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Drosophila melanogaster C3G guanyl-nucleotide exchange factor


LOCUS       NM_001272363            5027 bp    mRNA    linear   INV 26-DEC-2023
            (C3G), transcript variant J, mRNA.
ACCESSION   NM_001272363
VERSION     NM_001272363.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5027)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5027)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5027)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5027)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5027)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5027)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5027)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5027)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5027)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5027)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5027)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5027)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5027)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5027)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5027)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5027)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5027)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5027)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5027)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5027)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5027)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5027)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5027)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5027
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5027
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="C3G guanyl-nucleotide exchange factor"
                     /map="6D1-6D2"
                     /db_xref="FLYBASE:FBgn0259228"
                     /db_xref="GeneID:31618"
     CDS             385..4089
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="CG42328 gene product from transcript CG42328-RJ;
                     CG42328-PJ; C3G-PJ; C3G ortholog"
                     /codon_start=1
                     /product="C3G guanyl-nucleotide exchange factor, isoform
                     J"
                     /protein_id="NP_001259292.1"
                     /db_xref="FLYBASE:FBpp0306981"
                     /db_xref="GeneID:31618"
                     /db_xref="FLYBASE:FBgn0259228"
                     /translation="MRTTNNTLGRSHSPHSPRTKHGTKAPPTTEEVLRSTQTLETHVK
                     DISNALKHFRDVILKKKLEVLPGNGTVILETIASMYSVIQTYTLNENSAIMSSATLQV
                     YQSLGKLIKLCDEVMLSEDSGECASLSNENVREVIDLLEDAVRNLVTLAQGKLKEQDQ
                     CAFRYSGSGLGGIGAAAEIMGAVTASPGASVPGTGVMRVSAAESAAQRTSLPDIALTP
                     KERDILEQHNVNPMRGSHSTESILRDTSPPPKPPLPNRASNPPPLPPKRRSQPSASAG
                     TVGVGCSSSTSTSNQASPLPYAQSHNISLNSDLDCSSNISLLNYGVDRLSVRSRSPDE
                     NSQCSFDSALNHSREEEDQQQQHQHLRSFPKLAAMMDEDMDKMVSYSFVSMREFRTST
                     QTTDYSVQSSTKSSSSNSEIAFSISESTAVGSSSEYQQISQLVSHSQRHISSSSSSCT
                     TTTTSSSTTTGYGSSEVEQLQQQQQQQTTTTPADLAPALPPKSIQRSSLTRHDSPGVG
                     DELDEVQSSSGWASHRSSQSEVAELRQLSPLHHLNHHPHTASAGQLQQWHSKHHSLIE
                     GPRLQLAGSGSCSAFDQRHLDQEPPPLPIKKKHILAYMEICSASTRSIEQHRHTMHAC
                     NISRNISHSQTMNIMPMSKELSPELEMPPALPPKNYKQRKATSMVASPTLQPVIVTTP
                     PPSPKPTLGENGSTGRPDSRMATVCEELNDAVASEDAMPEPRSPVLDSNENVSAVDDG
                     QTFYCHSHQLPAAEMEMSEDASSADNQPITTPQVLEEQEEPTAESRPLVAVHESVKPA
                     NVDEDEEAERADMLINMLEEVNITRYLILKKREEDGPEVKGGYIDALIVHASRVQKVA
                     DNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFALLVRVVNDL
                     TSTDLTSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYKEPKVYGFVGELGGA
                     GSVGGAGIAGSGGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVLLFA
                     KDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNY
                     NSYLALLSALDSGPIRRLEWQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPY
                     IGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRF
                     FDNFKDFMGEEEMWQISEKIKPRGRRPVNY"
     misc_feature    2881..3291
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; Region: RasGEFN; smart00229"
                     /db_xref="CDD:214571"
     misc_feature    order(2938..2940,3073..3075,3085..3090,3097..3099,
                     3106..3111,3208..3210,3217..3219)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:100121"
     misc_feature    3376..4047
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; Region: RasGEF; cd00155"
                     /db_xref="CDD:238087"
     misc_feature    order(3475..3483,3505..3510,3514..3522,3526..3531,
                     3538..3543,3550..3552,3649..3651,3658..3663,3667..3675,
                     3679..3690,3694..3699,3751..3753,3766..3774,3781..3783,
                     3820..3828,3835..3843,3847..3855,3859..3870,3913..3915,
                     3925..3927,4027..4029,4036..4041)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Ras interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238087"
ORIGIN      
        1 ggctggaaat aaaaaagggc gaagcgacaa ttctcgaacg gcagcatcag ttctccatcc
       61 acgcccggca cctgttccag tggcatcgga gtgggcggtg gcggctgcag cagcagcagc
      121 aacaatagca tcaacagcgg cagctactcc accgcctgca ctccgccacc acccacgcat
      181 cagcatcact cgcagcacca gcagctgcag ggcacgccgg gaggatctag tcgggtaggg
      241 ggagcaggag caggcggagg tggtggtgta ccaccggcac cacccagtgc cggatcctcg
      301 ggccacaaga acagtctcaa gggcaccaag ctagcgcgcc gggcgcgttc ctttaaggac
      361 gacctcatcg agaagatttc cctgatgcga accaccaaca atacactggg tcgctcccac
      421 tcgccgcaca gtccgcgcac caagcacggc acaaaggcac cgcccaccac cgaggaggtg
      481 ctacggtcca cccaaaccct ggagacgcac gtcaaggaca tttcgaatgc cctgaagcac
      541 ttccgggatg ttatactcaa gaagaagctg gaggtgttgc cgggcaacgg aacggtcatt
      601 ctggaaacca tagccagcat gtactccgtg atccaaacct ataccctgaa tgaaaacagt
      661 gccatcatga gcagcgccac gctgcaggtt taccagagcc tgggcaagct catcaagctc
      721 tgcgacgagg tgatgctctc cgaggacagc ggcgagtgcg cctccctgag caacgagaat
      781 gtgcgggaag tcattgatct tctcgaggat gctgtgcgga atctcgttac gctggcgcag
      841 ggcaagctga aggagcagga tcagtgcgcc tttcgctaca gtggatctgg cttgggcggc
      901 attggagcgg cggcggagat catgggtgcg gtcaccgcct cgccgggagc gagtgttccc
      961 ggtactggag tcatgcgcgt ttcggccgcc gaatcagctg cccagcgtac ttcgttgccg
     1021 gacatagcgc tcacgcccaa ggagcgcgac atactggagc agcacaatgt gaacccgatg
     1081 cgcggctccc acagcaccga aagtatcctg cgcgacacga gtccaccgcc gaagccaccg
     1141 ctacccaata gggccagtaa tccgccgccg ttgccaccaa agcgacgcag ccagccgagc
     1201 gcatcagctg gtacagtggg cgtaggctgc tcatcgtcga catccacctc caatcaggcc
     1261 agtccactgc cctacgccca gtcccataat attagtctga actcggacct ggactgcagt
     1321 tccaatatct cgctgctgaa ttatggcgtg gatcgcctat ccgtgcgttc acggtcaccg
     1381 gatgagaata gtcagtgctc ctttgactcg gcgttgaatc actcacgcga ggaggaggac
     1441 cagcaacagc aacatcagca tctgaggtca tttccaaagt tggctgcgat gatggacgaa
     1501 gacatggaca agatggtcag ctacagtttc gtgtcgatgc gtgagtttcg cacttccaca
     1561 cagacgacgg actacagtgt ccagtcctcc acgaagtcgt ccagcagcaa ttcggagatt
     1621 gcgttcagca tcagtgagtc gacggcggtc ggcagcagta gcgagtacca gcagattagc
     1681 cagttggtgt cgcacagcca gcgtcatata tcctcgagca gtagcagctg caccaccacg
     1741 accaccagca gcagcacaac caccggctat ggcagcagcg aagtggagca gctgcagcag
     1801 cagcagcagc agcagacgac gacgacgccg gccgatctgg cgcccgcctt gccgccaaag
     1861 agcatccaac ggagcagcct aacccgccac gactcgcccg gagttggcga tgagctggac
     1921 gaggtgcagt cctcctccgg ctgggccagc catcggagca gccagtcgga ggtggccgag
