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LOCUS NM_001272401 6840 bp mRNA linear INV 26-DEC-2023 (Trf2), transcript variant G, mRNA. ACCESSION NM_001272401 VERSION NM_001272401.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 6840) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 6840) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 6840) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 6840) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 6840) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 6840) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 6840) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 6840) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 6840) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 6840) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 6840) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 6840) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 6840) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 6840) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 6840) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 6840) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 6840) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 6840) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 6840) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 6840) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 6840) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 6840) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 6840) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..6840 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..6840 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="TATA box binding protein-related factor 2" /map="7E7-7E9" /db_xref="FLYBASE:FBgn0261793" /db_xref="GeneID:31773" CDS 673..5820 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="CG18009 gene product from transcript CG18009-RG; CG18009-PG; Trf2-PG; lethal (1) G0295; lethal (1) G0425; TBP-related factor 2; lethal (1) G0039; TBP related factor 2; lethal (1) G0071; TATA box-binding protein related factor 2; TBP-like factor" /codon_start=1 /product="TATA box binding protein-related factor 2, isoform G" /protein_id="NP_001259330.1" /db_xref="FLYBASE:FBpp0303138" /db_xref="GeneID:31773" /db_xref="FLYBASE:FBgn0261793" /translation="MGSAVKKGDGSPTRILEEYQVARDLRNEDLFPEHPVEHPDEDSD KENQSPNQSPNPRAIGDCEQGPDIGKDTLNPNEADQFSSEEVEKNEANSSCNESGGDA RNSRDRLSSSHSEDEQLNQEYSTSSSGSTIGNREQGSDVGKDTSSRNEADQFSNEEVE KNEANSSGNESYGDACNSSDRLSSSNSEDEQLHQEYSTSSRGRTREYAQSDLNPGYQD LNIGNQDLNQVNREYQESNNEYQVSNQEYQHLNTEYQELNHGDQDSNDEYQELNHGNQ DSNDEYQESNHGNQDSNDEYQELNHSNQDSNDEYQELNHGDQDSSDEYQDLNHVNQDS