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LOCUS NM_001272259 9240 bp mRNA linear INV 26-DEC-2023 variant H, mRNA. ACCESSION NM_001272259 VERSION NM_001272259.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 9240) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 9240) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 9240) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 9240) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 9240) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 9240) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 9240) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 9240) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 9240) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 9240) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 9240) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 9240) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 9240) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 9240) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 9240) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 9240) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 9240) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 9240) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 9240) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 9240) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 9240) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 9240) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 9240) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..9240 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..9240 /gene="PsGEF" /locus_tag="Dmel_CG43947" /old_locus_tag="Dmel_CG14045" /old_locus_tag="Dmel_CG14047" /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947; DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2; FBgn0264598; null; psGEF; PsGef" /note="Protostome-specific GEF" /map="3A2-3A2" /db_xref="FLYBASE:FBgn0264598" /db_xref="GeneID:31224" CDS 260..6280 /gene="PsGEF" /locus_tag="Dmel_CG43947" /old_locus_tag="Dmel_CG14045" /old_locus_tag="Dmel_CG14047" /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947; DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2; FBgn0264598; null; psGEF; PsGef" /note="CG43947 gene product from transcript CG43947-RH; CG43947-PH; PsGEF-PH; protostome-specific GEF" /codon_start=1 /product="Protostome-specific GEF, isoform H" /protein_id="NP_001259188.1" /db_xref="FLYBASE:FBpp0305712" /db_xref="GeneID:31224" /db_xref="FLYBASE:FBgn0264598" /translation="MPTMTRMHRHSSSSAVVEESRGRRRGVGVPGVGDANKENFGVHF MSSPFGNASLIALQDLSNVHGKSPQRRSFSEGSGPRQATPQLAALRCLPRTTGGAVAL EDSQLSSSRMGDTTLDRMLDAIIESARKEVRCTKTLPGAGATTSTTILADNAEWSETS VHEMEVRTPTHLKRQRVVRRKNPHKTTTINQTQSHQAKKLEPLQLVPSTKRCLSFSSS SASSDLDEDEQQVAKRSSLASPTTTPPSHCTTTTSSISSSSSSNGGADMEASQRGSID