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Drosophila melanogaster C3G guanyl-nucleotide exchange factor


LOCUS       NM_001272362            5648 bp    mRNA    linear   INV 26-DEC-2023
            (C3G), transcript variant I, mRNA.
ACCESSION   NM_001272362
VERSION     NM_001272362.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5648)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5648)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5648)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5648)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5648)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5648)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5648)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5648)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5648)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5648)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5648)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5648)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5648)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5648)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5648)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5648)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5648)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5648)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5648)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5648)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5648)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5648)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5648)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5648
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5648
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="C3G guanyl-nucleotide exchange factor"
                     /map="6D1-6D2"
                     /db_xref="FLYBASE:FBgn0259228"
                     /db_xref="GeneID:31618"
     CDS             466..4710
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="CG42328 gene product from transcript CG42328-RI;
                     CG42328-PI; C3G-PI; C3G ortholog"
                     /codon_start=1
                     /product="C3G guanyl-nucleotide exchange factor, isoform
                     I"
                     /protein_id="NP_001259291.1"
                     /db_xref="FLYBASE:FBpp0306980"
                     /db_xref="GeneID:31618"
                     /db_xref="FLYBASE:FBgn0259228"
                     /translation="MNILQKIDGSISSPSTPGTCSSGIGVGGGGCSSSSNNSINSGSY
                     STACTPPPPTHQHHSQHQQLQGTPGGSSRVGGAGAGGGGGVPPAPPSAGSSGHKNSLK
                     GTKLARRARSFKDDLIEKISLMRTTNNTLGRSHSPHSPRTKHGTKAPPTTEEVLRSTQ
                     TLETHVKDISNALKHFRDVILKKKLEVLPGNGTVILETIASMYSVIQTYTLNENSAIM
                     SSATLQVYQSLGKLIKLCDEVMLSEDSGECASLSNENVREVIDLLEDAVRNLVTLAQG
                     KLKEQDQCAFRYSGSGLGGIGAAAEIMGAVTASPGASVPGTGVMRVSAAESAAQRTSL
                     PDIALTPKERDILEQHNVNPMRGSHSTESILRDTSPPPKPPLPNRASNPPPLPPKRRS
                     QPSASAGTVGVGCSSSTSTSNQASPLPYAQSHNISLNSDLDCSSNISLLNYGVDRLSV
