Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

Drosophila melanogaster topoisomerase related function 4-1,


LOCUS       NM_001272411            6812 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant J (Trf4-1), mRNA.
ACCESSION   NM_001272411
VERSION     NM_001272411.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6812)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6812)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6812)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6812)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6812)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6812)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6812)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6812)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6812)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6812)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6812)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6812)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6812)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6812)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6812)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6812)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6812)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6812)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6812)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6812)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6812)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6812)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6812)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6812
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6812
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /note="Topoisomerase related function 4-1"
                     /map="7F4-7F4"
                     /db_xref="FLYBASE:FBgn0030049"
                     /db_xref="GeneID:31795"
     CDS             586..3591
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /EC_number="2.7.7.-"
                     /EC_number="2.7.7.19"
                     /note="CG11265 gene product from transcript CG11265-RJ;
                     CG11265-PJ; Trf4-1-PJ"
                     /codon_start=1
                     /product="topoisomerase related function 4-1, isoform J"
                     /protein_id="NP_001259340.1"
                     /db_xref="FLYBASE:FBpp0304114"
                     /db_xref="GeneID:31795"
                     /db_xref="FLYBASE:FBgn0030049"
                     /translation="MDPFVGWFQKEQEGPSLCTWLKIWETNAQEMGALLNQQLQQATT
                     INGSTSSSSSSSNSGNNNNNNNNNIINNTITNTTNNTGNNSSAKPYLSRPYSSLNRVL
                     NFRADSLEILQQQQQQQQLNGTTQRNSTNINTTSGGSTSSSADSTTNRDNNSPANSSS
                     TNGPGAGTGTSTGAGGTGTNSPATTASSTAATTTGPATSMSDTSNNPPQSTTTPASRT
                     NSIYYNPSRKKRPENKAGGAHYYMNNHMEMIAKYKGEPWRKPDYPYGEGVIGLHEEIE
                     HFYQYVLPTPCEHAIRNEVVKRIEAVVHSIWPQAVVEIFGSFRTGLFLPTSDIDLVVL
                     GLWEKLPLRTLEFELVSRGIAEACTVRVLDKASVPIIKLTDRETQVKVDISFNMQSGV
                     QSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFTGGISSYSLILMCISFLQMHPR
