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Drosophila melanogaster integrator 6, transcript variant E (IntS6),


LOCUS       NM_001272332            5403 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001272332
VERSION     NM_001272332.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5403)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5403)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5403)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5403)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5403)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5403)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5403)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5403)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5403)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5403)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5403)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5403)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5403)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5403)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5403)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5403)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5403)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5403)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5403)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5403)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5403)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5403)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5403)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5403
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5403
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="Integrator 6"
                     /map="5B4-5B6"
                     /db_xref="FLYBASE:FBgn0261383"
                     /db_xref="GeneID:31496"
     CDS             230..4084
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="CG3125 gene product from transcript CG3125-RE;
                     CG3125-PE; IntS6-PE"
                     /codon_start=1
                     /product="integrator 6, isoform E"
                     /protein_id="NP_001259261.1"
                     /db_xref="FLYBASE:FBpp0304675"
                     /db_xref="GeneID:31496"
                     /db_xref="FLYBASE:FBgn0261383"
                     /translation="MTIILFLVDTSSSMCQKAYVNGVQKTYLDIAKGAVETFLKYRQR
                     TQDCLGDRYMLLTFEEPPANVKAGWKENHATFMNELKNLQSHGLTSMGESLRNAFDLL
                     NLNRMQSGIDTYGQGRCPFYLEPSVIIVITDGGRYSYRNGVHQEIILPLSNQIPGTKF
                     TKEPFRWDQRLFSLVLRMPGNKIDERVDGKVPHDDSPIERMCEVTGGRSYRVRSHYVL
                     NQCIESLVQKVQPGVVLQFEPMLPKEATSATAGEAAGASTISGMGISSTSGAGPAPDI
                     VFQPVKKMIYVQKHITQKTFPIGYWPLPEPYWPDSKAITLPPRDAHPKLKVLTPAVDE
                     PQLVRSFPVDKYEIEGCPLTLQILNKREMNKCWQVIVTNGMHGFELPFGYLKAAPNFS
                     QVHLYVLAYNYPALLPILHDLIHKYNMSPPSDLMYKFNAYVRSIPPYYCPFLRKALVN
                     INVPYQLLQFLLPENVDNYLSPTIANQLKHIKNTAKQDQENLCMKVYKQLKQPKPPYR
                     QVETGKLFTGAPLRRDLVRHPLLRDIFSKLHGEIDPVENYTIVVPQPTHQSSAKSHRN
                     PFDIPRRDLVEEIAKMRETLLRPVSLVAKDSGHCLPIAEMGNYQEYLKNKDNPLREIE
                     PTNVRQHMFGNPYKKDKHMVMVDEADLSDVAPMKSPNGNGPGGAPPGSPSGSGSPTGP
                     GPSSPGSSPGGGSGPGMPGMPGMGGGMSGLMLGAGGSGGSSKKLDGTSRGRKRKAGPL
                     PRSFEFRRSSTDSRSSSSGSESSTTGSAPGSPIPGATSSISGCDSAMGADGGPSSSCF
                     DEDSNSNSSFVSSTSEASASDSGMSNSHLDPLRISFVFIEEETSDQDTPLNGYVHNFI
                     NGISDDAETGETEAVPGGASLPGASSANEPSSIGASPAVSATPATSVIPASNGSEVCS
                     AVAAGSSSSISSSASSPGVLYVPLNGLTTHAAYSSNLGGPSSPLDNLSSLGGAAGGGG
                     SGLLGVSKPGSLPLANGYGHGHSSAISPPSPLSLVPLSPLGTSTPAASSSGLSSSSAY
