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Drosophila melanogaster dunce (dnc), transcript variant U, mRNA.


LOCUS       NM_001272274            9456 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_001272274
VERSION     NM_001272274.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 9456)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9456)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9456)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 9456)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 9456)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 9456)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 9456)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 9456)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 9456)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 9456)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 9456)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 9456)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 9456)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 9456)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 9456)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 9456)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 9456)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 9456)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 9456)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 9456)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 9456)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 9456)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 9456)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9456
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..9456
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="dunce"
                     /map="3C9-3D1"
                     /db_xref="FLYBASE:FBgn0000479"
                     /db_xref="GeneID:31309"
     CDS             2715..4862
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /EC_number="3.1.4.-"
                     /EC_number="3.1.4.17"
                     /EC_number="3.1.4.53"
                     /note="CG32498 gene product from transcript CG32498-RU;
                     CG32498-PU; dnc-PU; dunce phosphodiesterase"
                     /codon_start=1
                     /product="dunce, isoform U"
                     /protein_id="NP_001259203.1"
                     /db_xref="FLYBASE:FBpp0305509"
                     /db_xref="GeneID:31309"
                     /db_xref="FLYBASE:FBgn0000479"
                     /translation="MQAEQGSIGDLQKYHSRYLKNRRHTLANVRFDVENGQGARSPLE
                     GGSPSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRS
                     HGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQ
                     GEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSG
                     NQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMS
                     QISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRP
                     LTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVL
                     LNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHH
                     LAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKK
                     VAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERE
                     SGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQ
                     SMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGTTGTTA
                     ASALSGAGGGGGGGGGMAPRTGGCQNQPQHGGM"
     misc_feature    3039..3407
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="Phosphodiesterase 4 upstream conserved regions
                     (UCR); Region: PDE4_UCR; pfam18100"
                     /db_xref="CDD:465648"
     misc_feature    3840..4562
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="3'5'-cyclic nucleotide phosphodiesterase; Region:
                     PDEase_I; pfam00233"
                     /db_xref="CDD:459723"
ORIGIN      
        1 ttatttgcac gcatgtcgtc gaccaggacg aatcgtttgg cagagcgcgg ctgaaaaagg
       61 aatcgaaaac ggggctataa cggtaatagc ggcacacgcg tccaacggta aacacgcgtg
      121 ccaacgcgcc atctcgctcg cacgcgctaa tgccgcgatt taagttttgt tttatttttt
      181 gcaagtgttc gaatcaaaaa gcctaacaaa acacaaaacc cgaaacagtt ctcaagaaat
      241 acatagtctg cggttgataa agactttgat tgaaaattaa agcgtgcgct aaaaaataat
      301 tcggattcga taataaaaga aaaaaaaaaa aaaaattctt tgacttcatt gcaaggaaga
      361 tccgaagttt tgttaatttt aatttttttt tcggttactg tgctaatcag aaattacaaa
      421 ttagaaattc gaaaatcgaa atttttcggc gttaggccag cggaagctga taaacaacag
      481 agaagcggcg gcatctggaa aataataaaa ctcgaaggtt tgaggtgagt tccctatttg
      541 agtgtgaaaa tcgagtgaaa gagcggcggc tgcgcaccac ttatcgcggg cttttcgcac
      601 aagggggttt ttctcgtcga caaaaaaaaa aaaaaaaaca aaaaactgtc aaatgagcaa
      661 agaggcggaa aagagacgaa acaacaacaa atgcagcgga acaagaaaaa ataagaaagc
      721 aaatagaaaa cgacaacaaa aaagctggcc aaacaacaac aaatgtaacg cggaaaaggc
      781 agttttcttt ggccgcagca gcagcagcat gcgggaaaat catccgcaag ccgcagaata
      841 aatatgattt aataaataac taaacgcagt tagcaataac catgagcaat atctattaaa
      901 tccatttaaa taaatcgcta tatttttgtt aaaacaacac ttttttttcg agtgcccaaa
      961 gtgtgtgtgc ataaatattt ttaagaaaag ccacaagctg tgcagcaaaa aaatttttaa
     1021 cattaggtgt gccaaaaaat ttaaatgaaa aacccaacaa gctcggcaaa caaatgtata
     1081 aagtgtttga aaaccaaaga tgaaacactt cggcgggcaa ctaaatgaat aatagtgtcg
     1141 tggtaaatta atacatatac gtggattaaa tcaaggaaaa tcgaaatttt cctgcccaaa
     1201 tgaatatgca aaccaaaata aacaacaaaa taacataggc ggcattctgc agagagcaag
     1261 aagcagagca gaatccgagg agacaaaagc atcgcggcag tggcagtagc aacggcaccg
     1321 gaaacggaag cgggaccgga aacggccagg gattaggtgg cagctgcagt gccaacggcc
     1381 tggcagccac tggcggcgtt ggagggggcg gtgggagtgg cagcggcggc ggtgggtgtg
     1441 gcagcgggag tggcagtggg agtggcaagc ggaaatcaaa ggcaagaaca aagtgcttcg
     1501 gtggcacagt gtttcggtgt tgcctccctt gtcgcggggg cggctccgca gcccccgcca
     1561 caagtccgcc ccaaacacca gcccagacgc cggacgagct caaggtcatt ccggaggatt
     1621 gtaatctgga aaagtccgcg gagcaaaagc gcgacttact ggagcggaac aacaaggagg
     1681 acgatctgct gaaccgcacc gtatccggat ctgagctgga tctatacggc ggcgccggcg
     1741 gcggtacgaa aaagcattcg ctggcagaca ccatcgatac atcggtgacc accccgattt
     1801 ccctaaagac cctgatcaac gacgtcgacg aggagctgga ccagcaactg agtgcggcgg
