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Drosophila melanogaster corkscrew (csw), transcript variant D,


LOCUS       NM_001272245            7119 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001272245
VERSION     NM_001272245.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7119)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7119)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7119)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7119)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7119)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7119)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7119)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7119)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7119)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7119)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7119)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7119)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7119)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7119)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7119)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7119)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7119)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7119)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7119)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7119)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 7119)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7119)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 7119)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7119
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7119
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="corkscrew"
                     /map="2D1-2D2"
                     /db_xref="FLYBASE:FBgn0000382"
                     /db_xref="GeneID:45278"
     CDS             535..3219
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /EC_number="3.1.3.-"
                     /EC_number="3.1.3.48"
                     /note="CG3954 gene product from transcript CG3954-RD;
                     CG3954-PD; csw-PD; enhancer of sevenless 1A; corkscrew"
                     /codon_start=1
                     /product="corkscrew, isoform D"
                     /protein_id="NP_001259174.1"
                     /db_xref="FLYBASE:FBpp0305458"
                     /db_xref="GeneID:45278"
                     /db_xref="FLYBASE:FBgn0000382"
                     /translation="MHTPHCAPLFATVLHCAPLHLPLMTTWYAGQEAPEADHKRHSHN
                     GQWQLTTPICLPTGWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGN
                     EVTHIKIQNNGDFFDLYGGEKFATLPELVQYYMENGELKEKNGQAIELKQPLICAEPT
                     TERWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQD
                     KKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVHLRQPFNATRITAAGINARVEQLV
                     KGGFWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGA
                     EYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQC
                     AVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGP
                     GTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQ
                     QVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSEN
                     STSDYTLREFLVSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQ
                     AGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLV
                     QTEAQYKFVYYAVQHYIQTLIARKRAEEQSLQVGREYTNIKYTGEIGNDSQRSPLPPA