                     FSHNDINDASEISRILQTCHNGTSSGSSVGAGASNSNLNGNGSTESGGGVSSDDHASL
                     GGNSFDALKRTAGTAGSTAAGNPHYYWASGLNHHNNNNSSAAGAASGSTLSNNHNHRG
                     HNNSSPNKLEVKINSSCGSSPTHNNGGMGSPGQSLPLIFTEEQREAARLHNVELRLQI
                     FRDIRRPGRDYSQLLEHLNLVKGDQDMQSDFVDMCIVESLRFRRHRMASSIQEWWDRK
                     QQLTAVGTNEATPSAEQAVAKS"
     misc_feature    239..622
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="von Willebrand factor type A domain; Region: VWA_2;
                     pfam13519"
                     /db_xref="CDD:463909"
     misc_feature    3815..3997
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="INTS6/SAGE1/DDX26B/CT45 C-terminus; Region:
                     INT_SG_DDX_CT_C; pfam15300"
                     /db_xref="CDD:464626"
ORIGIN      
        1 caaatcattc gaactttgag aacggtagtg ttgtgttgtt attgctcggc agcaaagtaa
       61 aatccgaaga gaagcgagtc gaacaagaga agaagaagcg caggagtgga cgacagcaat
      121 gcaacaacag tgacgaggcg ccagtgtgca aaagatatca gagagagacg gaaagacacg
      181 caaattggga agaggaagag gtccctcgaa cgcaggatca atcatcgcca tgacaatcat
      241 actcttcctg gtggacactt cgtcgtccat gtgccagaag gcgtatgtga atggggtaca
      301 gaaaacgtat ctggacattg ccaagggagc cgtggagacg tttctcaagt atcgccagcg
      361 tacgcaggat tgcctgggag atcgctacat gctgctcaca ttcgaggagc caccggcaaa
      421 cgtgaaagct ggatggaagg agaaccatgc caccttcatg aacgagctga agaacctaca
      481 gagtcacggc ctcacctcga tgggtgaatc gctgcgcaat gcgttcgatt tgttaaatct
      541 gaatcgcatg cagtcgggca tcgatacgta cgggcagggc aggtgcccgt tttatctgga
      601 gccatcggtc atcattgtga ttacggacgg cggtcgctat tcgtaccgga atggtgtcca
      661 tcaggagatc atactgccgc taagtaacca aataccgggc acaaagttta ctaaggagcc
      721 atttcgctgg gatcagcgct tgttttcgct tgtcctccgc atgccgggca acaagattga
      781 cgagcgagtg gacggcaagg tgccgcatga cgattctccc atcgaacgga tgtgcgaggt
      841 aaccggcgga cgttcatatc gagtgcgaag ccactacgta ctcaaccagt gcattgaaag
      901 tcttgtccaa aaggttcagc ctggtgtggt gctgcagttc gagcctatgc tgcccaagga
      961 ggctacttcc gctaccgctg gcgaagcggc gggtgcgagc acgatatccg gcatgggaat
     1021 atcctcaacg tccggagcgg gtcccgctcc cgatattgtc ttccagccgg taaagaagat
     1081 gatctacgtg cagaagcaca tcacgcagaa aacctttccc atcggctatt ggccactgcc
     1141 ggagccctat tggccggact ccaaggcgat tacattgccg cctcgcgacg cacatcccaa
     1201 gctgaaggtc ctgacgccgg cggtggacga gccacagctg gtgcgcagct tccccgtcga
     1261 caagtacgag attgaaggct gtccgttaac gctgcagatt ctcaacaagc gcgagatgaa
     1321 caagtgctgg caggtgattg tgaccaatgg catgcatgga ttcgagctgc cctttggcta
     1381 cctaaaagcg gcgcctaact tttcgcaggt acacctctat gtactggcct acaattatcc
     1441 agcgttgctg cccattctgc atgacctcat tcacaagtac aatatgagtc cgccgagcga
     1501 tctgatgtac aaattcaacg cctatgtgcg ttcaataccg ccgtattact gcccgttcct
     1561 gcgcaaggcg ctggtcaaca tcaatgtgcc gtatcagctg ctgcagtttc tgctgccgga
     1621 gaatgtggac aactatctgt cgccaacgat cgccaatcag ctgaagcaca tcaagaatac
     1681 ggccaagcag gatcaggaga atctttgcat gaaggtgtac aagcagctga agcagccgaa
     1741 gccaccatat cgccaagtgg agacgggcaa actgttcaca ggtgcgccgt tgcgcagaga
     1801 tttggtgcgg catccactgc tccgggatat attttccaag ttgcatgggg aaatagatcc
     1861 cgtggagaat tatacgattg tggtgccgca gccaacgcat cagtcgtcgg ccaagtcgca
     1921 tcgcaatccc ttcgatatac cgcggcggga tttggtggag gaaatagcca agatgcgtga
     1981 gaccttactg cgacccgtct cgctggtggc caaggactcg ggccattgcc tgcccatcgc
     2041 cgagatgggc aactaccagg agtacctcaa gaacaaggac aatccgctgc gtgaaatcga
     2101 gccgacgaat gtgcggcagc acatgttcgg taatccgtac aagaaggaca agcacatggt
     2161 gatggtggac gaggcggatc tgagcgatgt ggcgccaatg aagtcgccaa atggcaatgg
     2221 accgggtgga gcgccgcccg gctcaccttc cggatcgggc tcgcccactg gaccgggtcc
     2281 ctcatccccg ggctcttcgc ccggcggtgg ttcgggtccc gggatgcccg gaatgccggg
     2341 aatggggggt ggaatgtcag gactgatgct gggcgcaggt ggcagtggcg gatcctctaa
