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LOCUS NM_001272388 9371 bp mRNA linear INV 26-DEC-2023 variant B, mRNA. ACCESSION NM_001272388 VERSION NM_001272388.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 9371) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 9371) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 9371) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 9371) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 9371) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 9371) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 9371) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 9371) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 9371) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 9371) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 9371) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 9371) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 9371) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 9371) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 9371) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 9371) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 9371) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 9371) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 9371) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 9371) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 9371) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 9371) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 9371) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..9371 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..9371 /gene="Ubr3" /locus_tag="Dmel_CG42593" /old_locus_tag="Dmel_CG1530" /old_locus_tag="Dmel_CG1531" /gene_synonym="CG1530; CG1531; CG42593; Dmel\CG42593; ubr3; UBR3" /note="Ubr3 ubiquitin ligase" /map="7C8-7D1" /db_xref="FLYBASE:FBgn0260970" /db_xref="GeneID:31713" CDS 1074..7784 /gene="Ubr3" /locus_tag="Dmel_CG42593" /old_locus_tag="Dmel_CG1530" /old_locus_tag="Dmel_CG1531" /gene_synonym="CG1530; CG1531; CG42593; Dmel\CG42593; ubr3; UBR3" /note="CG42593 gene product from transcript CG42593-RB; CG42593-PB; Ubr3-PB" /codon_start=1 /transl_except=(pos:7731..7733,aa:OTHER) /product="Ubr3 ubiquitin ligase, isoform B" /protein_id="NP_001259317.1" /db_xref="FLYBASE:FBpp0303730" /db_xref="GeneID:31713" /db_xref="FLYBASE:FBgn0260970" /translation="MDEDDNLSNADISIDDEEVVREQTHHPPMQEDQELDNEDGSSDV DLSSVYVVPPIVSAPSPASVRIAGGSTIGGGGVAAGAVPTTTDNSHSPFHDWDSSVAA AAAPPPPPPRTGPTTTTSSGTAAESGAASALSDDAGAKPSFFFGASSFSLRSRKEVAA LINTECCRGSPTPDLDSIMDTLFNPGTPIDNLDNIEWIRWLIAGGRTPQEFVKIVRSY DNHAKCGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQAGGACDC GDTSVMKAEGFCSDHGINNRVNRDPVPNNLLAVAEAIMPKLLFRLLQHFREHSDTPLE VQAITSYSCEEFANMLIDLNNMGEIMRKVMTRTLINPEVYAFFMEAPCQDTRNGRFLK ANREKYEDAVNRFPNPEPPDEYRDLPALGDKLVHTTLLEEFIFWTFKFEFPQTLVCFL