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Drosophila melanogaster checkpoint suppressor 1-like, transcript


LOCUS       NM_001272383            7773 bp    mRNA    linear   INV 26-DEC-2023
            variant C (CHES-1-like), mRNA.
ACCESSION   NM_001272383
VERSION     NM_001272383.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7773)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7773)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7773)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7773)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7773)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7773)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7773)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7773)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7773)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7773)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7773)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7773)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7773)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7773)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7773)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7773)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7773)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7773)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7773)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7773)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 7773)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7773)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 7773)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7773
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7773
                     /gene="CHES-1-like"
                     /locus_tag="Dmel_CG12690"
                     /gene_synonym="anon-EST:Posey7; CG12690; Ches-1-like;
                     ches1; Ches1; Dmches-1; Dmel\CG12690; FoxN; FoxN23"
                     /note="Checkpoint suppressor 1-like"
                     /map="7B6-7B6"
                     /db_xref="FLYBASE:FBgn0029504"
                     /db_xref="GeneID:31678"
     CDS             393..4196
                     /gene="CHES-1-like"
                     /locus_tag="Dmel_CG12690"
                     /gene_synonym="anon-EST:Posey7; CG12690; Ches-1-like;
                     ches1; Ches1; Dmches-1; Dmel\CG12690; FoxN; FoxN23"
                     /note="CG12690 gene product from transcript CG12690-RC;
                     CG12690-PC; CHES-1-like-PC; checkpoint suppressor
                     homologue; ches-1-like"
                     /codon_start=1
                     /product="checkpoint suppressor 1-like, isoform C"
                     /protein_id="NP_001259312.1"
                     /db_xref="FLYBASE:FBpp0301970"
                     /db_xref="GeneID:31678"
                     /db_xref="FLYBASE:FBgn0029504"
                     /translation="MSTDNPTQLLTTRDLSQLRGHLQSGTVAVPSTTTSVVAAAAATV
                     AAAHGYRTIAPPQQPANNSSTTTSATAASASASAQPPVIPPVISTSNSNMPASASKYV
