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Drosophila melanogaster Tousled-like kinase (Tlk), transcript


LOCUS       NM_001272292            4308 bp    mRNA    linear   INV 26-DEC-2023
            variant L, mRNA.
ACCESSION   NM_001272292
VERSION     NM_001272292.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4308)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4308)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4308)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4308)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4308)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4308)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4308)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4308)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4308)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4308)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4308)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4308)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4308)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4308)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4308)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4308)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4308)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4308)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4308)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4308)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4308)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4308)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4308)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4308
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4308
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /old_locus_tag="CG32781"
                     /old_locus_tag="CG32782"
                     /old_locus_tag="Dmel_CG32781"
                     /old_locus_tag="Dmel_CG32782"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="Tousled-like kinase"
                     /map="3E6-3F1"
                     /db_xref="FLYBASE:FBgn0283657"
                     /db_xref="GeneID:318206"
     CDS             708..3743
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /old_locus_tag="CG32781"
                     /old_locus_tag="CG32782"
                     /old_locus_tag="Dmel_CG32781"
                     /old_locus_tag="Dmel_CG32782"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /EC_number="2.7.11.1"
                     /note="CG34412 gene product from transcript CG34412-RL;
                     CG34412-PL; Tlk-PL; BEST:GH17330; tousled-like kinase;
                     tousled like kinase"
                     /codon_start=1
                     /product="Tousled-like kinase, isoform L"
                     /protein_id="NP_001259221.1"
                     /db_xref="FLYBASE:FBpp0305894"
                     /db_xref="GeneID:318206"
                     /db_xref="FLYBASE:FBgn0283657"
                     /translation="MDQFQTSLNPRKLELLESRITGVRMSPGAHLQMSPQNTSSLSQH
                     HPHQQQQLQPPQQQQQHFPNHHSAQQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHL
                     HKHPHQLQLHQQQQQQLHQQQQQHFHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDM
                     LSGGAATPGAAAAAIQQQHPAFAPTLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSV
                     LTVGKPRTPAERKRKRKMPPCATSADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMP
                     KVNMSLNLGDRLGGSAGSGVGAGGAGSGGGGAGSGSGSGGGKSARLMLPVSDNKKIND
                     YFNKQQTGVGVGVPGGAGGNTAGLRGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGS
                     AGGSAGNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQ
                     QQTSNQMVPPHVVVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASV
                     VPTHPHQLGSLGVVGMVGVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEV
                     SLHELQEREAEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLL
                     KEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQSRFNNHPVLNDRYLLLMLLGKGG
                     FSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLY
                     DVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPV
                     IHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPP
                     ECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQF
                     SNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQ
                     QQQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS"
     misc_feature    2754..3557
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /old_locus_tag="CG32781"
                     /old_locus_tag="CG32782"
                     /old_locus_tag="Dmel_CG32781"
                     /old_locus_tag="Dmel_CG32782"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Tousled-Like Kinase; Region: STKc_TLK; cd13990"
                     /db_xref="CDD:270892"
     misc_feature    order(2763..2765,2802..2804,2808..2810,2916..2918,
                     2967..2978,2988..2990,2994..2996,3111..3113,3117..3119,
                     3123..3128,3132..3134,3174..3176,3183..3185,3252..3263)
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="active site"
                     /db_xref="CDD:270892"
     misc_feature    order(2988..2990,2994..2996,3111..3113,3117..3119,
                     3123..3125,3183..3185,3252..3263)
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270892"
     misc_feature    order(3171..3209,3222..3263)
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270892"
ORIGIN      
        1 atatttttag gccatttctg cgtgtgtgcg ttcgtgtgaa tattgtgaat atttttttta
       61 ctgtgaaaat agacaaaaat cggctgtgga aaaccgaagt aaacacattt gggaatcatg
      121 gcgattggcc cttaacctta acccttaagt gtcgtgccga cagtgccacg ccacaaaccc
      181 aaatcccaaa gaaacaaaag cgaaagaaaa aaaaaaaaga acaacaaaaa gctatagttg
      241 cagcctctga aagtttaaga caatcgccga tccgatcgga agcggaagat atatgctcgc
      301 cacaccaaat ggcatggtaa acacctctcg ttcctctaaa tgtgatgtcg atgtcggaaa
      361 agccgtagaa atcgtacaat tcctaaaatc gcaaacttaa cctcgcagcg ttgtgtgcaa
      421 aaacggagag gggtgggggg gaaacaacgg aaaaaaaagg caacgcaaag caaagcaaac
      481 gaaaagcgaa gcgtgtgcga gcgagagatg aatttgtcac tttattattg ccatggctct
      541 gacaaatctt gtcgcactcg ttgccgacat ttgcaatcga tcaatattaa aatattgaat
      601 aactaaacca accacgagct aaaagaaaaa tttcagaaaa acttttgtat ctgaatcgaa
      661 aacaaaaaaa aaaacaaatt cctatcggcg cttataatca caaagtaatg gatcaatttc
      721 aaacttcact aaatccgcgg aaactcgagc ttctggagtc tcgaattact ggagtgcgga
      781 tgtcccccgg cgcccatttg cagatgtccc cgcagaacac ttcgtcccta agtcaacacc
      841 atccacatca acagcaacag ttacaacccc cacagcagca acaacagcat ttccctaacc
      901 atcacagcgc ccagcaacag tcgcagcagc agcagcaaca ggagcaacag aatccccagc
      961 agcaggcgca acagcagcag cagatactcc cacatcaaca tttgcagcac ctgcacaagc
     1021 atccgcatca gctgcaactg catcagcagc agcaacaaca actccaccag caacagcagc
     1081 aacacttcca ccagcagtcg ctgcaagggc tgcatcaggg tagcagcaat ccggattcga
     1141 atatgagcac tggctcctcg catagcgaga aggatgtcaa tgatatgctg agtggcggtg
     1201 cagcaacgcc aggagctgca gcagcagcga ttcaacagca acatcccgcc tttgcgccca
     1261 cactgggaat gcagcaacca ccgccgcccc cacctcaaca ctccaataat ggaggcgaga
     1321 tgggctactt gtcggcaggc acgaccacga cgacgtcggt gttaacggta ggcaagcctc