                     ISSISLVPSKTPLTPTSADLGTGMGLSMGVGMGVGNKHASKQQPPLPVVNCNNNNNGI
                     GNSGCSNGGGSSTTSSSNGSSNGNINALLGGIGLGLGGNMRKSNFYSDSLKQQQQREE
                     QAPAGAAKFKNIPKDMIGLRPPSHAPALPPPPTPPRKT"
     misc_feature    709..999
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="N-terminal Src homology 2 (N-SH2) domain found in
                     SH2 domain Phosphatases (SHP) proteins; Region:
                     SH2_N-SH2_SHP_like; cd10340"
                     /db_xref="CDD:198203"
     misc_feature    order(730..732,787..789,850..852,856..858)
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198203"
     misc_feature    order(847..855,895..897,952..963,967..969)
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198203"
     misc_feature    1021..1314
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="C-terminal Src homology 2 (C-SH2) domain found in
                     SH2 domain Phosphatases (SHP) proteins; Region:
                     SH2_C-SH2_SHP_like; cd09931"
                     /db_xref="CDD:198185"
     misc_feature    order(1105..1107,1111..1113,1126..1131)
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198185"
     misc_feature    order(1168..1170,1249..1251)
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198185"
     misc_feature    1447..2637
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="catalytic domain of tyrosine-protein phosphatase
                     non-receptor type 11 and type 6; Region: PTPc-N11_6;
                     cd14544"
                     /db_xref="CDD:350392"
ORIGIN      
        1 ttcttaaatc gactggccac accgcacagc ccagtaaaaa aatagttttt tttttgtatc
       61 caaccaacca actgtaaaaa taagtttaaa caaagcatct actcataagt ttcatttttt
      121 tccgttaagt gtcaacatta tttatttttt aagtgtgcat tcaataagaa aatgtcatcg
      181 cgaaggtaaa tccaataaga aatacgacaa tgttccgcac acacacgcac gcagtctcgc
      241 acacactcac acacacacac ggacacacac tcgcaatcac acacgcacgc acgctccgct
      301 cccaactggg ctatttacat atgtataagt agatacaaaa gcaaggcaga gcgaaaaaga
      361 aacagaaaca aaaaacaaaa ctgctgagat aaaaagtgca ccaaagtgtt ggtcgcgggg
      421 gggcgccagg gtggatgcag cggatccgtt gcctctgcac tgcttcatcc tcagcctcag
      481 cctgttgccc accgcggaag cagtgcggta accagtgaca attgaccgaa aacgatgcac
      541 acaccccact gtgccccact gttcgccact gtgctccact gtgcgccact gcacctgcca
      601 ctgatgacca cttggtatgc agggcaggag gcaccggagg ctgaccacaa acgacattcg
      661 cacaatggcc agtggcagct gacaacaccc atatgtttgc ccaccggatg gttccaccca
      721 acgatatctg gcatcgaagc tgagaaactg ctgcaggagc agggattcga cggctccttc
      781 ctcgcccgcc tctcctcctc gaatccgggc gccttcacgc tctccgtgcg ccgcggcaac
      841 gaggtgaccc acatcaaaat ccaaaacaat ggcgacttct ttgatctcta cggtggtgaa
      901 aagttcgcca cactgccgga actggtacaa tactacatgg agaatggcga gctaaaggag
      961 aagaacggcc aggccatcga actcaagcag ccgctgatct gcgccgagcc caccacggaa
     1021 agatggtttc atggcaatct ttccggaaag gaagcggaaa aattgatcct ggagcggggc
     1081 aagaatggtt cgtttctcgt ccgtgaatct cagagcaagc ctggcgactt cgtcctttcc
     1141 gtgcgcacgg acgacaaagt aacgcatgtc atgattcgat ggcaggacaa gaagtacgac
     1201 gtcggcggcg gggaatcctt tggcaccttg tcggaactga tcgatcacta caagcgtaat
     1261 cccatggtgg agacgtgcgg aaccgtggtg catctgcgac agccattcaa cgccacacga
     1321 atcacggcgg ccggcatcaa tgcccgggtg gaacagctgg tcaagggagg tttctgggag
     1381 gaattcgaat cgctgcaaca ggacagtcgg gacacattct cgcgcaacga gggctacaaa
     1441 caggagaacc gcctcaagaa tcgctaccgc aacatattgc catacgacca cacgcgcgtc