                     GIYHDTANLGVLLLEFFELYGRRFNYMKIGISIKNGGRYMPKDELQRDMVDGHRPSLL
                     CIEDPLTPGNDIGRSSYGVFQVQQAFKCAYRVLALAVSPLNLLGIDPRVNSILGRIIH
                     ITDDVIDYREWIRENFEHLVVVDRISPLPTAAPTAYATANGAPKYVIMPSGAVVQQLY
                     HHPVQVPTAHGHSHAHSHSHGHAHPGAHLCQPYVTGTTVSAVTTTTTMAVVTVGVSAG
                     GVQQQQQQQNATAHTHSQQQTQNQSQSRHRRGSTSSGDDSEDSKDGDVVETTSSAQEV
                     VDIALSTPNGLANMSMPMPVHAVGMPASNSWSGNGNGNGNSSSSTGSSPEIAHIAAQE
                     MDPELEDQQQQQQHQETSGGNGFIRPGDVGTGSNRGGGDGSGGRNYNQRNNHNSSGYY
                     HQQYYVPPPMQQQLSKSNSSSNYHQQHHHSHSHGNHSHRQQHHHQQQHHHQQRPQHLR
                     VGGGNRYQKSLGGSPIISAGNASNSSSNCSNSSSSSGSNNSRLPPLRGTLVNSSSAIS
                     IISISSESSIASSSSSSSRSGQDQQRDER"
     misc_feature    1396..>2334
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /note="DNA polymerase sigma [Replication, recombination
                     and repair]; Region: TRF4; COG5260"
                     /db_xref="CDD:227585"
ORIGIN      
        1 gtgcataaaa ggcatagagg cagcaaggag tgaaagagag agctccatcg gcagcgcaac
       61 gaaagtgagc gagaagcaga aattgttagt gcttataagg atatgtgaga agggagagtg
      121 agacagtaag aaagaacgga agaagcagca gcgacgccga ccgacaacaa ctgtaatttt
      181 ccattaattt ttgggcgggt tttgtgctgc acaataatac aactggcata atataacttg
      241 gcttattttt tataaccaac atgtgtattt tgttcacgtt ttgctgcgtg tgtaggtgtg
      301 agtatatgta tgtgtgataa acttgaaata caacgcaatc gcaacgagaa ccaaaacttg
      361 tcaagcactt gaatgctgac agcattcaaa gaggtttagt cccggcagcg actttaatta
      421 atttttccct gtggagcaca aagatcacat cggatctata tagagtcacg tctatatatt
      481 cagaccacca ggacgcagag gatagaggtg aaaggacgaa gcgaaggaga gacgcgcgcc
      541 cccctcgttt cccgcccagc caacagccgt gtgaacccgt cttgaatgga tccatttgtt
      601 ggctggtttc agaaggaaca ggagggacca tcgctgtgca catggttaaa gatttgggag
      661 acgaatgccc aagagatggg cgcattgctt aatcaacagc tacagcaggc gacgacgatc
      721 aacgggagca cgagcagcag cagcagcagc agcaatagtg gtaacaacaa caacaacaac
      781 aacaataaca tcatcaataa cactatcacc aacacgacca ataacactgg taacaattca
      841 tcggccaaac cctacttatc gcgaccctac agctcgctaa atcgggtgct caatttccga
      901 gcggattccc tggagatcct gcagcagcaa caacaacagc agcagctcaa cgggaccact
      961 cagcgcaaca gcaccaacat caataccaca agcggcggca gcactagctc gtcggcagat
     1021 tccaccacga atcgggacaa taactcaccc gccaatagca gttcaaccaa cggacccgga
     1081 gcaggaacgg gaacgtcaac aggagcagga ggtaccggta caaatagtcc ggcgacgaca
     1141 gcgtcaagca cagctgcgac cacgactggt ccagccacta gtatgagcga caccagcaac
     1201 aacccgccac aatcaacgac cacgcccgcc agccgcacga acagcatcta ctacaatcca
     1261 tcgcggaaga aacgaccgga gaacaaggct ggcggagccc actactatat gaacaaccat
     1321 atggagatga tcgccaagta caagggcgaa ccgtggcgca agccggacta tccgtatggc
     1381 gagggcgtta tcgggctgca cgaggagatc gagcatttct atcagtacgt cctgcccacg
     1441 ccctgcgaac acgccatccg caacgaggtg gtcaagcgta tcgaggccgt tgtccattcc
     1501 atctggccac aggcagtagt cgagatcttt ggctcctttc gcactggcct ctttttgccc
     1561 acctccgaca tagatctcgt tgtgttaggt ttgtgggaga agctgccgct gagaacgctg
     1621 gagttcgagc tagtgagccg tggtatcgcc gaggcttgta cggtgcgtgt tctggacaag
     1681 gcatcagtgc ccatcatcaa gctgacggac cgggaaacgc aagtgaaggt agacatatcg
