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LOCUS NM_001272400 7034 bp mRNA linear INV 26-DEC-2023 (Trf2), transcript variant I, mRNA. ACCESSION NM_001272400 VERSION NM_001272400.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 7034) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 7034) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 7034) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 7034) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 7034) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 7034) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 7034) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 7034) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 7034) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 7034) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 7034) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 7034) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 7034) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 7034) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 7034) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 7034) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 7034) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 7034) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 7034) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 7034) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 7034) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 7034) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 7034) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..7034 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..7034 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="TATA box binding protein-related factor 2" /map="7E7-7E9" /db_xref="FLYBASE:FBgn0261793" /db_xref="GeneID:31773" CDS 936..6080 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="CG18009 gene product from transcript CG18009-RI; CG18009-PI; Trf2-PI; lethal (1) G0295; lethal (1) G0425; TBP-related factor 2; lethal (1) G0039; TBP related factor 2; lethal (1) G0071; TATA box-binding protein related factor 2; TBP-like factor" /codon_start=1 /product="TATA box binding protein-related factor 2, isoform I" /protein_id="NP_001259329.1" /db_xref="FLYBASE:FBpp0305892" /db_xref="GeneID:31773" /db_xref="FLYBASE:FBgn0261793" /translation="MGSAVKKGDGSPTRILEEYQVARDLRNEDLFPEHPVEHPDEDSD KENQSPNQSPNPRAIGDCEQGPDIGKDTLNPNEADQFSSEEVEKNEANSSCNESGGDA RNSRDRLSSSHSEDEQLNQEYSTSSSGSTIGNREQGSDVGKDTSSRNEADQFSNEEVE KNEANSSGNESYGDACNSNRLSSSNSEDEQLHQEYSTSSRGRTREYAQSDLNPGYQDL NIGNQDLNQVNREYQESNNEYQVSNQEYQHLNTEYQELNHGDQDSNDEYQELNHGNQD SNDEYQESNHGNQDSNDEYQELNHSNQDSNDEYQELNHGDQDSSDEYQDLNHVNQDSN HEYQAWNHEYQDSNHEYQALNREYQYPESDEEEAARKRNIYTRLRSYACQVHLPRLGE