                     FLQHNHNGGFTAYDGSAATTAAGSTGTVGATSGNIVLLAAAPLEASSGEALVNVRTTE
                     DDGELRSLSWLSDTNLIKGIVTTTAGQAGKRAATVAIKSATGAAGTVGSGAPNGNLCI
                     VSDLIEELPTNLSETSEQESTGGAASGSAPAASTVYSTTTVHKGASGTTTVVEYKASK
                     ANQQQQNSPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTYLPTPTRTTMVGHGY
                     MPVVVSSASQPILSPAKQQLPQQIYVTSNGSSPAGGGTIYKAASQALSSPTTSSSSSS
                     NTTTHHPHKKYLREKMHVQMDHSSHVASTVTVVSSPASSNNSSISSSNTGSVSGSGSS
                     TAAVNGGNSPVPKTSSFSTVFEAVNYATSAASNSSSSSNSTPNSQAILHGQESPAVVT
                     TTTLISAGTLPPGYSFVNQVASTPHVLSTPAHVASPETPPGAALLPGTYYATSTTSAG
                     TTTTTLQARSLQLSVSPPPPNMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPN
                     SYASYDNEDSLKEFDLVVSSRLHTSTPQYSVSKNGANGYGNGNSNVNGSGAGSNTPQK
                     QKHPNNVPYDPLVHTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTA
                     PNGWKNSVRHNLSLNKSFVKVEKAPNMGKGSLWRVEPQQRQNLIQALNRSPFFPNSAV
                     DKISPSLKSPSGGSAYDSLDGGGSGSVSSAQPVAGGAGVPAAAAVALSTPTKSNGLAL
                     ANGASQATNAARPHSPNGGGSGSHARFDPYLFPNLSKAFRNIREDTVGQPMLQDALDD
                     ELSGDYHNNNNNNSGSKYNYMGANGSGGAGSGGVGSNANGASDGINFARLARDCGADS
                     IDDVHAAAAMLYLKHGPKIYSEPFQNGGPVITSSPSEDHTYSAGGNSNADSGSSTPLT
                     NGNALASVAQAVAQGQNNQGGAGSDSNCASSDAAYDSSEENHNITPEEMADRQRHRDG
                     VDALLSLSGSSIVECGSVATTHYHSNGSSGSSHGSPHKRASSHSLEEEHLQQHREQQL
                     QQQQQQQQHHHQQFGSSQAVYTNGSGSKMALLSSAAANVALAQQQQQQIHQDMYSSTA
                     GHNASMYLGGLNSHCLSGGGGVGVAAGMLPQHLSAATGASNKNKVKPLRGLRTKFKRK
                     SAWMR"
     misc_feature    2490..2717
                     /gene="CHES-1-like"
                     /locus_tag="Dmel_CG12690"
                     /gene_synonym="anon-EST:Posey7; CG12690; Ches-1-like;
                     ches1; Ches1; Dmches-1; Dmel\CG12690; FoxN; FoxN23"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     N2 (FOXN2) and similar proteins; Region: FH_FOXN2-like;
                     cd20031"
                     /db_xref="CDD:410805"
     misc_feature    order(2505..2507,2559..2564,2571..2573,2628..2633,
                     2637..2642,2649..2651,2670..2672,2697..2705,2709..2711)
                     /gene="CHES-1-like"
                     /locus_tag="Dmel_CG12690"
                     /gene_synonym="anon-EST:Posey7; CG12690; Ches-1-like;
                     ches1; Ches1; Dmches-1; Dmel\CG12690; FoxN; FoxN23"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:410805"
ORIGIN      
        1 agacaatacg gcaaacagag ggaagagtag aagggacaaa agaagacgat gaacaggcac
       61 cgtggaacga aaatgcaaat ggcaatggga taaaacaatt actaatgtgc atatgctttc
      121 cgatcaatca atggatacag tggacatgca aataggaaag gtacgcagat ttgaaattct
      181 aattatccaa aatacgcacc tatacaaaat ccagaaaact acagaataca cggatggacc
      241 tcaggtaggc taaatatgtc aattgaatat attaaaagct aaagatctaa agatctaaag
      301 attgcataga tctgcagatc tgggaaaacc tatttataaa ccagatacat aacattattt
      361 catttccaca ttcatatgcc attttttgca acatgtccac agataatccc acacagttgc
