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Drosophila melanogaster integrator 6, transcript variant C (IntS6),


LOCUS       NM_001272330            6077 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001272330
VERSION     NM_001272330.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6077)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6077)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6077)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6077)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6077)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6077)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6077)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6077)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6077)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6077)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6077)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6077)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6077)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6077)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6077)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6077)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6077)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6077)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6077)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6077)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6077)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6077)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6077)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6077
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6077
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="Integrator 6"
                     /map="5B4-5B6"
                     /db_xref="FLYBASE:FBgn0261383"
                     /db_xref="GeneID:31496"
     CDS             904..4758
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="CG3125 gene product from transcript CG3125-RC;
                     CG3125-PC; IntS6-PC"
                     /codon_start=1
                     /product="integrator 6, isoform C"
                     /protein_id="NP_001259259.1"
                     /db_xref="FLYBASE:FBpp0304673"
                     /db_xref="GeneID:31496"
                     /db_xref="FLYBASE:FBgn0261383"
                     /translation="MTIILFLVDTSSSMCQKAYVNGVQKTYLDIAKGAVETFLKYRQR
                     TQDCLGDRYMLLTFEEPPANVKAGWKENHATFMNELKNLQSHGLTSMGESLRNAFDLL
                     NLNRMQSGIDTYGQGRCPFYLEPSVIIVITDGGRYSYRNGVHQEIILPLSNQIPGTKF
                     TKEPFRWDQRLFSLVLRMPGNKIDERVDGKVPHDDSPIERMCEVTGGRSYRVRSHYVL
                     NQCIESLVQKVQPGVVLQFEPMLPKEATSATAGEAAGASTISGMGISSTSGAGPAPDI
                     VFQPVKKMIYVQKHITQKTFPIGYWPLPEPYWPDSKAITLPPRDAHPKLKVLTPAVDE
                     PQLVRSFPVDKYEIEGCPLTLQILNKREMNKCWQVIVTNGMHGFELPFGYLKAAPNFS
                     QVHLYVLAYNYPALLPILHDLIHKYNMSPPSDLMYKFNAYVRSIPPYYCPFLRKALVN
                     INVPYQLLQFLLPENVDNYLSPTIANQLKHIKNTAKQDQENLCMKVYKQLKQPKPPYR