                     RSRSPDENSQCSFDSALNHSREEEDQQQQHQHLRSFPKLAAMMDEDMDKMVSYKSTGY
                     AGAAIDDKTQTPLSTGGGIAGVAGGTGGAGEGVAAAASGDGETNSNRHSNESGFVSMR
                     EFRTSTQTTDYSVQSSTKSSSSNSEIAFSISESTAVGSSSEYQQISQLVSHSQRHISS
                     SSSSCTTTTTSSSTTTGYGSSEVEQLQQQQQQQTTTTPADLAPALPPKSIQRSSLTRH
                     DSPGVGDELDEVQSSSGWASHRSSQSEVAELRQLSPLHHLNHHPHTASAGQLQQWHSK
                     HHSLIEGPRLQLAGSGSCSAFDQRHLDQEPPPLPIKKKHILAYMEICSASTRSIEQHR
                     HTMHACNISRNISHSQTMNIMPMSKELSPELEMPPALPPKNYKQRKATSMVASPTLQP
                     VIVTTPPPSPKPTLGENGSTGRPDSRMATVCEELNDAVASEDAMPEPRSPVLDSNENV
                     SAVDDGQTFYCHSHQLPAAEMEMSEDASSADNQPITTPQVLEEQEEPTAESRPLVAVH
                     ESVKPANVDEDEEAERADMLINMLEEVNITRYLILKKREEDGPEVKGGYIDALIVHAS
                     RVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFALLV
                     RVVNDLTSTDLTSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYKEPKVYGFV
                     GELGGAGSVGGAGIAGSGGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIP
                     EVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHL
                     RKMNNYNSYLALLSALDSGPIRRLEWQKGITEEVRSFCALIDSSSSFRAYRQALAETN
                     PPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKCAYPFRRN
                     ERIIRFFDNFKDFMGEEEMWQISEKIKPRGRRPVNY"
     misc_feature    3502..3912
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; Region: RasGEFN; smart00229"
                     /db_xref="CDD:214571"
     misc_feature    order(3559..3561,3694..3696,3706..3711,3718..3720,
                     3727..3732,3829..3831,3838..3840)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:100121"
     misc_feature    3997..4668
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; Region: RasGEF; cd00155"
                     /db_xref="CDD:238087"
     misc_feature    order(4096..4104,4126..4131,4135..4143,4147..4152,
                     4159..4164,4171..4173,4270..4272,4279..4284,4288..4296,
                     4300..4311,4315..4320,4372..4374,4387..4395,4402..4404,
                     4441..4449,4456..4464,4468..4476,4480..4491,4534..4536,
                     4546..4548,4648..4650,4657..4662)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Ras interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238087"
ORIGIN      
        1 cacattgttt gggaagcatt ttagcagcac tgcgcgacgg tcaccgcatt ttgttgttgt
       61 gttgcgcgtt taaaattgta ttgttatttt ttatattttc ttttttttgg accgaatgag
      121 agccggccaa aagtgcagtg cgagtgcgat tgaatttaag tgaatacaaa gtgcggatcg
      181 caacacaact ttataaatat atgtacatat atgtgtagtt agagcgagac ggggcgaaat
      241 atcaaataaa aatactgtac tgtgtgtgtg agcaaatact aatactactc aagcggagaa
      301 cgatgaaaat gtgcgtgtga gaggaaaaga gaatttagtg ttttttatat tatttactgg
      361 cctgcggcta tgagcaaaaa gaaccgaata tcattgcgga aaaaggagaa tgaaaattgc
      421 caagagggaa atctgtgaat cctggcggaa acacacggcc tcatcatgaa tatactgcag
      481 aaaatcgacg gcagcatcag ttctccatcc acgcccggca cctgttccag tggcatcgga
      541 gtgggcggtg gcggctgcag cagcagcagc aacaatagca tcaacagcgg cagctactcc
      601 accgcctgca ctccgccacc acccacgcat cagcatcact cgcagcacca gcagctgcag