     1381 ggacgccagc ggagcggaaa cggaagcgaa aaatgcctcc atgtgccact agtgcggatg
     1441 aggcggggag tggcggtggc tctggcggag caggagcaac cgttgttaac aacagcagcc
     1501 tgaagggcaa atcattggcc tttcgtgata tgcccaaggt aaacatgagc ctgaatctgg
     1561 gcgatcgtct gggaggatct gcaggaagcg gagtaggagc cggtggcgcc ggaagcgggg
     1621 gaggtggcgc tggttccggt tctggaagcg gtggcggcaa aagcgcccgc ctgatgctgc
     1681 cagtcagcga caacaagaag atcaacgact atttcaataa gcagcaaacg ggcgtgggcg
     1741 tcggtgtgcc aggtggtgcg ggaggcaata ccgctggcct tcgaggatca catacgggag
     1801 gtggcagcaa gtcaccctca tccgcccagc agcagcaaac ggcggcacag cagcagggaa
     1861 gcggtgttgc gacgggaggc agtgcaggcg gttccgctgg caaccaggtg caagtgcaaa
     1921 cgagcagcgc ttacgccctt tacccaccag ctagtcccca aacccagacg tcacagcaac
     1981 agcagcagca gcaaccggga tcagactttc actatgtcaa ctccagcaag gcgcagcaac
     2041 aacagcagcg tcaacagcaa cagacttcca atcaaatggt tcctccacac gtggtcgttg
     2101 gccttggtgg tcatccactg agcctcgcgt ccattcagca gcagacgccc ttatcccagc
     2161 agcaacagca gcaacaacag cagcagcaac agcagcaact gggaccaccg accacatcga
     2221 cggcctccgt cgtgccaacg catccgcatc aactcggatc cctgggagtt gttgggatgg
     2281 tcggtgtggg tgttggcgtg ggcgttggag taaatgtggg tgtgggacca ccactgccac
     2341 caccaccgcc gatggccatg ccagcggcca ttatcactta tagtaaggcc actcaaacgg
     2401 aggtgtcgct gcatgaattg caggagcgcg aagcggagca cgaatcgggc aaggtgaagc
     2461 tagacgagat gacacggctg tccgatgaac aaaagtccca aattgttggc aaccagaaga
     2521 cgattgacca gcacaagtgc cacatagcca agtgtattga tgtggtcaag aagctgttga
     2581 aggagaagag cagcatcgag aagaaggagg cgcgacagaa gtgcatgcag aatcgcctca
     2641 ggctcggaca gtttgttacc caacgagtgg gcgccacatt ccagtcccgc tttaacaatc
     2701 atcccgtgct gaatgatcgc tatcttctgt tgatgctcct gggcaagggc ggcttctcag
     2761 aggtccacaa ggccttcgac ctgaaggagc aacgctatgt cgcatgtaag gtgcaccaat
     2821 taaacaagga ttggaaggag gataagaaag ctaattatat caaacacgct ttgcgggaat
     2881 acaacattca caaggcactg gatcatccgc gggtcgtcaa gctatacgat gtcttcgaga
     2941 tcgatgcgaa ttccttttgc acagtgctcg aatactgtga tggccacgat ctggacttct
     3001 atttgaagca acataagact atacccgagc gtgaagcgcg ctcgataata atgcaggttg
     3061 tatctgcact caagtatcta aatgagatta agcctccagt tatccactac gatctgaagc
     3121 ccggcaacat tctgcttacc gagggcaacg tctgcggcga gattaagatc accgacttcg
     3181 gtctgtcaaa ggtgatggac gacgagaatt acaatcccga tcacggcatg gatctgacct
     3241 ctcagggggc gggaacctac tggtatctgc cacccgagtg ctttgtcgtg ggcaaaaatc
     3301 cgccgaaaat ctcctccaaa gtggacgtat ggagtgtggg tgttatcttc taccagtgtc
     3361 tgtacggcaa aaagcccttc ggtcacaatc agtcgcaggc cacgattctc gaggagaata
     3421 cgatcctgaa ggccaccgaa gtgcagttct ccaacaagcc aaccgtttct aacgaggcca
     3481 agagtttcat tcggggatgc ttggcctatc gcaaggagga tcgcatggat gtgttcgcac
     3541 tggccaggca cgagtacatt cagccaccga taccgaaaca tgggcgcggt tcgctcaatc
     3601 agcaacagca ggcgcaacaa cagcagcagc aacaacagca acagcagcag caacagtcgt
     3661 cgacgtcaca ggccaattct acaggccaga catctttctc tgcccacatg tttggcaata
     3721 tgaatcagtc gagttcgtcc tagctgccaa ccaagcgcaa ttcgaactca taattcgccg
     3781 ccgccgcagt agcagcagct acattagctg ccagtagtca acagcaactt caacaccagc
     3841 aacagcaact ccaaatccag caataccagc agaatcagca acttcatttg caaaacagca
     3901 gtagcaatta tgcggccacg cttctagatg cagcggcctt ttgctacgaa accgtgatgg
     3961 atgcagccca cttccaaaac aacaataata acagcaccat catcaagaac aatatgcaga
     4021 caatgccggc aaacgctgcc aatgctgctg cagctgcagg gggaggggga acaccgacct
     4081 atcaggggaa atacaagcgc tggcagcagc aacagttaca acagcaggcg caactccaac
     4141 agcagcagca caagctgctg ttgcagcaag agctgctcta aaatatgaag ggaatgatga
     4201 caagcgagtt taagagaacg aggagctgcc tgccacactg ccgccgtcag caataacaac
     4261 atcccaagaa aattcacagc gagtcgcaaa agcatcaaca aacaaagc