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Drosophila melanogaster dunce (dnc), transcript variant P, mRNA.


LOCUS       NM_001272272           10159 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_001272272
VERSION     NM_001272272.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 10159)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10159)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10159)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 10159)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 10159)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 10159)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 10159)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 10159)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 10159)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 10159)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 10159)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 10159)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 10159)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 10159)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 10159)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 10159)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 10159)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 10159)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 10159)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 10159)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 10159)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 10159)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 10159)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10159
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..10159
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="dunce"
                     /map="3C9-3D1"
                     /db_xref="FLYBASE:FBgn0000479"
                     /db_xref="GeneID:31309"
     CDS             3637..5565
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /EC_number="3.1.4.-"
                     /EC_number="3.1.4.17"
                     /EC_number="3.1.4.53"
                     /note="CG32498 gene product from transcript CG32498-RP;
                     CG32498-PP; dnc-PP; dunce phosphodiesterase"
                     /codon_start=1
                     /product="dunce, isoform P"
                     /protein_id="NP_001259201.1"
                     /db_xref="FLYBASE:FBpp0305504"
                     /db_xref="GeneID:31309"
                     /db_xref="FLYBASE:FBgn0000479"
                     /translation="MSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILA
                     SLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEE
                     LDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQ
                     QEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSF
                     TGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELL
                     TSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEV
                     GGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDI
                     FCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDR
                     IQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNAT
                     IEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDEN
                     PQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGTTGTTAASALSGAGGGGGGGG
                     GMAPRTGGCQNQPQHGGM"
     misc_feature    3742..4110
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="Phosphodiesterase 4 upstream conserved regions
                     (UCR); Region: PDE4_UCR; pfam18100"
                     /db_xref="CDD:465648"
     misc_feature    4543..5265
                     /gene="dnc"
                     /locus_tag="Dmel_CG32498"
                     /gene_synonym="CG10791; CG10792; CG10797; CG14267;
                     CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce
                     PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3;
                     EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII"
                     /note="3'5'-cyclic nucleotide phosphodiesterase; Region:
                     PDEase_I; pfam00233"
                     /db_xref="CDD:459723"
ORIGIN      
        1 caacaacagc acagcggcag tagcaacaac gcagtaacag aagcagtagc agcagcaaca
       61 gcagcagcaa cagcaacagc aacatcactg tggcaaccgc aacagcacag cagcagcaac
      121 atcagcacgt gtgcgtgccc caaatgtgcg caacgacgaa agtgctcgag aaatccagca
      181 gagagataaa tacataaaac gccgagaaat tcaagagaaa agcaagaaaa aagttaaggc
      241 taaaaagcaa ttaaaacaaa ttgtgccgta agtcaagtcg gtgggcttac agcccagtcc
      301 cccgcaaata aaagaaaaaa taaaaaaaaa aataaaaaaa aaaatagaaa gaaacaaaga
      361 aaactgtaag aaaaaaagaa cagaaataca cgagtaacca ccgcaggatc cgcaggacaa
      421 cgtacccacc gatcccaaaa aagaaacgca cgagacaaaa caaaaaaaaa acgaaaaaaa
      481 gtgaaataaa aggaaaccat gtcccaggag agtaatggtg gcccagcagc aggaggcgga
      541 gcagcagcag caccaccacc accaccacaa tacataataa ccacacccag cgaggtggat
      601 cccgacgaag tgcgctccat ggccgaccta gagctgggat cccccgaaaa gcaggtgcag
      661 gtacagagtc aaaagttctc cagcacgtcg agcaccacca aggtggccac ccactcattt
      721 tcgatgagca gtagtgccgg cactactggg cagcaaagca aacaggacag cgcccagcaa
      781 atccaacagc ttcagcagct ccaacagctc cagcaactcc agcagcagca gcagcagcaa
      841 cagtcccaga gaatcatatc cagttcgacg agaagccaga gcctgcagtc cagcacaatt
      901 gtgggcgagg ccactacaat tacgagcgga gctgcccaaa tcctaagcgc ctcggcggcg
      961 gcttcgctgg cccagcagct gaaggcccaa agctccacct cgattatcac aagcagcgag
     1021 cagaggacga gcacaagcac cagtagcagc agcagcaccc gttacatagc cagcggctcg
     1081 agcaacctgg ccggtggcaa ttcgaattcg gccagctcgg ccagcagcaa gactcgcttc
     1141 cagagtttcc ttcagcagcc ggagggtgcg cacggttttc tgacggccca tcagaagcat
     1201 gtgcgtcaat ttgtgcgctc cacatcggca cattcggagg cggcagccgg agtggctggg
     1261 gcacgggcgg agaagtgcat acgcagcgct tccacacaga tcgatgatgc cagtgtggcc
     1321 ggtgtggtgg agtcggctgg taacttgact gacagctccg ccacgggagg atccatgcag
     1381 ctgtcgatga gcaaactggg cctgcagcag tcatcgtcca tattgatctc caagtcggcc
     1441 gaaacgatcg agatgaagag ctcgtcggcg ggcatgcgca cccagttgac attgagcggt
     1501 ggcttcttgg cgccgccggg caatcgaaaa ataaccattt tgagtccaat tcacgcaccg
     1561 cccggtctgc atgatatgct caagcgggcc caaggacgat cgccgctatc gcccaggatc
     1621 agctttcccg gcagcgattc ggacctcttt gggtaagtcg attatgtgcc gcctatcttt
     1681 aatgtcagcg aaaatctttg gtaagcctat ttcattggga aatcaaagta aagtaaatgt
     1741 aagctagata ttgcgcatac gccatgtgaa acgggaaatt ccacaataat ggtaattcag
     1801 tagcaatgag ctacagatgc ggcataaact taaacagcat tctcaaaact ggctttaatg
     1861 ttgttgtgaa cgggtccact atttgtactc catatatttg gtgttttttt ttttttgctt
     1921 tttttttata tttgaaaggg ggccggtctg cattgttagt gcttttgaga taagagcttg
     1981 gtggttagct ggtgttgttg tagttgcaaa ctgataagag tccaaagagt cggcacgctt
