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Drosophila melanogaster integrator 6, transcript variant D (IntS6),


LOCUS       NM_001272331            5747 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001272331
VERSION     NM_001272331.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5747)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5747)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5747)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5747)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5747)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5747)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5747)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5747)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5747)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5747)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5747)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5747)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5747)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5747)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5747)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5747)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5747)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5747)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5747)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5747)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5747)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5747)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5747)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5747
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5747
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="Integrator 6"
                     /map="5B4-5B6"
                     /db_xref="FLYBASE:FBgn0261383"
                     /db_xref="GeneID:31496"
     CDS             574..4428
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="CG3125 gene product from transcript CG3125-RD;
                     CG3125-PD; IntS6-PD"
                     /codon_start=1
                     /product="integrator 6, isoform D"
                     /protein_id="NP_001259260.1"
                     /db_xref="FLYBASE:FBpp0304674"
                     /db_xref="GeneID:31496"
                     /db_xref="FLYBASE:FBgn0261383"
                     /translation="MTIILFLVDTSSSMCQKAYVNGVQKTYLDIAKGAVETFLKYRQR
                     TQDCLGDRYMLLTFEEPPANVKAGWKENHATFMNELKNLQSHGLTSMGESLRNAFDLL
                     NLNRMQSGIDTYGQGRCPFYLEPSVIIVITDGGRYSYRNGVHQEIILPLSNQIPGTKF
                     TKEPFRWDQRLFSLVLRMPGNKIDERVDGKVPHDDSPIERMCEVTGGRSYRVRSHYVL
                     NQCIESLVQKVQPGVVLQFEPMLPKEATSATAGEAAGASTISGMGISSTSGAGPAPDI
                     VFQPVKKMIYVQKHITQKTFPIGYWPLPEPYWPDSKAITLPPRDAHPKLKVLTPAVDE
                     PQLVRSFPVDKYEIEGCPLTLQILNKREMNKCWQVIVTNGMHGFELPFGYLKAAPNFS
                     QVHLYVLAYNYPALLPILHDLIHKYNMSPPSDLMYKFNAYVRSIPPYYCPFLRKALVN