SEVDSDDRRHNPINQPFNQPINRPNQKSDSSLESSSPERQDSESESRQASDEESSSGD SDYLIDPVTGWLSRRRETSTEREEKSDQSQQESSEEITDEQKEESDDVEQQSPAEHTS SDRRDHSPDKQQNKRKSLGTGNSSYSKKPLLDGDKGDPRSHLSSLGSRRSLKRKWPFD CTDSKKFKPNLQSEEDKSEEEKREDTESECSDEEDSDSSSFDTDSNSDSDSNLDLDSD SDSHSDFESSSSSEESAQDPAPEGETDQDPAPEGEADQDPAPEGGVDQDPAPEGGVDQ DPAPEGEVDQDPAPEGESDQDLAPEGGVDQDPAPEFGTDQDPHPYYNDQDPAPYYDDQ DPASYYDDHICDSEEDYKPFIFSKERKFLKFVTNPLGDDKSSLDLSIQLYKVFGAYKL EDVYSSIDEEGQPEQDLQLKQQQKHLKKYQKLQLVVFWHQEKFFSKEQLLLYEYLKLL LQKFFPQEQQEKRLQQEKLLQQEKLLQQEKRLQQEKRLQQEKRLQQEKRLQQEKRLQQ QKLLQQQKLLQQEKLLQQQKLLQQEKLLQQEKLLQQEKQLQQEKHLPQERQLQQDKVF LQLRQLQQKKELEEQRERKRHLFEQQKQFVLEKLRQQKEQHRRQQNRVKRERKLRQKK EKQRLEYERFLKEYREDCKRQLRLQREHYLIKIKQLEKASQRSLKGNRKHKLMQNDMV SIPVANLNGGLKAASSGSGVGVVTSGGVVSSAVLANAPRVYLTPSSTFMTNRQMAGVA STGRMSGQVVGGSSGTASTAGTVRYFSQFSKMQTAGGPSLQRKLANGDTIVLATGSKN MFLTSSENKANLPTVASNGNGLITAKMDLLEEEVMQSITVIDDDDEEKKEVAEDEEES SNNAKPIDLHQPIADNEHELDIVINNVVCSFSVGCHLKLREIALQGSNVEYRRENGMV TMKLRHPYTTASIWSSGRITCTGATSESMAKVAARRYARCLGKLGFPTRFLNFRIVNV LGTCSMPWAIKIVNFSERHRENASYEPELHPGVTYKMRDPDPKATLKIFSTGSVTVTA ASVNHVESAIQHIYPLVFDFRKQRSAEELQHLRQKQRLQAGGDPHELEKNVLADNKTA SLDNIFVNTTAAHSKSSSNDQTSAPATILSSTVDSMPRLKQMVNYHQMMKQTQEERRH IMFNGEKANPASTSSAAAAPSTSSSSSSSGDNICANARRRATECWATKLQNKRPRYND PGTTGTINAASSTASAATSSLASQATHLRNPLKTAALANARMLGAKVTTCTRNSIIVQ QPQRIQMQQQQQQLQPQQQQTSFSPSEFDVDDLIEEEENNELDMPF" misc_feature <1335..2042 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="MSCRAMM family adhesin clumping factor ClfA; Region: MSCRAMM_ClfA; NF033609" /db_xref="CDD:468110" misc_feature <2862..3128 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="hypothetical E4 protein; Provisional; Region: PHA03418" /db_xref="CDD:177646" misc_feature <3603..>4196 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="Family of unknown function (DUF5401); Region: DUF5401; pfam17380" /db_xref="CDD:375164" misc_feature 4779..5300 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the...; Region: TLF; cd04517" /db_xref="CDD:239953" misc_feature order(4794..4799,4803..4805,4881..4886,4896..4898, 4902..4904,4923..4925,4929..4931,4941..4943,4947..4949, 4953..4955,4959..4961,5049..5051,5064..5066,5070..5072, 5157..5162,5175..5177,5214..5216,5220..5222,5226..5228, 5238..5240) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative DNA interaction surface [nucleotide binding]; other site" /db_xref="CDD:239953" misc_feature order(4839..4841,4860..4868,4872..4874,4884..4886, 4902..4904,4908..4910) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative TFIIA interaction surface [polypeptide binding]; other site" /db_xref="CDD:239953" misc_feature order(5100..5105,5139..5153,5160..5162,5175..5177) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative TFIIB interaction surface [polypeptide binding]; other site" /db_xref="CDD:239953" ORIGIN 