     2041 tgtagaatcc accgaaagcc accagaaaag caaataaatt cgaggctatt gtcgatttta
     2101 ttttttatca catgtgataa atgaatatgg gaaagcagcc gagcgattag cgaaccaaag
     2161 gaataaaccg ttgaggattt cacatatttt cttcttcttc atgactcttg gccactgatc
     2221 aaaacgcact atattttttt ctctttatct atatatgtat atatttggga aaagcttacg
     2281 tgtgtgtaat tacttcctaa cttcgaaaac agttgcattt gcgagttaat taatttgaaa
     2341 aaaaaaaaaa tggccattaa attgattgcg catttgactt gattgcagaa accagaaaat
     2401 ggcttaattt attaagctgg caaagtatga caccgaattt atggctgcat aaatcacaca
     2461 tgtgtactta catgtgtatg cagattatac tacatgtgtc tgaatttgaa ttccccaaac
     2521 aacaattgaa aagtcccctc ttttttctat atatctatgt acatacatat ttacatttac
     2581 tttatatgta tgtgtatatt ttcgccagac ttttttgcac accccaattt ttccggcatt
     2641 tttccttttt tttttttttt gagtctttgt gcaagaagtt aaaaaatgta aaagtaatga
     2701 aaaaagcaac gacgacgcta tgtctgcccg atctgcttat aattggattt ccgctgtgtg
     2761 ctaaagagag agggctatac tagaaggaga gggcgctact ctgcgagtga gagggcatta
     2821 ggcggcggca gctgtttgat gatgaatctc aagtcgctgt ctcattacaa ctttcaattt
     2881 caattgcttc tttcgcttct attcgccctc tcgttttcgc attatgctta gcatctacgc
     2941 tctcacgcat ggctcttatt ttaggctaca ccgcgaataa ctttcgtatt tttacgcccg
     3001 ttaatgttga attataagtg tctagttgtg caccttaaat tgccacctta agtttgccta
     3061 tttattatgt ttgtatagga attgtatttg gaacatcgat agaaggcatg ctttgaagtt
     3121 caacaagtat ttcgctcagt gcaatagcct cctctcgctc gcactcccag ctgttggcgc
     3181 ctggctcgcc ttcgcctcaa ttcgaattcg ttattcgcct cgcttcgttc gtttttcgcc
     3241 gccaactgct ctgccggcgg cgacagcgac gccggcgcag ggtctcgttt tcgctttcgc
     3301 ttcgcatcgt tttcatcgtt ttcatcgtct ccgtcatata acaacgttcg ccgttcgctc
     3361 cgcacacaca atttgcgtta aaaaaaaagt tccgcaaaat cgcaattcgc gaaaatcgtg
     3421 cacaattcgt gaaacggtaa aaaatcggtc gaaaaccgcg gattaatctg gaaaaatcaa
     3481 caaaatatat aacgggcgaa agcgaatttc gatgtagaaa atggccaggg cgctagatca
     3541 ccgctcgagg gcggctcacc cagcgccggt ttggtactac agaatttgcc gcagcgtcgc
     3601 gaatcgtttc tatatcgctc cgattcggac tttgagatgt cacccaagtc catgtcccga
     3661 aactcaagca tcgctagcga aaggtttaaa gaacaggaag cctctatact cgttgaccga
     3721 tcccatggcg aggatctcat tgtgacgcct ttcgcccaaa ttttagccag cttacgttca
     3781 gtgcgcaaca atttattaag tctgacaaat gttccagcat caaacaaatc caggcggccc
     3841 aaccaatcgt cgtcggcctc gcgatcagga aatccaccag gagccccgct atcccaaggc
     3901 gaggaggcat acacccgcct ggccaccgac acaatcgagg agctggactg gtgcctcgac
     3961 cagctggaga ccatccagac ccatcgcagc gtctccgaca tggcgtcgct taagttcaaa
     4021 cgcatgctca acaaggagct gtcgcacttt agcgagtcca gcagatcggg aaatcagatt
     4081 tccgaatata tatgttccac atttttggac aagcaacagg agttcgactt gccatcgctg
     4141 cgcgtggagg ataatcccga gctggtcgcc gccaatgcag ccgctggtca acagtccgct
     4201 ggacagtatg cacgctcccg atcgccgcgc ggtccgccca tgtcgcagat cagcggcgtg
     4261 aagagaccgc tgtcgcatac gaatagcttt accggcgaac gtttgcccac cttcggtgtg
     4321 gagacaccca gggagaatga gctgggcacg ctgctcggcg aactggacac ctggggtatt
     4381 cagatattca gcatcggcga gttcagtgtc aatcgaccgc tcacctgtgt ggcatacacc
     4441 atatttcaga gtagagaatt actgaccagt cttatgatac caccgaaaac ttttcttaac
     4501 tttatgtcta ctctggagga ccactacgtc aaagacaatc cgtttcacaa ttcgctgcat
     4561 gccgccgatg tgacacaaag cactaatgtg ctactcaata caccggcgct ggagggcgta
     4621 ttcacgccgc tcgaagtggg cggggcgctg ttcgccgctt gcatacacga tgttgatcat
     4681 cccggcttaa ccaatcagtt cttggttaac tcaagttccg aactagcatt aatgtacaat