      661 ggcacgccgg gaggatctag tcgggtaggg ggagcaggag caggcggagg tggtggtgta
      721 ccaccggcac cacccagtgc cggatcctcg ggccacaaga acagtctcaa gggcaccaag
      781 ctagcgcgcc gggcgcgttc ctttaaggac gacctcatcg agaagatttc cctgatgcga
      841 accaccaaca atacactggg tcgctcccac tcgccgcaca gtccgcgcac caagcacggc
      901 acaaaggcac cgcccaccac cgaggaggtg ctacggtcca cccaaaccct ggagacgcac
      961 gtcaaggaca tttcgaatgc cctgaagcac ttccgggatg ttatactcaa gaagaagctg
     1021 gaggtgttgc cgggcaacgg aacggtcatt ctggaaacca tagccagcat gtactccgtg
     1081 atccaaacct ataccctgaa tgaaaacagt gccatcatga gcagcgccac gctgcaggtt
     1141 taccagagcc tgggcaagct catcaagctc tgcgacgagg tgatgctctc cgaggacagc
     1201 ggcgagtgcg cctccctgag caacgagaat gtgcgggaag tcattgatct tctcgaggat
     1261 gctgtgcgga atctcgttac gctggcgcag ggcaagctga aggagcagga tcagtgcgcc
     1321 tttcgctaca gtggatctgg cttgggcggc attggagcgg cggcggagat catgggtgcg
     1381 gtcaccgcct cgccgggagc gagtgttccc ggtactggag tcatgcgcgt ttcggccgcc
     1441 gaatcagctg cccagcgtac ttcgttgccg gacatagcgc tcacgcccaa ggagcgcgac
     1501 atactggagc agcacaatgt gaacccgatg cgcggctccc acagcaccga aagtatcctg
     1561 cgcgacacga gtccaccgcc gaagccaccg ctacccaata gggccagtaa tccgccgccg
     1621 ttgccaccaa agcgacgcag ccagccgagc gcatcagctg gtacagtggg cgtaggctgc
     1681 tcatcgtcga catccacctc caatcaggcc agtccactgc cctacgccca gtcccataat
     1741 attagtctga actcggacct ggactgcagt tccaatatct cgctgctgaa ttatggcgtg
     1801 gatcgcctat ccgtgcgttc acggtcaccg gatgagaata gtcagtgctc ctttgactcg
     1861 gcgttgaatc actcacgcga ggaggaggac cagcaacagc aacatcagca tctgaggtca
     1921 tttccaaagt tggctgcgat gatggacgaa gacatggaca agatggtcag ctacaaatcc
     1981 accggttacg caggcgccgc aatcgacgac aaaacgcaga caccactttc gactggtggt
     2041 ggtatagctg gtgttgctgg tggaactgga ggagcaggcg aaggtgtagc tgctgcagcg
     2101 tctggtgacg gggaaactaa cagcaatcgc cactcaaacg aatcgggttt cgtgtcgatg
     2161 cgtgagtttc gcacttccac acagacgacg gactacagtg tccagtcctc cacgaagtcg
     2221 tccagcagca attcggagat tgcgttcagc atcagtgagt cgacggcggt cggcagcagt
     2281 agcgagtacc agcagattag ccagttggtg tcgcacagcc agcgtcatat atcctcgagc
     2341 agtagcagct gcaccaccac gaccaccagc agcagcacaa ccaccggcta tggcagcagc
     2401 gaagtggagc agctgcagca gcagcagcag cagcagacga cgacgacgcc ggccgatctg
     2461 gcgcccgcct tgccgccaaa gagcatccaa cggagcagcc taacccgcca cgactcgccc
     2521 ggagttggcg atgagctgga cgaggtgcag tcctcctccg gctgggccag ccatcggagc
     2581 agccagtcgg aggtggccga gctgcgtcag ctgtcgccgc tccatcacct caatcaccat
     2641 ccgcatactg cgtccgccgg tcaactgcag cagtggcact ccaagcacca cagcctgatc
     2701 gagggacccc gcctccagct ggcggggagt ggcagctgca gtgcgttcga tcagcgacac
     2761 ttggatcagg agccaccgcc gctgccaata aaaaagaagc acattctggc gtacatggaa
     2821 atctgttcgg cgtccacgcg atccattgag cagcatcgtc acacaatgca cgcctgcaac
     2881 ataagtcgca acatctcgca cagccagacc atgaacatta tgcccatgag caaggaactg
     2941 tcgccggagc tcgagatgcc acctgccctg ccgccaaaga actacaagca gcgcaaggcg
     3001 acaagcatgg tagcatcacc cacgctgcag cccgtcattg tgaccacgcc accgccgagt
     3061 ccgaagccga cgctgggcga gaatgggtcg acgggcaggc cggacagccg gatggccacc
     3121 gtatgcgagg agctgaacga tgcagtggcc agcgaggatg cgatgccgga gccccgttcg
