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Drosophila melanogaster small conductance calcium-activated


LOCUS       NM_001272324            5179 bp    mRNA    linear   INV 26-DEC-2023
            potassium channel (SK), transcript variant Q, mRNA.
ACCESSION   NM_001272324
VERSION     NM_001272324.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5179)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5179)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5179)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5179)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5179)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5179)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5179)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5179)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5179)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5179)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5179)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5179)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5179)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5179)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5179)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5179)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5179)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5179)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5179)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5179)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5179)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5179)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5179)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001272324.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5179
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5179
                     /gene="SK"
                     /locus_tag="Dmel_CG10706"
                     /gene_synonym="BcDNA:GM01744; CG10706; CG12733; CG4179;
                     Dmel\CG10706; dSK; Sk"
                     /note="small conductance calcium-activated potassium
                     channel"
                     /map="4F5-4F9"
                     /db_xref="FLYBASE:FBgn0029761"
                     /db_xref="GeneID:31456"
     CDS             604..3390
                     /gene="SK"
                     /locus_tag="Dmel_CG10706"
                     /gene_synonym="BcDNA:GM01744; CG10706; CG12733; CG4179;
                     Dmel\CG10706; dSK; Sk"
                     /note="CG10706 gene product from transcript CG10706-RQ;
                     CG10706-PQ; SK-PQ"
                     /codon_start=1
                     /product="small conductance calcium-activated potassium
                     channel, isoform Q"
                     /protein_id="NP_001259253.1"
                     /db_xref="FLYBASE:FBpp0303994"
                     /db_xref="GeneID:31456"
                     /db_xref="FLYBASE:FBgn0029761"
                     /translation="MSIQKLNDTTNSGYVSSEETDSLLVSSSNPSKGGGRTALLRQVK
                     SNSTNGPTTGASTSSSGSVSGGGGGSGSGGGSASGSAAGASKPTLMRQDRTSTYLTSP
                     QQSQHARMGSEESMRGGASGAAGHDEDVEQGLVRSSIVPDIEVHEEDQEQHSQQLNAT
                     TMATMTNNQQQQQPTISIMNLSLKPGDSHSHSSSPGSHPNLGTSSYQNLASSIPPSVP
                     SRCRACRNCSRRASTTPTTLIDRSASRDSVKSAFQQGNLSGSMAICISNSALPQQQQL
                     QQQYHLQQQQQQHYQLQQHHLHQQQLQQSQQQVPPVLITSSPTNGSRIIRQSSQPESS
                     STAICCGPHSACVGHAHSHSHTVPNVSLKQLRESSGDGIAGIAADSLRINGGMRPFKQ
                     LRKPASTLSIPGSMKTPSIANREQISSGCNEEAAEALVGIHSDYPRYMEERALTGGNT
                     SRKPSTNSAKHKPNVGYRLGKRKALFEKRKRISDYALVMGMFGIIVMVIENELSSAGV
                     YTKASFYSTALKTLISVSTVILLGLIVAYHALEVQVRLFMIDNCADDWRIAMTWQRIS
                     QIGLELFICAIHPIPGEYYFQWTTKLANKNKTIGTEMVPYDVALSLPMFLRLYLICRV
                     MLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLR
                     QCERFHDEEHANLLNAMWLIAITFLSVGFGDIVPNTYCGRGIAVSTGIMGAGCTALLV