     4741 gacgaatctg ttttggaaaa tcatcattta gctgttgcct ttaaattatt acaaaatcaa
     4801 ggatgtgata tattctgtaa tatgcaaaag aaacaacgcc aaacattgag gaaaatggtt
     4861 attgatattg tgctgtccac ggacatgtcc aagcacatga gtctgctggc cgacctaaag
     4921 acaatggtgg aaaccaaaaa ggtggccggc tccggagtac tgctgctgga caactacacc
     4981 gatcgcatac aggtgcttga gaatctggtg cactgcgccg atctgagcaa tcccaccaag
     5041 ccgctgccgc tttacaagcg ctgggtagcc ctgctcatgg aggagttctt cctgcagggc
     5101 gataaggaac gcgaatcggg catggacatt agtcccatgt gcgatcgcca taatgccacc
     5161 attgagaagt cgcaggtggg cttcatcgac tacatcgtcc acccgctatg ggagacctgg
     5221 gcggacctgg tgcatccgga tgcccaggat atactcgaca cgcttgaaga gaacagagac
     5281 tactaccaga gcatgatacc gccttcgccg ccgccatcgg gcgtcgatga gaatccgcag
     5341 gaggacagga tacgctttca agtaaccctt gaggaatccg atcaggagaa cctcgccgaa
     5401 ctggaggagg gcgacgagag tggtggcgag agcaccacca caggcacaac cggaaccacc
     5461 gctgcatccg cgctaagcgg agctggtggc ggtggcggtg gaggcggggg aatggcaccc
     5521 agaacgggtg gctgccaaaa ccaaccgcaa cacggtggaa tgtgacggag agtcgtggga
     5581 atttatcgca aattacagga aaaggctcac aactttttcc tattacgtta gtgactacta
     5641 ttaacacaga aaaaaccaaa acaaaaacct aaaacgaaaa gcaaaaaaaa aaacaaagaa
     5701 aaactcttgg aaaaaatgca aaaaaaaatc cacaaaaaaa aaaccaaaaa acccaagtaa
     5761 ggaaatatta aaccaatgtt taaacgcata caaaaatcca aacagcaata gcaaaactaa
     5821 cgttaaacct ataaagtcta gagaaaatcg aaaaaggaaa ttagaaattt acttaatgga
     5881 acccgagatt gatgttgaaa atacactgaa aaagaaggag gaggccgagc taactaagat
     5941 aaaatcgtac atattgttaa aaacaaaaca aaaaaacata gacacactaa attcaagaca
     6001 aagcaaagat aataagaaaa attgataagt tacaaaaaat aagacgatac cgaaaactcc
     6061 cgccccaaaa gcctaagaaa tcccagtacc cccccccccc ctccactccc ctttatatat
     6121 atatatatac aatttttgtt gcatgtgtag gtaaatgatt tttgtcaaaa ttcatctgaa
     6181 gtagtacatc catcagaggc agccccttag ctgagtctcc tcttttaatc cattgactaa
     6241 agtgaaatat ttaaaaaaca gagaatcagg cgaacgaaaa ggaataatta atatgaccta
     6301 gcttataaga gaagttatta agtttttaaa tgttttgcat gcccgaacag atttatttta
     6361 cttgattgat tgataacgct agatctaact gataaacgat aacagcaaca catggagttt
     6421 tttttttata taatttagac cacagcgata gaagcgaaag aaaatcaacc atgtaaagtt
     6481 taagaaccca gtgaattaaa ccaaaattga aagccaaccg agttgaaacc aatttaattc
     6541 taaatctaaa tctaaatcca caacccaaaa cccaaaaccc caagcaacaa aaaagaaaga
     6601 aagaaggaaa agtaaggaac agtctacagc cagactgtag ttgtatagta atatatatga
     6661 tataaatatt ttttttaaat attatttgta aataatttaa atgttggact cgaatttaaa
     6721 tcaagcggct agcaaatgtt gcagctaaac taaaatgaaa acaaagccaa aaaacacaca
     6781 cataaatagg taaactaagt gaaaaatgtg gaaaaggaaa aactattgta caattagcta
     6841 aagaatttcc atttcaattt tcaatttgaa ttgcaattta atttgcttcc agaaatgaat
     6901 gaaaggagac aagaaaaaga tagggagata aaccgaaaat tagtttcaaa cgctgtcttc
     6961 gcaaatattt ttcgctatat atatatatat atattactta taacattatt ttactagtta
     7021 ctaagctact tactgagcca cacaaattta aaacgaaaga gacaagacac caggacaaga
     7081 aagagaagga gctttcatga atttagtgaa caaacataac tggcaatggc cacacacaca
     7141 cacacaattt acaaagcgaa caacaccaaa aaaaataaat aaaaagactc ttcaagcaca
     7201 aaaaaaactg tttagttttc agtaaacagt aaaaccaaag caaagcaaaa taacacacaa
     7261 gatataatcc ccaaaaaagt cattggctat aatatgatta cttaacctaa cctatacaat
     7321 atatagatat atagatatat cctatatgca tatgtaaagt cacgatactg gcgctggtgc
     7381 gcggatcgat caatgtggca ggccaaattc taaatgcgca taatttaact attgtttaca