     1501 aagctgctgg acgtggagca tagcgtggcc ggagccgagt acatcaatgc caactacata
     1561 cggctgccca ccgacggcga cctgtacaac atgagcagct cgtcggagag cctgaacagc
     1621 tcggtgccct cgtgccccgc ctgcacggct gcccagacac agcggaactg ctccaactgc
     1681 cagctgcaaa acaagacgtg cgtgcagtgc gccgtgaaga gcgccattct gccgtatagc
     1741 aactgtgcca cctgcagccg caagtcagac tccctgagca agcacaagcg gagcgaatcc
     1801 tcggcctctt catcgccctc ctccggctct gggtccggac caggatcgtc gggcaccagc
     1861 ggagtgagca gcgtcaatgg acccggcaca cccaccaatc tcacgagcgg cacagccgga
     1921 tgtctggtcg gcctgctgaa gagacactcg aacgactcgt ccggagctgt ttctatatcg
     1981 atggccgaac gggaacgcga gagggagcgc gagatgttta agacctacat cgccacccag
     2041 ggctgtctgc tcacccagca agtgaacacg gtgacggact tctggaacat ggtctggcag
     2101 gagaacacgc gggtgatcgt catgaccacc aaggagtacg agcgcggcaa agaaaagtgc
     2161 gcccgctact ggccggacga gggtagatcg gagcagttcg gccacgcgcg gatacagtgc
     2221 gtctcggaga actcgaccag tgactatacg ctgcgcgagt tcctcgtctc gtggcgggat
     2281 cagccggcgc gccggatctt tcactaccat ttccaggtgt ggccggatca cggagtgccc
     2341 gccgatccgg gctgtgtgct caacttcctg caagatgtca acacgcgtca gagtcacctg
     2401 gctcaagcgg gcgagaagcc gggtccgatc tgcgtgcact gctctgcggg catcggtcgc
     2461 actggcacct ttattgtgat cgatatgatt ctcgatcaga ttgtgcgcaa tggattggat
     2521 actgaaatcg acatccagcg caccattcag atggtccgat cgcagcgttc cggtcttgtg
     2581 caaaccgagg cgcaatacaa gttcgtctac tatgcggtgc agcactatat acagaccctg
     2641 atcgcccgga aacgagctga ggagcagagc ctgcaggttg gccgcgagta caccaatata
     2701 aagtacacgg gcgaaattgg aaacgattca caaagatctc cattaccacc agcaatttct
     2761 agcataagtt tagttccgag taagacgcca ctgacgccga catcggcgga tttgggcact
     2821 gggatgggcc taagcatggg cgtgggcatg ggcgtcggca acaagcacgc atcgaagcag
     2881 cagccgccgt tgccggtggt caactgcaac aataataaca acggcattgg caatagcggc
     2941 tgcagcaacg gcggcgggag cagcaccacc agcagcagca acggcagcag caacggtaac
     3001 atcaacgccc tactgggcgg catcggcttg gggctgggcg gcaatatgcg caagtcgaac
     3061 ttttacagcg actcgctgaa gcagcaacag cagcgcgagg agcaggctcc ggcgggagca
     3121 gcaaaattca aaaacattcc caaagacatg atcggcttgc gaccgccaag ccatgcgcct
     3181 gcgttgccgc cgccaccgac accgccgcgc aaaacatgac aaatgaattt ctaagtcgcg
     3241 acgccccctt gacacgcccc cttgacacgc ccccctgaca cccacctccc tccacacgca
     3301 cacagaccac atatggtttt cattttaaat gtcacccagc cgccgcccca aacccaaaac
     3361 ccaatccctc gactatgttt tactgttgta ccacgttcta cgtttttttt ttttttttat
     3421 aattgtaatc tatatacttt tttgtaattg tgtgtaatgt aatgtttagt tttatgttat
     3481 tgtctcgctt tatgttgtaa gtgttccctg cacacgaaaa gcagtaaccc caccaccacc
     3541 ccaaaaccca aaacccagca tatttatgta gtagtattgt aagaatcccc gaaccggtag
     3601 ttgaggatac aatctgggcg gaactgcagc agatccgcca aaaaacaaaa acacattttt
     3661 aagcagaatc gcagcaacaa aatataacac ccgttccctg ttccaaaccg cttgaatttg
     3721 gtggaatcgg ccttgatagt atttcacttt cttgaaaata ttcgctttag ataagaaaat
     3781 tgacttgtga caaatattta catgtattgc gctggttaca aaccacaaaa gttgcttaac
     3841 tttaaatttt acgaatcgac atttatgata tttcgcatgc ttgaaaatag ttgtagtttc
     3901 ctatttggga atcattgaaa aatccattta taaagcgaaa tccagttctg gcacgttcaa
     3961 tttgaatcgg ttaatttcta atctagttgg cgaaaaagtg aagaaaagtg aagtccacct
     4021 cctccaaatt caacttgaaa cggaaacggg ttaccggttg gagtgcaaat aaagttttta
     4081 gtgtagtaag tgttgacaaa atcgatagag aagaaattag aggagtaact gaggcagtaa
     4141 gcacgtaacg ataatgatac aaaaagcgtt gattgtgatt cgagtgacag cgagaacaga
     4201 aactgaaaca gtaacagtaa cagtaacaga tgagaacaga tgcgaatggg atcagtacag
     4261 aacagaacag aacagcggag acgccaaccg aacagaacag aaatgaacag aagagaagag
