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Drosophila melanogaster dunce (dnc), transcript variant Q, mRNA.


LOCUS       NM_001272273            8328 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_001272273
VERSION     NM_001272273.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 8328)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8328)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8328)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 8328)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 8328)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 8328)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 8328)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 8328)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 8328)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 8328)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 8328)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 8328)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 8328)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 8328)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 8328)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 8328)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 8328)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 8328)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 8328)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 8328)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 8328)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 8328)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 8328)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8328
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..8328
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="dunce"
                     /map="3C9-3D1"
                     /db_xref="FLYBASE:FBgn0000479"
                     /db_xref="GeneID:31309"
     CDS             1623..3734
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /EC_number="3.1.4.-"
                     /EC_number="3.1.4.17"
                     /EC_number="3.1.4.53"
                     /note="CG32498 gene product from transcript CG32498-RQ;
                     CG32498-PQ; dnc-PQ; dunce phosphodiesterase"
                     /codon_start=1
                     /product="dunce, isoform Q"
                     /protein_id="NP_001259202.1"
                     /db_xref="FLYBASE:FBpp0305505"
                     /db_xref="GeneID:31309"
                     /db_xref="FLYBASE:FBgn0000479"
                     /translation="MVCSFCCCCYNFRNSPSSFDVENGQGARSPLEGGSPSAGLVLQN
                     LPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQ
                     ILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDT
                     IEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFL
                     DKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHT
                     NSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSR
                     ELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTP
                     LEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQG
                     CDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNY
                     TDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRH
                     NATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGV
                     DENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGTTGTTAASALSGAGGGGG
                     GGGGMAPRTGGCQNQPQHGGM"
     misc_feature    1911..2279
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="Phosphodiesterase 4 upstream conserved regions
