcatt
      721 atgcaattta aatggtgacg gctctgcggc gcagtcgacg tctcagtcgc agtcgcagtc
      781 gccggccgca accgctgcag cagctccgtt gctgcctcac tcgcactcgc acacgctaca
      841 gccggagagt acgccgctgc ttttgggaca cgagcagagc ggcagcgctg cgccagaggg
      901 cagcggcggc ggtgacgtca cagacggagc ggtaacatcc attgaaatgc ccactgttgt
      961 tgccgacgat gccggtgtac cgccgctgcc gctgcctctg ccgcagtcga cgccgcagcc
     1021 gctgcttatg gcactgcccg ccaatttaaa cttcattacg ggacccacga ctcagcaact
     1081 gatgatcggt aatggcgcca tgggcgtaat tccctcgacc aatgatagca acaataacaa
     1141 taacaacaac aacaatgtgg acaatactag cgacgaatcg aacccggtca ccatttacag
     1201 gtgccgggct cccattgcgt cactcgactg tatggaggag ttcagtggtc gttcgatcag
     1261 tttgggctcc aatccggcgc taccattgcg ccatggatcc acaccaacgc cgggactgcg
     1321 gtacaagaat ctgggcaaaa gcgggttgcg tatctcgaat gtgggattgg gtacctggcc
     1381 ggtattttcg ccgggcgtga gcgatgacca ggcggaggca atccttaagc tggccatcga
     1441 gagcggtatc aatctgttcg acatctcgga ggcgcactcg gagacggaga tcggcaagat
     1501 actgcagcgg gcgggctgga agaggaccgc ctatgtcatc accacgaagg tctactggag
     1561 caccaagtcg gaggaacgtg gtctctcccg gaaacacatc atcgaatgtg ttcgtgccag
     1621 tttgcagcga ttgcagctgc agtacatcga tatcgtcatc atccacaagg cggatcccat
     1681 gtgtcccatg gaggtggtgc gcgccatgag ctacgtgata cagcagggct gggcaatgta
     1741 ttggggcacc gctcgatgga gccaggtgga gatcatggag gcctatacca actgccgcca
     1801 gttcaactgc atcacgccca ttgtggagca gtccgagtac catatgttct gtcgcgaaaa
     1861 gtgcgaactc tacctgccgg agatgtacaa caagatcgga gtgggcctca tggcctgggg
     1921 tccactctcg atggccctca gcgacaccca gaatggggac aagcttttcc tgcccaaggg
     1981 ctccttcaag acgaagagct tctcgtggac cgaggacgag atcaatcgta atgccgctct
     2041 gtcgccgcag ggcagttggg gtaaggaccg gatcgatgag gggcgccgcc actgcgaccg
     2101 tctccgcgac cttgccgccc tcgccgagaa gctgggctgc agccccaccc agctgtccat
     2161 cgcctggtcg ctgaaacatg agccagtgca atgcctgctg ctgggcgcca catcggcgga
     2221 gcagctgcac caaagtctgc agtcgttgca gctgctgcca cgactctcat cgagcgttat
     2281 gctggagctg gaaaggatat tggaaaacaa gccggtgcgg ccgccgatga tctcgacctt
     2341 ggcgctccgg tgacaatcag cgtgcccgca ggggccgctc agcctgagcg gtggcggacc
     2401 ctgcggcgcc gattcgccca agcacgagga tgaggccttc atcgaggagg tggacgctgc
     2461 caaggacgct gccaagcaag gcttctgcct catccagtga caaaaggagt ccttagataa
     2521 cgataataaa tttttgaaag tgattagcag taaaactagc ctaagtagca ataccatgac
     2581 gacaacaata agcaagcagg agcagcaaca gcagcagcag cagcaacaac agcagcaaca
     2641 tctccagcct cagcagtatg tgcaactaca gcagcaacat ttgatggcca gcggcagcac
     2701 cagcgattcg gcggcagctg ttcccattgc agctgaactc cagttcgact ccctgaataa
     2761 caataacaac aacaacaata ataataccaa tggcagtccg gaacaggcac tgcccaccag
     2821 cgatgaacgc caaaaacgtc gctccctgct caactttaag tccctggact ttcatctaaa
     2881 gtccctgtac agtggcctac ggagtaactc aggaacaact ccacccagtc aaccgaatag
     2941 ctctgttccg gcggtggatc agccgcagcg tagaatgccc tatttgcggg tggagagtgt
     3001 tgatcccgag gagccaagag gatcagttct gcccggacat tcgcccagct ttctgtcacc
     3061 ctacagtggc gttggcggtg gagccggaag cctgcagttg ccctcaaacg atggaggcac
     3121 catcaggaga tcctcaacat ccgacattgt taattgcaga cggggagggg gagcaggggg
     3181 atcgggcgga ggagcagcct ctgcccagga cagcaggagg ccgagcacat cggatttgct
     3241 cagaaaggca agggaacgaa agggcagtga ggccaggatg ggcagaagtg tctcccacag