VSIAFDAKEQQLNVHVIRCRDLQRSHGSGNGSINAYVKVALSGGAQPPGYGGHSSGGS MSSGYQRTAVHRHSGRPYFDQRFNFQISSGEETAGQYLQLAVWHRDRHLKRSEFLGCS TFPLNELVHPDSGVSAGSYKLHAQACPPPTSRHSQPKANAGQDQKQETEAAKDQDKQQ DDSPAEMAAAVTVTPQKPVATGSGSGSNSAAMALNDEVISISIDSMGKEDPLLPQQPQ QPMKLSKKALHQRDADENLFLRFLELDPPADGNANSTTTQAQATGSQSSASKANESNA NHLNNGTSGGRRQSTMPNSGGSSVGGAVRQQQGRTPFTMTKRLTRTEERGFGFSIVWT HPPRVEKIEAGLSADRCGILPGDYVIFVDKHNVVTMPEADVLNLIRSQGSSLTLEIFR RSGAGATTITSTDLGQNNVHISTRLGAAVGLGSEEHTLATTATGTTTVMSLQRTTSTR IQPLANSMSRPATACSGTTSSIEAAKRRLHLPQVTFSKESIVPVTDNRRRFLLQLISR EQNFTAALHFGVDRFVQPLGERKDLISPNDHRTLFQNIDELLRIAEDILEQLCSSDQQ DQEPQMNFASRVYLSKTTAICAAYKKYCNGIKRADCVLVNKSRQTGSEFIAFITEPAV PRKRPDLTMFIHRPLQHFREILKLMQLLAGNCHVDTEEHKNFSTVINELQAAYREITV SSGLMEPLGEGRPLLTLQDLESRMVFTKCKPFTLAVQGRQWIFGGDLSRVEGRSVKPY WTLLFSDIIVFAKVSRDRVLFITEEPIPIANVVDSCFHMRKKTTEFRLTVDPNGRLAE SPTGYCAPDLTRTPKRGARRKSLILRAPSLELKAVWQNLLQRQIFLVNAALGSTPLSS PLDSPDVLNTLVPLSDIGLTTASMGSMKLPSLDSIHLKQQQKQQRTNNSHGHVHSATG VATDRTADRSHGHNHGIHGGHVEQIELLIDEKCRILNKTGTPKSSALHLANWMKGQLD KQQQQARLAAIARSQENVSAEDEQLIFNSDSEQDERITYWTRQQLEKRTKELNLAKEN GGLSARPNFGGKRLSGVEELSMSATSDIYSTSEAEGVTSVISQSHSTTSDSQITVRSS PIVLDKLAVCRHCHKNCQQSGPGGARPGGGGGVNNSSSTPVLLCNSLKVQHSQSSPNR CCKLSNGIAGATEMANPKNSNRTGTGTGSVTSMSSSTITGELSSKVVASSSRRETGDT ESDVAQLITDEISQSQSEATDDSVGAMPNSSRSAGEGNPVITGSRLRHLDPPVSVSSL PNGHCSAGVGGGSPKPLPPPRRTRVVAQMCQEPPRPKANQQVKAIVTITETARIMRSS PTKGSGSGSATGTGSVGGSPAKYAACHCRCTPEDFTHAQLSPDKMEHQTCKLLESPKQ TTTTLEQKQEDEQLSLMLIGLAQLAPAATLCGQERIPKEENSTPTIAVVPPTPDSVLT KTSTHVWDNSGCSSNGGGTSTTSTATTTTKQPRQAIIENIPEDSCDESPLDEEPPYRP MSSALRRFGTMSSLEKLPSDDRMDEADELDDDLDSFKPNGHDGNSPQNEEDDEDADSE RALVQNDLGASSSSGVIVNGEGLASGAWTNRAGAYVSDKMSFFEESRAFIDKYLGRWN AGDAQQQHQQGTASETDEQMDECTSGATSGEEVWGTPTSGGDNDDQDLQLINSENTHS SPTKSSTSLNDDDDTELMMDELLMAPPMTASTIRGLLPRGKQRPMATT" misc_feature <494..886 /gene="PsGEF" /locus_tag="Dmel_CG43947" /old_locus_tag="Dmel_CG14045" /old_locus_tag="Dmel_CG14047" /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947; DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2; FBgn0264598; null; psGEF; PsGef" /note="Domain of unknown function (DUF4799); Region: DUF4799; pfam16056" /db_xref="CDD:318308" misc_feature 1115..1498 /gene="PsGEF" /locus_tag="Dmel_CG43947" /old_locus_tag="Dmel_CG14045" /old_locus_tag="Dmel_CG14047" /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947; DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2; FBgn0264598; null; psGEF; PsGef" /note="C2 domain; Region: C2; pfam00168" /db_xref="CDD:425499" misc_feature 2084..2299 /gene="PsGEF" /locus_tag="Dmel_CG43947" /old_locus_tag="Dmel_CG14045" /old_locus_tag="Dmel_CG14047" /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947; DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2; FBgn0264598; null; psGEF; PsGef" /note="canonical PDZ domain; Region: PDZ_canonical; cl49608" /db_xref="CDD:483948" misc_feature 