     3181 cccgtgctgg acagcaatga gaatgtgagc gccgtcgatg atggacagac tttctactgt
     3241 cactcacatc agttgcccgc cgccgaaatg gagatgagcg aggatgcgag cagtgccgac
     3301 aaccagccaa taaccacgcc ccaagtgctc gaggagcagg aggagccaac ggcggagtcc
     3361 cgaccactgg tcgctgtgca cgagtcggtt aagccagcga acgtcgacga ggatgaggag
     3421 gcggagcgag cggatatgct gatcaacatg ctggaagagg tcaacatcac acggtacctg
     3481 atactcaaga agagagagga ggacgggccc gaggtgaagg gcggctacat cgatgccctc
     3541 atcgtgcacg ccagccgtgt ccaaaaggtc gccgacaatg cattctgcga ggccttcatc
     3601 accacctttc gcaccttcat ccagccgatc gacgtgatcg agaagctgac ccatcgctac
     3661 acatacttct tctgtcaagt gcaggacaac aagcagaagg ccgctaagga gacctttgcg
     3721 ctgctggtcc gagtcgtcaa cgatctaacg tcgacggatc taaccagcca gctgttgagc
     3781 ctgctggtgg agttcgtcta tcagttggtt tgctctgggc aattgtactt ggccaagttg
     3841 ctgcgcaaca agttcgtgga gaaggtgacg ctgtacaagg agcccaaggt gtacggcttt
     3901 gttggggagt tgggcggagc cggtagtgtc ggcggagcag gaatcgccgg cagtggtgga
     3961 tgcagtggta cagctggtgg tggaaaccag cctagtctgc tcgacctcaa gtcgctggag
     4021 attgccgaac agatgacgct gctggatgcg gagctgttca cgaagatcga gatacccgaa
     4081 gtattactat ttgccaaaga tcagtgcgag gagaagtcgc ccaacctaaa caagttcacc
     4141 gagcacttca acaagatgtc ctactgggcg cgctccaaaa tcctgcgcct gcaggatgcc
     4201 aaggagcggg agaagcatgt gaacaagttt atcaaaatca tgaagcatct acgcaagatg
     4261 aacaactaca actcgtatct ggcgttgttg tcggccctcg attcgggtcc cataagaaga
     4321 ttggagtggc aaaaaggcat caccgaggag gtgcgatcat tctgcgccct catcgattcc
     4381 agctccagtt ttcgcgccta tcgacaggcg ctggccgaaa ctaatccgcc ctgcataccc
     4441 tacatcggcc taattctgca ggatctaacg tttgtgcatg tgggcaacca ggactacttg
     4501 tccaagggcg tcataaactt ctccaagcgc tggcagcagt acaacataat tgacaacatg
     4561 aaacgtttta agaaatgtgc ctatccattt cgacgcaacg agcgcattat acgcttcttt
     4621 gataacttca aggactttat gggcgaggag gagatgtggc agatatcgga gaagatcaag
     4681 ccgcgtggac gccgccccgt taactattag tcttcaagca gcaacagcaa aacaccaata
     4741 ttatatatga taaagtatat acaccgtatt aattaaacag ttcaaaacgg ttgccacgtc
     4801 taggaggagg atcagcatcg ggagcagcca acaactattc taatgggtct gagcaataat
     4861 gttcgctatt ctctgtctat atatatacaa ttatacaaga tatttagctg taattaccag
     4921 ccgatgccga atcggaaata catatacata cttacttaag atgtagcgat tcagatacgg
     4981 atacggatac atgtagccgc gtacaaataa cgagccgatc tgtagtttaa ctattaagct
     5041 ctatgagtca ttgggtcgat ggacctaacc tcagctaact ccccaccaat attcgaatcc
     5101 gaatccctgt ctgcgagtcc caaaaacttt ttcccggact tttgccagca ctagaacacc
     5161 aaactaacta actaacttac ttaccaccag agacaaccaa tcaagaaatc agcaattttc
     5221 gcttttgttt tgagatctct tttttacaca agaacacaac gaattttgaa agcaagctac
     5281 gtgaacgtag aggccaaccg acaaactata ttcgacgata tatgtagcga tatctcggac
     5341 tataaatcga tgcaatccac gagcagaaca ccaagcgaac cctagcacaa agcgcgttat
     5401 atgcaattct ctctccaaac aaccaatatt aaatacccgt gtgtgtgtat gtgtgttaga
     5461 agttattcaa attgaaattg aactcaaaat caaaatcaga gatttcagag tgcacgaaac
     5521 agaaaacaga aggcggtatc tatcgatcaa atcaatcaat caatgaaatc aatcaaaaat
     5581 tcattttgcg actcaattaa ttgaagaaac ttttaaagtt acaaaacaaa acaaaataca
     5641 aaaaatac