     4321 aacagattag aggtaaaaga aaaagctaag aagcgcttaa gcgtgtcgtc cctagaataa
     4381 gaaaactaat attacagctc cacagatcca gattcagatc cagatctata tctctagcag
     4441 ccaatttctg atttcccctt ccctcttagt tttcccatta atttagtgat tgtgtgtata
     4501 tttttaattg tatattgaag attatttata gcgattgtcc attgtgttac atttcaaatg
     4561 ttcgaaagaa ttgtatttag aaagtttgta ctttagaaat tatgcattaa ttgtgtgtct
     4621 gtgtctctct acccagtctc cctatctctg tctctctctc tctctctccc tcactgtcta
     4681 tgcacgagtg ttttcttaac taagtttatt atttcaacgc tgaagcgtaa tcaaactata
     4741 tatgcaatat ttaagcacag taccttgggc gctgcaaaga aattaaaaaa ttttaaaata
     4801 aaaacaaact gctaaatcat aaatacaaaa tatatacagg aaggaataat agcagcgaaa
     4861 tgtaaatcaa ttagattatt gtgcaaattt gagtaatata tttaaaacat acccttattt
     4921 tatcttattt aactttatgc ttttgtaagt gctttaaatt gttattcatc ttgatcttgc
     4981 aaaaaaatga aaaaaccaca aaactgaaaa acgaatacaa aactaaaaaa caacacaaat
     5041 tatatttgta tttatacaga aaaataaaac attttatatg cgatacacga tagcacatta
     5101 ttttttattt tccctgcatg tttgttgaac gcttttccct ttttggttct caacttcagt
     5161 tatgttacca cacatcacca acgaactgaa agaaacccga acactttgga acatagcctt
     5221 atataaaacg cctcgacgac caagacggaa agttgaatca caccacggag aagagggaga
     5281 catctcccct ctcccagtta gaacaataag taatcatgtg ttcaccccca ccacccacac
     5341 gaatctaaac tgacccctga ccttccacca aagacactag aataatatta ttctaatgtc
     5401 tttgcttcca cccaccatct gagcactagc gggtgatccc gatcggacga caaacgtgtg
     5461 tgtaagtgcg tgatctagta ctttatatag ttagcctata atacgattat tcaaacggaa
     5521 tatgtcgaag cctggcttcg actgggcggc gacctagtgg cccccaaaaa acgaaggtga
     5581 atccgaatat gaatcccact ggggatacga tatgttttga tcttggagcg cggggcgaac
     5641 aaagtcgcgc gcttcttgtg ttgaattttt atagcatata gaaagaggtg gatatcggat
     5701 atggatattg aagaacgcag tccaatggag cagccggcgg agggagagat gaatgccaaa
     5761 gcacaaaagc caacagcaac aaaacaccaa taggcctcat cgcagtcatt tgaccacaaa
     5821 tctgacaaac aacgatgtta taatcaataa gagcgaacca aaatcaaaat aacgacgtga
     5881 atattgaggg agggatcgat ggagacccaa acaccaaaac aaaaaaaaaa aaaaacaaaa
     5941 aaaacaagag caaggaaacg ctttaaactt aaataattct aaaattgtat ctaggcaata
     6001 tcgaaatgta aaccacacac caactatcca tagtagacaa acaaacaaac accaagaaaa
     6061 aattgcttga gtgacttact ttagataacg atattctcgg gtaggacctc gaaaccccag
     6121 caacctcgga cctcaaccga tttcctcgtg ccctcgaccc gaatccaacc caacgtcccc
     6181 tcctccagta cgtctataag ctaaccacgc gatccaacct caacccgtgt tcataatccg
     6241 atgagaagtt gtgcgatttt tagtgaaacc tcggtgcggt ttcgatgttg caagaattaa
     6301 aaccaaatag agacgacgtt ttctttgttc aaatgttgcc aatttgcaaa atacaagtgt
     6361 taaactacca tatagtatat ggagtatgaa taatatatat ttagatgcga aatacagctc
     6421 agtactcagc tcagaagcat tttcattgag cccaaaacga gacggcgagg caaacgttta
     6481 tgtatcggta tacaagaagc agctgagagg tagttctcct gccatataaa atattaatcg
     6541 acccaaaaac attagaaatc cgtgtagaat actgcgattt gattgaaact atagataaca
     6601 atcgagaaca aaatggtaaa cgagcccacg acgaaacgcg attgacgcaa taaacaaagt
     6661 tttcgtagct ctagatcgta agataaacaa attaatgaaa cgcaacaaaa cgatcgcgaa
     6721 atcgagacaa aaggcaacac caaataaatt gtaaacaaaa ccaaagtcgt tgtaatgttg
     6781 aagcaaatct atatgtaaat caatctgcaa gcgctaacta aacgtaacaa acataaaaat
     6841 taaacacagc cacaaaatat tattatgaaa ttaaattgaa accttaagat gcatagctgt
     6901 tcgaaacatt ataccgataa caatattgaa gatatattct acatttttat gtgtctgcat
     6961 atttgaaaga aaaatatata taattgaata aaccatattt caaataacct ttcggaaaat
     7021 taccatgtgt ttttagaatg agtgactact acccacatat ttgtttcaat atccacatat
     7081 ttggcaagaa ggtacgaaat gaacaattcc aataaaact