     1741 ttcaacatgc agagtggtgt tcagtcggcg gagctgatta agaagtttaa gcgcgactat
     1801 ccagtgctgg agaagctagt gcttgtgctg aagcagttct tactacttcg cgatctcaac
     1861 gaggtgttca cgggcggcat ctcctcctac tcgctgatcc ttatgtgcat cagcttcctg
     1921 cagatgcatc cgcgcggtat ctaccacgat acagccaatc tgggggtgct tctcctcgag
     1981 ttcttcgaac tttatggacg tcgcttcaac tacatgaaga tcggcatctc cataaagaac
     2041 ggtggccgct acatgcccaa ggatgagctg cagcgtgaca tggtcgatgg ccatcgaccc
     2101 tcgctcctgt gcatcgagga tccgctgacg ccaggcaatg atatcggtcg aagcagctac
     2161 ggcgtcttcc aggtgcaaca ggcattcaag tgcgcctacc gcgtgctcgc ccttgccgtc
     2221 agtccgctca accttctcgg catcgatccg cgcgtcaact cgatactggg tcgaatcatt
     2281 cacatcaccg acgacgtgat cgattatcgc gaatggatcc gcgagaactt cgaacatctg
     2341 gtggtggtgg atcgtatctc gccgctgccc actgccgctc ccactgcgta cgccaccgcc
     2401 aatggggcgc caaaatatgt gattatgccc tcgggcgccg ttgtccagca gctgtaccat
     2461 catccggtgc aggtgcccac cgctcacggg cacagccatg cgcacagcca cagtcacggg
     2521 cacgcgcatc ctggcgccca tctgtgccag ccgtatgtga ccgggaccac tgtatctgct
     2581 gtaacgacga ctacaacgat ggcggtggtg accgtgggcg tgtcagccgg cggagtccaa
     2641 cagcagcaac agcaacagaa tgcgacggcc catacccact cgcaacagca gacacagaac
     2701 caatcgcagt cgcgccatag acgcggcagc acctcgtcgg gcgatgactc cgaggatagc
     2761 aaggacggcg atgttgtcga gacgacgtcg agtgctcagg aggtcgttga catcgcgcta
     2821 tcgacgccaa atggcctggc caacatgtcc atgcccatgc cagtgcatgc tgtcggaatg
     2881 cctgcgtcga acagttggag cggtaatggc aatggaaacg gaaacagcag ctcatccacg
     2941 ggctcgtcgc cggaaatcgc acacatcgct gcccaggaaa tggaccccga gcttgaggat
     3001 caacagcaac aacagcagca ccaagagact tctggaggta atggcttcat ccgaccgggt
     3061 gacgtcggca ccggttccaa caggggaggc ggtgacggca gtggcggccg caattacaac
     3121 cagcggaaca accacaactc cagcggctac taccaccagc agtactacgt gccaccgccg
     3181 atgcaacagc agctgagcaa gtccaactcc tcctccaact atcaccagca acaccatcac
     3241 agccacagcc atggcaatca tagtcaccga caacagcatc accaccagca gcagcaccac
     3301 caccagcagc ggccgcagca tctgcgtgtg ggcggcggca atcgatacca gaaatcgttg
     3361 ggcggatcgc ccatcatcag tgctggcaat gcgtcgaaca gcagcagtaa ttgcagcaac
     3421 agcagcagca gcagcggcag caacaacagc cgactgccgc cgctaagggg cacgctggtc
     3481 aactcatcgt cagcaatatc aatcatttcc atatcctcag aatcatccat tgctagcagc
     3541 agctccagtt cgtcaagatc cggtcaggat cagcagcgtg acgagcgata ggaataggat
     3601 gtaggaagat attgtgtatg tctatgacac agagagaaag agagtgcgac acagagggac
     3661 agagaatgag agagaaagag atagttacgg tgttagcaat atttatgggt tacatttctt
     3721 tctcaggtta attgtaaact acgctgcatt tttctaataa atatcattga cccccccgcc
     3781 cccccgcctc tacctaatcc gaaagcatct cctcaaccaa tgtaactgcg atcagatttt
     3841 cttttacact gctgtcttgc ttaaattggg agagcgacgc agacctacta agcctagtgt
     3901 taggaacttt gcctctgatc gcgctaaatg tatttcagtt tgtttctaaa ataaacatga
     3961 aagcaaagaa tatatatata tatatatata tatatttata tatatagata tatattaaat
     4021 taaattaaat tgtaccataa gcataactgt tagctcataa gtagattgta agggtttaaa
     4081 agatcgataa actgaagtat gaaattatgc taatctcttt tcccataccc cccccccccc
     4141 ctttttatcc atcatcatgc gcattcaagc ttctaaagta ttttgtagtt tctgaaatgc
     4201 tctccgtcta gtgcaatggt aaacattttt gcaaacgtaa ctaattccct atccacccca