                     QVETGKLFTGAPLRRDLVRHPLLRDIFSKLHGEIDPVENYTIVVPQPTHQSSAKSHRN
                     PFDIPRRDLVEEIAKMRETLLRPVSLVAKDSGHCLPIAEMGNYQEYLKNKDNPLREIE
                     PTNVRQHMFGNPYKKDKHMVMVDEADLSDVAPMKSPNGNGPGGAPPGSPSGSGSPTGP
                     GPSSPGSSPGGGSGPGMPGMPGMGGGMSGLMLGAGGSGGSSKKLDGTSRGRKRKAGPL
                     PRSFEFRRSSTDSRSSSSGSESSTTGSAPGSPIPGATSSISGCDSAMGADGGPSSSCF
                     DEDSNSNSSFVSSTSEASASDSGMSNSHLDPLRISFVFIEEETSDQDTPLNGYVHNFI
                     NGISDDAETGETEAVPGGASLPGASSANEPSSIGASPAVSATPATSVIPASNGSEVCS
                     AVAAGSSSSISSSASSPGVLYVPLNGLTTHAAYSSNLGGPSSPLDNLSSLGGAAGGGG
                     SGLLGVSKPGSLPLANGYGHGHSSAISPPSPLSLVPLSPLGTSTPAASSSGLSSSSAY
                     FSHNDINDASEISRILQTCHNGTSSGSSVGAGASNSNLNGNGSTESGGGVSSDDHASL
                     GGNSFDALKRTAGTAGSTAAGNPHYYWASGLNHHNNNNSSAAGAASGSTLSNNHNHRG
                     HNNSSPNKLEVKINSSCGSSPTHNNGGMGSPGQSLPLIFTEEQREAARLHNVELRLQI
                     FRDIRRPGRDYSQLLEHLNLVKGDQDMQSDFVDMCIVESLRFRRHRMASSIQEWWDRK
                     QQLTAVGTNEATPSAEQAVAKS"
     misc_feature    913..1296
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="von Willebrand factor type A domain; Region: VWA_2;
                     pfam13519"
                     /db_xref="CDD:463909"
     misc_feature    4489..4671
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="INTS6/SAGE1/DDX26B/CT45 C-terminus; Region:
                     INT_SG_DDX_CT_C; pfam15300"
                     /db_xref="CDD:464626"
ORIGIN      
        1 caaatcattc gaactttgag aacggtagtg ttgtgttgtt attgctcggc agcaaagtaa
       61 aatccgaaga gaagcgagtc gaacaagaga agaagaagcg caggagtgga cgacagcaat
      121 gcaacaacag tgacgaggcg ccagtgtgca aaagtatgtg tgcgagtgcg tgtaagcaac
      181 aactccccga tacaaaccta cgagcgagag ggggacggcg atagcgacgg tcgttcggtc
      241 ggtcggtccg accgctagtc gcgtctgtcg gtcgttctcg cctatgcacc tcggcggcag
      301 agcgaaagag agcgcactct ggctgtgtgt gtgcgtgtgt gttctcgctc tctcgcgcgg
      361 tggtgataaa tttctgttgg cacaaagtaa aaatataaca gaataaaaaa tcgtggcgcg
      421 gcatatagaa gctaatcgaa aattattgcg agtattgggt ggaggagaaa cattcctctt
      481 cttttcgctg ttgttgttgt ttctccagtc caaatgtcag ctgttgcacg caacatgtac
      541 catagaagcg gaacagcgaa acgcagaaaa agagcaaatc gatcaagccc aggacaagaa
      601 caacaagtgc aagagaatcg gcagcaaaaa caacaagcag ataaagagag ctgctaacaa
      661 cgtaaacaaa acctaaacac ctatacacac gcaaagggag atagcaacaa atacaaaaac
      721 aacaaccaca aatagcaaga atatagcaga aagcgagaga gaaggagagg gagaaagtgc
      781 acctgagagg ggaaataaaa gatcaacgat aaaagataag agataaagat atcagagaga
      841 gacggaaaga cacgcaaatt gggaagagga agaggtccct cgaacgcagg atcaatcatc
      901 gccatgacaa tcatactctt cctggtggac acttcgtcgt ccatgtgcca gaaggcgtat
      961 gtgaatgggg tacagaaaac gtatctggac attgccaagg gagccgtgga gacgtttctc
     1021 aagtatcgcc agcgtacgca ggattgcctg ggagatcgct acatgctgct cacattcgag
     1081 gagccaccgg caaacgtgaa agctggatgg aaggagaacc atgccacctt catgaacgag
     1141 ctgaagaacc tacagagtca cggcctcacc tcgatgggtg aatcgctgcg caatgcgttc