      421 tgaccacccg tgatttgagc caactgcgtg gacatctgca atccggaaca gtagcggtgc
      481 cctccacgac cacttctgtg gtggcagcag cagcagcaac agtggctgcc gcccatggat
      541 accgcaccat tgcaccaccc caacaacccg ccaacaacag cagcacaaca acatctgcaa
      601 cagcagcatc agcatcagca tcagctcaac cacctgtaat accaccagtt atatccacaa
      661 gcaatagcaa catgccggca agtgcctcaa aatatgtatt tctgcaacac aatcacaatg
      721 gtggttttac ggcatacgat ggctctgcag ccacaacagc ggcgggcagc accggaactg
      781 taggtgcaac cagtggcaat atagtactac tggcagccgc accgctggaa gccagttccg
      841 gcgaggcttt ggtcaatgtg cgaacaactg aagatgatgg cgagttgcgt tcactgtcct
      901 ggctcagcga taccaattta attaagggca ttgtgaccac aacggccgga caggcaggaa
      961 aacgtgctgc aacggtggcc atcaagtcgg cgactggggc agcaggcaca gtaggatccg
     1021 gtgctcccaa tggcaatctg tgtatagtca gcgatttaat agaagagcta cccactaatc
     1081 tgagtgaaac cagtgaacag gagtcgaccg gaggagcagc aagtggatcg gcaccagcag
     1141 catcaactgt gtacagcacc acaacggtgc acaaaggagc cagtggcacc accaccgtgg
     1201 tggagtacaa ggccagcaaa gccaatcagc agcaacaaaa ttcgccgcaa cagcagcagc
     1261 agcagcagca gcagcagcaa caacaacaac aacaacaaca acaacaacaa caacaacaac
     1321 aacaacaaca acaacaacaa cagacgacct atttgccaac gccgacaaga accaccatgg
     1381 tgggtcacgg ctatatgccg gtagtggtga gcagtgccag ccaacccata ttatcgcccg
     1441 ccaaacagca gctaccgcaa cagatttacg ttaccagcaa tggcagttcg ccagccggcg
     1501 gaggaaccat ctacaaggca gccagccagg cacttagctc gccaaccacc agcagcagca
     1561 gcagtagcaa caccaccacc caccatccgc acaagaaata tctgcgcgaa aagatgcacg
     1621 tccagatgga tcacagcagt catgtggcct caaccgtaac ggtggtcagt tcgccagcat
     1681 cctcgaacaa ttcctcgatt agcagctcca acacaggctc ggtatccggt tcgggttcct
     1741 cgacagcggc tgtgaatggt ggcaatagcc cagtgcccaa gaccagtagc tttagcaccg
     1801 tattcgaggc ggtcaactat gccacatcgg cggccagcaa tagcagcagc agcagcaaca
     1861 gtacacccaa cagtcaagcc atactccatg gccaagagtc gccggctgtg gtgaccacaa
     1921 cgacattgat cagtgccggt accctgccgc cgggctatag cttcgtcaat caagtggcca
     1981 gcacgccgca tgtgctttct acaccagcgc atgttgcatc tccggagacg ccacccggag
     2041 cggctttgtt gccgggaact tattatgcca caagcaccac atcagcgggc acaaccacaa
     2101 ccactttgca ggcgcgtagt ctgcagttat ccgtctcgcc accgccgcca aatatgacgc
     2161 ccacgagtca agtgcacaat ggatcactag gaggaggagg aggaggggga ggaggatctg
     2221 gaggaggagg aggaggagga ggagccaacc tgcggagtcc taatagctat gccagctacg
     2281 ataacgagga ttccctcaag gaattcgatc tggtggtcag ctcacgcttg cacacaagca
     2341 cgccgcaata ttcagtgtcc aaaaatggag ccaacggcta tggtaacggc aacagcaatg
     2401 tgaatggcag cggagctggt tccaatacgc cgcaaaagca aaagcatccc aataacgtgc
     2461 catacgatcc gttagtgcat accaataaca agccgccata tagctttagt tccttgatct
     2521 tcatggccat tgagggttcg aatgagaagg cactgcccgt taaagagatc tatgcgtgga
     2581 ttgtccagca ctttccgtac ttcaagacgg ctcccaatgg ctggaaaaat agcgtgcgcc
     2641 acaatctctc gctgaacaag agctttgtca aggtggagaa ggctccaaac atgggcaagg
     2701 gatcgttgtg gcgtgtggag ccacagcagc gccagaatct catccaggcg ctgaaccgtt
     2761 cgccattctt tcccaactcg gcggtggata aaattagtcc atcgcttaag agtcccagtg
     2821 gtggatccgc atacgatagc ctcgatggcg gtggcagtgg ttccgtttct tcggctcagc