     1861 atatagcggc cgccagtttg gccagcggtc tggttgcccg ccgagcggaa ccagaaacac
     1921 tgagcgacgc cagtgtctca cccaccgcgg tggtgcagca gcagcagcag cagcagcagc
     1981 agctgcagca accactcttg caatcacaac cacattttgt gcccagcagc ggcaatatcc
     2041 ttagccaggt caccctgtac agcggcagca atccctcgac aaatccctgc cagagtgcag
     2101 tgcagaatca aggccaaaac tccaatccca atcccaatca gaatccaaac acaaatccga
     2161 accagaatca acagcgttgc agttgccagc cgcagacttc cccattgccg catatcaaag
     2221 aggaggagga atccgatcag gccaacttta aacaccagac gagcctgaag gagcatcagc
     2281 ctctcccgcc accgatcacc atagccactg gctactgcgg cagctgcgag agcgttcatc
     2341 actcatccgc aacctcgtct tcggcgggca cagtacctcc ggggggtcag caaactcagg
     2401 agtatattgc cggtacctct tcgacgccct cgccgcgcat caaactaaag ttccgcaagc
     2461 cgcacaagtc ctgctggtcg cgaatcgtcc ttgcgcccat tggatcggcg ggtggctcct
     2521 catcggccac cactgtcatt ggcagcaatt cgaacgagac tttggcctcc agcagcacca
     2581 ccggcggcac cgccaccacc acccagaaca gcagcagcgt tagcgttgcc gcacaccacc
     2641 ggctaacctc gtcgtcggcc tccgccctcg ccacctcgca ccccagcaac tcgcagctgc
     2701 tgcccaccag caagatgcag gcggagcagg gatccatcgg tgacctgcag aagtaccata
     2761 gtcggtatct caagaatcgt cgccatactc tggccaatgt tcgtttcgat gtagaaaatg
     2821 gccagggcgc tagatcaccg ctcgagggcg gctcacccag cgccggtttg gtactacaga
     2881 atttgccgca gcgtcgcgaa tcgtttctat atcgctccga ttcggacttt gagatgtcac
     2941 ccaagtccat gtcccgaaac tcaagcatcg ctagcgaaag gtttaaagaa caggaagcct
     3001 ctatactcgt tgaccgatcc catggcgagg atctcattgt gacgcctttc gcccaaattt
     3061 tagccagctt acgttcagtg cgcaacaatt tattaagtct gacaaatgtt ccagcatcaa
     3121 acaaatccag gcggcccaac caatcgtcgt cggcctcgcg atcaggaaat ccaccaggag
     3181 ccccgctatc ccaaggcgag gaggcataca cccgcctggc caccgacaca atcgaggagc
     3241 tggactggtg cctcgaccag ctggagacca tccagaccca tcgcagcgtc tccgacatgg
     3301 cgtcgcttaa gttcaaacgc atgctcaaca aggagctgtc gcactttagc gagtccagca
     3361 gatcgggaaa tcagatttcc gaatatatat gttccacatt tttggacaag caacaggagt
     3421 tcgacttgcc atcgctgcgc gtggaggata atcccgagct ggtcgccgcc aatgcagccg
     3481 ctggtcaaca gtccgctgga cagtatgcac gctcccgatc gccgcgcggt ccgcccatgt
     3541 cgcagatcag cggcgtgaag agaccgctgt cgcatacgaa tagctttacc ggcgaacgtt
     3601 tgcccacctt cggtgtggag acacccaggg agaatgagct gggcacgctg ctcggcgaac
     3661 tggacacctg gggtattcag atattcagca tcggcgagtt cagtgtcaat cgaccgctca
     3721 cctgtgtggc atacaccata tttcagagta gagaattact gaccagtctt atgataccac
     3781 cgaaaacttt tcttaacttt atgtctactc tggaggacca ctacgtcaaa gacaatccgt
     3841 ttcacaattc gctgcatgcc gccgatgtga cacaaagcac taatgtgcta ctcaatacac
     3901 cggcgctgga gggcgtattc acgccgctcg aagtgggcgg ggcgctgttc gccgcttgca
     3961 tacacgatgt tgatcatccc ggcttaacca atcagttctt ggttaactca agttccgaac
     4021 tagcattaat gtacaatgac gaatctgttt tggaaaatca tcatttagct gttgccttta
     4081 aattattaca aaatcaagga tgtgatatat tctgtaatat gcaaaagaaa caacgccaaa
     4141 cattgaggaa aatggttatt gatattgtgc tgtccacgga catgtccaag cacatgagtc
     4201 tgctggccga cctaaagaca atggtggaaa ccaaaaaggt ggccggctcc ggagtactgc
     4261 tgctggacaa ctacaccgat cgcatacagg tgcttgagaa tctggtgcac tgcgccgatc
     4321 tgagcaatcc caccaagccg ctgccgcttt acaagcgctg ggtagccctg ctcatggagg