                     AVVSRKLELTRAEKHVHNFMMDTQLTKRLKNAAANVLRETWLIYKHTRLVKRVNPGRV
                     RTHQRKFLLAIYALRKVKMDQRKLMDNANTITDMAKTQNTVYEIISDMSSRQDAIEER
                     LTNLEDKMQSIQEHMESLPDLLSRCLTQHQERIEQRRNFLHPDTAAVAPIQAPTPQSM
                     FNAAPMLFPHSSES"
     misc_feature    2008..2346
                     /gene="SK"
                     /locus_tag="Dmel_CG10706"
                     /gene_synonym="BcDNA:GM01744; CG10706; CG12733; CG4179;
                     Dmel\CG10706; dSK; Sk"
                     /note="Calcium-activated SK potassium channel; Region:
                     SK_channel; pfam03530"
                     /db_xref="CDD:460958"
     misc_feature    2608..2847
                     /gene="SK"
                     /locus_tag="Dmel_CG10706"
                     /gene_synonym="BcDNA:GM01744; CG10706; CG12733; CG4179;
                     Dmel\CG10706; dSK; Sk"
                     /note="Ion channel; Region: Ion_trans_2; pfam07885"
                     /db_xref="CDD:462301"
     misc_feature    2887..3111
                     /gene="SK"
                     /locus_tag="Dmel_CG10706"
                     /gene_synonym="BcDNA:GM01744; CG10706; CG12733; CG4179;
                     Dmel\CG10706; dSK; Sk"
                     /note="Calmodulin binding domain; Region: CaMBD;
                     pfam02888"
                     /db_xref="CDD:460739"
ORIGIN      
        1 tcagtatcgc acaaacaaca ctaacggaaa catcaacgtg aaagcgagac ggacgccctc
       61 cgtcccgtta tatgctgtgt ctgtctttaa tatatatata gttaaacaaa ataaaaatat
      121 caaataaaaa acaagtgcaa gcaaagagaa aagcgcccaa tgcggccaat ggaaatgcca
      181 aagaaaatgc agcagctaca aattcgacaa caaatgcaaa tgcgacagca acagcagaag
      241 aagcagcagc agcaacaaca tcaactgcaa tttctcaaca cataagtcca ccgaattttc
      301 cgtctttgtc gcgcgcgctc acacatatac aagcacacac atccatacac ggagacacat
      361 gcatgtgcat aaatggcaat atggacgaac agcagcagca tttgcgttgt ataccaacac
      421 agtgacacgc gcgtgccaaa tattgccgat tttatcacac gaacaacaac aacagcaaca
      481 acaacaccag cgggaccagc tattaactaa aggagccatt acaacaacaa taacaagatc
      541 cagcaaagca acaacaacaa cgaaagcaac gaacattgct ggaaggcgtc gcaaaatatc
      601 aaaatgtcaa ttcagaagct taacgacacc acaaactcgg gctacgtgag ttccgaggag
      661 acggactcgc tgctggtgag cagctcgaat ccgtcgaagg gcggcggtcg gacggctctg
      721 ctccgccagg tgaagagtaa ctcgacaaat gggccaacga cgggggcgtc cacatcgtcc
      781 tcgggatcgg tatcgggcgg cggtggtgga tccggttccg gtggcggatc agcatcgggc
      841 tcagcagctg gggcttccaa gccaacgcta atgcgtcagg atcgaacatc cacctacctg
      901 acaagtccgc agcagtcgca gcacgcgaga atgggttccg aggagagcat gcgaggtgga
      961 gccagcggag ctgccggaca cgacgaggat gtggaacagg gcctggtccg tagcagcata
     1021 gtgcctgata tcgaagtaca cgaagaggac caagagcaac acagccagca gttaaatgca
     1081 acgacgatgg caacgatgac caataaccaa cagcaacagc aaccgaccat atcaattatg
     1141 aatttaagcc tcaagccagg cgatagccat agccatagct ccagtccggg tagtcatccc
     1201 aatttgggca cctcatcata tcagaatctg gcatcgagca taccgcccag cgtaccgagt
     1261 cgctgcaggg cgtgccgcaa ttgcagtcga cgtgcttcca ccacgcccac cacgctgatc
     1321 gatcgctccg cctcccgcga cagtgtgaaa agtgccttcc agcagggcaa tcttagcggc
     1381 tccatggcca tttgcatatc gaactcggcc ctgccgcagc agcagcagtt gcagcaacag
     1441 tatcacctgc aacagcaaca gcagcagcac tatcagttgc agcaacacca tctgcatcag
     1501 cagcaactgc agcagtcgca gcagcaggtg ccgccggtgc taatcacatc atcgccaacg
     1561 aatggatcac ggataatacg gcaaagttca cagccggaat cgagcagcac ggccatttgt
     1621 tgtggtcccc attccgcttg cgttggccac gcccactcgc actcgcacac ggtaccgaat
     1681 gtttcgctga agcagctgcg cgagagttcc ggcgatggaa tcgcgggcat tgcagccgac
     1741 tctctgcgga tcaacggtgg catgcggccc ttcaagcagc tccgcaaacc ggcgtcgaca
     1801 ctctcaattc ctggctcgat gaaaacacct tccattgcga accgggaaca gatctcatct
     1861 ggatgcaacg aagaagcggc cgaggcacta gtgggtatcc actcagacta ccctaggtat
     1921 atggaagaac gtgctcttac tggcggcaat acgtccagga agccatcaac aaactcggcc
     1981 aaacacaaac ccaatgtggg ctatcgcctg ggaaagagga aagccctctt cgagaagcgc