                     INVPYQLLQFLLPENVDNYLSPTIANQLKHIKNTAKQDQENLCMKVYKQLKQPKPPYR
                     QVETGKLFTGAPLRRDLVRHPLLRDIFSKLHGEIDPVENYTIVVPQPTHQSSAKSHRN
                     PFDIPRRDLVEEIAKMRETLLRPVSLVAKDSGHCLPIAEMGNYQEYLKNKDNPLREIE
                     PTNVRQHMFGNPYKKDKHMVMVDEADLSDVAPMKSPNGNGPGGAPPGSPSGSGSPTGP
                     GPSSPGSSPGGGSGPGMPGMPGMGGGMSGLMLGAGGSGGSSKKLDGTSRGRKRKAGPL
                     PRSFEFRRSSTDSRSSSSGSESSTTGSAPGSPIPGATSSISGCDSAMGADGGPSSSCF
                     DEDSNSNSSFVSSTSEASASDSGMSNSHLDPLRISFVFIEEETSDQDTPLNGYVHNFI
                     NGISDDAETGETEAVPGGASLPGASSANEPSSIGASPAVSATPATSVIPASNGSEVCS
                     AVAAGSSSSISSSASSPGVLYVPLNGLTTHAAYSSNLGGPSSPLDNLSSLGGAAGGGG
                     SGLLGVSKPGSLPLANGYGHGHSSAISPPSPLSLVPLSPLGTSTPAASSSGLSSSSAY
                     FSHNDINDASEISRILQTCHNGTSSGSSVGAGASNSNLNGNGSTESGGGVSSDDHASL
                     GGNSFDALKRTAGTAGSTAAGNPHYYWASGLNHHNNNNSSAAGAASGSTLSNNHNHRG
                     HNNSSPNKLEVKINSSCGSSPTHNNGGMGSPGQSLPLIFTEEQREAARLHNVELRLQI
                     FRDIRRPGRDYSQLLEHLNLVKGDQDMQSDFVDMCIVESLRFRRHRMASSIQEWWDRK
                     QQLTAVGTNEATPSAEQAVAKS"
     misc_feature    583..966
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="von Willebrand factor type A domain; Region: VWA_2;
                     pfam13519"
                     /db_xref="CDD:463909"
     misc_feature    4159..4341
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="INTS6/SAGE1/DDX26B/CT45 C-terminus; Region:
                     INT_SG_DDX_CT_C; pfam15300"
                     /db_xref="CDD:464626"
ORIGIN      
        1 caaatcattc gaactttgag aacggtagtg ttgtgttgtt attgctcggc agcaaagtaa
       61 aatccgaaga gaagcgagtc gaacaagaga agaagaagcg caggagtgga cgacagcaat
      121 gcaacaacag tgacgaggcg ccagtgtgca aaattcgctg ttgttgttgt ttctccagtc
      181 caaatgtcag ctgttgcacg caacatgtac catagaagcg gaacagcgaa acgcagaaaa
      241 agagcaaatc gatcaagccc aggacaagaa caacaagtgc aagagaatcg gcagcaaaaa
      301 caacaagcag ataaagagag ctgctaacaa cgtaaacaaa acctaaacac ctatacacac
      361 gcaaagggag atagcaacaa atacaaaaac aacaaccaca aatagcaaga atatagcaga
      421 aagcgagaga gaaggagagg gagaaagtgc acctgagagg ggaaataaaa gatcaacgat
      481 aaaagataag agataaagat atcagagaga gacggaaaga cacgcaaatt gggaagagga
      541 agaggtccct cgaacgcagg atcaatcatc gccatgacaa tcatactctt cctggtggac
      601 acttcgtcgt ccatgtgcca gaaggcgtat gtgaatgggg tacagaaaac gtatctggac
      661 attgccaagg gagccgtgga gacgtttctc aagtatcgcc agcgtacgca ggattgcctg
      721 ggagatcgct acatgctgct cacattcgag gagccaccgg caaacgtgaa agctggatgg
      781 aaggagaacc atgccacctt catgaacgag ctgaagaacc tacagagtca cggcctcacc
      841 tcgatgggtg aatcgctgcg caatgcgttc gatttgttaa atctgaatcg catgcagtcg
      901 ggcatcgata cgtacgggca gggcaggtgc ccgttttatc tggagccatc ggtcatcatt
      961 gtgattacgg acggcggtcg ctattcgtac cggaatggtg tccatcagga gatcatactg