     1201 gatttgttaa atctgaatcg catgcagtcg ggcatcgata cgtacgggca gggcaggtgc
     1261 ccgttttatc tggagccatc ggtcatcatt gtgattacgg acggcggtcg ctattcgtac
     1321 cggaatggtg tccatcagga gatcatactg ccgctaagta accaaatacc gggcacaaag
     1381 tttactaagg agccatttcg ctgggatcag cgcttgtttt cgcttgtcct ccgcatgccg
     1441 ggcaacaaga ttgacgagcg agtggacggc aaggtgccgc atgacgattc tcccatcgaa
     1501 cggatgtgcg aggtaaccgg cggacgttca tatcgagtgc gaagccacta cgtactcaac
     1561 cagtgcattg aaagtcttgt ccaaaaggtt cagcctggtg tggtgctgca gttcgagcct
     1621 atgctgccca aggaggctac ttccgctacc gctggcgaag cggcgggtgc gagcacgata
     1681 tccggcatgg gaatatcctc aacgtccgga gcgggtcccg ctcccgatat tgtcttccag
     1741 ccggtaaaga agatgatcta cgtgcagaag cacatcacgc agaaaacctt tcccatcggc
     1801 tattggccac tgccggagcc ctattggccg gactccaagg cgattacatt gccgcctcgc
     1861 gacgcacatc ccaagctgaa ggtcctgacg ccggcggtgg acgagccaca gctggtgcgc
     1921 agcttccccg tcgacaagta cgagattgaa ggctgtccgt taacgctgca gattctcaac
     1981 aagcgcgaga tgaacaagtg ctggcaggtg attgtgacca atggcatgca tggattcgag
     2041 ctgccctttg gctacctaaa agcggcgcct aacttttcgc aggtacacct ctatgtactg
     2101 gcctacaatt atccagcgtt gctgcccatt ctgcatgacc tcattcacaa gtacaatatg
     2161 agtccgccga gcgatctgat gtacaaattc aacgcctatg tgcgttcaat accgccgtat
     2221 tactgcccgt tcctgcgcaa ggcgctggtc aacatcaatg tgccgtatca gctgctgcag
     2281 tttctgctgc cggagaatgt ggacaactat ctgtcgccaa cgatcgccaa tcagctgaag
     2341 cacatcaaga atacggccaa gcaggatcag gagaatcttt gcatgaaggt gtacaagcag
     2401 ctgaagcagc cgaagccacc atatcgccaa gtggagacgg gcaaactgtt cacaggtgcg
     2461 ccgttgcgca gagatttggt gcggcatcca ctgctccggg atatattttc caagttgcat
     2521 ggggaaatag atcccgtgga gaattatacg attgtggtgc cgcagccaac gcatcagtcg
     2581 tcggccaagt cgcatcgcaa tcccttcgat ataccgcggc gggatttggt ggaggaaata
     2641 gccaagatgc gtgagacctt actgcgaccc gtctcgctgg tggccaagga ctcgggccat
     2701 tgcctgccca tcgccgagat gggcaactac caggagtacc tcaagaacaa ggacaatccg
     2761 ctgcgtgaaa tcgagccgac gaatgtgcgg cagcacatgt tcggtaatcc gtacaagaag
     2821 gacaagcaca tggtgatggt ggacgaggcg gatctgagcg atgtggcgcc aatgaagtcg
     2881 ccaaatggca atggaccggg tggagcgccg cccggctcac cttccggatc gggctcgccc
     2941 actggaccgg gtccctcatc cccgggctct tcgcccggcg gtggttcggg tcccgggatg
     3001 cccggaatgc cgggaatggg gggtggaatg tcaggactga tgctgggcgc aggtggcagt
     3061 ggcggatcct ctaaaaaact ggacggaacg tctcgtgggc gaaagaggaa agcaggaccg
     3121 ctgccacgta gctttgaatt ccgtcgatca tctacggact cgcgatcttc gagctccggc
     3181 tccgaatcat caacaacggg tagtgcacca ggatcaccga taccaggcgc cacgtcatcc
     3241 atatccggct gcgattccgc catgggcgct gatggcggtc ccagttccag ctgtttcgac
     3301 gaggacagca atagcaacag cagctttgtg agctccacat cggaggcctc ggccagtgat
     3361 tcagggatgt caaactcgca tttggatccc ttgcgaatca gtttcgtttt catcgaggag
     3421 gagaccagcg atcaggatac gccgctcaat ggttatgtgc acaatttcat caatggcatc
     3481 agcgacgatg cagaaacggg cgaaacggaa gcagttccag gcggggcatc cctgccgggt
     3541 gcgtcttcag ctaacgaacc gtcgtcaatt ggagcatcac cagcagtttc agccacgcca
     3601 gcaacatctg tgatccccgc cagcaatggc agcgaagttt gctccgccgt cgcggccggc