1 gctcaaagtg aaacggccaa acgaagaaga cgtatcgtgt gtgctcagac ttgtgctctc 61 aaaatttttg agttttaact aaaaaagatc acaagccaaa aaaaaaaaaa acaaagagaa 121 acctaaagaa atatcaacca aaagtgtgca aaatccaaaa gattctacaa tccgaatcga 181 aaacaaaaac ataagaacca caaaagcagc agcagaaaga gacacagaga gcagcgaaaa 241 cttaactgcg aattcagcgg ctgaagcaaa gcagcggagc ccaagtgcaa gcgagacggc 301 agcagagctc cgctgcaagg caacgggata gaaagagaga taaatagaga gacagcgcag 361 cagcgatata gagtgagagc aggcgggaga gcgagtagcg gcagcgacag caacacagcc 421 acaaaagaga tcgtgagagg gagggagagc tagacgacga cctactacac aaaaaaaggc 481 tctgtggtcg cgattaccag cgtctacgac aagctagaaa acaaaaaaaa gaaaaaatca 541 ttcaaataat taagactgct aaacggaaca actaaaaact acaagcaaat ttaaccagga 601 gaaaagaacg gaagactaga cataatcata aacatagtag atagaattag agaaccagca 661 aacccaacaa ctagaacact aagaaaacat taattctaat acaaaatcac acataaaaaa 721 gtattttttg gccttaagtg caaacatact cacatacaaa cacatacata cacatccaca 781 tgaacgaaac aatggaaaga atgtaataca acaccaagga agaatcacct ttagccttat 841 atacaattaa atataattaa gaagctagca agaaaacgca gagcaagagt cctatcaaga 901 aacccaaaaa gataacaaga aatatttttt taacgatggg cagtgccgtc aaaaaggggg 961 atggttcccc gactcgaata cttgaagaat accaagtagc tagagactta aggaacgagg 1021 atttgtttcc ggaacatccg gttgaacatc cggacgaaga ttcggataag gagaaccaat 1081 cgccgaatca atcccccaat ccaagagcca tcggtgattg tgagcaagga cctgacattg 1141 gtaaagatac tctaaatccc aacgaagctg accagttttc gagcgaagaa gttgagaaga 1201 acgaagccaa cagcagctgt aacgagtcgg gcggggatgc tcgcaattct agagatcgtt 1261 taagttcctc tcatagcgag gacgaacagc ttaaccaaga atattcaact tcatcaagcg 1321 gaagcaccat cggaaatcgt gagcaaggct ctgacgttgg taaagatact tcaagtcgca 1381 acgaagctga ccagttttcg aacgaagaag ttgagaagaa cgaagccaac agcagcggta 1441 acgagtcgta cggggatgcc tgcaattcta atcgcttaag ttcttctaat agcgaggacg 1501 aacagctgca ccaagaatat tcaacttcat caagaggaag aacaagggaa tatgcacaat 1561 ctgacttgaa tcccgggtac caggacttga atatcggtaa ccaggacttg aatcaagtta 1621 atcgcgagta ccaggagtct aataacgagt accaggtttc aaaccaagag taccagcact 1681 tgaataccga gtaccaggag ttgaatcacg gcgatcagga ctcaaatgac gagtaccagg 1741 agttgaatca cggcaaccag gactcaaatg acgagtacca ggaatcaaat cacggcaacc 1801 aggactcaaa tgacgagtac caggagttga atcacagcaa ccaggactca aatgacgagt 1861 accaggagtt gaatcacggc gatcaggact caagtgacga gtaccaggat ttgaatcacg 1921 tcaaccaaga ctcaaatcac gagtaccagg cttggaatca cgaataccag gactcaaatc 1981 acgagtatca ggccttgaat cgagagtacc aatatcctga atctgatgag gaagaggccg 2041 ctagaaaaag aaacatatat acccgtttac gatcctacgc ttgtcaggta catctccctc 2101 gtttaggaga atcagaagtt gatagcgacg atcgtcgcca taacccaatc aatcagccat 2161 tcaatcagcc aatcaatagg ccaaatcaaa aatcggattc atctttagag tcatcttcgc 2221 cggagagaca agactctgaa agcgagtcgc gacaagcttc agatgaggaa tcgtcttctg 2281 gggactcgga ctacttaatc gatccagtta ctgggtggct atcgcgccgg cgagaaactt 2341 ctaccgaacg