     2881 cagtggctgg tggtgctgga gttccggctg ccgcagccgt ggcactgtcc acgcccacca
     2941 aaagcaatgg tctggcgctg gccaatggtg ctagtcaggc cacaaacgcg gccaggccgc
     3001 atagtcccaa tggtggtggc agtggcagtc atgcccgttt cgatccctac ctattcccca
     3061 atctgtccaa agcttttcgc aatatacgcg aagatacggt cgggcagcca atgctgcaag
     3121 atgccctcga tgacgagctg tccggcgatt atcacaataa taataacaat aatagtggca
     3181 gcaagtacaa ttacatgggt gcgaatgggt caggtggagc tggcagcggt ggtgttgggt
     3241 ccaacgcaaa tggagcttcc gacggcatca atttcgcgcg actggcccgc gattgcggag
     3301 cggacagcat tgatgatgtg catgcggcgg cggcgatgct ctacctcaaa cacggaccaa
     3361 agatctatag tgagcccttc cagaatggtg gcccggtgat aacgagctcg ccaagcgagg
     3421 atcacaccta ctcggcgggt ggcaacagca atgcggacag cggctcctcc acgccactga
     3481 ccaatggcaa tgctctggcc agcgtggcgc aagcagtggc ccagggtcag aataaccagg
     3541 gaggagctgg atccgatagc aattgcgcca gctcggatgc tgcctacgat agcagtgagg
     3601 agaatcacaa catcacgccc gaggagatgg ccgatcggca gcgacatcgc gacggcgtgg
     3661 acgccctgct ctcgctatcc ggctcctcga ttgtggagtg cggctcagtg gccaccacac
     3721 attatcacag caacggcagc agcggcagca gccatggatc cccgcacaag cgagcctcga
     3781 gtcacagttt ggaggaggag cacctgcagc agcacaggga acagcagttg cagcaacagc
     3841 aacagcagca gcaacatcat caccagcaat ttggcagcag ccaagcggtc tacaccaatg
     3901 gcagtggcag caagatggct ttattgagca gtgctgccgc caatgtggca ctcgctcaac
     3961 agcagcagca gcagattcac caggacatgt actcctcgac ggctggacac aatgccagta
     4021 tgtatctggg cgggctgaac agtcactgcc tgtccggtgg cggcggtgtg ggcgtggcgg
     4081 cgggcatgtt gccacagcat ttgagtgctg caacgggggc aagtaataaa aataaggtga
     4141 aaccattgcg aggattacgc accaagttca agcgaaagtc cgcctggatg cggtgaatat
     4201 ggcgacaggc tggcggcaaa tggacgtaat acagccgttc aaagatcgcc accctaacca
     4261 cgcccccgcc catacgccct cccgcccatg cgatctgttg ttgtctcttt ctaaagcaaa
     4321 aattgttcaa atcacagagc atttagacta aattttgtaa tcttagcaag ttcatagttt
     4381 cttcagattt tttttattgc tctacctttt acaaattctt gtgtgttttc gtttttgtta
     4441 tagaagtttt ttttttgact accatttttt tttgattatt aattttaaac cttagacctt
     4501 atgtttttag gatttttttt ctgtgacttt actgtgcccc gcaattaaat gttggccatt
     4561 taattattac ttgattaact attacaatat gatttaaagg ccatcctagc tgcaatttct
     4621 tacaactcct agatgttaag tgacttcttc atattgtagc ttgtaatttt aaattgtgca
     4681 aatattttac agaccaatcg caaaacgaaa ttacttttaa tggcaaccag ttgaaatcgt
     4741 aaccagagtt ataatgaaaa agtatctggt tattcagggc ccacaattcg ttgttaactt
     4801 ttaatacata caaaactcta gtttatttgt tttttttttc aactcgcgac acgagggaca
     4861 caagcaaagt gaacttttcc agcgtatcag tgacaaggtt tatatcaaaa gagaacatac
     4921 acataaaaca ccaacaaatt gagctaagta ggaatgagta gctaagtaaa agaaaataag
     4981 aaaaaaaatt gtaaaaagcg caagaaaaag gaaaaaatgt agaaagcaaa cgcaacgttt
     5041 gtacaaatag caaaccagag ttaagattct tttttatttc ggttttgtgc cgcaagaaaa
     5101 aggtttttcc tacacttata agatccaaaa caccctactt acatgatcta aaaacaagcg
     5161 atataaaaat atatacatat atatatatac atatacatat agagaaaagt aagataagcc
     5221 aagcaaaaaa aaaaaaccca caaagaaaca cacatttagc gccttatata tggagtcctt
     5281 agctaaaaac gaaagagaga aaatgttgaa ttgtttgaac tgctttgtta tacgaatgca
