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LOCUS NM_001272293 7490 bp mRNA linear INV 26-DEC-2023 variant M, mRNA. ACCESSION NM_001272293 VERSION NM_001272293.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 7490) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 7490) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 7490) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 7490) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 7490) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 7490) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 7490) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 7490) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 7490) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 7490) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 7490) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 7490) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 7490) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 7490) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 7490) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 7490) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 7490) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 7490) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 7490) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 7490) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 7490) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 7490) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 7490) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..7490 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..7490 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Tousled-like kinase" /map="3E6-3F1" /db_xref="FLYBASE:FBgn0283657" /db_xref="GeneID:318206" CDS 396..4124 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /EC_number="2.7.11.1" /note="CG34412 gene product from transcript CG34412-RM; CG34412-PM; Tlk-PM; BEST:GH17330; tousled-like kinase; tousled like kinase" /codon_start=1 /product="Tousled-like kinase, isoform M" /protein_id="NP_001259222.1" /db_xref="FLYBASE:FBpp0305895" /db_xref="GeneID:318206" /db_xref="FLYBASE:FBgn0283657" /translation="MSPGAHLQMSPQNTSSLSQHHPHQQQQLQPPQQQQQHFPNHHSA QQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHLHKHPHQLQLHQQQQQQLHQQQQQH FHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDMLSGGAATPGAAAAAIQQQHPAFAP TLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSVLTVGKPRTPAERKRKRKMPPCATS ADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMPKVNMSLNLGDRLGGSAGSGVGAGG AGSGGGGAGSGSGSGGGKSARLMLPVSDNKKINDYFNKQQTGVGVGVPGGAGGNTAGL RGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGSAGGSAGNQVQVQTSSAYALYPPAS PQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHVVVGLGGHPLSLA SIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLGVVGMVGVGVGVG VGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLHELQEREAEHESGKVKLDEMTR LSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQ FVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGRKRNN NSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAG AIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSG GVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNA LKKEDADLQLEMEKLERERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGF SEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYD VFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVI HYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPE CFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFS NKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQ QQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS" misc_feature <2001..