LNMLPDQDYKEHLTRTFVMHYSRIPSVLEMSRDPDTLSNRVVHMSVQLFSNESLALKM VNELSLLHVMIISLKLMMSKILIQNTLHDPNKNFHFVIDCTRQVMKDHCYWPLVSDFN NVLSHESVALVFLRDDNLIDMWFQFLQMLQGMNVNVRETASHVEFEPNSYYAAFSCEL EASAYPMWSIISHLQDGTHAHLAKKIINYCVTTLHEWLDSIYFMEARLSMEEMMQASF HFPLHRYLAAFVCQAVTKMGISLNDVLPSRPYLLPLLMIHPLRVQSFFYEILAGKWVR NGLQIKGQAMTYIQANFCNSMADMDLFFLQICATNLPQYFFLQNTIELFDVGQWLETA PLKQPQKAEQSSMLEGFLTFLATLVTSRTNLGNDEATQCIIEISALLATENKTHSQLL ELMPERSGNVHTKNFETFLKKLSVYKAPSSGSENLEQGLFTPIDEVWEKHYDPLHVLL RAVHRRDFQSSLDRFTNYVKSKDKMPASGNLWPPFRLPHALPATSSFSDPCKILNSRI FHSTILSIFFRAVHTRDVSEHLLALAVFLLEIAVETSDDVGSGTGDRAPPALAAVVES SSGPGYHGYGTGRHEPPKLFHCYPTDNLSCNLRHVVKKVSLKSRDPQVITSSYRSNPF YSDLDFEVEADPEQSMRMIGQGDPEGDEATGGAGLGMGAHSRRNVSQALVPMRVPGME VALPPDLSVVAETGVVIRQDSNEDDLLREGNHAMDMSPPAALDFHFPLQQITLPESGM EVAIRRDLLLAETNNMGAIAGGAGGGANASATPPAGASNEMFSPTTPTGSGMLLPFQR VQPVAVPSSGNMDIVPSNAMGAGGSFTSGVSGSGTGRRMNYETGGARKRSVDIAIGGS NKDELHLDESILSLLLKLHSQLSGTLDSFSLSDGEDQSSDDDSTMDVDCNEASTSMAA AESTALAERGRSKRNYKNIHVSSSRIGDGPFFIGNLLRKIAKQDEQCAQSIDDIRARL WPNQREKQAEAKAREAKEKEERRKKARERQQKMMQDFANKQKLFMQSAAASSSGMGYG PEDEDDEELYEEQPREKEYDCIICNCTTPSTESNPIGLVVLVESSGIVGHRRRIAERL PLPINAEDESRLAHTTRLAAEFNRRTELLSLKFGDESWYLSNNMAYDNGVHVQSCGHH VHLSCLEAYLKTLYTTQRQPVQDRGEFYCPVCRQLSNSVLPLSPQLDRPTHLVRSGNQ PFERLVADLTDLIKENETIPQPTKLTEAMGHAMEVMTNIAQRKVKCSSITFRKLFIFV TSIARTNLEAEIIQRGGSLCTANATRYKPKRECIVPLLHVLSVHVRVLVEWPLWSSWA SLAGLPVTATEPLPAHCLELIPSILADPIALLLKFILLAPLQLDQDYFTCMVKVMYNL LYYQIVVQLCVTLTDLECDHIVKVYGSTSVGSDNSAAESQQQESAAGTTNNRRRAGQQ QQSSSQLGKAMALVLSQTNDLVHLRRDCIPSTSSSAAASAAGSSSTTSTNHGASAATA SSATTIEVNLKSMELQLQALCLPFLRVAALLRQHLYRHEMPEISAPGLEFVRLVYYLE LVTDSMDWDCFNASKGLCFIPGTETTLPQFWCQQLMEVRPPADTVRELVLINQHSLWQ QPRLLELPREYERLFTYYHERPCLNCYKVPKESSICLLCGTIVCLKQNCCAENDCCEA VRHTLSCGGGIGIFLVVTSTYIIVIRGRRACLWGSLYLDDFDEEDRDLKRGKPLYLSK DRFNLLESQWLSHKFAHTKHTWVFHRDLLXNMEDLLRSIQELVGQI" misc_feature 1743..1949 /gene="Ubr3" /locus_tag="Dmel_CG42593" /old_locus_tag="Dmel_CG1530" /old_locus_tag="Dmel_CG1531" /gene_synonym="CG1530; CG1531; CG42593; Dmel\CG42593; ubr3; UBR3" /note="UBR-box found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins; Region: UBR-box_UBR3; cd19673" /db_xref="CDD:439071" misc_feature order(1743..1745,1791..1793,1818..1820,1827..1829, 1845..1847,1893..1895,1899..1901,1935..1937) /gene="Ubr3" /locus_tag="Dmel_CG42593" /gene_synonym="CG1530; CG1531; CG42593; Dmel\CG42593; ubr3; UBR3" /note="Zn binding site [ion binding]; other site" /db_xref="CDD:439071" misc_feature <5301..5504 /gene="Ubr3" /locus_tag="Dmel_CG42593" /old_locus_tag="Dmel_CG1530" /old_locus_tag="Dmel_CG1531" /gene_synonym="CG1530; CG1531; CG42593; Dmel\CG42593; ubr3; UBR3" /note="Flagellar FliJ protein; Region: FliJ; pfam02050" /db_xref="CDD:426581" misc_feature 5874..6026 /gene="Ubr3" /locus_tag="Dmel_CG42593" /old_locus_tag="Dmel_CG1530" /old_locus_tag="Dmel_CG1531" /gene_synonym="CG1530; CG1531; CG42593; Dmel\CG42593; ubr3; UBR3" /note="RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins; Region: RING-H2_UBR3; cd16483" /db_xref="CDD:438146" misc_feature 6237..7679 /gene="Ubr3" /locus_tag="Dmel_CG42593" /old_locus_tag="Dmel_CG1530" /old_locus_tag="Dmel_CG1531" /gene_synonym="CG1530; CG1531; CG42593; Dmel\CG42593; ubr3; UBR3" /note="Proteolysis_6 C-terminal; Region: PRT6_C; pfam18995" /db_xref="CDD:465944" ORIGIN 1 caggtgtaga gcggtcacac tggatgaaat tcaagaccta tcgatatcct gatatacacg 61 ccaacgaaga ccgtgtgtgg attcgtggag caaatcgaag ttggcaggat taaaggcatt 121 cgcgaacgca gaggcagcag ctaaagggcc acccatgcac caaagaaaca aactagctgg 181 cccagcggtt catttatctg cgactaacaa gctaaaatcg gcgtaattgg caagttcaat 241 gcacgactaa tatatttggc cacacttgcc agtgtatgtt tgttcgtgtg cgtgcctgtt 301 tgtgtggtgt cgtctccgta cgtgtttgtg tgtgtgtccg cgacgagtat gtgtgcgcac 361 atattcgtat atctgcaaga ctcgcggatg aaacagcgtg aaaagtgagc aaaatatcgg 421 ggaaaaacgg cacggtacgg ccacagaacg gaacggtacg gtgcgatacg atatcgagaa 481 aaggccatca gccagagtac tcctcgatcc ggaaacggat aatggggata tagatgatac 541 agccaatagc tccccgaaag ccacagcaca caataggtcg gtcggtcggt cggttggttg 601 ggcgacgtcg ccgagagtta aacatcaaaa atcaaaccca ggaaccgacg gagctaagtg 661 tcaagtgttt ggtgttgtga aatttttcgt ttccagctct ccgttcagcg ttcagccaat 721 ttgccaacct tttcccctct ttaatttgtt atccccggac accacaagag tttcgatcaa 781 aattttcaat tgaacgcaac atcgccataa acaaaaacat aaaggtaaaa ttcggccact 841 acccaaacaa caaaaaaata aaatcataag aaaaaatcac gcagtaacgt agaagaagca 901 gcagccgaag ccgaaaaaag acgaaaagaa aacttgtttg aaaaggccga accgaaagaa 961 gaaaaagagc agcagcagca gcacagcggc caagtttgga agaatttcag aatttcagcg 1021 tgctaggaac ggagcagcgg accggcgacg tcaccaaata aacgcccatc accatggacg 1081 aggatgacaa cctgtccaat gccgacataa gcatagatga cgaggaggtg gtgcgggagc 1141 agacccacca tccgcccatg caagaggatc aggagctgga taacgaagat gggtcatccg 1201 acgtggatct gtcttcggtg tacgtcgtgc cacccatagt ctcggcacca tcgcccgcat 1261 cagtgcgcat cgctggtgga tccacaattg gtggcggagg ggtcgcagct ggagcagttc 1321 caacaaccac cgataactcg cattccccct tccacgattg ggattccagt gtggcggccg 1381 ctgctgctcc accgccgcca ccgcccagga caggaccaac tacaactaca agctccggca 1441 cagccgcgga atcgggagcc gcgtccgcct tatccgacga tgccggcgcc aagccaagtt 1501 tcttctttgg cgcctcctcg ttcagtttgc gcagccgcaa ggaggtggcc gccctgatca 1561 acacggaatg ctgccgtggc agccccacac ccgatctcga ctccataatg gataccctat 1621 tcaatccggg gacgcccatc gacaatctgg acaacatcga gtggatacga tggctcattg 1681 ccggcggacg gacgccgcag gagtttgtta aaattgtgcg cagctatgac aaccacgcca 1741 aatgcggtct ggtatgggta ccgcatgtgg tggcctacag gtgccgcact tgcggcatat 1801 cgccctgcat gtccatatgc cgggactgct tcaagaaggg caaccacacg aaccacgact 1861 tcaatatgtt cctgtcacag gcgggcggtg cctgcgattg tggtgacacc tcggtcatga 1921 aggcggaggg tttttgcagt gatcatggca tcaataatcg ggtgaatcgc gatccggtgc 1981 caaacaatct tttggcagtg gccgaggcca taatgcccaa gctgctcttc cgcctgctgc 2041 agcacttccg tgagcacagc gacaccccac tggaggtgca agcgataacg tcgtactcct 2101 