     1981 ctgcgtcagc tgtcgccgct ccatcacctc aatcaccatc cgcatactgc gtccgccggt
     2041 caactgcagc agtggcactc caagcaccac agcctgatcg agggaccccg cctccagctg
     2101 gcggggagtg gcagctgcag tgcgttcgat cagcgacact tggatcagga gccaccgccg
     2161 ctgccaataa aaaagaagca cattctggcg tacatggaaa tctgttcggc gtccacgcga
     2221 tccattgagc agcatcgtca cacaatgcac gcctgcaaca taagtcgcaa catctcgcac
     2281 agccagacca tgaacattat gcccatgagc aaggaactgt cgccggagct cgagatgcca
     2341 cctgccctgc cgccaaagaa ctacaagcag cgcaaggcga caagcatggt agcatcaccc
     2401 acgctgcagc ccgtcattgt gaccacgcca ccgccgagtc cgaagccgac gctgggcgag
     2461 aatgggtcga cgggcaggcc ggacagccgg atggccaccg tatgcgagga gctgaacgat
     2521 gcagtggcca gcgaggatgc gatgccggag ccccgttcgc ccgtgctgga cagcaatgag
     2581 aatgtgagcg ccgtcgatga tggacagact ttctactgtc actcacatca gttgcccgcc
     2641 gccgaaatgg agatgagcga ggatgcgagc agtgccgaca accagccaat aaccacgccc
     2701 caagtgctcg aggagcagga ggagccaacg gcggagtccc gaccactggt cgctgtgcac
     2761 gagtcggtta agccagcgaa cgtcgacgag gatgaggagg cggagcgagc ggatatgctg
     2821 atcaacatgc tggaagaggt caacatcaca cggtacctga tactcaagaa gagagaggag
     2881 gacgggcccg aggtgaaggg cggctacatc gatgccctca tcgtgcacgc cagccgtgtc
     2941 caaaaggtcg ccgacaatgc attctgcgag gccttcatca ccacctttcg caccttcatc
     3001 cagccgatcg acgtgatcga gaagctgacc catcgctaca catacttctt ctgtcaagtg
     3061 caggacaaca agcagaaggc cgctaaggag acctttgcgc tgctggtccg agtcgtcaac
     3121 gatctaacgt cgacggatct aaccagccag ctgttgagcc tgctggtgga gttcgtctat
     3181 cagttggttt gctctgggca attgtacttg gccaagttgc tgcgcaacaa gttcgtggag
     3241 aaggtgacgc tgtacaagga gcccaaggtg tacggctttg ttggggagtt gggcggagcc
     3301 ggtagtgtcg gcggagcagg aatcgccggc agtggtggat gcagtggtac agctggtggt
     3361 ggaaaccagc ctagtctgct cgacctcaag tcgctggaga ttgccgaaca gatgacgctg
     3421 ctggatgcgg agctgttcac gaagatcgag atacccgaag tattactatt tgccaaagat
     3481 cagtgcgagg agaagtcgcc caacctaaac aagttcaccg agcacttcaa caagatgtcc
     3541 tactgggcgc gctccaaaat cctgcgcctg caggatgcca aggagcggga gaagcatgtg
     3601 aacaagttta tcaaaatcat gaagcatcta cgcaagatga acaactacaa ctcgtatctg
     3661 gcgttgttgt cggccctcga ttcgggtccc ataagaagat tggagtggca aaaaggcatc
     3721 accgaggagg tgcgatcatt ctgcgccctc atcgattcca gctccagttt tcgcgcctat
     3781 cgacaggcgc tggccgaaac taatccgccc tgcataccct acatcggcct aattctgcag
     3841 gatctaacgt ttgtgcatgt gggcaaccag gactacttgt ccaagggcgt cataaacttc
     3901 tccaagcgct ggcagcagta caacataatt gacaacatga aacgttttaa gaaatgtgcc
     3961 tatccatttc gacgcaacga gcgcattata cgcttctttg ataacttcaa ggactttatg
     4021 ggcgaggagg agatgtggca gatatcggag aagatcaagc cgcgtggacg ccgccccgtt
     4081 aactattagt cttcaagcag caacagcaaa acaccaatat tatatatgat aaagtatata
     4141 caccgtatta attaaacagt tcaaaacggt tgccacgtct aggaggagga tcagcatcgg
     4201 gagcagccaa caactattct aatgggtctg agcaataatg ttcgctattc tctgtctata
     4261 tatatacaat tatacaagat atttagctgt aattaccagc cgatgccgaa tcggaaatac
     4321 atatacatac ttacttaaga tgtagcgatt cagatacgga tacggataca tgtagccgcg
     4381 tacaaataac gagccgatct gtagtttaac tattaagctc tatgagtcat tgggtcgatg
     4441 gacctaacct cagctaactc cccaccaata ttcgaatccg aatccctgtc tgcgagtccc
     4501 aaaaactttt tcccggactt ttgccagcac tagaacacca aactaactaa ctaacttact
     4561 taccaccaga gacaaccaat caagaaatca gcaattttcg cttttgtttt gagatctctt
     4621 ttttacacaa gaacacaacg aattttgaaa gcaagctacg tgaacgtaga ggccaaccga
     4681 caaactatat tcgacgatat atgtagcgat atctcggact ataaatcgat gcaatccacg
     4741 agcagaacac caagcgaacc ctagcacaaa gcgcgttata tgcaattctc tctccaaaca
     4801 accaatatta aatacccgtg tgtgtgtatg tgtgttagaa gttattcaaa ttgaaattga
     4861 actcaaaatc aaaatcagag atttcagagt gcacgaaaca gaaaacagaa ggcggtatct
     4921 atcgatcaaa tcaatcaatc aatgaaatca atcaaaaatt cattttgcga ctcaattaat
     4981 tgaagaaact tttaaagtta caaaacaaaa caaaatacaa aaaatac