     4261 tttcctgcca tacaaaaaaa aaaaaaaaat tcaaaaaacg gaaatcacgc gcgcaaaatg
     4321 ttacgctaat attactaagt gaatttgcgc gcaaaatgta aaaaaaagca acataaccgc
     4381 taatgcaatt gaaaattacc attttccaaa gaaataatag aaatgcgcaa tgacccttgt
     4441 aacttccaaa aactcgttta attatattat tccgagttag ttttatgcct aaaatgtaaa
     4501 tgtttttatg ataccactat tactattatg attaagccta tatttgaagc ctatacttag
     4561 ttttaattat tattattata attaaggtaa aaaaaattgt gagcctactt aaattgttcg
     4621 aacacattgt ccaaccccaa agcaattgtg ttttaaagct aaaacaaaaa aaaaaaaaca
     4681 aaaaaacaaa acaaagaaac aaaacaaaac gacaaaaaaa gcaaaaaaaa cctacaacgc
     4741 atcttttgtt taaacttatt tatgattaat tgactattat gattatgcaa tgttgtgcat
     4801 tttgcataga ttcctgccat ttgtttgtat agttgttcac aaatctctgt aaatacttag
     4861 ttaccgccca tccccctgtg acgcaccgcc acgcctcccg ccccacccac cacgcccctt
     4921 ctaaacgcac tgccattttg agaaaggttt ttaaaaaaca cgtcgaaaag gagctagcag
     4981 aagagtagaa aagaagattt agactttgta catgtataac attttaggct gttcttcttt
     5041 ttccatttgt aagagacaaa gaaacaaaga aagcaaaaca aaaaaaaagc ccaaaccaga
     5101 aacataaacc caactaattg taaagtcacc taaatagtct acgaacatgt ttgtcaatcg
     5161 agtcgcgaac atagagctct gtaatactag gcggcaacat ttaaaatttc attctgaaag
     5221 tgcaacattt ctgattcttg gagattgtaa atgacataca caaaaaaaaa aaaacgcggc
     5281 tttaaatgta catcaaaaca tgttgcaata cttgaatatg gatttctctg ttgtatggtg
     5341 tgatagcaca atttttgttt gcatcattta tgtatagttc tgtaatgtct aatgtcttaa
     5401 tatttaactt ctattatagt ttctcatttg gctttccttt cgatcatatg tatgtatttg
     5461 tgaactgttg cgacattaag cttgtttgtg aatcgtgagc taagagttca tagtattgaa
     5521 tctgaagtat cgaccttgag tggttcaaaa cctaaagtta attttttaat tttcgaaatg
     5581 tgtgtgaaag agaaacgtca tttaggaccc tcgatatttc agaaaaatcg agattaggtt
     5641 caatatcttt tttttttctg ttgcctagtg tgaattaaag cgatgttcaa tgttgacaaa
     5701 ggccgaaggt gcgctctccc tttcgcacga cgactcctac aagctggcag ctttgaagcc
     5761 caccttacac atacacactt tctcactcac atcacaaaca cacacaagcg caaaggctcc
     5821 ccccacacag atacccgaac agagagggac acttaacgat aaagttagca tagaaagttg
     5881 gggaagacgg ggcaatgagc cgttagtaag aatgagaaag cggttgcgat agagcgagat
     5941 aaagtaataa ggaacgaaat agagagcgag cgagagtaac atataagaat tattaaattt
     6001 atgcactcgt ctgttgaata tttatatgaa ttatatgtat gtagttacta atattaacta
     6061 attgataaat atacaatatt tatatgcata acttgtggat taatgtgaac aaacaaatgt
     6121 ttagaattag caatctagcc acgtaagact cgtaaatggt aaatcgtaaa tcgacaacta
     6181 cttagactac ataactgtgt accagagcat atgtaagcac ataagcactc ccacacacac
     6241 acacacgaat acaccactac atgcatactc gctatgaatg ttgagattat gtcgtagatt
     6301 ttttcaatat cgatcacgtt ttcgcctagc ctagcaagta agccgcagat ctaactgtaa
     6361 aactaaccca tttccccact ggattccatg cattcgaaat cgtttcatcc ttcgtccatc
     6421 attgcccatt cagtccttcg ttttcgtttc agtttgcgct ccgttcgcag ttcccaactt
     6481 tcatattacg tgtgccgtta ttgttatata acacacatgc atatactcga aacatacaca
     6541 gttttttgtc gtcgcgatat tagtgggtat taataaatta aattaaattt aattaactac
     6601 atttaacgca actaaattca attcaagtga atcaaatgaa tcgatcgata atacatgtat
     6661 gtatatgata gagttcaata gctgtgtaag aatcggaatc gtaacaattt agtatgcaaa
     6721 aatcgtaaat ctaactgatt gtataattag cgaaaagaga ataacggatg cgataagcaa
     6781 aacgatgcga caaataaaag ccggcaaaaa ct