gcgaggagtt cgccaacatg ctgatcgatc tgaacaacat gggcgaaata atgcgcaaag 2161 tgatgacgcg cacgctgata aatccggagg tgtatgcctt cttcatggaa gcaccgtgcc 2221 aggacacccg gaatggacgc ttcttgaagg cgaaccgaga gaagtacgag gatgccgtca 2281 atagattccc aaacccagag ccacccgatg agtacagaga tctgcccgcg ctgggcgaca 2341 aattggtcca caccacgcta ctcgaagagt tcatcttctg gacatttaag ttcgagtttc 2401 cacagactct ggtctgcttt ctgctgaaca tgctgcctga tcaggattac aaggaacacc 2461 tcacccgcac atttgtgatg cactacagcc gcataccgtc cgtgttggaa atgtcccgtg 2521 atccggacac gctcagcaac cgggtggtcc acatgagcgt ccaactcttc tctaacgaaa 2581 gtctggccct caagatggtc aacgagctgt cgctgctgca cgtaatgatt attagtctga 2641 agctaatgat gtccaagata ctcatacaga atacattgca tgatcccaac aagaattttc 2701 atttcgtcat cgactgcacg cgtcaggtga tgaaggacca ctgctactgg ccactagtct 2761 cggactttaa caacgtcctt tcacacgaat cggtggccct ggtctttctg cgggacgaca 2821 atctcatcga tatgtggttc cagtttctcc agatgctcca gggcatgaat gtcaatgtgc 2881 gcgagacggc ttctcatgtg gaattcgagc caaatagcta ctatgcggcg ttctcctgtg 2941 agcttgaggc cagtgcctat cccatgtggt cgattatctc gcatctgcag gatggcacac 3001 atgcccatct ggcaaagaag atcatcaact actgtgtgac gacgctgcac gagtggctag 3061 actctattta ctttatggag gcgcgtctat ctatggagga gatgatgcag gcttcgttcc 3121 actttcccct gcatcgttat ctggctgcct ttgtttgcca ggcggtaact aaaatgggaa 3181 tcagtctgaa cgatgtgctg ccctcacgcc cctatctgct gcccctgctg atgatccatc 3241 cacttcgcgt ccagagtttt ttctacgaga tcctggccgg aaaatgggtg cgcaatggtc 3301 tccaaatcaa gggacaagcg atgacctata tccaggcgaa cttctgcaac tcgatggccg 3361 acatggacct gttcttcctg caaatctgtg ccaccaacct gccgcagtac ttctttctgc 3421 agaacaccat cgagttgttc gacgtaggtc aatggctgga gacagctccc ttgaagcagc 3481 ctcaaaaggc ggagcaatcc tcgatgctgg agggattcct aaccttcttg gccaccctgg 3541 tgacgagtcg cactaatctg ggaaacgatg aagccaccca atgcattatt gagatcagtg 3601 ccttgttggc taccgagaac aagacgcatt cgcagctcct tgaactaatg ccggagcggt 3661 cgggcaatgt gcataccaaa aactttgaga ccttccttaa gaagctatcg gtttacaagg 3721 ctccgtcgag tgggagcgag aacctggagc agggtctctt cacgcccatc gacgaggtgt 3781 gggagaagca ctacgatccg ctgcacgtcc ttttgcgagc agttcatcgt cgagactttc 3841 aatcatcgct ggaccgcttt acaaactatg tgaagagcaa ggataagatg ccggcaagtg 3901 gtaacctatg gccacccttc cgattgcctc atgctctgcc cgcaacgagc tccttcagtg 3961 atccctgcaa gattttgaac tcgcgcatct ttcactccac catcctgtcg atatttttcc 4021 gtgcagttca cacacgtgat gtttccgagc atctgctggc tctggctgtg ttcctcttag 4081 agattgctgt ggaaacaagt gatgatgttg gcagtggaac tggagatcgg gcccctcctg 4141 cgctggctgc tgtggtggag tcatctagcg ggccgggcta tcatggctac ggcacgggac 4201 ggcatgagcc gcccaagctt ttccactgct atcccacgga caatctaagc tgcaatctgc 4261 gccacgtggt caagaaagtg tcgctgaagt cacgcgatcc gcaagtgatc acctccagct 4321 atcggtcgaa cccattttac tcagatctgg actttgaggt tgaagcggat ccagagcaat 4381 cgatgcgcat gattggtcaa ggggaccccg aaggagatga ggcaacgggt ggagctggac 4441 tgggaatggg agctcatagc agaaggaatg tctctcaggc gctggtgccg atgagagtgc 4501 ccggcatgga ggtcgcccta ccaccggatc