2654..3172 /gene="PsGEF" /locus_tag="Dmel_CG43947" /old_locus_tag="Dmel_CG14045" /old_locus_tag="Dmel_CG14047" /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947; DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2; FBgn0264598; null; psGEF; PsGef" /note="Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; Region: RhoGEF; cl02571" /db_xref="CDD:470622" ORIGIN 1 atttccgttt ctgagctcgt gctaagcaga cacgtgaact tcatagcaga aaagaacgaa 61 aatacctttg gcttgaagaa attagttggc ttattttttt tttcgtgtaa aagatctatc 121 aaaatttgtg tgccgccgac gcgcaaggat cacattttta aacaaaatca gtgctgttaa 181 tcaagttgaa cctaagctaa atcgagttgc agttcgccag gcgacgtagt cgcaaaaaga 241 tcaagttacc agtagggaca tgccaaccat gacacggatg catcgccact ccagttccag 301 tgccgtggtg gaggagtcgc gtggccggcg ccgtggagtg ggcgtgccag gagtcggaga 361 cgcgaacaag gagaatttcg gggtgcactt catgagcagt cccttcggca atgccagttt 421 gattgccctg caggatttga gcaacgtgca cggaaagagt ccgcagcgca ggagtttcag 481 cgagggcagt ggtccgcggc aggccacgcc acaattggcg gcactgcgct gcttgccacg 541 caccaccggt ggtgcagttg ctctggagga ttctcagctc tcctcatcgc gaatgggcga 601 taccacactg gaccgcatgc tggatgccat catagagtcg gccaggaagg aggtgaggtg 661 tacgaagaca ctgccaggcg ccggcgccac cacttcgacc accattttgg cggataatgc 721 cgagtggagc gagaccagtg tccacgaaat ggaggtgcgc acgcccaccc acttgaagcg 781 gcagcgggtg gtgcggcgca agaacccaca caagactacc accattaacc aaacgcaaag 841 tcaccaagcc aagaagttgg agccactgca gttggttccc agcaccaaac gctgcctgag 901 cttctcatcc agttccgcct cgagtgattt ggacgaggat gagcagcagg tggccaagag 961 gagttcgctg gcctccccca ccaccacacc tccctcccac tgcaccacca ccaccagcag 1021 catcagcagc agcagcagca gtaatggtgg tgcggacatg gaggccagtc agcggggcag 1081 catcgatgtg agcatcgcat tcgatgccaa ggagcagcaa cttaatgtac atgtgattcg 1141 ctgtcgcgac ttgcagcgct cccatggcag tggaaacggc agcatcaacg cctacgtcaa 1201 ggtggccctg tccggaggag cccagccacc cggatacggt ggccactcgt cggggggaag 1261 catgagttcc gggtaccaac gcaccgccgt ccatcggcac tcgggccgcc cgtacttcga 1321 tcagcgattc aacttccaga tttccagtgg cgaggagacc gctggacagt atcttcagtt 1381 ggccgtgtgg catcgggatc gccatttaaa acgcagcgag ttcctgggct gcagcacttt 1441 tccactgaat gagttagtgc atccggattc gggcgtctcg gcaggatcct acaagctgca 1501 tgcacaggca tgtcctccgc ctactagccg ccatagccaa ccaaaagcca acgcaggcca 1561 ggatcaaaag caggaaacgg aagcggcgaa ggatcaggat aaacagcagg acgattcccc 1621 cgcagaaatg gcagcagccg tcacagtcac gccccaaaaa ccggttgcca ctggatccgg 1681 ttcgggatcg aattccgcag cgatggcact gaacgacgag gtgatcagca ttagcatcga 1741 tagcatgggc aaagaggatc ctctgctacc ccagcagccc cagcagccca tgaagctcag 1801 caagaaggca ctccaccagc gagatgccga cgagaatctc tttttaagat tcctggagct 1861 ggatccgcca gcggatggca atgcaaacag taccaccacc caggcacaag cgacgggctc 1921 ccagtcctcg gcgtcgaagg ccaacgaaag caatgccaac cacttgaaca atgggacatc 1981 cggtggacgc agacagtcca ccatgccaaa tagcggagga tctagcgtag gaggcgctgt 2041 ccgccagcag cagggacgta ccccattcac