     1021 ccgctaagta accaaatacc gggcacaaag tttactaagg agccatttcg ctgggatcag
     1081 cgcttgtttt cgcttgtcct ccgcatgccg ggcaacaaga ttgacgagcg agtggacggc
     1141 aaggtgccgc atgacgattc tcccatcgaa cggatgtgcg aggtaaccgg cggacgttca
     1201 tatcgagtgc gaagccacta cgtactcaac cagtgcattg aaagtcttgt ccaaaaggtt
     1261 cagcctggtg tggtgctgca gttcgagcct atgctgccca aggaggctac ttccgctacc
     1321 gctggcgaag cggcgggtgc gagcacgata tccggcatgg gaatatcctc aacgtccgga
     1381 gcgggtcccg ctcccgatat tgtcttccag ccggtaaaga agatgatcta cgtgcagaag
     1441 cacatcacgc agaaaacctt tcccatcggc tattggccac tgccggagcc ctattggccg
     1501 gactccaagg cgattacatt gccgcctcgc gacgcacatc ccaagctgaa ggtcctgacg
     1561 ccggcggtgg acgagccaca gctggtgcgc agcttccccg tcgacaagta cgagattgaa
     1621 ggctgtccgt taacgctgca gattctcaac aagcgcgaga tgaacaagtg ctggcaggtg
     1681 attgtgacca atggcatgca tggattcgag ctgccctttg gctacctaaa agcggcgcct
     1741 aacttttcgc aggtacacct ctatgtactg gcctacaatt atccagcgtt gctgcccatt
     1801 ctgcatgacc tcattcacaa gtacaatatg agtccgccga gcgatctgat gtacaaattc
     1861 aacgcctatg tgcgttcaat accgccgtat tactgcccgt tcctgcgcaa ggcgctggtc
     1921 aacatcaatg tgccgtatca gctgctgcag tttctgctgc cggagaatgt ggacaactat
     1981 ctgtcgccaa cgatcgccaa tcagctgaag cacatcaaga atacggccaa gcaggatcag
     2041 gagaatcttt gcatgaaggt gtacaagcag ctgaagcagc cgaagccacc atatcgccaa
     2101 gtggagacgg gcaaactgtt cacaggtgcg ccgttgcgca gagatttggt gcggcatcca
     2161 ctgctccggg atatattttc caagttgcat ggggaaatag atcccgtgga gaattatacg
     2221 attgtggtgc cgcagccaac gcatcagtcg tcggccaagt cgcatcgcaa tcccttcgat
     2281 ataccgcggc gggatttggt ggaggaaata gccaagatgc gtgagacctt actgcgaccc
     2341 gtctcgctgg tggccaagga ctcgggccat tgcctgccca tcgccgagat gggcaactac
     2401 caggagtacc tcaagaacaa ggacaatccg ctgcgtgaaa tcgagccgac gaatgtgcgg
     2461 cagcacatgt tcggtaatcc gtacaagaag gacaagcaca tggtgatggt ggacgaggcg
     2521 gatctgagcg atgtggcgcc aatgaagtcg ccaaatggca atggaccggg tggagcgccg
     2581 cccggctcac cttccggatc gggctcgccc actggaccgg gtccctcatc cccgggctct
     2641 tcgcccggcg gtggttcggg tcccgggatg cccggaatgc cgggaatggg gggtggaatg
     2701 tcaggactga tgctgggcgc aggtggcagt ggcggatcct ctaaaaaact ggacggaacg
     2761 tctcgtgggc gaaagaggaa agcaggaccg ctgccacgta gctttgaatt ccgtcgatca
     2821 tctacggact cgcgatcttc gagctccggc tccgaatcat caacaacggg tagtgcacca
     2881 ggatcaccga taccaggcgc cacgtcatcc atatccggct gcgattccgc catgggcgct
     2941 gatggcggtc ccagttccag ctgtttcgac gaggacagca atagcaacag cagctttgtg
     3001 agctccacat cggaggcctc ggccagtgat tcagggatgt caaactcgca tttggatccc
     3061 ttgcgaatca gtttcgtttt catcgaggag gagaccagcg atcaggatac gccgctcaat
     3121 ggttatgtgc acaatttcat caatggcatc agcgacgatg cagaaacggg cgaaacggaa
     3181 gcagttccag gcggggcatc cctgccgggt gcgtcttcag ctaacgaacc gtcgtcaatt
     3241 ggagcatcac cagcagtttc agccacgcca gcaacatctg tgatccccgc cagcaatggc
     3301 agcgaagttt gctccgccgt cgcggccggc agcagcagtt ccatcagctc cagcgccagt
     3361 tccccgggcg ttctctacgt gcccctcaac ggactgacca cccatgcggc ctacagcagt
