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LOCUS NM_001272291 7403 bp mRNA linear INV 26-DEC-2023 variant K, mRNA. ACCESSION NM_001272291 VERSION NM_001272291.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 7403) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 7403) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 7403) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 7403) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 7403) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 7403) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 7403) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 7403) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 7403) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 7403) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 7403) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 7403) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 7403) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 7403) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 7403) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 7403) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 7403) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 7403) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 7403) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 7403) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 7403) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 7403) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 7403) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..7403 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..7403 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Tousled-like kinase" /map="3E6-3F1" /db_xref="FLYBASE:FBgn0283657" /db_xref="GeneID:318206" CDS 240..4037 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /EC_number="2.7.11.1" /note="CG34412 gene product from transcript CG34412-RK; CG34412-PK; Tlk-PK; BEST:GH17330; tousled-like kinase; tousled like kinase" /codon_start=1 /product="Tousled-like kinase, isoform K" /protein_id="NP_001259220.1" /db_xref="FLYBASE:FBpp0305893" /db_xref="GeneID:318206" /db_xref="FLYBASE:FBgn0283657" /translation="MRSKRNTSDLGLLQRTCIVGGKSMSPGAHLQMSPQNTSSLSQHH PHQQQQLQPPQQQQQHFPNHHSAQQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHLH KHPHQLQLHQQQQQQLHQQQQQHFHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDML SGGAATPGAAAAAIQQQHPAFAPTLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSVL TVGKPRTPAERKRKRKMPPCATSADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMPK VNMSLNLGDRLGGSAGSGVGAGGAGSGGGGAGSGSGSGGGKSARLMLPVSDNKKINDY FNKQQTGVGVGVPGGAGGNTAGLRGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGSA GGSAGNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQ QTSNQMVPPHVVVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVV PTHPHQLGSLGVVGMVGVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVS LHELQEREAEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLK EKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAERE EIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGV VTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNST QANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDP VSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQS RFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYI KHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPERE ARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDEN YNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFG HNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEY IQPPIPKHGRGSLNQQQQAQQQQQQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQS SSS" misc_feature <1914..