                     (UCR); Region: PDE4_UCR; pfam18100"
                     /db_xref="CDD:465648"
     misc_feature    2712..3434
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="3'5'-cyclic nucleotide phosphodiesterase; Region:
                     PDEase_I; pfam00233"
                     /db_xref="CDD:459723"
ORIGIN      
        1 cagcagagag catcgcatcg gcatcacaac gcatatcgca tttcgtgtgt gtgtgtgtgc
       61 gtgtgggtgc gtgtgtgtgc gcgcgcgccg cctaaaaata ataaaataaa aaagcaccac
      121 atccccataa tcataataat aataaacaat aatttcgcgt agtggtcgca agtgctaaaa
      181 tattcgctgt acaaaaaagc attgcccgtg aattttttgt tcttgtgcat taccattttt
      241 ttttttaagt gctcctcgca cgtgtgtgca aaacaacaac aaaaagcagg agaaggggcg
      301 aaaaaagaga agctgtaaat tacataaaag aagcagcaga agttaagata acagagtgga
      361 aaatgataag cggcagaaaa taaagctaca caatataata caccaaaaat atggccagta
      421 attacagaaa atatatgcaa aaagtcgttt aaaagttagt gcaaaataaa taaaaacaaa
      481 aaccaaacaa agggcggcat ccagaaatgc aaaaggtgtg ctaacaaagc acacacgcaa
      541 gtgaacacta aaaactgata gcaacaaaaa aaaaaaaact tgaaaaacta ccaaaactct
      601 tccaactaaa atcgcaaagc caagaaaatt gccaaagttg caaaataaat aactatacta
      661 tataatcaaa actttgatgt gtgttacaat aaaaaaccct cagtgaaaat acaataaata
      721 aatcaaagta ctccattaga aacaaaacta atgaataacg aacaataata acaaactgaa
      781 atcaagttgt tgactaataa acaaaatatt aaaccaataa taataataat aataaacaga
      841 aaattgtatt tggataaata gtccatattc aaaagaaaaa ttgaaaacaa gaaagataat
      901 agtaaatgcg attctagaat gccgccgccg cgacgtcgac gcagtgcgtg attgtgtgcg
      961 tgcgcctagt actcatgtgt gtcgtgtgag cttctgaact ggcgaccaaa actgacgacg
     1021 ccgtcgctgc ctctgcctca gccgcagtcg ccgcctccgc agcagcagca gcagcagcaa
     1081 caactacaac aacaacaaca acagccacca gggcagcaac aaccacacca gttacaacag
     1141 ccccaacacc aacagcgata acaacaacat atagatcgcg gaatctgctg aaagccaccg
     1201 ccaaagtgaa gaagaagaaa aagtggaagc aaatctcctt cgtcgacgac cagcaacgct
     1261 tgaagcaagc agcgacgtcg gcggagcgca aacgctccac cagcagcgcc ccgcccgccc
     1321 tcgagagcaa cgtaccgccg cggttggggc gctttctgcg gcaaaagagc agcgaaacta
     1381 acagcgctgc aacgtcagca gcagcggcgg cagtgcaaac ggaagcggaa acaggacgcc
     1441 ggaaatcgtc ggcggcatcg ataatcgcag cggcagcggg cgctgctggt ttgcacaaca
     1501 ataacagcag cagctgcgca gcgaccgcca gcgaggagca aaactcgagc ggtacgctca
     1561 ccggcagcag cggcaatact tccacgtcga cgtggtgcgg cagcatcaac ttcctggtgt
     1621 atatggtgtg ctcgttttgc tgctgttgct acaactttcg caattcgccg tctagtttcg
     1681 atgtagaaaa tggccagggc gctagatcac cgctcgaggg cggctcaccc agcgccggtt
     1741 tggtactaca gaatttgccg cagcgtcgcg aatcgtttct atatcgctcc gattcggact
     1801 ttgagatgtc acccaagtcc atgtcccgaa actcaagcat cgctagcgaa aggtttaaag
     1861 aacaggaagc ctctatactc gttgaccgat cccatggcga ggatctcatt gtgacgcctt
     1921 tcgcccaaat tttagccagc ttacgttcag tgcgcaacaa tttattaagt ctgacaaatg
     1981 ttccagcatc aaacaaatcc aggcggccca accaatcgtc gtcggcctcg cgatcaggaa
     2041 atccaccagg agccccgcta tcccaaggcg aggaggcata cacccgcctg gccaccgaca
     2101 caatcgagga gctggactgg tgcctcgacc agctggagac catccagacc catcgcagcg
     2161 tctccgacat ggcgtcgctt aagttcaaac gcatgctcaa caaggagctg tcgcacttta
     2221 gcgagtccag cagatcggga aatcagattt ccgaatatat atgttccaca tttttggaca
     2281 agcaacagga gttcgacttg ccatcgctgc gcgtggagga taatcccgag ctggtcgccg
     2341 ccaatgcagc cgctggtcaa cagtccgctg gacagtatgc acgctcccga tcgccgcgcg
     2401 gtccgcccat gtcgcagatc agcggcgtga agagaccgct gtcgcatacg aatagcttta
     2461 ccggcgaacg tttgcccacc ttcggtgtgg agacacccag ggagaatgag ctgggcacgc
     2521 tgctcggcga actggacacc tggggtattc agatattcag catcggcgag ttcagtgtca