NHEYQAWNHEYQDSNHEYQALNREYQYPESDEEEAARKRNIYTRLRSYACQVHLPRLG ESEVDSDDRRHNPINQPFNQPINRPNQKSDSSLESSSPERQDSESESRQASDEESSSG DSDYLIDPVTGWLSRRRETSTEREEKSDQSQQESSEEITDEQKEESDDVEQQSPAEHT SSDRRDHSPDKQQNKRKSLGTGNSSYSKKPLLDGDKGDPRSHLSSLGSRRSLKRKWPF DCTDSKKFKPNLQSEEDKSEEEKREDTESECSDEEDSDSSSFDTDSNSDSDSNLDLDS DSDSHSDFESSSSSEESAQDPAPEGETDQDPAPEGEADQDPAPEGGVDQDPAPEGGVD QDPAPEGEVDQDPAPEGESDQDLAPEGGVDQDPAPEFGTDQDPHPYYNDQDPAPYYDD QDPASYYDDHICDSEEDYKPFIFSKERKFLKFVTNPLGDDKSSLDLSIQLYKVFGAYK LEDVYSSIDEEGQPEQDLQLKQQQKHLKKYQKLQLVVFWHQEKFFSKEQLLLYEYLKL LLQKFFPQEQQEKRLQQEKLLQQEKLLQQEKRLQQEKRLQQEKRLQQEKRLQQEKRLQ QQKLLQQQKLLQQEKLLQQQKLLQQEKLLQQEKLLQQEKQLQQEKHLPQERQLQQDKV FLQLRQLQQKKELEEQRERKRHLFEQQKQFVLEKLRQQKEQHRRQQNRVKRERKLRQK KEKQRLEYERFLKEYREDCKRQLRLQREHYLIKIKQLEKASQRSLKGNRKHKLMQNDM VSIPVANLNGGLKAASSGSGVGVVTSGGVVSSAVLANAPRVYLTPSSTFMTNRQMAGV ASTGRMSGQVVGGSSGTASTAGTVRYFSQFSKMQTAGGPSLQRKLANGDTIVLATGSK NMFLTSSENKANLPTVASNGNGLITAKMDLLEEEVMQSITVIDDDDEEKKEVAEDEEE SSNNAKPIDLHQPIADNEHELDIVINNVVCSFSVGCHLKLREIALQGSNVEYRRENGM VTMKLRHPYTTASIWSSGRITCTGATSESMAKVAARRYARCLGKLGFPTRFLNFRIVN VLGTCSMPWAIKIVNFSERHRENASYEPELHPGVTYKMRDPDPKATLKIFSTGSVTVT AASVNHVESAIQHIYPLVFDFRKQRSAEELQHLRQKQRLQAGGDPHELEKNVLADNKT ASLDNIFVNTTAAHSKSSSNDQTSAPATILSSTVDSMPRLKQMVNYHQMMKQTQEERR HIMFNGEKANPASTSSAAAAPSTSSSSSSSGDNICANARRRATECWATKLQNKRPRYN DPGTTGTINAASSTASAATSSLASQATHLRNPLKTAALANARMLGAKVTTCTRNSIIV QQPQRIQMQQQQQQLQPQQQQTSFSPSEFDVDDLIEEEENNELDMPF" misc_feature <2602..2868 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="hypothetical E4 protein; Provisional; Region: PHA03418" /db_xref="CDD:177646" misc_feature <3343..>3936 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="Family of unknown function (DUF5401); Region: DUF5401; pfam17380" /db_xref="CDD:375164" misc_feature 4519..5040 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the...; Region: TLF; cd04517" /db_xref="CDD:239953" misc_feature order(4534..4539,4543..4545,4621..4626,4636..4638, 4642..4644,4663..4665,4669..4671,4681..4683,4687..4689, 4693..4695,4699..4701,4789..4791,4804..4806,4810..4812, 4897..4902,4915..4917,4954..4956,4960..4962,4966..4968, 4978..4980) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative DNA interaction surface [nucleotide binding]; other site" /db_xref="CDD:239953" misc_feature order(4579..4581,4600..4608,4612..4614,4624..4626, 4642..4644,4648..4650) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative TFIIA interaction surface [polypeptide binding]; other site" /db_xref="CDD:239953" misc_feature order(4840..4845,4879..4893,4900..4902,4915..4917) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative TFIIB interaction surface [polypeptide binding]; other site" /db_xref="CDD:239953" ORIGIN 1 