     5341 tgagtacata tatatatata tatatataaa ttctatatat atttaagacc ccatccctat
     5401 tttgacctgc ccagtaaccc cttccctccg ctccccttcc catcacgaca ctcaagaaaa
     5461 tgttaaatca aagatattta gttaataagc cagggagtaa accgaaaatc ctaattgtaa
     5521 gcttcattta gatggttaca cgtacatagt tgaaatatgc taaacatttg ttaacacgaa
     5581 tccaatcgta agctagccga ttttagttga atgaacctcc tgcaattttc ctacccaagg
     5641 tgtacatata tacaaaatgg attaagctgt tgaaatgatg ctgcacatct ttacataggc
     5701 atattgtgga aaccaagaaa tacttattaa ttaaataatt aaataggcga aaggaaaaaa
     5761 acttgacaaa gaacgcccta agtgtttaca cttcatgtac ctttttagca aaaagcaaaa
     5821 aacgcaaaag caaagatcgc attaaaattg tatacataca ttatatttaa actaccaatt
     5881 acgaaactaa actaaatgtt gatgtcaaag agaaaccaat ttgctagttg ttaccaatca
     5941 gaaaagaaca cataaaacaa aaaacaaaaa acaaaaaaac agaaaaacaa tgttaaaact
     6001 attttgttcc ctcaacaact tattattaag attatggttt ttgttttttt tttttagttt
     6061 aattacataa aaatattgcc ttgatgcata ttttggggaa agaatgtgac taaaatacca
     6121 gaagcgagaa caacaaaata attgtatgcc tagctttaac ttaaggtcct aaaagcaaga
     6181 aaaaaaaacc aaaatacaaa cctttttcat aaaatccttg gcacgacaca cagtgaaaga
     6241 caatcgccgc ccgtgttgtt gtcgttgtcg cttaagttta aagtttaaac aaattctatg
     6301 tagctatagt acgagtaaaa tatatatata tatatagatt acacacacac acacacacag
     6361 caatagcaaa gtacatatac aacaaatatt gttatacaac cttaagcttt tgccgagata
     6421 aggtggagaa aactattttc ccgaacccac agatagattc tatatcccat tatccaacca
     6481 ccatgtatct ccacaaaaaa caaaaaacaa tcgatgagct aaccagtttt gttaccgcgt
     6541 tttttcttct actttaatta ttatattgca tcattattat tattaccgta tatattcatg
     6601 gtatatatac ttacatatat gattatacaa ctttttttgc gtaccaaata cacaccaatc
     6661 aaaatgtgaa atattttctt tatcctacta tgtgttttat ttcggttcaa tttctcacat
     6721 cattttatca ttttgtgggt tgttatttta tcaactttaa tttgtattcc tattgacagc
     6781 aatgtgaata tagcttgtag ttgtacataa atgaatatag agtttatata gagagatcgg
     6841 attttgttga actatagtaa gtgcctgcct cctcccatga tgaagttaaa attaaaacct
     6901 ggtccaaaac cagagtagag ctttgattaa atgtcgcact gttgccaatt ttcatagatt
     6961 cgtttgttaa agtgttagct tgaagctaaa agaactcgat ccttaagccc cgccttgctt
     7021 tagcctgaaa aaaatatata acaacgataa gacactcacc tacacacaat gtacagacta
     7081 cagggtatcc aaaacatctc gaacaaaccg aagggattga gatatatttg cacccacata
     7141 caaacaaact tatatatctc tccgataaat aggatgatca atctgtttgc cctccaaggt
     7201 ttcaactagc gcctgttttt atgtctttaa aacctctgta ccaaaaaaaa taaaaagaaa
     7261 acaaaataag caaaaaatac aaaatatata caaaagcaaa gtaaatcaat taagttactt
     7321 aagaaatacc aagcaaaaat taagcaaatc aaacataaat tctatttata tatatacata
     7381 tgtatgtaca tacgtagatg tacgtatgta tgaaagcaaa gataaaaacg tttaggatga
     7441 aaatgttacc ctgtattttt ttagacataa catttttcta ctttttggac gatgtaaaac
     7501 taaaagacaa acaacaagaa aacgaaaacc aaagaaacga ttgtaaaaaa caatgtatgc
     7561 atatgaaagg taaaatttat aattttcatt tgttgctaat ttatagaaaa cacacggaac
     7621 aagacgagca aaccaagtgc gaaaccgatt tgggactgat ctttgggcct gtatctttgt
     7681 gtataagcga attgtgtatg aatatacaat aaataaatta ctctccaccc atctgttgat
     7741 atcgagcaaa ttcgtctggc tcttttttca tgg