     2581 atcgaccgct cacctgtgtg gcatacacca tatttcagag tagagaatta ctgaccagtc
     2641 ttatgatacc accgaaaact tttcttaact ttatgtctac tctggaggac cactacgtca
     2701 aagacaatcc gtttcacaat tcgctgcatg ccgccgatgt gacacaaagc actaatgtgc
     2761 tactcaatac accggcgctg gagggcgtat tcacgccgct cgaagtgggc ggggcgctgt
     2821 tcgccgcttg catacacgat gttgatcatc ccggcttaac caatcagttc ttggttaact
     2881 caagttccga actagcatta atgtacaatg acgaatctgt tttggaaaat catcatttag
     2941 ctgttgcctt taaattatta caaaatcaag gatgtgatat attctgtaat atgcaaaaga
     3001 aacaacgcca aacattgagg aaaatggtta ttgatattgt gctgtccacg gacatgtcca
     3061 agcacatgag tctgctggcc gacctaaaga caatggtgga aaccaaaaag gtggccggct
     3121 ccggagtact gctgctggac aactacaccg atcgcataca ggtgcttgag aatctggtgc
     3181 actgcgccga tctgagcaat cccaccaagc cgctgccgct ttacaagcgc tgggtagccc
     3241 tgctcatgga ggagttcttc ctgcagggcg ataaggaacg cgaatcgggc atggacatta
     3301 gtcccatgtg cgatcgccat aatgccacca ttgagaagtc gcaggtgggc ttcatcgact
     3361 acatcgtcca cccgctatgg gagacctggg cggacctggt gcatccggat gcccaggata
     3421 tactcgacac gcttgaagag aacagagact actaccagag catgataccg ccttcgccgc
     3481 cgccatcggg cgtcgatgag aatccgcagg aggacaggat acgctttcaa gtaacccttg
     3541 aggaatccga tcaggagaac ctcgccgaac tggaggaggg cgacgagagt ggtggcgaga
     3601 gcaccaccac aggcacaacc ggaaccaccg ctgcatccgc gctaagcgga gctggtggcg
     3661 gtggcggtgg aggcggggga atggcaccca gaacgggtgg ctgccaaaac caaccgcaac
     3721 acggtggaat gtgacggaga gtcgtgggaa tttatcgcaa attacaggaa aaggctcaca
     3781 actttttcct attacgttag tgactactat taacacagaa aaaaccaaaa caaaaaccta
     3841 aaacgaaaag caaaaaaaaa aacaaagaaa aactcttgga aaaaatgcaa aaaaaaatcc
     3901 acaaaaaaaa aaccaaaaaa cccaagtaag gaaatattaa accaatgttt aaacgcatac
     3961 aaaaatccaa acagcaatag caaaactaac gttaaaccta taaagtctag agaaaatcga
     4021 aaaaggaaat tagaaattta cttaatggaa cccgagattg atgttgaaaa tacactgaaa
     4081 aagaaggagg aggccgagct aactaagata aaatcgtaca tattgttaaa aacaaaacaa
     4141 aaaaacatag acacactaaa ttcaagacaa agcaaagata ataagaaaaa ttgataagtt
     4201 acaaaaaata agacgatacc gaaaactccc gccccaaaag cctaagaaat cccagtaccc
     4261 cccccccccc tccactcccc tttatatata tatatataca atttttgttg catgtgtagg
     4321 taaatgattt ttgtcaaaat tcatctgaag tagtacatcc atcagaggca gccccttagc
     4381 tgagtctcct cttttaatcc attgactaaa gtgaaatatt taaaaaacag agaatcaggc
     4441 gaacgaaaag gaataattaa tatgacctag cttataagag aagttattaa gtttttaaat
     4501 gttttgcatg cccgaacaga tttattttac ttgattgatt gataacgcta gatctaactg
     4561 ataaacgata acagcaacac atggagtttt ttttttatat aatttagacc acagcgatag
     4621 aagcgaaaga aaatcaacca tgtaaagttt aagaacccag tgaattaaac caaaattgaa
     4681 agccaaccga gttgaaacca atttaattct aaatctaaat ctaaatccac aacccaaaac
     4741 ccaaaacccc aagcaacaaa aaagaaagaa agaaggaaaa gtaaggaaca gtctacagcc
     4801 agactgtagt tgtatagtaa tatatatgat ataaatattt tttttaaata ttatttgtaa
     4861 ataatttaaa tgttggactc gaatttaaat caagcggcta gcaaatgttg cagctaaact
     4921 aaaatgaaaa caaagccaaa aaacacacac ataaataggt aaactaagtg aaaaatgtgg
     4981 aaaaggaaaa actattgtac aattagctaa agaatttcca tttcaatttt caatttgaat
     5041 tgcaatttaa tttgcttcca gaaatgaatg aaaggagaca agaaaaagat agggagataa
     5101 accgaaaatt agtttcaaac gctgtcttcg caaatatttt tcgctatata tatatatata
     5161 tattacttat aacattattt tactagttac taagctactt actgagccac acaaatttaa
     5221 aacgaaagag acaagacacc aggacaagaa agagaaggag ctttcatgaa tttagtgaac
     5281 aaacataact ggcaatggcc acacacacac acacaattta caaagcgaac aacaccaaaa
     5341 aaaataaata aaaagactct tcaagcacaa aaaaaactgt ttagttttca gtaaacagta
     5401 aaaccaaagc aaagcaaaat aacacacaag atataatccc caaaaaagtc attggctata