gtgagtgcgc acacacacgc acgcacgcgc gcacgcagca attgtgttgg tgcaagtgac 61 gtttcccatt tctttttgtt ttgcttcgtt tcgtttgctg attactattt acagaaaata 121 acggcaagtt gcgacgcgaa ttaactgtga tcctttacta aaagatgcag attctttgaa 181 aattcgtgaa taaaaaccaa gcgatcgaat tcaaagattc atccgcataa gttggtagta 241 aatagcggtg atccttctca aatgcaacga gaaattgtaa ctgttaaaca gactgctaaa 301 cggaacaact aaaaactaca agcaaattta accaggagaa aagaacggaa gactagacat 361 aatcataaac atagtagata gaattagaga accagcaaac ccaacaacta gaacactaag 421 aaaacattaa ttctaataca aaatcacaca taaaaaagta ttttttggcc ttaagtgcaa 481 acatactcac atacaaacac atacatacac atccacatga acgaaacaat ggaaagaatg 541 taatacaaca ccaaggaaga atcaccttta gccttatata caattaaata taattaagaa 601 gctagcaaga aaacgcagag caagagtcct atcaagaaac ccaaaaagat aacaagaaat 661 atttttttaa cgatgggcag tgccgtcaaa aagggggatg gttccccgac tcgaatactt 721 gaagaatacc aagtagctag agacttaagg aacgaggatt tgtttccgga acatccggtt 781 gaacatccgg acgaagattc ggataaggag aaccaatcgc cgaatcaatc ccccaatcca 841 agagccatcg gtgattgtga gcaaggacct gacattggta aagatactct aaatcccaac 901 gaagctgacc agttttcgag cgaagaagtt gagaagaacg aagccaacag cagctgtaac 961 gagtcgggcg gggatgctcg caattctaga gatcgtttaa gttcctctca tagcgaggac 1021 gaacagctta accaagaata ttcaacttca tcaagcggaa gcaccatcgg aaatcgtgag 1081 caaggctctg acgttggtaa agatacttca agtcgcaacg aagctgacca gttttcgaac 1141 gaagaagttg agaagaacga agccaacagc agcggtaacg agtcgtacgg ggatgcctgc 1201 aattctagtg atcgcttaag ttcttctaat agcgaggacg aacagctgca ccaagaatat 1261 tcaacttcat caagaggaag aacaagggaa tatgcacaat ctgacttgaa tcccgggtac 1321 caggacttga atatcggtaa ccaggacttg aatcaagtta atcgcgagta ccaggagtct 1381 aataacgagt accaggtttc aaaccaagag taccagcact tgaataccga gtaccaggag 1441 ttgaatcacg gcgatcagga ctcaaatgac gagtaccagg agttgaatca cggcaaccag 1501 gactcaaatg acgagtacca ggaatcaaat cacggcaacc aggactcaaa tgacgagtac 1561 caggagttga atcacagcaa ccaggactca aatgacgagt accaggagtt gaatcacggc 1621 gatcaggact caagtgacga gtaccaggat ttgaatcacg tcaaccaaga ctcaaatcac 1681 gagtaccagg cttggaatca cgaataccag gactcaaatc acgagtatca ggccttgaat 1741 cgagagtacc aatatcctga atctgatgag gaagaggccg ctagaaaaag aaacatatat 1801 acccgtttac gatcctacgc ttgtcaggta catctccctc gtttaggaga atcagaagtt 1861 gatagcgacg atcgtcgcca taacccaatc aatcagccat tcaatcagcc aatcaatagg 1921 ccaaatcaaa aatcggattc atctttagag tcatcttcgc cggagagaca agactctgaa 1981 agcgagtcgc gacaagcttc agatgaggaa tcgtcttctg gggactcgga ctacttaatc 2041 gatccagtta ctgggtggct atcgcgccgg cgagaaactt ctaccgaacg cgaggaaaaa 2101 agcgaccaaa gccaacagga gtcgtcagag gaaattacag acgaacagaa ggaagaaagc 2161 gacgacgtcg aacaacagtc gccggctgaa catacttctt ctgatagacg cgatcattcg 2221 ccagacaagc aacagaataa gcgaaaatcg ttaggcactg ggaattcttc gtattcgaag 2281 aaaccattat