>2411 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Family of unknown function (DUF5401); Region: DUF5401; pfam17380" /db_xref="CDD:375164" misc_feature 3135..3938 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; Region: STKc_TLK; cd13990" /db_xref="CDD:270892" misc_feature order(3144..3146,3183..3185,3189..3191,3297..3299, 3348..3359,3369..3371,3375..3377,3492..3494,3498..3500, 3504..3509,3513..3515,3555..3557,3564..3566,3633..3644) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="active site" /db_xref="CDD:270892" misc_feature order(3369..3371,3375..3377,3492..3494,3498..3500, 3504..3506,3564..3566,3633..3644) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270892" misc_feature order(3552..3590,3603..3644) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="activation loop (A-loop); other site" /db_xref="CDD:270892" ORIGIN 1 gaactttgac attgtaatgt tttcactgag gatttgatag ggtattcaac ttttcgtctt 61 ttgctttcaa tccgtcattc gtgagttttt attttgtgcg aattttctgt tctgtcgcct 121 tttattatta ttactacagt tttatatatt tttttgtgtg aagcgtactc tgccgacgtc 181 gctgccactg ccagcgctgt cgctttgacg atttgcgctt tgcgttgcgc ttactcacaa 241 tcaaatctca cgccgcattt ttagtctcaa taataactga aacgaaaaac acgcgcagcc 301 gaaacgaagc gcaaaccaaa gagtaaagcg aaagaagcaa ggaaggcaaa cggcgaacaa 361 aaacgcaaaa cgaaaacgac gacacgtcgt caaacatgtc ccccggcgcc catttgcaga 421 tgtccccgca gaacacttcg tccctaagtc aacaccatcc acatcaacag caacagttac 481 aacccccaca gcagcaacaa cagcatttcc ctaaccatca cagcgcccag caacagtcgc 541 agcagcagca gcaacaggag caacagaatc cccagcagca ggcgcaacag cagcagcaga 601 tactcccaca tcaacatttg cagcacctgc acaagcatcc gcatcagctg caactgcatc 661 agcagcagca acaacaactc caccagcaac agcagcaaca cttccaccag cagtcgctgc 721 aagggctgca tcagggtagc agcaatccgg attcgaatat gagcactggc tcctcgcata 781 gcgagaagga tgtcaatgat atgctgagtg gcggtgcagc aacgccagga gctgcagcag 841 cagcgattca acagcaacat cccgcctttg cgcccacact gggaatgcag caaccaccgc 901 cgcccccacc tcaacactcc aataatggag gcgagatggg ctacttgtcg gcaggcacga 961 ccacgacgac gtcggtgtta acggtaggca agcctcggac gccagcggag cggaaacgga 1021 agcgaaaaat gcctccatgt gccactagtg cggatgaggc ggggagtggc ggtggctctg 1081 gcggagcagg agcaaccgtt gttaacaaca gcagcctgaa gggcaaatca ttggcctttc 1141 gtgatatgcc caaggtaaac atgagcctga atctgggcga tcgtctggga ggatctgcag 1201 gaagcggagt aggagccggt ggcgccggaa gcgggggagg tggcgctggt tccggttctg 1261 gaagcggtgg cggcaaaagc gcccgcctga tgctgccagt cagcgacaac aagaagatca 1321 acgactattt caataagcag caaacgggcg tgggcgtcgg tgtgccaggt ggtgcgggag 1381 gcaataccgc tggccttcga ggatcacata cgggaggtgg cagcaagtca ccctcatccg 1441 cccagcagca gcaaacggcg gcacagcagc agggaagcgg tgttgcgacg ggaggcagtg 1501 caggcggttc cgctggcaac caggtgcaag tgcaaacgag cagcgcttac gccctttacc 1561 caccagctag tccccaaacc cagacgtcac agcaacagca gcagcagcaa ccgggatcag 1621 actttcacta tgtcaactcc agcaaggcgc agcaacaaca gcagcgtcaa cagcaacaga 1681 cttccaatca aatggttcct ccacacgtgg tcgttggcct tggtggtcat ccactgagcc 1741 tcgcgtccat tcagcagcag acgcccttat cccagcagca acagcagcaa caacagcagc 1801 agcaacagca gcaactggga ccaccgacca catcgacggc