cgaggaaaaa agcgaccaaa gccaacagga gtcgtcagag gaaattacag 2401 acgaacagaa ggaagaaagc gacgacgtcg aacaacagtc gccggctgaa catacttctt 2461 ctgatagacg cgatcattcg ccagacaagc aacagaataa gcgaaaatcg ttaggcactg 2521 ggaattcttc gtattcgaag aaaccattat tggacggtga caaaggagac ccacgttcac 2581 atttatcgtc tctgggaagt cgcagatcct taaagcgtaa atggcctttt gattgtacag 2641 actctaagaa atttaaacca aacttgcaga gtgaggaaga caaatctgag gaggaaaaac 2701 gtgaagatac ggaaagcgaa tgctctgacg aagaagactc agatagttca agtttcgata 2761 cagattcaaa ttcagattca gattcaaatt tagatttaga ttccgattcc gattcccatt 2821 ccgatttcga atcatcttca agttctgagg aatctgccca ggatccagct cctgaaggcg 2881 aaaccgatca agatccagct cctgaaggcg aagccgatca agatccagct cctgaaggcg 2941 gagtcgatca agatccagct cctgaaggcg gagtcgatca agatccagct cctgaaggcg 3001 aagtcgatca agatccagct cctgaaggcg aatccgatca agatctagct cctgaaggcg 3061 gagtcgatca agatccagct cctgaattcg gaaccgatca agatccacat ccttattaca 3121 acgatcagga tccagctcct tattacgacg atcaggatcc agcttcttat tacgacgatc 3181 acatttgtga ttctgaggag gattataaac catttatctt ctcaaaggaa aggaagttct 3241 tgaaattcgt aacaaatcct ttaggggatg ataaatctag tttggacctt agcatacagc 3301 tctataaggt atttggagct tacaaactgg aagacgtata cagcagtatt gatgaggaag 3361 gccaaccaga acaggacctg caactgaagc agcaacagaa acatttaaaa aaatatcaaa 3421 agttgcaact ggtggtattc tggcaccagg agaaattctt ttcaaaggag caactgttgc 3481 tatatgagta tctgaaacta cttttgcaga aattctttcc acaagagcaa caggagaaac 3541 ggttgcaaca ggagaaactt ttgcaacagg agaaactctt gcaacaggag aaacggttgc 3601 aacaggagaa acggttgcaa caggagaaac ggttgcaaca ggagaaacgg ttgcaacagg 3661 agaaacggtt gcaacagcag aaactcttgc aacagcagaa actcttgcaa caggagaaac 3721 tcttgcaaca gcagaaactc ttgcaacagg agaaactctt gcaacaggag aaactcttgc 3781 aacaggagaa acaattgcaa caggagaaac acttgccaca ggagcgacag ttgcaacagg 3841 ataaagtctt cctacagcta cgacagttgc aacagaagaa agaactggag gagcagcgag 3901 agcgaaagcg ccacctcttt gagcaacaga aacagtttgt cctagaaaaa ttgcgccaac 3961 agaaggagca gcatcgtcgt cagcaaaatc gcgtaaaacg cgaacgtaaa ttgcgccaga 4021 aaaaggagaa acagcgcttg gaatacgaac gattcttgaa ggaatatagg gaggactgta 4081 aacgtcagtt gcgtttgcag cgcgagcatt atctgatcaa gattaagcag ctggagaagg 4141 ccagtcagcg ctcgttgaag gggaatcgaa agcacaagct gatgcaaaac gatatggtca 4201 gcataccggt ggccaatttg aacggcggcc ttaaagcggc cagcagcggt tccggagttg 4261 gtgtagtgac ctccggcggc gtcgtatcct cggcggtgct ggccaatgcc ccacgtgtat 4321 acctaacgcc ctcctccaca ttcatgacca atcgccaaat ggcgggagtg gcgtccaccg 4381 gaagaatgag cggacaagtc gtcggtggtt catctggcac agcctcaaca gccggtaccg 4441 ttcgctattt ttcgcaattc agcaaaatgc aaacggccgg cggacccagt ttgcaaagga 4501 aacttgccaa cggggatacc attgttctgg caaccggcag taaaaatatg ttccttacta 4561 gcagcgaaaa taaggctaat ctgccgaccg tcgccagcaa tggcaatggt ctgatcacag 4621 ccaaaatgga tctattggag gaggaggtca tgcagtcgat aactgtgatt gatgacgatg 4681 acgaggagaa