     7441 ttatgtttta ttgttattaa tttattacca aaaacgaaaa cattattttt tcagacctag
     7501 tgctataaat ttcttttttg tgttgaagcg ggcaggatcc gcgcataaaa tagtgttttt
     7561 tttttttttg taattacaaa tatatataaa gatacataca tatatatata tatatataat
     7621 atgatatgtg aatgaaatgt aatgaaatga agtggaacct tgatggtcta aaaatatcat
     7681 taaaagctga tggagatgga aagttgaaga acaagatact ttatagcaat ttaagcagca
     7741 ttgtaaatgt gcgcttcaga actacttttt tttcgaaact taatcgacct tcagcaaata
     7801 cagcaagata tattacctac attacaaaca tatattatta attgaaccat agttgcgaca
     7861 caaaacaaaa atgacggcaa gtccatggca aacttaagca aaaaccaaaa gctactttaa
     7921 caaattgagt gaaataaata aaagaaagaa aacaaacaaa aaaaaaaaaa cacaaaaaaa
     7981 aaccatatga cttttttctc ctctcacaaa ataaaagcga aaaacagaaa aataaactag
     8041 tattgtattg tatttgtaac acgaattttc ctgcgagtga acactttacg cagaaccata
     8101 aagccggaaa ctgaaaacct acagagattc cgcagcaatc gcggcactgg tatgtgtgta
     8161 tagctaatag ctatactcat tatgtaattt accagagtat taatcgaaca atttaaattt
     8221 acatatatgc atatgcatac caacatacta ggaatactag gaatatatgc agtaacggac
     8281 atttgatgta tactcgagtt gaaacataac cctaaccaaa tgttgtatgt gtatgtgtaa
     8341 ttcgatgaac ttaaaagtcc aaagccatac gtgaaaataa gaacaagcaa tttatagtga
     8401 aaaagtcgaa aagtatctaa atgtaattgt tagaaaatgc caagtaaatc cgaaagttac
     8461 cacagagtta atgaggaggc atcatctatc ttgtcatcca agaaatcccc aaatcaattt
     8521 ttgactgaaa ttgaatcgtc ctagtagagg cactcgattc gtactccttc cttaccccta
     8581 ccgccccccc ccctcaccaa cttcctttgc cccaactatt gtactttatc caatattttc
     8641 ctatcgacgt gccgccaatt atatcagtgt atataaacta tttgaaaatc acgcatatat
     8701 atgcacacat agagtttttg tagcgtcata tgtgtcatta aggatgccca cttacataca
     8761 tatatgaagg gaaataaata agcaagtaaa tatacaatac aatacataca tatatgtgtg
     8821 tgttgtgggt aacgagagat cagcatttgt agcacaggtt ggccaaattt attgggaata
     8881 acgagttgcc gaagttgccg aagaaaaacc aaatgaaaac tgtttgttgt gctgttagcc
     8941 gtaaatgaga actttttttt gagataactt aatacctata tatataaata tgtattacaa
     9001 tatatgtatc tataaatata taaaacaggc gacaaaccaa attaaaccaa ataccggaac
     9061 aaaaaaaaaa aaacgaaaaa gaagagagag aaaaaataat acaagcgata ttgaaaatgg
     9121 cacgttttgt actataatga aatgagaaaa caccaaagac gaatgcaaaa caaaaaaaaa
     9181 tgcaaacaca taacaaaata tacaagaaat attcttaaca aaaagaaaaa aataccataa
     9241 attgtgcgct ggcgacgacg gttgtttgaa aaaaagagaa agcaaaaaac aggacatgcc
     9301 gcttgaagtg ccgatcgtaa gcgagtcctt tcgattcgca aatcgtcggc atttcaatcg
     9361 attgaagaat cgggagatat tatatacata tagaacacgt aacgctggcg ttactgggca
     9421 aacagttagg catttttttt ttttcttttt tggaaattta tacaattaca tatacaaaaa
     9481 gagctcaccc ccacaacaac aaggacaact gcagaagaag aacaaaaaaa atacacacat
     9541 acatggaaac actaacgcgt acacggacag cgatttgccg gaacaaaatt ctgggtattt
     9601 cgaaccgaga aagggaacgg aaacggaaac ggaaacgaaa atatagaacg cggcaagtta
     9661 tttaacactg aaactgatcg ggtgtaacta tagtaccgaa atggggctta cacaggctga
     9721 ttcacccaaa ataagtatac atgtattgta gtaacgagcg ctggcttttg ttattaagtt
     9781 atgtatttgt ttcgattatg ttttgcctct ctcagaatat atatatatat atatatatat
     9841 atatatatat gtatattcta tgtatatata tatattagtt atgtatgtga aaaaagcgta
     9901 atcatttatg aaaccaatga aaatctaacc tgaaaacaaa gagaaaaccc caagtcaaat
     9961 acacaattgc atgcaagagt aagtaatatt aatgaaatct aagaacaaag gtcactcccg
    10021 ggcttaaaaa aaaaaaaaga agaaaaaaaa tgggccgcat ggcaaatgat aaatggtaaa
    10081 acaaaacaat gagcaggtgg cattatgaac agatttgaat gattacggaa tacagactaa
    10141 aaatgaaaat gaaaaattt