tttcagtagt tgccgaaacc ggtgtggtta 4561 tccgccagga tagcaacgaa gatgatctac tgagagaagg caatcatgcc atggatatga 4621 gtccaccggc tgctctcgat ttccactttc cgctgcagca gatcactttg ccggagagcg 4681 gaatggaggt ggctattcgg agagatcttc tgctagccga aacgaataat atgggcgcaa 4741 ttgcaggtgg agctggaggt ggcgccaatg catcggccac accaccagca ggggcttcca 4801 atgagatgtt ctcgcctacc acacccacag gcagcggtat gctcctgcct ttccagcggg 4861 ttcagcctgt agccgtaccc agtagcggta atatggatat tgtaccatca aatgccatgg 4921 gtgccggcgg aagtttcaca tccggcgtaa gtggtagcgg cactggacgt agaatgaact 4981 acgaaacggg tggagcacgt aagcgatccg tggacattgc catcggtggc agcaataagg 5041 atgagctgca tttggacgaa agcattttgt ccctgctact aaagcttcat tctcagctct 5101 caggcacact agatagcttc tcgttgagcg acggtgaaga tcaatcatct gacgacgatt 5161 cgaccatgga tgtggactgt aacgaagcca gcacctccat ggcagcagcg gagagcactg 5221 ccctggctga gagaggacgc agtaagcgca actacaagaa cattcatgta tcctcctcgc 5281 gcatcggtga cggaccattc tttattggta atctgctgcg aaagatcgcc aagcaggatg 5341 agcagtgcgc ccagagcatc gacgacatcc gtgccagact ctggccgaat cagcgtgaaa 5401 aacaagcaga ggcgaaagca cgcgaggcca aggagaagga ggagcgccgc aaaaaagcac 5461 gtgagcgcca gcagaagatg atgcaagact tcgccaacaa gcagaagctc ttcatgcaat 5521 ccgctgcagc gtcatccagt ggcatgggct acggaccgga ggacgaggac gatgaggagt 5581 tgtacgagga gcagccgcgt gagaaagagt acgattgcat aatctgcaat tgcactacgc 5641 ccagtaccga atcgaatcct atcggcttgg tcgttctggt cgagtccagc ggcattgttg 5701 gtcatcggcg gcgcatcgcc gagcgattgc cgctgccgat aaacgcggag gatgagtccc 5761 gactggcgca caccactcga ctggcggctg aattcaacag gcgcacggaa ctgctcagtc 5821 tgaagtttgg cgatgagtcc tggtatctgt ccaataatat ggcctacgac aacggtgtac 5881 atgtgcagtc gtgtggccac cacgttcatc tcagttgcct agaggcatac cttaagacgc 5941 tgtacaccac ccaacgtcag ccagttcagg atcgtggcga gttctactgt cccgtgtgcc 6001 gacagctctc aaactcggtg ctgccgctga gtccacaact ggacagaccc acgcacctgg 6061 tccgctctgg taatcagcca ttcgaacgtc tggtcgccga tctaacagat ctgattaaag 6121 agaacgaaac gataccgcag ccaacaaaac tgacagaggc catgggccat gccatggagg 6181 tgatgacaaa cattgcccag cgcaaggtta aatgctcctc gataacgttc cgcaagctgt 6241 tcattttcgt tacctcgatt gcgcgtacaa acctggaggc ggagatcatc cagcggggcg 6301 gatcactatg tacagcgaat gccacgcggt acaagccaaa gcgggaatgc atcgtaccgc 6361 tactgcacgt gctatcggta catgtgcgtg tcttggttga atggccgctg tggagcagct 6421 gggcctcgtt agctggcctg cccgttaccg ctacggaacc gttgccggcg cactgcctcg 6481 aattgattcc cagcatatta gcggatccca ttgctctgct gctcaagttt atcctgctgg 6541 cgccactgca actcgatcag gattacttta cgtgcatggt gaaagtcatg tacaatctgc 6601 tgtactatca aattgtggtt cagctgtgcg ttactctcac cgatttagag tgcgatcaca 6661 ttgtcaaagt ttacggcagc actagcgttg gcagtgacaa ctctgctgcg gaatcccaac 6721 agcaggagtc tgccgccggg acaacgaaca accgtcgccg tgctggacaa cagcagcaga 6781 gctcctcgca gctaggaaag gccatggccc tggtgctgag ccagacaaat gacctagttc 6841 acttgcgacg cgactgcata cccagtacca gcagctcggc ggcagcgtcg gcggctggtt 6901 cctcctccac aacgtccaca aaccatggag ctagcgcagc cacagcctcc