>2324 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Family of unknown function (DUF5401); Region: DUF5401; pfam17380" /db_xref="CDD:375164" misc_feature 3048..3851 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; Region: STKc_TLK; cd13990" /db_xref="CDD:270892" misc_feature order(3057..3059,3096..3098,3102..3104,3210..3212, 3261..3272,3282..3284,3288..3290,3405..3407,3411..3413, 3417..3422,3426..3428,3468..3470,3477..3479,3546..3557) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="active site" /db_xref="CDD:270892" misc_feature order(3282..3284,3288..3290,3405..3407,3411..3413, 3417..3419,3477..3479,3546..3557) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270892" misc_feature order(3465..3503,3516..3557) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="activation loop (A-loop); other site" /db_xref="CDD:270892" ORIGIN 1 gttttcgttg cgcgtaggca aagaaaaact cactacagct cgaaacactt cttttttttc 61 tgtgtacttc cacttagtta tctgattaaa tattcaagca aacaagaaaa gaatacgaat 121 acatacatac tccaaattcc gtaatagaag tgaaaaaaca gtgtgttatg tgtgtgtacg 181 gttgttaata gttgttgaag agaaaagcga gaagcaggaa aaaaatcagc agccggagaa 241 tgcgcagcaa acgaaatacc agcgatttgg gcctattgca gcgcacctgc attgtcgggg 301 gaaaatcgat gtcccccggc gcccatttgc agatgtcccc gcagaacact tcgtccctaa 361 gtcaacacca tccacatcaa cagcaacagt tacaaccccc acagcagcaa caacagcatt 421 tccctaacca tcacagcgcc cagcaacagt cgcagcagca gcagcaacag gagcaacaga 481 atccccagca gcaggcgcaa cagcagcagc agatactccc acatcaacat ttgcagcacc 541 tgcacaagca tccgcatcag ctgcaactgc atcagcagca gcaacaacaa ctccaccagc 601 aacagcagca acacttccac cagcagtcgc tgcaagggct gcatcagggt agcagcaatc 661 cggattcgaa tatgagcact ggctcctcgc atagcgagaa ggatgtcaat gatatgctga 721 gtggcggtgc agcaacgcca ggagctgcag cagcagcgat tcaacagcaa catcccgcct 781 ttgcgcccac actgggaatg cagcaaccac cgccgccccc acctcaacac tccaataatg 841 gaggcgagat gggctacttg tcggcaggca cgaccacgac gacgtcggtg ttaacggtag 901 gcaagcctcg gacgccagcg gagcggaaac ggaagcgaaa aatgcctcca tgtgccacta 961 gtgcggatga ggcggggagt ggcggtggct ctggcggagc aggagcaacc gttgttaaca 1021 acagcagcct gaagggcaaa tcattggcct ttcgtgatat gcccaaggta aacatgagcc 1081 tgaatctggg cgatcgtctg ggaggatctg caggaagcgg agtaggagcc ggtggcgccg 1141 gaagcggggg aggtggcgct ggttccggtt ctggaagcgg tggcggcaaa agcgcccgcc 1201 tgatgctgcc agtcagcgac aacaagaaga tcaacgacta tttcaataag cagcaaacgg 1261 gcgtgggcgt cggtgtgcca ggtggtgcgg gaggcaatac cgctggcctt cgaggatcac 1321 atacgggagg tggcagcaag tcaccctcat ccgcccagca gcagcaaacg gcggcacagc 1381 agcagggaag cggtgttgcg acgggaggca gtgcaggcgg ttccgctggc aaccaggtgc 1441 aagtgcaaac gagcagcgct tacgcccttt acccaccagc tagtccccaa acccagacgt 1501 cacagcaaca gcagcagcag caaccgggat cagactttca ctatgtcaac tccagcaagg 1561 cgcagcaaca acagcagcgt caacagcaac agacttccaa tcaaatggtt cctccacacg 1621 tggtcgttgg ccttggtggt catccactga gcctcgcgtc cattcagcag cagacgccct 1681 tatcccagca gcaacagcag caacaacagc agcagcaaca gcagcaactg ggaccaccga 1741 ccacatcgac ggcctccgtc gtgccaacgc atccgcatca actcggatcc