ctccgtcgtg ccaacgcatc 1861 cgcatcaact cggatccctg ggagttgttg ggatggtcgg tgtgggtgtt ggcgtgggcg 1921 ttggagtaaa tgtgggtgtg ggaccaccac tgccaccacc accgccgatg gccatgccag 1981 cggccattat cacttatagt aaggccactc aaacggaggt gtcgctgcat gaattgcagg 2041 agcgcgaagc ggagcacgaa tcgggcaagg tgaagctaga cgagatgaca cggctgtccg 2101 atgaacaaaa gtcccaaatt gttggcaacc agaagacgat tgaccagcac aagtgccaca 2161 tagccaagtg tattgatgtg gtcaagaagc tgttgaagga gaagagcagc atcgagaaga 2221 aggaggcgcg acagaagtgc atgcagaatc gcctcaggct cggacagttt gttacccaac 2281 gagtgggcgc cacattccag gagaactgga cggacggcta tgcgttccag gagctgagtc 2341 ggcggcaaga agaaataacc gctgagcgtg aagagataga tcggcagaaa aagcagctga 2401 tgaaaaagcg tccggcggag tccggacgca agcgcaacaa caacagtaac cagaacaacc 2461 agcagcagca gcaacagcaa caccagcaac agcagcagca acaaaattcc aactcgaacg 2521 attccacgca gctgacgagc ggagttgtta ccggtccagg cagtgatcgt gtgagcgtaa 2581 gcgtcgacag cggattgggt ggcaataatg cgggcgcgat cggtggcgga accgttggtg 2641 gtggcgttgg aggtggtggt gttggaggcg gtggtgtcgg aggcggcggt ggacgtggac 2701 tttctcgcag caattcgacg caggccaatc aggctcaatt gctgcacaac ggcggtggtg 2761 gttcgggcgg caatgtcggc aactcgggcg gcgttggcga ccgcttgtca gatcgaggag 2821 gaggaggtgg cggcatcggc ggaaacgata gcggcagctg ctcggactcg ggcactttcc 2881 tgaagccaga ccccgtatcg ggtgcctaca cagcgcagga gtattacgag tacgatgaga 2941 tcctcaagtt gcgacaaaat gccctcaaaa aggaggacgc cgacctgcag ctggagatgg 3001 agaagctgga gcgggagcgc aatctgcaca tccgagagct caagcggatt cttaacgagg 3061 atcagtcccg ctttaacaat catcccgtgc tgaatgatcg ctatcttctg ttgatgctcc 3121 tgggcaaggg cggcttctca gaggtccaca aggccttcga cctgaaggag caacgctatg 3181 tcgcatgtaa ggtgcaccaa ttaaacaagg attggaagga ggataagaaa gctaattata 3241 tcaaacacgc tttgcgggaa tacaacattc acaaggcact ggatcatccg cgggtcgtca 3301 agctatacga tgtcttcgag atcgatgcga attccttttg cacagtgctc gaatactgtg 3361 atggccacga tctggacttc tatttgaagc aacataagac tatacccgag cgtgaagcgc 3421 gctcgataat aatgcaggtt gtatctgcac tcaagtatct aaatgagatt aagcctccag 3481 ttatccacta cgatctgaag cccggcaaca ttctgcttac cgagggcaac gtctgcggcg 3541 agattaagat caccgacttc ggtctgtcaa aggtgatgga cgacgagaat tacaatcccg 3601 atcacggcat ggatctgacc tctcaggggg cgggaaccta ctggtatctg ccacccgagt 3661 gctttgtcgt gggcaaaaat ccgccgaaaa tctcctccaa agtggacgta tggagtgtgg 3721 gtgttatctt ctaccagtgt ctgtacggca aaaagccctt cggtcacaat cagtcgcagg 3781 ccacgattct cgaggagaat acgatcctga aggccaccga agtgcagttc tccaacaagc 3841 caaccgtttc taacgaggcc aagagtttca ttcggggatg cttggcctat cgcaaggagg 3901 atcgcatgga tgtgttcgca ctggccaggc acgagtacat tcagccaccg ataccgaaac 3961 atgggcgcgg ttcgctcaat cagcaacagc aggcgcaaca acagcagcag caacaacagc 4021 aacagcagca gcaacagtcg tcgacgtcac aggccaattc tacaggccag acatctttct 4081 ctgcccacat gtttggcaat atgaatcagt cgagttcgtc ctagctgcca accaagcgca 4141 attcgaactc ataattcgcc gccgccgcag tagcagcagc tacattagct gccagtagtc 4201 aacagcaact tcaacaccag caacagcaac tccaaatcca gcaataccag cagaatcagc 4261 aacttcattt gcaaaacagc agtagcaatt atgcggccac gcttctagat gcagcggcct 4321 tttgctacga aaccgtgatg gatgcagccc acttccaaaa caacaataat aacagcacca 4381 tcatcaagaa caatatgcag acaatgccgg caaacgctgc caatgctgct gcagctgcag 4441 ggggaggggg aacaccgacc tatcagggga aatacaagcg ctggcagcag caacagttac 4501 aacagcaggc gcaactccaa cagcagcagc acaagctgct gttgcagcaa gagctgctct 4561 aaaatatgaa gggaatgatg acaagcgagt ttaagagaac gaggagctgc ctgccacact 4621 gccgccgtca gcaataacaa catcccaaga aaattcacag