     3301 tgggctaacc aggggcggac ccggcggagg aggtggtggc ctgggcggga gacgaaccag
     3361 catggccttc taaaaacaga aataatagtg aaaaaaaaaa aaactatgga aaaaaaaact
     3421 taagcaatga ggtatggcga aaaaaaaaac tgttgatcaa atctgaatca gaaataggct
     3481 gacaaaatgg cgcttatgaa tttttatcta gtgaaaagaa aattaaaaaa aaaagaaaac
     3541 aagaaaaaaa taacaataat agagcagcta ttaaggaacg actttttttg tggatctatt
     3601 atcattataa ttatattata tggttactac aattgcgcct cgaaagaact aaagttagta
     3661 gataaattaa agcaagtaat gaacagaaac ataacatttc atctctctta aactctgtat
     3721 ctctctctct ctcccccact cccggcaaat ttataatata tatatatata taaatatata
     3781 tttaaagaac ccccaacttt tatgacaata ttagaaccta actatcgtgt actatcgtta
     3841 actatcgcct ggcaaaagct ctaaaactaa cctgcgttcc aacccaaaaa accaacaatg
     3901 attcaagatc gatccattat atcaccgcac tgtgagagtt catatcaagc gagaaggata
     3961 atgtatggag gataaacgat gaaggatacc caaatatgta ctatcctatg ggatagtgtc
     4021 tttttcatta atcgatttgt agacttaacg agtgttaaac gattgttaac gattgacttg
     4081 aggcgaggcg ctgaataaaa tgatcgaagc gaatagcgac taaagattac tacatatata
     4141 cgaaacagca atggtgtgct cgttgtatga ttaaatttta gctaaactaa tgaacaaata
     4201 aatgagtata aataaaaact caaatggaaa acaaagaaac aattcaaatc aaatcttatt
     4261 aaatagacat tactagcatt atgtagttaa ttaaataaca attcaagcga aattttttta
     4321 aatcaacaaa cgaaaaacaa agcaaatgcc tttcataaca gcaacaacaa caacaacaaa
     4381 tttatatttt aaatatatgc agtatatata tagatataca caaacacaca cacatacata
     4441 tgtgaaaata acgaaagcga tgaaataaaa caaagcagca acaaattgtt attaattaat
     4501 tgtagtccat tatcccgatg gcccatatcc catatttcat ataagtgaac aaaacaaaaa
     4561 aaaacaccaa tatagcaata tgtaggatat acatatagag gagttcccga ataccatgta
     4621 ttttatcatc attatcgagt acatatataa agtctttctc acatacggac tgtgatttca
     4681 tataaaagta aacgtaaaag taaacaatta attattatat ctaacctaat gtaattaaat
     4741 gctaagttca ttcgaaagat cttacagata cacacacaca cacacacaca cacacacaca
     4801 cacacacaca ttgcccccaa aaacacgcat gtaatttgag gatctgttta agaaagcaga
     4861 agcataaata gcaattttca aatcgaatgg cattatatac tactgatact ctacaattaa
     4921 ttaaccaaat gcgattgcct taataaagaa taatgaatta aaaacattgg atctaatcag
     4981 atcgtatcgg atcagatcgg atataaccca gtcggggggc cggtttcctc aaacttcagt
     5041 tccagatcgg aatacattat atatacacgc atccattcgc atatatattc cccgcactgt
     5101 tgcttgagaa atcgccccgc gcaaagaaat acaatatatg tatacataca taaattggtt
     5161 tagctccatc ggatcactca gaataaatat atatacatat atatatatat atatataggg
     5221 aatacttata tatacgagag taattgcatt ttttagtaag tagttaatcc gtcctcaaca
     5281 aacggccaac caaaaaagca acaagttttt gcgatcgggc gctgctcagt tgataaccca
     5341 tagcaaaatt tccaaaatat tgaatattta aattcagaca aattcgaaaa tatttgaaac
     5401 tttaacttta gatcattttc gagcttttca attgcagagc attgtaaaga ttagagtttg
     5461 ttatttggag gttgtgatat taattgaaaa attgctgaaa aaatcaaata catatctgca
     5521 aatgggcgaa ttatgttact ttgatacatt tttatgtgtt gagctcacta aagttcaaac
     5581 taagcgttat tgagcaatat ccttagcaat attagccatt aggttgagca attaacttga
     5641 tttcttactg catatttagt tatatagcta caagttaatt atgtataaac ataactagaa
     5701 tgtgtatttc gctttgtaag gcttaaagag tagtttatac ctttaaagct tctgcttaat
     5761 ttaaattgaa agtcactatg ctgaacgggt aatcaattaa aaaagcagcg cctgtcgata
     5821 gatccaatca tcaattgtgg ccaagccccc taaaaagtaa tacaaacaaa aaaaaaaaaa