ctgggagttg 1801 ttgggatggt cggtgtgggt gttggcgtgg gcgttggagt aaatgtgggt gtgggaccac 1861 cactgccacc accaccgccg atggccatgc cagcggccat tatcacttat agtaaggcca 1921 ctcaaacgga ggtgtcgctg catgaattgc aggagcgcga agcggagcac gaatcgggca 1981 aggtgaagct agacgagatg acacggctgt ccgatgaaca aaagtcccaa attgttggca 2041 accagaagac gattgaccag cacaagtgcc acatagccaa gtgtattgat gtggtcaaga 2101 agctgttgaa ggagaagagc agcatcgaga agaaggaggc gcgacagaag tgcatgcaga 2161 atcgcctcag gctcggacag tttgttaccc aacgagtggg cgccacattc caggagaact 2221 ggacggacgg ctatgcgttc caggagctga gtcggcggca agaagaaata accgctgagc 2281 gtgaagagat agatcggcag aaaaagcagc tgatgaaaaa gcgtccggcg gagtccggac 2341 gcaagcgcaa caacaacagt aaccagaaca accagcagca gcagcaacag caacaccagc 2401 aacagcagca gcaacaaaat tccaactcga acgattccac gcagctgacg agcggagttg 2461 ttaccggtcc aggcagtgat cgtgtgagcg taagcgtcga cagcggattg ggtggcaata 2521 atgcgggcgc gatcggtggc ggaaccgttg gtggtggcgt tggaggtggt ggtgttggag 2581 gcggtggtgt cggaggcggc ggtggacgtg gactttctcg cagcaattcg acgcaggcca 2641 atcaggctca attgctgcac aacggcggtg gtggttcggg cggcaatgtc ggcaactcgg 2701 gcggcgttgg cgaccgcttg tcagatcgag gaggaggagg tggcggcatc ggcggaaacg 2761 atagcggcag ctgctcggac tcgggcactt tcctgaagcc agaccccgta tcgggtgcct 2821 acacagcgca ggagtattac gagtacgatg agatcctcaa gttgcgacaa aatgccctca 2881 aaaaggagga cgccgacctg cagctggaga tggagaagct ggagcgggag cgcaatctgc 2941 acatccgaga gctcaagcgg attcttaacg aggatcagtc ccgctttaac aatcatcccg 3001 tgctgaatga tcgctatctt ctgttgatgc tcctgggcaa gggcggcttc tcagaggtcc 3061 acaaggcctt cgacctgaag gagcaacgct atgtcgcatg taaggtgcac caattaaaca 3121 aggattggaa ggaggataag aaagctaatt atatcaaaca cgctttgcgg gaatacaaca 3181 ttcacaaggc actggatcat ccgcgggtcg tcaagctata cgatgtcttc gagatcgatg 3241 cgaattcctt ttgcacagtg ctcgaatact gtgatggcca cgatctggac ttctatttga 3301 agcaacataa gactataccc gagcgtgaag cgcgctcgat aataatgcag gttgtatctg 3361 cactcaagta tctaaatgag attaagcctc cagttatcca ctacgatctg aagcccggca 3421 acattctgct taccgagggc aacgtctgcg gcgagattaa gatcaccgac ttcggtctgt 3481 caaaggtgat ggacgacgag aattacaatc ccgatcacgg catggatctg acctctcagg 3541 gggcgggaac ctactggtat ctgccacccg agtgctttgt cgtgggcaaa aatccgccga 3601 aaatctcctc caaagtggac gtatggagtg tgggtgttat cttctaccag tgtctgtacg 3661 gcaaaaagcc cttcggtcac aatcagtcgc aggccacgat tctcgaggag aatacgatcc 3721 tgaaggccac cgaagtgcag ttctccaaca agccaaccgt ttctaacgag gccaagagtt 3781 tcattcgggg atgcttggcc tatcgcaagg aggatcgcat ggatgtgttc gcactggcca 3841 ggcacgagta cattcagcca ccgataccga aacatgggcg cggttcgctc aatcagcaac 3901 agcaggcgca acaacagcag cagcaacaac agcaacagca gcagcaacag tcgtcgacgt 3961 cacaggccaa ttctacaggc cagacatctt tctctgccca catgtttggc aatatgaatc 4021 agtcgagttc gtcctagctg ccaaccaagc gcaattcgaa ctcataattc gccgccgccg 4081 cagtagcagc agctacatta gctgccagta gtcaacagca acttcaacac cagcaacagc 4141 aactccaaat ccagcaatac cagcagaatc agcaacttca tttgcaaaac agcagtagca 4201 attatgcggc cacgcttcta gatgcagcgg ccttttgcta cgaaaccgtg atggatgcag 4261 cccacttcca aaacaacaat aataacagca ccatcatcaa gaacaatatg cagacaatgc 4321 cggcaaacgc tgccaatgct gctgcagctg cagggggagg gggaacaccg acctatcagg 4381 ggaaatacaa gcgctggcag cagcaacagt tacaacagca ggcgcaactc caacagcagc 4441 agcacaagct gctgttgcag caagagctgc tctaaaatat gaagggaatg atgacaagcg 4501 agtttaagag aacgaggagc tgcctgccac actgccgccg tcagcaataa caacatccca 4561 agaaaattca cagcgagtcg caaaagcatc aacaaacaaa