catgacgaaa agacttacgc gaaccgagga 2101 acggggcttt ggattctcta ttgtctggac gcatccgcca cgggtggaga aaatcgaggc 2161 gggactctcg gccgatcggt gtggcatttt gcccggcgac tatgtgatct ttgtggacaa 2221 gcataacgtc gtcacgatgc ccgaggctga tgttctgaat ttgatacgat cgcagggctc 2281 gtccttgacg ttggagatat tcagaaggtc aggcgcgggc gccacaacaa tcacgtcgac 2341 ggacttgggc cagaacaatg tacacataag caccagattg ggcgcggcag tgggcttggg 2401 cagcgaggag cacaccctgg ccaccaccgc aacaggaacg accaccgtaa tgagtctgca 2461 aaggaccacc agtacgagga tccagccatt ggcaaatagc atgagccggc cggctaccgc 2521 atgctcggga accacctcct ccatcgaggc ggccaaaagg aggcttcacc tgccacaggt 2581 caccttcagc aaggagtcga ttgtgcctgt cacggacaac cgtaggcgct tcctgctcca 2641 gctgattagt cgggagcaga acttcacggc tgccctgcac ttcggagtgg accgctttgt 2701 gcagccgctt ggcgaacgaa aggatctgat ctcgccgaac gatcatcgca ctttgttcca 2761 gaacatcgac gagctgctca ggattgccga ggacatcctg gagcagttgt gcagcagcga 2821 tcagcaggac caggagccac aaatgaactt tgcctcgcgg gtctacctat caaaaactac 2881 agcgatctgt gcggcataca agaagtactg caatggaatt aagcgggccg actgtgtttt 2941 ggtcaataag tcccgacaga ctggctccga gtttatagcc ttcattacgg aaccggccgt 3001 tccacgtaaa agacccgatc tcaccatgtt catccatcga ccactgcagc attttcgtga 3061 aatccttaaa ctgatgcagt tgctcgctgg aaattgccat gtggatacgg aggagcacaa 3121 gaactttagc acggttatca acgaactgca ggctgcctat cgggagatca ctgtgagcag 3181 tggtctgatg gaaccactgg gagaaggtcg ccccctgctc accctccagg atctggagtc 3241 ccggatggtc tttaccaaat gcaagccttt tacgttggcc gttcaggggc gccagtggat 3301 ctttggcggc gatttgtccc gggtcgaagg tcgctccgtt aagccctatt ggacactact 3361 attcagtgat atcatcgttt ttgccaaggt cagccgtgat cgagtcctgt ttatcacaga 3421 ggagcccatt cccatcgcca atgtggttga ctcttgtttc catatgcgca agaaaaccac 3481 cgagtttcgt ctcacagtgg atcccaatgg acgcctggcg gagagtccga cgggttactg 3541 tgctcccgat ctcacccgca ctccaaagcg aggagcccgc cgcaagagcc ttattttaag 3601 ggcaccttcg ctggaactta aggccgtttg gcagaatctt ctccagcggc agatctttct 3661 agttaacgcc gcccttggct ccacgccctt gtccagtccc ttggactcgc cggatgttct 3721 caacaccctg gtgccgctga gtgatattgg tctgaccacc gcctccatgg ggtcgatgaa 3781 gttaccatcg ctggacagca tccacctgaa gcagcagcag aaacagcagc gtaccaacaa 3841 ttcccacgga cacgtccatt ccgccacagg agtggcaacc gatcgaactg cggatcgctc 3901 gcacggccac aaccatggca tccacggtgg tcatgtggaa cagatcgagc tgctgatcga 3961 cgagaagtgt cgcattctga acaagacagg cactcccaag tcgagcgcct tgcatctggc 4021 caactggatg aagggtcagc tggacaagca gcagcagcag gctcgactgg cggcgatcgc 4081 gcgatcccag gagaatgtga gtgccgagga cgagcaactg attttcaaca gcgatagcga 4141 gcaggacgaa cggatcacct actggacgcg tcagcagctg gagaagcgta ccaaggagct 4201 caatctggcc aaggaaaatg gcgggctatc ggctaggccc aattttgggg gcaagcgtct 4261 gagtggcgtc gaggaactga gcatgagcgc cacctcggat atctactcca cgtcggaggc 4321 ggagggcgtg accagtgtga tcagtcagtc gcatagcacc acatccgaca gccagatcac 4381 cgtacgctct agtcccattg tgctggacaa gctggccgtt tgccgtcatt gccacaagaa 4441 ttgccagcag agcggaccgg