     4381 agttcttcct gcagggcgat aaggaacgcg aatcgggcat ggacattagt cccatgtgcg
     4441 atcgccataa tgccaccatt gagaagtcgc aggtgggctt catcgactac atcgtccacc
     4501 cgctatggga gacctgggcg gacctggtgc atccggatgc ccaggatata ctcgacacgc
     4561 ttgaagagaa cagagactac taccagagca tgataccgcc ttcgccgccg ccatcgggcg
     4621 tcgatgagaa tccgcaggag gacaggatac gctttcaagt aacccttgag gaatccgatc
     4681 aggagaacct cgccgaactg gaggagggcg acgagagtgg tggcgagagc accaccacag
     4741 gcacaaccgg aaccaccgct gcatccgcgc taagcggagc tggtggcggt ggcggtggag
     4801 gcgggggaat ggcacccaga acgggtggct gccaaaacca accgcaacac ggtggaatgt
     4861 gacggagagt cgtgggaatt tatcgcaaat tacaggaaaa ggctcacaac tttttcctat
     4921 tacgttagtg actactatta acacagaaaa aaccaaaaca aaaacctaaa acgaaaagca
     4981 aaaaaaaaaa caaagaaaaa ctcttggaaa aaatgcaaaa aaaaatccac aaaaaaaaaa
     5041 ccaaaaaacc caagtaagga aatattaaac caatgtttaa acgcatacaa aaatccaaac
     5101 agcaatagca aaactaacgt taaacctata aagtctagag aaaatcgaaa aaggaaatta
     5161 gaaatttact taatggaacc cgagattgat gttgaaaata cactgaaaaa gaaggaggag
     5221 gccgagctaa ctaagataaa atcgtacata ttgttaaaaa caaaacaaaa aaacatagac
     5281 acactaaatt caagacaaag caaagataat aagaaaaatt gataagttac aaaaaataag
     5341 acgataccga aaactcccgc cccaaaagcc taagaaatcc cagtaccccc cccccccctc
     5401 cactcccctt tatatatata tatatacaat ttttgttgca tgtgtaggta aatgattttt
     5461 gtcaaaattc atctgaagta gtacatccat cagaggcagc cccttagctg agtctcctct
     5521 tttaatccat tgactaaagt gaaatattta aaaaacagag aatcaggcga acgaaaagga
     5581 ataattaata tgacctagct tataagagaa gttattaagt ttttaaatgt tttgcatgcc
     5641 cgaacagatt tattttactt gattgattga taacgctaga tctaactgat aaacgataac
     5701 agcaacacat ggagtttttt ttttatataa tttagaccac agcgatagaa gcgaaagaaa
     5761 atcaaccatg taaagtttaa gaacccagtg aattaaacca aaattgaaag ccaaccgagt
     5821 tgaaaccaat ttaattctaa atctaaatct aaatccacaa cccaaaaccc aaaaccccaa
     5881 gcaacaaaaa agaaagaaag aaggaaaagt aaggaacagt ctacagccag actgtagttg
     5941 tatagtaata tatatgatat aaatattttt tttaaatatt atttgtaaat aatttaaatg
     6001 ttggactcga atttaaatca agcggctagc aaatgttgca gctaaactaa aatgaaaaca
     6061 aagccaaaaa acacacacat aaataggtaa actaagtgaa aaatgtggaa aaggaaaaac
     6121 tattgtacaa ttagctaaag aatttccatt tcaattttca atttgaattg caatttaatt
     6181 tgcttccaga aatgaatgaa aggagacaag aaaaagatag ggagataaac cgaaaattag
     6241 tttcaaacgc tgtcttcgca aatatttttc gctatatata tatatatata ttacttataa
     6301 cattatttta ctagttacta agctacttac tgagccacac aaatttaaaa cgaaagagac
     6361 aagacaccag gacaagaaag agaaggagct ttcatgaatt tagtgaacaa acataactgg
     6421 caatggccac acacacacac acaatttaca aagcgaacaa caccaaaaaa aataaataaa
     6481 aagactcttc aagcacaaaa aaaactgttt agttttcagt aaacagtaaa accaaagcaa
     6541 agcaaaataa cacacaagat ataatcccca aaaaagtcat tggctataat atgattactt
     6601 aacctaacct atacaatata tagatatata gatatatcct atatgcatat gtaaagtcac
     6661 gatactggcg ctggtgcgcg gatcgatcaa tgtggcaggc caaattctaa atgcgcataa
     6721 tttaactatt gtttacatta tgttttattg ttattaattt attaccaaaa acgaaaacat
     6781 tattttttca gacctagtgc tataaatttc ttttttgtgt tgaagcgggc aggatccgcg
     6841 cataaaatag tgtttttttt ttttttgtaa ttacaaatat atataaagat acatacatat
     6901 atatatatat atataatatg atatgtgaat gaaatgtaat gaaatgaagt ggaaccttga