tggacggtga caaaggagac ccacgttcac atttatcgtc tctgggaagt 2341 cgcagatcct taaagcgtaa atggcctttt gattgtacag actctaagaa atttaaacca 2401 aacttgcaga gtgaggaaga caaatctgag gaggaaaaac gtgaagatac ggaaagcgaa 2461 tgctctgacg aagaagactc agatagttca agtttcgata cagattcaaa ttcagattca 2521 gattcaaatt tagatttaga ttccgattcc gattcccatt ccgatttcga atcatcttca 2581 agttctgagg aatctgccca ggatccagct cctgaaggcg aaaccgatca agatccagct 2641 cctgaaggcg aagccgatca agatccagct cctgaaggcg gagtcgatca agatccagct 2701 cctgaaggcg gagtcgatca agatccagct cctgaaggcg aagtcgatca agatccagct 2761 cctgaaggcg aatccgatca agatctagct cctgaaggcg gagtcgatca agatccagct 2821 cctgaattcg gaaccgatca agatccacat ccttattaca acgatcagga tccagctcct 2881 tattacgacg atcaggatcc agcttcttat tacgacgatc acatttgtga ttctgaggag 2941 gattataaac catttatctt ctcaaaggaa aggaagttct tgaaattcgt aacaaatcct 3001 ttaggggatg ataaatctag tttggacctt agcatacagc tctataaggt atttggagct 3061 tacaaactgg aagacgtata cagcagtatt gatgaggaag gccaaccaga acaggacctg 3121 caactgaagc agcaacagaa acatttaaaa aaatatcaaa agttgcaact ggtggtattc 3181 tggcaccagg agaaattctt ttcaaaggag caactgttgc tatatgagta tctgaaacta 3241 cttttgcaga aattctttcc acaagagcaa caggagaaac ggttgcaaca ggagaaactt 3301 ttgcaacagg agaaactctt gcaacaggag aaacggttgc aacaggagaa acggttgcaa 3361 caggagaaac ggttgcaaca ggagaaacgg ttgcaacagg agaaacggtt gcaacagcag 3421 aaactcttgc aacagcagaa actcttgcaa caggagaaac tcttgcaaca gcagaaactc 3481 ttgcaacagg agaaactctt gcaacaggag aaactcttgc aacaggagaa acaattgcaa 3541 caggagaaac acttgccaca ggagcgacag ttgcaacagg ataaagtctt cctacagcta 3601 cgacagttgc aacagaagaa agaactggag gagcagcgag agcgaaagcg ccacctcttt 3661 gagcaacaga aacagtttgt cctagaaaaa ttgcgccaac agaaggagca gcatcgtcgt 3721 cagcaaaatc gcgtaaaacg cgaacgtaaa ttgcgccaga aaaaggagaa acagcgcttg 3781 gaatacgaac gattcttgaa ggaatatagg gaggactgta aacgtcagtt gcgtttgcag 3841 cgcgagcatt atctgatcaa gattaagcag ctggagaagg ccagtcagcg ctcgttgaag 3901 gggaatcgaa agcacaagct gatgcaaaac gatatggtca gcataccggt ggccaatttg 3961 aacggcggcc ttaaagcggc cagcagcggt tccggagttg gtgtagtgac ctccggcggc 4021 gtcgtatcct cggcggtgct ggccaatgcc ccacgtgtat acctaacgcc ctcctccaca 4081 ttcatgacca atcgccaaat ggcgggagtg gcgtccaccg gaagaatgag cggacaagtc 4141 gtcggtggtt catctggcac agcctcaaca gccggtaccg ttcgctattt ttcgcaattc 4201 agcaaaatgc aaacggccgg cggacccagt ttgcaaagga aacttgccaa cggggatacc 4261 attgttctgg caaccggcag taaaaatatg ttccttacta gcagcgaaaa taaggctaat 4321 ctgccgaccg tcgccagcaa tggcaatggt ctgatcacag ccaaaatgga tctattggag 4381 gaggaggtca tgcagtcgat aactgtgatt gatgacgatg acgaggagaa aaaggaagtc 4441 gctgaagacg aagaagagag cagcaataat gccaaaccca ttgaccttca ccagccaatt 4501 gctgataatg agcacgagct ggacattgtg ataaacaatg tggtctgctc gtttagcgtc 4561 