gtggagcgcg tcctggcggc ggaggcggag tcaacaactc 4501 cagttccacg cccgtcctgc tctgcaattc gttgaaagtg cagcacagcc aatcgtcgcc 4561 aaatcgctgc tgcaagctta gcaatggtat tgcgggagcc acggaaatgg ctaacccgaa 4621 aaacagcaat cgaactggaa ctgggacagg aagcgtgacc agcatgtcca gcagcactat 4681 tacgggggaa ctgtcctcca aagtggtggc cagtagcagt cgtcgggaaa ccggcgacac 4741 cgagagcgac gtggcccaac tgataaccga tgaaatttcc caatcgcaat cagaggccac 4801 cgatgacagc gtcggagcga tgcccaatag cagtagaagt gccggagaag gaaacccagt 4861 tatcaccggc tccagactac gtcatctaga tccgccagtc tcagtttcat ccttgcccaa 4921 tggccactgc tccgctggcg tcggtggtgg ttcgccaaaa ccgctgccac caccacgtcg 4981 cacccgcgtt gtggcccaaa tgtgccagga gccaccaagg ccaaaggcca accagcaggt 5041 gaaggccatt gtgaccatta cggagacggc caggataatg cggagcagtc caacgaaagg 5101 ctcgggttcg ggatcggcaa cgggcacggg ctcggtgggt ggttccccag ccaagtatgc 5161 cgcctgccac tgtcgctgta ctccagagga ctttacccac gctcaactct cgccggacaa 5221 aatggagcac cagacctgca agctactgga atcacccaag caaacgacca ccacactgga 5281 gcagaaacag gaagacgagc agttgtccct gatgctcatt ggtctggcgc agcttgctcc 5341 agctgccaca ctttgtgggc aggaaaggat ccccaaggag gagaatagta cacccaccat 5401 agccgtggtg ccgcccactc ccgattcggt gctcactaaa accagcactc acgtttggga 5461 caacagtggc tgctcgtcaa acggcggagg aacctcaacc accagcaccg ctaccactac 5521 aacgaaacaa ccaaggcagg ccattattga gaatattcca gaggactcgt gtgacgagtc 5581 cccattggat gaggaaccac cctatcgacc catgagcagt gctcttcgcc gattcggcac 5641 catgtcaagc ttagagaaac taccttccga tgatcgaatg gatgaggccg atgagctaga 5701 tgatgatttg gattcattta agccaaatgg ccacgacggc aacagtcccc aaaacgagga 5761 agacgacgag gatgcggact cggaacgagc tttggtacaa aacgacctgg gggcctccag 5821 ttcgtccgga gtgattgtca atggcgaggg cctggccagt ggtgcgtgga caaatcgggc 5881 gggagcctat gtctccgaca agatgtcctt cttcgaggaa tcgcgcgctt tcattgataa 5941 gtacttgggt cgctggaatg ctggcgatgc acaacagcag caccagcagg gaaccgcctc 6001 ggagacggat gagcaaatgg acgagtgcac ctcgggagcc accagtggtg aagaggtctg 6061 gggcacaccc accagtggcg gggataacga tgatcaggac ttgcagctga tcaactcgga 6121 aaacacacat tcgtcgccaa ccaagtcgag cacctccttg aatgacgacg acgacacgga 6181 gttgatgatg gacgagctgt taatggcgcc acctatgact gccagcacaa ttcggggatt 6241 gttgccacgg gggaagcaac gaccaatggc cactacctag aggattcggc tggaagttca 6301 agcgacagcg agtcggtgcc accagcccca ccactagttc ctcggccagt ggtgccggat 6361 cgggaggagg atccgtcagc ggagggccag caggagaatc tggcgatgga ggaccaggag 6421 gacttgcact ccagcgtgga gcgactgctt ccgaatctgg ccacgagtgc gatggggccg 6481 cgtcccttac tcaccacccg tctactgccc accacggcta tcgatcctca gccgccggca 6541 gtactggtgg cctcatcctg cgagtatctg ctcgatcagc gcccctcgag cgtaccagga 6601 cgcgatctcg ccggcgggag cataggcacc accacgatga catcctctcg gccgacgcct 6661 ctgtctccgg cgaaggcagc agcgacaccg atcgggatga atgcgacgat gacaacgaag 6721 acgacgacga ccacgatgat gacgccgagt cgagctccct catcgactat ttcaacaatc 6781 agcagcgcga gcgacactac cagctccggc ggcagagcca gcggcagacc tccgagattt 6841 gtaccgccgc