cgagtcgcaa aagcatcaac 4681 aaacaaagca aaaaacgcaa aaaaggatta caaagacgca gagaataggg gacatttgca 4741 atgggaaata acaaattatt gcattatctg ctggattgtg attgtggttc aaacattaaa 4801 aatacactta ctcatacaca caaggtagac actgcagact aattttgcct taaaagaaac 4861 aaaacgaata atgttaactg taaattttca ctttgtgtcc atgcatagtt actagtaatg 4921 atgatataaa tatataaata tatataaaat ataaaaatta tataaatgta taaatttata 4981 tttatatata tatatatata tatatatata tatctgcata aacattgaag catactagta 5041 aatctttata aatatattta tatatatatt tatctcttcc ttttaacgct tttaatcgga 5101 aaaaacatcc caattatatt ttaattcaat ttgaaatata aaagtcattt ttgtttgttt 5161 tgtatcaaaa tccaaaaaaa attgatttaa atataaaaat accataaaca ttaacaccac 5221 acacacacac acacacacat atatatatat atatatatat atatatatat atacatatat 5281 atatacattt gtatatagtc gtatctgaac cacaaacaaa tccacagata aaaaaaactg 5341 aaaaattcat agaatcaaac cattttttta tatgccacaa agaaaagaaa ataagtagaa 5401 atgcaagaaa aatcgagaaa aagcgtaatt catgagatca gatcggatca gaaaaatcaa 5461 cagaaaataa acctatttga agtaaaatac ttctaaatac atagtaaact aatgtaatag 5521 tttttattaa aattacacat atatgtatcg atatatatac atgttttttt ttttttaatt 5581 ttaaaattat aattgtaatg cactatgcgt aaattgtatt aaatattaat atccaaggca 5641 tattaataga aatatatata catatataaa acctgcaaaa aaaaaacatg aactaccaag 5701 ctaaatgttt caataatata tagatctata tgtatgtaaa accgatatga aatctgccta 5761 cagccagaca aaaaaaacct taaagagaaa gatcagaaga ggaacagaag agtatgagcg 5821 gggagtgaaa gatgcaagat tcatccaaaa gcgaaaaaca tttttttctt aagtctacgc 5881 aaaacaaaat gaatgaaaag taacccgaaa ttagttttta gagtataagt ataaaaaatg 5941 gaaaatatcg cgatagaaag aaacaaaaat ggacgcagat aaggacggca agcagaacaa 6001 gagtaataaa gcagcggcaa gaactcccta aaaatagcaa agagcattgt aaatatttat 6061 ataaataatt tatgcctaat taaagtttaa attaatgaag aaaaccagca aaaaaacata 6121 aaaaaccaga agaaccattt cagatttgta tgcaaatttg tatatgtacg tactttcctt 6181 taattttagc caatcagttt gtaagattaa attttttttt tgcatctcta taaagaataa 6241 tgatatgagg ataatgattc cgattttttt ttccgtttaa tgtaaccgtt agaattagcc 6301 cataatggtc gatatctaaa tgtgtgtgta tatcgatgtg atgtcatcga ttgtcgataa 6361 cgattggatg cgagtgtgtg ttaatttaat ttgataaaag ataaaggaaa gcaaggaatg 6421 tgaagataat gaaaggagat gcatagagaa tgagagcgaa tctatctatt atataattat 6481 gtaaaatgca catctttaaa ttataaatta tacatattta aaaggaaact attattatta 6541 ttttgattac cattatcatt attttttatt atcacttaac ggtttcggtt tgatccacag 6601 cgaaaccaac aacaaccaag aaacagaaac aacaaaaaga gaaacaaaat aaacaagcga 6661 aatgtttgat aaaaaaaacc acgagatgtt ttaatttatt tgtctttaat tcttcgattt 6721 tattgagttt ttcatagaga aagttgtcac actcaagaac acacacgcaa gcgtataaag 6781 ctaaacaaat taatacctac taagtgttta aatagtacta aacgaatcaa aatataaata 6841 cttaaaaaga aaaaaaaacg aaaataaaaa taaaaacagc agcagaaaaa aacgatgaga 6901 cagttgagca gacgagaaaa acaaagccca ttaaattatt tgttgagtat tttattaaaa 6961 aataattacg ataataatta aaaagtttaa attgaacgaa ttacgaaaaa caaactgaat 7021 atacatatat gtgtgcatat atacatatat gtatgtatta tatataaaca aattatttaa 7081 tagttatgct aaaaaattat ttaaagtgaa cggatatgaa aaatatttgt atgcgtgcga 7141 gcacggagag aagggcactc agaataggcc atcgacacca cccactccct tccgataccc 7201 gaacatcacc accagttttc accattttct gacccttaac cccttcaacc agacacacac 7261 caaacacaag aaaaggcgaa gaaagccgaa aaaaaaacaa tgcaaacacg aaataggcgg 7321 cgacgacaga gataagcgcg aagaagatac taaatcaata agtaaacata aaaattaatt 7381 aataaattaa ttccaaaaca aaatgaaaaa agctaaaaaa aaaacatcaa gaaaacaaaa 7441 gacaaaagca aacaaaaaac atgacgaaac attgaaaata aaaaaatact