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LOCUS NM_001272456 2596 bp mRNA linear INV 26-DEC-2023 variant F (Hecw), mRNA. ACCESSION NM_001272456 VERSION NM_001272456.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 2596) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 2596) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 2596) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 2596) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 2596) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 2596) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 2596) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 2596) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 2596) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 2596) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 2596) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 2596) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 2596) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 2596) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 2596) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 2596) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 2596) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 2596) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 2596) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 2596) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 2596) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 2596) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 2596) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..2596 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..2596 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="Hecw ubiquitin protein ligase" /map="8F1-8F2" /db_xref="FLYBASE:FBgn0261931" /db_xref="GeneID:31905" CDS 518..1822 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="CG42797 gene product from transcript CG42797-RF; CG42797-PF; Hecw-PF" /codon_start=1 /product="hecw ubiquitin protein ligase, isoform F" /protein_id="NP_001259385.1" /db_xref="FLYBASE:FBpp0305179" /db_xref="GeneID:31905" /db_xref="FLYBASE:FBgn0261931" /translation="MGFLSKAAYIVWAVLFEQEIMGFVPIEERSPQGSPVLNSRMPQR APPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQ RGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFV DNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQ WIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRL ERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYH DNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGK PNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE" misc_feature 743..1813 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; Region: HECTc; cd00078" /db_xref="CDD:238033" misc_feature order(761..763,854..856,887..889,1070..1072,1598..1600, 1703..1708,1715..1729,1787..1789,1808..1810) /gene="Hecw" /locus_tag="Dmel_CG42797" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="catalytic cleft [active]" /db_xref="CDD:238033" misc_feature order(1154..1156,1163..1168,1172..1177,1184..1186, 1208..1210,1214..1216,1226..1228,1232..1234,1250..1252, 1265..1267,1316..1318,1328..1330) /gene="Hecw" /locus_tag="Dmel_CG42797" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="E2 interaction site [active]" /db_xref="CDD:238033" ORIGIN 1 cggatagcag ctatatgcta ttagctatat tagctatatg ctgtatattc gaatcggtta 61 agaatatatc gcaaaaacca ccctgttttg ggaagctttg ctttgttctt tatatttttg 121 tgataatact attttattat tgtttattgg tgactccgcc ggtttcgttc cgttcgtttt 181 tgacgctgct gccgcttcaa ccgcttcaac cgttccaatc gctactaccg cttctgtcgc 241 ctccgttgcg acttcgttcc gttcgtcgga tagttagctt ctatcaccag aagcatttca 301 acagccggag cgtgagcaca cagtcttcaa tcgtttatgt gtttcttttt tttgttcttg 361 tttatccgct tgataaccga taccacccga tacgcaaccg tttcgcgcca ttattttttt 421 tcttgccata tttcgtttag cgaaatattc taacggcacg gagtgatctc agtgatgatt 481 aactatttga tgctcaagac ttggagcgca caacaaaatg ggctttctat cgaaggctgc 541 ctacatcgtg tgggccgtcc tgttcgagca ggagatcatg ggctttgttc ctattgaaga 601 gcgcagtccg cagggatcgc cggtcctcaa ctcccggatg ccacagcgtg cgccgccacc 661 atttcgcaga gatttcgagg ccaaactgcg cagtttctat cgcaaactag agtccaaggg 721 ctacggacaa ggaccacaca agcttaaact gcacattcgt cgcagccatt tgctggagga 781 cgccttccgg cgcatcatgt ccgccaacaa gaaggacctg caacgcggcc gactcgccgt 841 gctctgggat acggaggagg gcctggacta tggcggacca tcacgcgagt tcttcttcct 901 actttcgcgc gaactgttta atccgtacta cggactgttc gagtactcag ccaacgatac 961 gtacaccgtg caggtgtcac cattgtcggc gttcgtggat aattgccacg attggttccg 1021 ctttagtgga cgagttttgg gattggcact ggtacatcag tatctactgg acgcattctt 1081 tacgcgtccc ttttacaagg cgctgctgcg cctgcccgtg gctctcagtg atttggagtc 1141 gctggacaat gagttccatc agtcgctcca atggatacgc gacaatgaca tcggcacggg 1201 cgtggatctt ggcctaacgt tctgtgtcac agaggagctg cttggcagtg tggtggacag 1261 ggaactgaag cccggtggca agaatatcat catcaacgag aagaacaaaa aggagtactt 1321 ggagcgcatg attaagtggc gtctggagcg cggtgttcag gagcagaccg agtcgctggt 1381 gcgcggcttt tacgaggtga tcgactcgcg cctcgtttcc gtctttgatg cccgagagtt 1441 ggagctggtt attgccggca ctgcagaaat agacacaaac gattggcgcc tgaacacaga 1501 gtatcgttct ggttaccatg ataaccacca ggtgatcgtt tggttctggc aggttatcga 1561 gcgctttagc aacgagcagc gtcttcgtct gcttcagttc gtgactggca cgtcgagcat 1621 accgtacgaa ggattctcgg cattacgcgg atcgactggc ccgaggcgtt tctgcatcga 1681 gaagtggggc aagccaaatg cactgccccg tgcccacaca tgcttcaatc ggctggattt 1741 gccgccgtat ccaacacccg aactgctgta cgagaagctg ctgctggccg tcgaggagac 1801 caacacgttc ggcattgagt agacacgtga tattgcaccc acatacacat acacaaacaa 1861 aaacacatac acatacacat acagatacac aaaacacgcg cctaaacgct ttatttcgat 1921 tttagaagtt tttataactt gcctaagtct agaaattcgc gagctatgca gaaatcctag 1981 ggatttggac acaacaagtt gcagttttta ttgaatagca atgcattctt tgtaaattag 2041 ttttaaagtt caatttaatt ttttcttctt aatatgaacc gttattggtt atattagttt 2101 gcgatgatta ttcttaaaaa tagaacttgt tacgattaaa tttaggtaaa cgagttagtt 2161 aatacttcga atttgttagc tatttttagg cacctaaatg ctattaaaat ccactgggat 2221 ttctgcaacc ctcataattg tactgtagtt atttatatac gtaggtggtc ccccttccga 2281 aaatgaacaa aattgtaaag caaataaatg cctagccata gacagacttg ctactttagg 2341 catggcatcc cactagtttg tagacaattt gccttcgcct tcgtttgccg ttcattgaat 2401 ggaagttacc tcaagagcaa aacggcttgc cagcgccgcc agtcattagt cctaagatct 2461 acacgccccc ggataatttc taagcctaag tatccttcgc ttgactctgc ctgatttaca 2521 ctcgaaacgt tgccaactgc cctctagaga aaattacgac gcgtaaacgc tgttccagat 2581 ccagttcagc agtttc