     3421 aatctgggtg gtccgagctc gccgttggac aaccttagct ccctgggtgg agcggcgggt
     3481 ggcggaggat cgggactact cggtgtcagc aagccgggat cgctgccact ggccaatggt
     3541 tatggacacg gtcatagttc agccatttcc ccaccttcgc cattgtcctt ggtgcctcta
     3601 tcaccattgg gaacaagtac gcccgctgcc agcagctcgg gactatcgtc tagttccgcc
     3661 tacttcagcc acaatgacat caacgatgcc tcggagatct cgcgcatact gcagacctgt
     3721 cacaatggaa ccagcagtgg ctcctcggtc ggagcgggcg caagcaacag caatttgaat
     3781 ggcaatggca gcacggagag tggcggagga gtctcatccg acgatcatgc ctcgctgggt
     3841 ggcaacagtt tcgatgccct gaaacggaca gcgggtactg cgggcagcac tgcagcggga
     3901 aatccccact actactgggc cagtggtctc aatcatcaca acaataacaa cagcagcgcc
     3961 gctggagcag ctagcggttc gacgttgagc aacaatcaca accaccgggg tcacaacaac
     4021 agcagcccca acaaactgga ggtgaagatc aactccagct gcggctcctc accgacgcac
     4081 aacaacgggg gcatgggctc accgggacag agcctgccgc tcattttcac cgaggagcag
     4141 cgcgaagcgg cccggttgca caacgtcgaa ctacgattgc agatcttccg tgatatacgg
     4201 cgacccggcc gagactacag ccagctgctg gagcacctga atctggtcaa gggcgaccag
     4261 gatatgcagt cggatttcgt ggacatgtgt atcgtggaat cgctgcgctt ccgccgccat
     4321 cgcatggcgt ccagcataca ggagtggtgg gatcgcaagc agcagttaac tgccgtggga
     4381 accaatgaag cgacccccag cgcggagcag gccgtcgcca agagttaacg atggctcatg
     4441 tggcaccact gagcccgcgg ggtcatccaa tccatctgtc tgtgatgtca acaaaatcga
     4501 aatcgaaatc taaaccgaaa ctgggaaggg gaagagcagc cgcggaagcc aagaattctc
     4561 gtcaatttcc atatactgta aataattgcc aggacaggta gcccacagga tctggatggg
     4621 gatcaacgca taccaaacaa gcaacaataa tattaacaat ttccatatac tgtaaataat
     4681 tgccaggaca ggtagcccac aggatctgga tggggatcaa cgcataccaa acaagcaaca
     4741 ataatattaa caacaaaacc aacaagcagc cacaattcta aatgagagaa aacaccacat
     4801 ttttagggca agctagctac atgtaattat aacatatata taaataaata cttaagctag
     4861 ccgttagtta gcaatagaat ataaagtata aagcgaaggg attttgtagc agccgtttca
     4921 gttgtagttt tttttttact tagtataaat atgtaagcgt aaattaaaat ttactcttga
     4981 gcttaggaat aattttaaat agacttagat aaattaagat aaatctaagt gtagtgtatg
     5041 tgtataaaaa aaaagggaaa agtttaggaa aagcttgagc ttaatgagcc ccacacgttt
     5101 tagccaattt tttgttggac ctgtttcaag aacactttgc tttgatttta gccaaaacga
     5161 atagagaacg taaaaaacaa aagcgatgac ccttcaaaaa cagatatata tgtgtatgtt
     5221 tatatacata tatgtatata gaggatatta cataaatcgg gtcagcgttt tattattaaa
     5281 aagaattgta ttaccttgta tttccttgaa tcctccaata tattatttgc tattatgtta
     5341 tgtttatttt ataaaatatt tatgcgaatt gtaatgtgag catagcctgt agaaaggcag
     5401 acaaaacgat aagcgaaaac gtacagtttg ttatatacat atagaaaaac aagaaaaaag
     5461 taatacattt ttgcactatt tttttacgtg tatgtttgta tgcatggcct gtgagtaatt
     5521 gagatataac aaaaacgaaa aacacaaaga gaaaacgttt actagtagtt aggcggcggg
     5581 cagtgtttta gaactgcttc attattaaat aatgatgtac aatttagagt ctgcgtattt
     5641 aacaaatttc ataagacaac caccacaaca gaatcaacag agcagcagca aagcaaactg
     5701 aaatcaatac gaaatcaaac gaaaataaaa agaggagcat tgcattc