     3661 agcagcagtt ccatcagctc cagcgccagt tccccgggcg ttctctacgt gcccctcaac
     3721 ggactgacca cccatgcggc ctacagcagt aatctgggtg gtccgagctc gccgttggac
     3781 aaccttagct ccctgggtgg agcggcgggt ggcggaggat cgggactact cggtgtcagc
     3841 aagccgggat cgctgccact ggccaatggt tatggacacg gtcatagttc agccatttcc
     3901 ccaccttcgc cattgtcctt ggtgcctcta tcaccattgg gaacaagtac gcccgctgcc
     3961 agcagctcgg gactatcgtc tagttccgcc tacttcagcc acaatgacat caacgatgcc
     4021 tcggagatct cgcgcatact gcagacctgt cacaatggaa ccagcagtgg ctcctcggtc
     4081 ggagcgggcg caagcaacag caatttgaat ggcaatggca gcacggagag tggcggagga
     4141 gtctcatccg acgatcatgc ctcgctgggt ggcaacagtt tcgatgccct gaaacggaca
     4201 gcgggtactg cgggcagcac tgcagcggga aatccccact actactgggc cagtggtctc
     4261 aatcatcaca acaataacaa cagcagcgcc gctggagcag ctagcggttc gacgttgagc
     4321 aacaatcaca accaccgggg tcacaacaac agcagcccca acaaactgga ggtgaagatc
     4381 aactccagct gcggctcctc accgacgcac aacaacgggg gcatgggctc accgggacag
     4441 agcctgccgc tcattttcac cgaggagcag cgcgaagcgg cccggttgca caacgtcgaa
     4501 ctacgattgc agatcttccg tgatatacgg cgacccggcc gagactacag ccagctgctg
     4561 gagcacctga atctggtcaa gggcgaccag gatatgcagt cggatttcgt ggacatgtgt
     4621 atcgtggaat cgctgcgctt ccgccgccat cgcatggcgt ccagcataca ggagtggtgg
     4681 gatcgcaagc agcagttaac tgccgtggga accaatgaag cgacccccag cgcggagcag
     4741 gccgtcgcca agagttaacg atggctcatg tggcaccact gagcccgcgg ggtcatccaa
     4801 tccatctgtc tgtgatgtca acaaaatcga aatcgaaatc taaaccgaaa ctgggaaggg
     4861 gaagagcagc cgcggaagcc aagaattctc gtcaatttcc atatactgta aataattgcc
     4921 aggacaggta gcccacagga tctggatggg gatcaacgca taccaaacaa gcaacaataa
     4981 tattaacaat ttccatatac tgtaaataat tgccaggaca ggtagcccac aggatctgga
     5041 tggggatcaa cgcataccaa acaagcaaca ataatattaa caacaaaacc aacaagcagc
     5101 cacaattcta aatgagagaa aacaccacat ttttagggca agctagctac atgtaattat
     5161 aacatatata taaataaata cttaagctag ccgttagtta gcaatagaat ataaagtata
     5221 aagcgaaggg attttgtagc agccgtttca gttgtagttt tttttttact tagtataaat
     5281 atgtaagcgt aaattaaaat ttactcttga gcttaggaat aattttaaat agacttagat
     5341 aaattaagat aaatctaagt gtagtgtatg tgtataaaaa aaaagggaaa agtttaggaa
     5401 aagcttgagc ttaatgagcc ccacacgttt tagccaattt tttgttggac ctgtttcaag
     5461 aacactttgc tttgatttta gccaaaacga atagagaacg taaaaaacaa aagcgatgac
     5521 ccttcaaaaa cagatatata tgtgtatgtt tatatacata tatgtatata gaggatatta
     5581 cataaatcgg gtcagcgttt tattattaaa aagaattgta ttaccttgta tttccttgaa
     5641 tcctccaata tattatttgc tattatgtta tgtttatttt ataaaatatt tatgcgaatt
     5701 gtaatgtgag catagcctgt agaaaggcag acaaaacgat aagcgaaaac gtacagtttg
     5761 ttatatacat atagaaaaac aagaaaaaag taatacattt ttgcactatt tttttacgtg
     5821 tatgtttgta tgcatggcct gtgagtaatt gagatataac aaaaacgaaa aacacaaaga
     5881 gaaaacgttt actagtagtt aggcggcggg cagtgtttta gaactgcttc attattaaat
     5941 aatgatgtac aatttagagt ctgcgtattt aacaaatttc ataagacaac caccacaaca
     6001 gaatcaacag agcagcagca aagcaaactg aaatcaatac gaaatcaaac gaaaataaaa
     6061 agaggagcat tgcattc