     5881 aacagccacg tcgtgtgaac cggaaagcaa taattcaaaa tgctgctgaa aaacagttcg
     5941 actaacaaat tgatgtacat atgatcacaa gcaaagtaaa gaagaagcac atacacgcag
     6001 ttgcattatg agattaattt tagtctgttg ttatcgcaat tattatcacg attattatga
     6061 ttacgattat tattaacacg tagctagtta aatcgaatga gaatcagcaa tttatctgcc
     6121 taagcctgaa agtaaccaca attacactca cacccacact cattacacac acacacacgc
     6181 acacacacac tcccttacaa atacactgac aaaaagatga aaaaaaaaag caactgctaa
     6241 tgcagcaaac aaaagcaaaa atgtaacgga aagtattaag aagcggggaa gtgtagcgtt
     6301 taaatctaga aaacaaaatt ttactttaca tcaaaacaga aatatttata acaattgcaa
     6361 taactaacaa aatgagaggc gataaaatgg aagcatatat ataataatat atcttaaaat
     6421 tattttctta tcgaaactgg caataataaa tattaatata aatttaaaca actaaataat
     6481 taaactatac acgcgcgaga actttgtaag ttaactttgc atagatgaca cattttggat
     6541 cgaattacac tgaatgaaag gctcgcacac acgccaagcg tttacacaca cacacacaca
     6601 ccaacacaca cactcgaaga cagacagtcg cgcaggaagt tcgatcatca tttaccgtta
     6661 atgcaccagt gtacacacac ctacacacaa gaaatcagct ttactttaga ttttcgataa
     6721 ttaattgcag ggttgtcgcc tagggttgct tagaaatcga tgggagaatc caattcagac
     6781 gcttgcatat aggcgtagat aagaaaatat atatacaaag tacatacata aacaagcaat
     6841 atcgcaatag cgctcgtatt atttcgctaa gttactagaa aaccgaataa taataaaaca
     6901 gacaaacctc tttgattacc gtacgtataa aatgcaagaa atgcaatttg agggcaaatt
     6961 gtttacactt cacttttaaa gccacattta atactaatat ttcgaaaaaa gctaattaaa
     7021 ataggttata acaataacga acaacaacaa caacaagaac aagtggatga acaacaacaa
     7081 gaacaaacaa tgaacagcaa aaaaacaaca cagctaaaat actgaaaaat tatataaaaa
     7141 tacaaactct tatctttcaa ccaaagaaat cggtgttttt cattacttaa ctcgcatctt
     7201 acaggtattt ctagtgtctg ttttgatttc aacttgaaat taacaaaggt tttgagaata
     7261 ttgagttcaa tactccaaag cccatccatt ttgaaaaaat tacaaaataa catatgtatt
     7321 cgaaatatgt accactctgt catcacattg tgtcggtatg taaaaaagcc atcgcctgcg
     7381 gaattttggt aaaaaaaaca tttcaatcga cacatttaaa cagatatgac agatatcgta
     7441 aaccacattt ttggattaca taacccgatt tcggaccacg cggcactgcc cattgattag
     7501 ttggcgacta tttgcacaca ccacgtcaaa tcgaacgcat tatggtaatt ccccccaatt
     7561 ccattcagat tccgattcag agagccccgg actctgggaa cccgacacga gatgctgtga
     7621 catccagcgt ataaacaaca cttcaagtcc cactgtgcac acaacaacaa caacaacaga
     7681 gatgggtgat tacaatacaa acgcttcgaa atgcacagtg gaatgtcaaa agattggtca
     7741 aaactttggc gaaatcaaca atggacatat atagcgaaat aatatcatta tttattaata
     7801 tttaagtaat ataaagtata taaattcttg ggaatgttta atgataactt taatgaaaca
     7861 tttaacacca agcatttaaa attatagatt ccggctattg cccacaagca tttgggccat
     7921 taaaaaaaat gttcaagcaa atcgtctcca ccatgcatca tgcacttaat tactctttta
     7981 ctttcgatca taatcttgca cttttcggac ccaaaacgaa gtatgtattt gtaaccaacc
     8041 atccattagt cagcttagtc tatggtcaat taatttcgtt ggatctgcag aagttcaact
     8101 gtgttatggt tacttttttt ttgaactgca actgatatta aaaacgaaaa ctaaaaaaaa
     8161 accgtgctgg caacgggtca tcggcgaatt gggcggtggg agggccgagt gggaaagaga
     8221 tgggcaatgt gggctgcgca tgcgcaatag cgcgcattaa ataatttata caaaaatgca
     8281 cagaaaatta acaaatttga aaacgctgtt gcatgatata ataatccggc tgcctgggat
     8341 tccgagatgc caatccatga gcacagccac tggcccttcc cagcccaaaa tatctgttgc
     8401 aatacaagca tgtatactgg gcgaaaagtg ggtcaacatt tctatgcttt