caccgcctcc gcgtcgcttg ctcctcacgc agaccgatct aatcgctggt 6901 caggccaaaa cggagctacc tcgaaaaaaa tctggcgcta ctgctgacag tggctgctcg 6961 gtggctgtcg gcgacgccgc cagcgcttcg gacccaaccg ctatcgggtc aaggacaatg 7021 ccatcaacac cgagtaccag cagcttggcg tcagcggtgg ccccaaaacg accgtcatca 7081 acgataatag agacctgcct gctgggggca cccaggcccg cctcagccac ttcatcagca 7141 acagcctcga gaatggcaaa gccgatccgc cagagtccac ccacccagca ccagtcgcag 7201 ccgaggggtc agagctgccc ggctgcagtg ccagcaccat cgacggctgc gccagacgca 7261 cccactgtcc caatgcccca cgctggatgc ggcctaagcc caaggctgga aatgcggctg 7321 gccctcaacc acgacattct cggggacgag gacttgatct gctacgagcc tggtcccgat 7381 ctaacgacta ttctggggca cgacctctcc acatttcatc gtctgacggg tcgcgattta 7441 ttgagtcgtt cagccacgaa cagggtgcag ccaaaagagg ctgtcatatc gtactctcaa 7501 caacgcaact caaagatgga cacgccgacg gtgaaccgcc ggccccgccc cctctcagcg 7561 ggcgccttgg gcggctccac cagcaacagc aatccgaaca acagtcgcag cagcagcagc 7621 cacggcaaca gtccgctcgg cggtggttta acccgtgccg gcgtcgagcc agtgggccaa 7681 cagcagctgg tggttcaagc aggtggtgga tctgctggtc gagtaggcgg cgggagcgga 7741 agcgccggcg gcaacagcac cgcctgcagc tccaacagag gcgggagcaa attaggcgat 7801 ctggaaatct tagcgagacg cgagaagata tactccatgt ctcaatcgag gagtggctgt 7861 cgagtcaggg agacgacgtc cacgaccact ctgatggcca tggctacgga gatgcgttcg 7921 gggatggatt cggagaaacg cgactcttcc tggcccaaac gagcagctgc agcagcctct 7981 ctgacgagga cgaggagttc tacttcgatg gacggagcgg gagccatcag taccacaacc 8041 acaaccacca caacaatgac tgaggaggcc ttccttgaga ccgaagtggg cagatctaag 8101 cgcttgataa actttataaa gcgtcgcaac tccgagataa ccgccagtag caccagcagc 8161 acccccaact tctccgacgg cgccattggc gagcagcccc aaccgagcca cagccagagc 8221 agtcttcttc tccagaagct gccgccgggt caatcgcagg cccaggactc agtggaaatg 8281 gcccaaatgt cgccgcgcaa ggataacgac aagccatcgc tgaatcgccg cctctggaag 8341 caaatcacca aacgcagacg caccaactcc gtgtcccaaa tagtcgcagg ctaggggagt 8401 caccacccgt tgatccgtcg atccgtcgcc cccacttgtc ccctctgtta ctttcactaa 8461 ccgtgttgtg tggctagatc ttagcctcga tccgcgattg ccgctgagca gcagcagcaa 8521 tcgacgagcg atggcagaca acaatttgca cgggacagcc cgtcgatagg cagtaatcaa 8581 ctgtaaccat atcacggtga tcttcacggg ctgtcccacc gaaagaactg gcaaaagcta 8641 aaccaaaaac ttagtagtat gttaagaatt ttgatacgac tttgtagcta gcgaatcccc 8701 cggatcgcaa cgataccggg cagctctagg cgtccaattg cgtccaaaaa aacgataagc 8761 gataagcgat aagcgactaa aacgataaaa atgatagaaa tgataaaagt cgattctcct 8821 gccagcagag ccaaggaacc gagtcccagc caaatatgat atagacaacg aacgttggta 8881 gtactgggca cactcactca ctcactcact tcaaaataga cattgtagac atcaaaaaca 8941 aaaaaaaaaa aacttaacac ataacaaata acacttcagt ccagccaaat gaattaggat 9001 ctagaggagt tcgtaaactg actatttttt agagatcatg attatgtctt agcttagcag 9061 ttttgggttt atgttgcggg attgagacag tgaatttgcc ttacgtatcc aatgaactat 9121 tgtatgggta gcttaacgta gtagtcttta tacacataaa atttacagcc tcagcagttc 9181 gtagtagtca gtcgttagta gttggtcgta ataaaagttt aagtacttca attccacgtt