     5461 atatgattac ttaacctaac ctatacaata tatagatata tagatatatc ctatatgcat
     5521 atgtaaagtc acgatactgg cgctggtgcg cggatcgatc aatgtggcag gccaaattct
     5581 aaatgcgcat aatttaacta ttgtttacat tatgttttat tgttattaat ttattaccaa
     5641 aaacgaaaac attatttttt cagacctagt gctataaatt tcttttttgt gttgaagcgg
     5701 gcaggatccg cgcataaaat agtgtttttt ttttttttgt aattacaaat atatataaag
     5761 atacatacat atatatatat atatataata tgatatgtga atgaaatgta atgaaatgaa
     5821 gtggaacctt gatggtctaa aaatatcatt aaaagctgat ggagatggaa agttgaagaa
     5881 caagatactt tatagcaatt taagcagcat tgtaaatgtg cgcttcagaa ctactttttt
     5941 ttcgaaactt aatcgacctt cagcaaatac agcaagatat attacctaca ttacaaacat
     6001 atattattaa ttgaaccata gttgcgacac aaaacaaaaa tgacggcaag tccatggcaa
     6061 acttaagcaa aaaccaaaag ctactttaac aaattgagtg aaataaataa aagaaagaaa
     6121 acaaacaaaa aaaaaaaaac acaaaaaaaa accatatgac ttttttctcc tctcacaaaa
     6181 taaaagcgaa aaacagaaaa ataaactagt attgtattgt atttgtaaca cgaattttcc
     6241 tgcgagtgaa cactttacgc agaaccataa agccggaaac tgaaaaccta cagagattcc
     6301 gcagcaatcg cggcactggt atgtgtgtat agctaatagc tatactcatt atgtaattta
     6361 ccagagtatt aatcgaacaa tttaaattta catatatgca tatgcatacc aacatactag
     6421 gaatactagg aatatatgca gtaacggaca tttgatgtat actcgagttg aaacataacc
     6481 ctaaccaaat gttgtatgtg tatgtgtaat tcgatgaact taaaagtcca aagccatacg
     6541 tgaaaataag aacaagcaat ttatagtgaa aaagtcgaaa agtatctaaa tgtaattgtt
     6601 agaaaatgcc aagtaaatcc gaaagttacc acagagttaa tgaggaggca tcatctatct
     6661 tgtcatccaa gaaatcccca aatcaatttt tgactgaaat tgaatcgtcc tagtagaggc
     6721 actcgattcg tactccttcc ttacccctac cgcccccccc cctcaccaac ttcctttgcc
     6781 ccaactattg tactttatcc aatattttcc tatcgacgtg ccgccaatta tatcagtgta
     6841 tataaactat ttgaaaatca cgcatatata tgcacacata gagtttttgt agcgtcatat
     6901 gtgtcattaa ggatgcccac ttacatacat atatgaaggg aaataaataa gcaagtaaat
     6961 atacaataca atacatacat atatgtgtgt gttgtgggta acgagagatc agcatttgta
     7021 gcacaggttg gccaaattta ttgggaataa cgagttgccg aagttgccga agaaaaacca
     7081 aatgaaaact gtttgttgtg ctgttagccg taaatgagaa cttttttttg agataactta
     7141 atacctatat atataaatat gtattacaat atatgtatct ataaatatat aaaacaggcg
     7201 acaaaccaaa ttaaaccaaa taccggaaca aaaaaaaaaa aacgaaaaag aagagagaga
     7261 aaaaataata caagcgatat tgaaaatggc acgttttgta ctataatgaa atgagaaaac
     7321 accaaagacg aatgcaaaac aaaaaaaaat gcaaacacat aacaaaatat acaagaaata
     7381 ttcttaacaa aaagaaaaaa ataccataaa ttgtgcgctg gcgacgacgg ttgtttgaaa
     7441 aaaagagaaa gcaaaaaaca ggacatgccg cttgaagtgc cgatcgtaag cgagtccttt
     7501 cgattcgcaa atcgtcggca tttcaatcga ttgaagaatc gggagatatt atatacatat
     7561 agaacacgta acgctggcgt tactgggcaa acagttaggc attttttttt tttctttttt
     7621 ggaaatttat acaattacat atacaaaaag agctcacccc cacaacaaca aggacaactg
     7681 cagaagaaga acaaaaaaaa tacacacata catggaaaca ctaacgcgta cacggacagc
     7741 gatttgccgg aacaaaattc tgggtatttc gaaccgagaa agggaacgga aacggaaacg
     7801 gaaacgaaaa tatagaacgc ggcaagttat ttaacactga aactgatcgg gtgtaactat
     7861 agtaccgaaa tggggcttac acaggctgat tcacccaaaa taagtataca tgtattgtag
     7921 taacgagcgc tggcttttgt tattaagtta tgtatttgtt tcgattatgt tttgcctctc
     7981 tcagaatata tatatatata tatatatata tatatatatg tatattctat gtatatatat
     8041 atattagtta tgtatgtgaa aaaagcgtaa tcatttatga aaccaatgaa aatctaacct
     8101 gaaaacaaag agaaaacccc aagtcaaata cacaattgca tgcaagagta agtaatatta
     8161 atgaaatcta agaacaaagg tcactcccgg gcttaaaaaa aaaaaaagaa gaaaaaaaat
     8221 gggccgcatg gcaaatgata aatggtaaaa caaaacaatg agcaggtggc attatgaaca
     8281 gatttgaatg attacggaat acagactaaa aatgaaaatg aaaaattt