tctgccacga 6961 cgatcgaggt taatctgaag tccatggaat tacagctgca ggcgctatgc ttgccgtttt 7021 tgcgagtagc tgccctgctg cgccagcatc tctatcgcca tgagatgccg gagatctcgg 7081 caccgggact ggaatttgtg cgccttgttt actatttgga actcgtaaca gattctatgg 7141 actgggattg ctttaatgcc agcaaggggc tatgctttat tcccggcact gagacaacgc 7201 tgccccagtt ctggtgccag cagttgatgg aggtgcgtcc gccggccgat acggtcagag 7261 aattggtgct catcaatcag cattcgttgt ggcagcagcc gcgacttctt gaattgccgc 7321 gcgagtacga acgcttgttc acgtactacc atgagcggcc gtgcctcaat tgctataaag 7381 tgcccaagga gagctccatc tgcctgctgt gcgggacgat cgtatgcctc aagcagaact 7441 gctgcgcgga gaatgactgc tgcgaggctg ttcgccatac gctatcctgt ggcggtggca 7501 taggcatctt tttggtggtc acctccacgt acatcattgt tatccgcgga cgacgcgcct 7561 gcctttgggg ctcactctat ctggacgact tcgatgagga ggatcgcgat ctcaagcgcg 7621 gcaaaccttt gtatttgagc aaagaccgct tcaatctcct ggagtcgcag tggctgtccc 7681 ataagtttgc tcatacaaaa cacacatggg tgtttcaccg ggatctcttg tgaaatatgg 7741 aagatctact gcgcagcatc caggagctgg ttggccagat ctgagatgcc ctatccacgc 7801 ctagtcgaac cagtcaacca caaaaccacc caaccacaca accacacgat cacccgtccc 7861 caaaatccgc cttcagcagc tgaatcacca ctaatccaat caaccacctg actaaaagct 7921 agtttccaca ttttgtcggc ttttcgtatc cgtttacgca tctgcatttt gtttacggct 7981 ttcgatcccc atcccccacc acatgcccca aacgcaccta gaagcaatgt aggcaatttg 8041 caattaattg atattaaaca ttttttttta atacataaac aatacttata aatatggatg 8101 caaagggata cgaaataccg acaactatac tattgtttgt tgtcaacttt ttaagtgaga 8161 aacgcataat acaccttata cagaagatca cataatcttg cgatcgacaa caatatttaa 8221 caaccaatta taaattacaa atattattac ccacccactt gctgggcaaa gacgacgcga 8281 aaacagcctg gataaaacgg agatggtgca tcgcgcgggt cttcagttgc gttctaccta 8341 aactaagtct taagtcctta actttataga tttttttttt tagggaaaga aaggcaagaa 8401 ggcaaataac aaattacgag taacaaataa cacgatacta cacaatataa aattgcctac 8461 attggactca tgagtttgtg catgtaaaaa atgaaaaaaa gattatatag ttaatatata 8521 caaatacaat atacactaca gttaattgca acataaacga aaaatgatac aaaaaaaaaa 8581 aaaaaaacaa taaacgaaaa gcgaattgtg aaatgcatag aaactagttt gcatgcccca 8641 ttatacataa atattatgta attaagaagc ataagaaaaa agatgattga aagaacgaga 8701 agggtaatca atctgaattg gaaacgctag gatcatcgga tgtgaatttg ttattagttt 8761 ttacaaattg tgtgttattt aggcggcgct tcaagggaac ttcgatattg tttgagcgca 8821 tatgtttatt ttgaacgatc aaattgagcc actgcaaaga ctagctaata tttcaatatc 8881 tagaagtata tacatacata tatataatag gtttttcaag caaattcaaa attgttgaag 8941 atagtatctt cggcaaaaaa aaacctggtt gtctagtaat tggtataaat ttccatcaag 9001 ttatagaaaa attgcatgtg cgttacacga aaagacatgg aagaattgct acgaattgta 9061 aatacactga aaacgaagct gcatcttgta taattaaata ttaatatatc acagttttat 9121 cttttttttt tttttactag ttatacaaat ctagatgttt tggttggcct cctagactaa 9181 ctaaattcaa ttctgcaaaa caaacaaaca agaaaaacac atgatttaag agattaaatg 9241 gcacagcaca gcaatacaca atacacactc aatacacaca atacacacac agcccctagt 9301 actctagtac acccaaaaaa gataatgtaa acgtgcattc tgagtgacaa accgaaaacc 9361 cttaataaaa t