     2401 aaaactggac ggaacgtctc gtgggcgaaa gaggaaagca ggaccgctgc cacgtagctt
     2461 tgaattccgt cgatcatcta cggactcgcg atcttcgagc tccggctccg aatcatcaac
     2521 aacgggtagt gcaccaggat caccgatacc aggcgccacg tcatccatat ccggctgcga
     2581 ttccgccatg ggcgctgatg gcggtcccag ttccagctgt ttcgacgagg acagcaatag
     2641 caacagcagc tttgtgagct ccacatcgga ggcctcggcc agtgattcag ggatgtcaaa
     2701 ctcgcatttg gatcccttgc gaatcagttt cgttttcatc gaggaggaga ccagcgatca
     2761 ggatacgccg ctcaatggtt atgtgcacaa tttcatcaat ggcatcagcg acgatgcaga
     2821 aacgggcgaa acggaagcag ttccaggcgg ggcatccctg ccgggtgcgt cttcagctaa
     2881 cgaaccgtcg tcaattggag catcaccagc agtttcagcc acgccagcaa catctgtgat
     2941 ccccgccagc aatggcagcg aagtttgctc cgccgtcgcg gccggcagca gcagttccat
     3001 cagctccagc gccagttccc cgggcgttct ctacgtgccc ctcaacggac tgaccaccca
     3061 tgcggcctac agcagtaatc tgggtggtcc gagctcgccg ttggacaacc ttagctccct
     3121 gggtggagcg gcgggtggcg gaggatcggg actactcggt gtcagcaagc cgggatcgct
     3181 gccactggcc aatggttatg gacacggtca tagttcagcc atttccccac cttcgccatt
     3241 gtccttggtg cctctatcac cattgggaac aagtacgccc gctgccagca gctcgggact
     3301 atcgtctagt tccgcctact tcagccacaa tgacatcaac gatgcctcgg agatctcgcg
     3361 catactgcag acctgtcaca atggaaccag cagtggctcc tcggtcggag cgggcgcaag
     3421 caacagcaat ttgaatggca atggcagcac ggagagtggc ggaggagtct catccgacga
     3481 tcatgcctcg ctgggtggca acagtttcga tgccctgaaa cggacagcgg gtactgcggg
     3541 cagcactgca gcgggaaatc cccactacta ctgggccagt ggtctcaatc atcacaacaa
     3601 taacaacagc agcgccgctg gagcagctag cggttcgacg ttgagcaaca atcacaacca
     3661 ccggggtcac aacaacagca gccccaacaa actggaggtg aagatcaact ccagctgcgg
     3721 ctcctcaccg acgcacaaca acgggggcat gggctcaccg ggacagagcc tgccgctcat
     3781 tttcaccgag gagcagcgcg aagcggcccg gttgcacaac gtcgaactac gattgcagat
     3841 cttccgtgat atacggcgac ccggccgaga ctacagccag ctgctggagc acctgaatct
     3901 ggtcaagggc gaccaggata tgcagtcgga tttcgtggac atgtgtatcg tggaatcgct
     3961 gcgcttccgc cgccatcgca tggcgtccag catacaggag tggtgggatc gcaagcagca
     4021 gttaactgcc gtgggaacca atgaagcgac ccccagcgcg gagcaggccg tcgccaagag
     4081 ttaacgatgg ctcatgtggc accactgagc ccgcggggtc atccaatcca tctgtctgtg
     4141 atgtcaacaa aatcgaaatc gaaatctaaa ccgaaactgg gaaggggaag agcagccgcg
     4201 gaagccaaga attctcgtca atttccatat actgtaaata attgccagga caggtagccc
     4261 acaggatctg gatggggatc aacgcatacc aaacaagcaa caataatatt aacaatttcc
     4321 atatactgta aataattgcc aggacaggta gcccacagga tctggatggg gatcaacgca
     4381 taccaaacaa gcaacaataa tattaacaac aaaaccaaca agcagccaca attctaaatg
     4441 agagaaaaca ccacattttt agggcaagct agctacatgt aattataaca tatatataaa
     4501 taaatactta agctagccgt tagttagcaa tagaatataa agtataaagc gaagggattt
     4561 tgtagcagcc gtttcagttg tagttttttt tttacttagt ataaatatgt aagcgtaaat
     4621 taaaatttac tcttgagctt aggaataatt ttaaatagac ttagataaat taagataaat
     4681 ctaagtgtag tgtatgtgta taaaaaaaaa gggaaaagtt taggaaaagc ttgagcttaa
     4741 tgagccccac acgttttagc caattttttg ttggacctgt ttcaagaaca ctttgctttg
     4801 attttagcca aaacgaatag agaacgtaaa aaacaaaagc gatgaccctt caaaaacaga
     4861 tatatatgtg tatgtttata tacatatatg tatatagagg atattacata aatcgggtca
     4921 gcgttttatt attaaaaaga attgtattac cttgtatttc cttgaatcct ccaatatatt
     4981 atttgctatt atgttatgtt tattttataa aatatttatg cgaattgtaa tgtgagcata
     5041 gcctgtagaa aggcagacaa aacgataagc gaaaacgtac agtttgttat atacatatag
     5101 aaaaacaaga aaaaagtaat acatttttgc actatttttt tacgtgtatg tttgtatgca
     5161 tggcctgtga gtaattgaga tataacaaaa acgaaaaaca caaagagaaa acgtttacta
     5221 gtagttaggc ggcgggcagt gttttagaac tgcttcatta ttaaataatg atgtacaatt
     5281 tagagtctgc gtatttaaca aatttcataa gacaaccacc acaacagaat caacagagca
     5341 gcagcaaagc aaactgaaat caatacgaaa tcaaacgaaa ataaaaagag gagcattgca
     5401 ttc