ggctgtcacc tgaagctgcg cgaaattgcg ctgcagggat caaatgtgga gtaccgtcgc 4621 gagaacggaa tggtgacaat gaagctccgc catccataca ccactgcctc gatttggtcg 4681 tcggggagga ttacctgcac tggtgccact tccgagtcaa tggccaaggt cgctgcacgc 4741 cgctatgcca gatgccttgg caagctggga tttcccactc gtttcctcaa ctttcgcatt 4801 gtcaacgtac tgggcacctg cagcatgccg tgggccatca agatcgtcaa cttttcggag 4861 cgccatcgcg agaacgccag ctacgagccc gagctgcatc ctggagtgac ttacaagatg 4921 cgcgatcccg atccaaaggc caccctgaag atcttctcca ccggcagcgt aacagtcacc 4981 gcggctagcg taaaccacgt tgaatcggct atccagcaca tatacccgct ggtctttgat 5041 ttccgcaagc aacgttcggc ggaggagctg cagcatctgc gtcaaaagca gcgtctgcaa 5101 gccggcggtg atccccacga actggagaaa aatgtcttgg ccgataacaa gactgcttcc 5161 cttgataata tctttgttaa tacaacagcg gcgcactcta aatcatcgtc gaatgaccaa 5221 acatcagcac ccgcgaccat cttgtccagc acagttgata gtatgcctcg tctgaaacag 5281 atggtcaact atcaccagat gatgaagcaa acccaggaag agcgccgcca tataatgttt 5341 aatggggaga aggccaatcc ggcctccacc tcatcggcgg cagcagctcc ctccacctcc 5401 tcctcatcgt cctcatccgg ggataatatc tgtgccaatg cccgtcgccg ggccaccgaa 5461 tgctgggcaa ccaagctgca gaataagcgt ccacgttaca atgatcccgg taccacgggc 5521 acaattaacg ccgcatcgtc cacagcatca gccgccacat cttcgttagc ctcccaggcg 5581 acacatctgc gtaatcctct caagacggcc gcgttggcca atgcacgtat gttaggcgcc 5641 aaggtgacaa catgcacacg caacagcata atcgtgcagc agccgcaacg tatccaaatg 5701 cagcagcagc agcaacagct gcaaccgcag cagcaacaga ccagcttctc gcccagcgaa 5761 ttcgatgttg atgacttgat cgaggaggag gagaacaacg aattggatat gcccttctaa 5821 gctagcgctg cccgtgccaa aaaaaaattt caactaaaat ggttcaaatc gatgatgaaa 5881 cactacaaca ctaaacacgc cacactcaca aatagccacg agcttctttt cgaatttgtt 5941 ggttattcgt tcaagtcatt tttcatcaca tttattttcg tgtgcttgcc gcatttaaac 6001 taaactcgag aaagcctgga caccgaagcg aaaagcaccc acagcgaagc aacaacaaca 6061 aacaacaaac aaaacaccgc agcaacaaca aaatcaagag ccaaatattt aaaatataag 6121 atttacgttt aaactacttt gtaagttaag cgagcacacc agaaacaaac aagcagagat 6181 agcgaataga tgatttcgat cccgaagtat cccagaaacc tcaataacat ctagatggta 6241 agcaagggag cttaccacac ggtaaacata agtttagact taaagaaaat acgtatgcga 6301 cagcgtttta cgtatataac cgaaatctgt ggatagcctg gatgagtcac catcaatcat 6361 cgcaattgca atcaattgtg gtgaaagtaa gagaacacac atgtagaact aatcaccagg 6421 acaggaagag gacgatacga gcaaggtgcc caggcggatc ggatctcgca gcttcctatc 6481 ttattttaaa tttttttttg aagctgaact ccaattcagt tctggccaag caaactacaa 6541 ttctcaagta aaaatccgtg gagaggaggt ggggccagag aaaagcccac taggatagtt 6601 atcaattatc tgaagaacaa ctgattaatt tcttgtatat tcataggaaa ttttttttgt 6661 tttcgctata agtcctacat aataaatgct atacataagt gctgcgtgtg ggcgcataac 6721 aaacgaaacg aaatgcgttt gaatgcgatt ataatattaa tattattatg catatataca 6781 acacacacaa atacctatat ctggtcactt ctaaccaatt ataaacaaaa ctggaaaagc