gcaaaaaacg caaaaaagga 4621 ttacaaagac gcagagaata ggggacattt gcaatgggaa ataacaaatt attgcattat 4681 ctgctggatt gtgattgtgg ttcaaacatt aaaaatacac ttactcatac acacaaggta 4741 gacactgcag actaattttg ccttaaaaga aacaaaacga ataatgttaa ctgtaaattt 4801 tcactttgtg tccatgcata gttactagta atgatgatat aaatatataa atatatataa 4861 aatataaaaa ttatataaat gtataaattt atatttatat atatatatat atatatatat 4921 atatatctgc ataaacattg aagcatacta gtaaatcttt ataaatatat ttatatatat 4981 atttatctct tccttttaac gcttttaatc ggaaaaaaca tcccaattat attttaattc 5041 aatttgaaat ataaaagtca tttttgtttg ttttgtatca aaatccaaaa aaaattgatt 5101 taaatataaa aataccataa acattaacac cacacacaca cacacacaca catatatata 5161 tatatatata tatatatata tatatacata tatatataca tttgtatata gtcgtatctg 5221 aaccacaaac aaatccacag ataaaaaaaa ctgaaaaatt catagaatca aaccattttt 5281 ttatatgcca caaagaaaag aaaataagta gaaatgcaag aaaaatcgag aaaaagcgta 5341 attcatgaga tcagatcgga tcagaaaaat caacagaaaa taaacctatt tgaagtaaaa 5401 tacttctaaa tacatagtaa actaatgtaa tagtttttat taaaattaca catatatgta 5461 tcgatatata tacatgtttt ttttttttta attttaaaat tataattgta atgcactatg 5521 cgtaaattgt attaaatatt aatatccaag gcatattaat agaaatatat atacatatat 5581 aaaacctgca aaaaaaaaac atgaactacc aagctaaatg tttcaataat atatagatct 5641 atatgtatgt aaaaccgata tgaaatctgc ctacagccag acaaaaaaaa ccttaaagag 5701 aaagatcaga agaggaacag aagagtatga gcggggagtg aaagatgcaa gattcatcca 5761 aaagcgaaaa acattttttt cttaagtcta cgcaaaacaa aatgaatgaa aagtaacccg 5821 aaattagttt ttagagtata agtataaaaa atggaaaata tcgcgataga aagaaacaaa 5881 aatggacgca gataaggacg gcaagcagaa caagagtaat aaagcagcgg caagaactcc 5941 ctaaaaatag caaagagcat tgtaaatatt tatataaata atttatgcct aattaaagtt 6001 taaattaatg aagaaaacca gcaaaaaaac ataaaaaacc agaagaacca tttcagattt 6061 gtatgcaaat ttgtatatgt acgtactttc ctttaatttt agccaatcag tttgtaagat 6121 taaatttttt ttttgcatct ctataaagaa taatgatatg aggataatga ttccgatttt 6181 tttttccgtt taatgtaacc gttagaatta gcccataatg gtcgatatct aaatgtgtgt 6241 gtatatcgat gtgatgtcat cgattgtcga taacgattgg atgcgagtgt gtgttaattt 6301 aatttgataa aagataaagg aaagcaagga atgtgaagat aatgaaagga gatgcataga 6361 gaatgagagc gaatctatct attatataat tatgtaaaat gcacatcttt aaattataaa 6421 ttatacatat ttaaaaggaa actattatta ttattttgat taccattatc attatttttt 6481 attatcactt aacggtttcg gtttgatcca cagcgaaacc aacaacaacc aagaaacaga 6541 aacaacaaaa agagaaacaa aataaacaag cgaaatgttt gataaaaaaa accacgagat 6601 gttttaattt atttgtcttt aattcttcga ttttattgag tttttcatag agaaagttgt 6661 cacactcaag aacacacacg caagcgtata aagctaaaca aattaatacc tactaagtgt 6721 ttaaatagta ctaaacgaat caaaatataa atacttaaaa agaaaaaaaa acgaaaataa 6781 aaataaaaac agcagcagaa aaaaacgatg agacagttga gcagacgaga aaaacaaagc 6841 ccattaaatt atttgttgag tattttatta aaaaataatt acgataataa ttaaaaagtt 6901 taaattgaac gaattacgaa aaacaaactg aatatacata tatgtgtgca tatatacata 6961 tatgtatgta ttatatataa acaaattatt taatagttat gctaaaaaat tatttaaagt 7021 gaacggatat gaaaaatatt tgtatgcgtg cgagcacgga gagaagggca ctcagaatag 7081 gccatcgaca ccacccactc ccttccgata cccgaacatc accaccagtt ttcaccattt 7141 tctgaccctt aaccccttca accagacaca caccaaacac aagaaaaggc gaagaaagcc 7201 gaaaaaaaaa caatgcaaac acgaaatagg cggcgacgac agagataagc gcgaagaaga 7261 tactaaatca ataagtaaac ataaaaatta attaataaat taattccaaa acaaaatgaa 7321 aaaagctaaa aaaaaaacat caagaaaaca aaagacaaaa gcaaacaaaa aacatgacga 7381 aacattgaaa ataaaaaaat act