aaaggaagtc gctgaagacg aagaagagag cagcaataat gccaaaccca 4741 ttgaccttca ccagccaatt gctgataatg agcacgagct ggacattgtg ataaacaatg 4801 tggtctgctc gtttagcgtc ggctgtcacc tgaagctgcg cgaaattgcg ctgcagggat 4861 caaatgtgga gtaccgtcgc gagaacggaa tggtgacaat gaagctccgc catccataca 4921 ccactgcctc gatttggtcg tcggggagga ttacctgcac tggtgccact tccgagtcaa 4981 tggccaaggt cgctgcacgc cgctatgcca gatgccttgg caagctggga tttcccactc 5041 gtttcctcaa ctttcgcatt gtcaacgtac tgggcacctg cagcatgccg tgggccatca 5101 agatcgtcaa cttttcggag cgccatcgcg agaacgccag ctacgagccc gagctgcatc 5161 ctggagtgac ttacaagatg cgcgatcccg atccaaaggc caccctgaag atcttctcca 5221 ccggcagcgt aacagtcacc gcggctagcg taaaccacgt tgaatcggct atccagcaca 5281 tatacccgct ggtctttgat ttccgcaagc aacgttcggc ggaggagctg cagcatctgc 5341 gtcaaaagca gcgtctgcaa gccggcggtg atccccacga actggagaaa aatgtcttgg 5401 ccgataacaa gactgcttcc cttgataata tctttgttaa tacaacagcg gcgcactcta 5461 aatcatcgtc gaatgaccaa acatcagcac ccgcgaccat cttgtccagc acagttgata 5521 gtatgcctcg tctgaaacag atggtcaact atcaccagat gatgaagcaa acccaggaag 5581 agcgccgcca tataatgttt aatggggaga aggccaatcc ggcctccacc tcatcggcgg 5641 cagcagctcc ctccacctcc tcctcatcgt cctcatccgg ggataatatc tgtgccaatg 5701 cccgtcgccg ggccaccgaa tgctgggcaa ccaagctgca gaataagcgt ccacgttaca 5761 atgatcccgg taccacgggc acaattaacg ccgcatcgtc cacagcatca gccgccacat 5821 cttcgttagc ctcccaggcg acacatctgc gtaatcctct caagacggcc gcgttggcca 5881 atgcacgtat gttaggcgcc aaggtgacaa catgcacacg caacagcata atcgtgcagc 5941 agccgcaacg tatccaaatg cagcagcagc agcaacagct gcaaccgcag cagcaacaga 6001 ccagcttctc gcccagcgaa ttcgatgttg atgacttgat cgaggaggag gagaacaacg 6061 aattggatat gcccttctaa gctagcgctg cccgtgccaa aaaaaaattt caactaaaat 6121 ggttcaaatc gatgatgaaa cactacaaca ctaaacacgc cacactcaca aatagccacg 6181 agcttctttt cgaatttgtt ggttattcgt tcaagtcatt tttcatcaca tttattttcg 6241 tgtgcttgcc gcatttaaac taaactcgag aaagcctgga caccgaagcg aaaagcaccc 6301 acagcgaagc aacaacaaca aacaacaaac aaaacaccgc agcaacaaca aaatcaagag 6361 ccaaatattt aaaatataag atttacgttt aaactacttt gtaagttaag cgagcacacc 6421 agaaacaaac aagcagagat agcgaataga tgatttcgat cccgaagtat cccagaaacc 6481 tcaataacat ctagatgcgt tttacgtata taaccgaaat ctgtggatag cctggatgag 6541 tcaccatcaa tcatcgcaat tgcaatcaat tgtggtgaaa gtaagagaac acacatgtag 6601 aactaatcac caggacagga agaggacgat acgagcaagg tgcccaggcg gatcggatct 6661 cgcagcttcc tatcttattt taaatttttt tttgaagctg aactccaatt cagttctggc 6721 caagcaaact acaattctca agtaaaaatc cgtggagagg aggtggggcc agagaaaagc 6781 ccactaggat agttatcaat tatctgaaga acaactgatt aatttcttgt atattcatag 6841 gaaatttttt ttgttttcgc tataagtcct acataataaa tgctatacat aagtgctgcg 6901 tgtgggcgca taacaaacga aacgaaatgc gtttgaatgc gattataata ttaatattat 6961 tatgcatata tacaacacac acaaatacct atatctggtc acttctaacc aattataaac 7021 aaaactggaa aagc