     2041 aaacggatca gcgattacgc cctggtcatg ggcatgttcg ggatcatcgt gatggttatc
     2101 gaaaacgaac tgagcagtgc cggtgtctac acaaaggcat cgttctactc gacagcgtta
     2161 aaaaccttaa tatctgtttc gactgtgatt cttttaggac ttatagtagc ttaccatgct
     2221 ttggaagtgc aggtgagatt attcatgata gataactgcg ctgacgattg gaggatcgca
     2281 atgacatggc aacgaattag tcaaataggg ttagaacttt ttatatgcgc tatacatcca
     2341 attcctggcg aatactattt ccagtggacg acgaaattgg ccaataagaa taaaacaatt
     2401 ggcaccgaaa tggtgccata tgacgtagct ttatcattac ctatgttcct tcgattatat
     2461 ttaatctgcc gcgtaatgct gctgcattca aagctattca cagatgcatc atcacggagc
     2521 attggcgctc tcaataggat taattttaac acaagattcg ttttaaaaac tctaatgaca
     2581 atatgtccgg gaacggttct attggtcttc atggtctcgc tgtggatcat cgcatcgtgg
     2641 acgctgcgtc agtgcgaaag atttcatgat gaagaacacg cgaatctttt gaatgcaatg
     2701 tggctgatag cgataacatt tttgagtgtt ggtttcggtg atattgttcc gaatacgtac
     2761 tgtggacgtg gtatcgctgt cagtacagga ataatgggcg ccggctgtac ggctctactg
     2821 gtggccgtag tctctcggaa actggagctg acccgtgctg agaagcatgt gcacaacttc
     2881 atgatggaca cgcagttgac gaaacggctg aaaaatgctg cggcgaatgt tctgcgtgaa
     2941 acttggctca tttacaaaca tacaagacta gtaaaacggg ttaatcccgg ccgtgtaaga
     3001 acccaccaaa gaaagttcct tctagctata tatgcgttgc gaaaagttaa aatggatcag
     3061 cgcaaactaa tggataatgc aaacacaata actgacatgg ctaagacaca aaacacggtc
     3121 tacgagataa tatcggacat gtctagccgt caggatgcca tcgaagagcg tttaaccaac
     3181 ctagaggaca aaatgcagag catacaagag cacatggaaa gccttccaga cctattgtct
     3241 cgatgtctga cccagcacca ggagcggatc gagcagcggc ggaacttttt acatcctgac
     3301 acagctgcag ttgcccccat tcaagcgcca acgccccaat cgatgttcaa tgcagcgccc
     3361 atgctgtttc cacattctag cgaatcgtag agctcaaggg gtacttcgag aatcatgctt
     3421 caacaaccgt aactcttcta gccaaaccag gtccaataga acatacatat gtatgtacat
     3481 acgtgtgtat gtatagccca gtcaatgcca atgctaatga agaactggat tcgtgttttc
     3541 gaaaacgttt cgaaccggat tgtgacgaag cagccatttt ggtgtattta cacgatagaa
     3601 tctagaaatg ggtccttctc ccaaaaatat cccccacacc ccaaatccct cctctcgtgc
     3661 gcccaactag atcggggtat gcaaaatata tatggttaca tatacaatat ctagatatac
     3721 aacacacata catatactcg tatatacatg tacagacggt caatgaggtg tatacccaac
     3781 agcccaaaag ccagaaacaa aaaaaaaaac ccaaaagaaa ataataaaaa aaaaaacaaa
     3841 acaaaaaaaa acacactaat aagatcatat ttgactttat atgtattata gtaatgtatt
     3901 cagtagctaa atcgaaagcc gaagcaaaga ccaatttatt aacaacaaac taataaggaa
     3961 aacccaactg gaaaacaatt attatgttaa actaaacaat aaaaacataa gaggaaggcg
     4021 aaacaatttt ttatggagaa aaaaagatgt gaaaacaaaa gagaagtaat gaaagtaaac
     4081 tagaatgcgt tgcatgaatt aaacgaagtg gagaaaaact aatagaaagc aaaacttgaa
     4141 taaagctaaa caaatgtcaa ctaaaaccaa actttaacta aacctacact aatgctaaaa
     4201 ctaaaactaa aataacatta aattaaacca actaaaagaa ggacgattta atttctaaaa
     4261 gaaataaagt aagaaactaa actgaaaaaa aaaaaacaac agcaaaaatt cagtgactaa
     4321 tgaaatagtt tattttgaat ttactgtatt gtatatttaa atttaacaag ggaaacaacc
     4381 cccccaaaca aagtatattg ttatatctta tcgaggaacc gtgttttgca aaagctttaa
     4441 tataatattt agggtgccta catttgctaa attagtattt tacgatttaa aaaccaagga
     4501 acaaaccaaa aaaaatataa gaaaaaaaat gaagagaaaa taaatacaaa tactaaaacc
     4561 aacacctaca tacacgaaat agtgaaaagc ttgattaaaa cgaacccaaa aagttaggag
     4621 cctcgatttc caaaacgaaa tacactgaat atagagaaac cgaaatcgat accaaaacaa
     4681 attaagaaca gctaaagcaa atattgtatt tgtatttgag atatgaattt taagaatgtt
     4741 tattagactt acgatttgtt attttgtata catatatata tatatatata tatatatata
     4801 tatatattat atgtattatg tatgtagtat aaactgatct gatctgaaga cgattgtaat
     4861 tgtttttttt ttttgctcat taagcattta cctcataaga attcccacta tttatagcaa
     4921 atttaccata ttacataaat caattgctgt actgttataa tgtacgatcc ccaagaaagc
     4981 gaaaagcaac aagaagagcc attaaatgaa agagatcaat ggaagtcgag gggagatagg
     5041 aaaactcata aaattgtaaa ttattaatta ataaagaaac caaagagaat aattgaaatt
     5101 ttaacaataa taaagggctt tgtatgaaag aaaaacaaac aaaaactgaa taaaaatgaa
     5161 ataaaaataa aagaaaatc