     6961 tggtctaaaa atatcattaa aagctgatgg agatggaaag ttgaagaaca agatacttta
     7021 tagcaattta agcagcattg taaatgtgcg cttcagaact actttttttt cgaaacttaa
     7081 tcgaccttca gcaaatacag caagatatat tacctacatt acaaacatat attattaatt
     7141 gaaccatagt tgcgacacaa aacaaaaatg acggcaagtc catggcaaac ttaagcaaaa
     7201 accaaaagct actttaacaa attgagtgaa ataaataaaa gaaagaaaac aaacaaaaaa
     7261 aaaaaaacac aaaaaaaaac catatgactt ttttctcctc tcacaaaata aaagcgaaaa
     7321 acagaaaaat aaactagtat tgtattgtat ttgtaacacg aattttcctg cgagtgaaca
     7381 ctttacgcag aaccataaag ccggaaactg aaaacctaca gagattccgc agcaatcgcg
     7441 gcactggtat gtgtgtatag ctaatagcta tactcattat gtaatttacc agagtattaa
     7501 tcgaacaatt taaatttaca tatatgcata tgcataccaa catactagga atactaggaa
     7561 tatatgcagt aacggacatt tgatgtatac tcgagttgaa acataaccct aaccaaatgt
     7621 tgtatgtgta tgtgtaattc gatgaactta aaagtccaaa gccatacgtg aaaataagaa
     7681 caagcaattt atagtgaaaa agtcgaaaag tatctaaatg taattgttag aaaatgccaa
     7741 gtaaatccga aagttaccac agagttaatg aggaggcatc atctatcttg tcatccaaga
     7801 aatccccaaa tcaatttttg actgaaattg aatcgtccta gtagaggcac tcgattcgta
     7861 ctccttcctt acccctaccg cccccccccc tcaccaactt cctttgcccc aactattgta
     7921 ctttatccaa tattttccta tcgacgtgcc gccaattata tcagtgtata taaactattt
     7981 gaaaatcacg catatatatg cacacataga gtttttgtag cgtcatatgt gtcattaagg
     8041 atgcccactt acatacatat atgaagggaa ataaataagc aagtaaatat acaatacaat
     8101 acatacatat atgtgtgtgt tgtgggtaac gagagatcag catttgtagc acaggttggc
     8161 caaatttatt gggaataacg agttgccgaa gttgccgaag aaaaaccaaa tgaaaactgt
     8221 ttgttgtgct gttagccgta aatgagaact tttttttgag ataacttaat acctatatat
     8281 ataaatatgt attacaatat atgtatctat aaatatataa aacaggcgac aaaccaaatt
     8341 aaaccaaata ccggaacaaa aaaaaaaaaa cgaaaaagaa gagagagaaa aaataataca
     8401 agcgatattg aaaatggcac gttttgtact ataatgaaat gagaaaacac caaagacgaa
     8461 tgcaaaacaa aaaaaaatgc aaacacataa caaaatatac aagaaatatt cttaacaaaa
     8521 agaaaaaaat accataaatt gtgcgctggc gacgacggtt gtttgaaaaa aagagaaagc
     8581 aaaaaacagg acatgccgct tgaagtgccg atcgtaagcg agtcctttcg attcgcaaat
     8641 cgtcggcatt tcaatcgatt gaagaatcgg gagatattat atacatatag aacacgtaac
     8701 gctggcgtta ctgggcaaac agttaggcat tttttttttt tcttttttgg aaatttatac
     8761 aattacatat acaaaaagag ctcaccccca caacaacaag gacaactgca gaagaagaac
     8821 aaaaaaaata cacacataca tggaaacact aacgcgtaca cggacagcga tttgccggaa
     8881 caaaattctg ggtatttcga accgagaaag ggaacggaaa cggaaacgga aacgaaaata
     8941 tagaacgcgg caagttattt aacactgaaa ctgatcgggt gtaactatag taccgaaatg
     9001 gggcttacac aggctgattc acccaaaata agtatacatg tattgtagta acgagcgctg
     9061 gcttttgtta ttaagttatg tatttgtttc gattatgttt tgcctctctc agaatatata
     9121 tatatatata tatatatata tatatatgta tattctatgt atatatatat attagttatg
     9181 tatgtgaaaa aagcgtaatc atttatgaaa ccaatgaaaa tctaacctga aaacaaagag
     9241 aaaaccccaa gtcaaataca caattgcatg caagagtaag taatattaat gaaatctaag
     9301 aacaaaggtc actcccgggc ttaaaaaaaa aaaaagaaga aaaaaaatgg gccgcatggc
     9361 aaatgataaa tggtaaaaca aaacaatgag caggtggcat tatgaacaga tttgaatgat
     9421 tacggaatac agactaaaaa tgaaaatgaa aaattt