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LOCUS NM_001272234 12551 bp mRNA linear INV 26-DEC-2023 (Hr4), mRNA. ACCESSION NM_001272234 VERSION NM_001272234.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 12551) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 12551) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 12551) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 12551) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 12551) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 12551) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 12551) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 12551) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 12551) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 12551) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 12551) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 12551) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 12551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 12551) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 12551) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 12551) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 12551) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 12551) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 12551) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 12551) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 12551) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 12551) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 12551) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..12551 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..12551 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /exception="dicistronic gene" /note="Hormone receptor 4" /map="2B16-2C1" /db_xref="FLYBASE:FBgn0264562" /db_xref="GeneID:31162" CDS 1604..7135 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="CG43934 gene product from transcript CG43934-RK; CG43934-PK; Hr4-PK" /codon_start=1 /product="hormone receptor 4, isoform K" /protein_id="NP_001259163.1" /db_xref="FLYBASE:FBpp0305537" /db_xref="GeneID:31162" /db_xref="FLYBASE:FBgn0264562" /translation="MNAQQPLILEPGSKASSVVAAAAELEAATTTAALATSSATEASA ADSYPAVQQNGGHEEQRLNGNHGCRREQPDDRTDQPEQLDQQDEPEPVKDVANKLTII KTPLNKTLLKKCNSNGSLQMPHANNGSSININNRNNTNNTNNNNSNNNNNAASNDVCD SGLQSGNSNEQEPFANNDRHHHIYHHHHHHYHHHHGGDKSEASGDVASSSSADPNSQV KDEPTAQDSQDNQAAGAAEAGGATAVAATCSPSKCNKCNSHNNNSNCNNNNNTISNNN NNTSSNTNTNSNSNNNANNNNNNNNNNHYNNYNNYYKKKSRMPPICRIMTLSRGPYSE LDKMSLFQDLKLKRRKIDSRCSSDGESIADTSTSSPDLLAPMSPKLCDSGSAGASLGA SLPLPLALPLPMALPLPMSLPLPLTAASSAVTVSLAAVVAAVAETGGAGAGGAGTAVT ASGAGPCVSTSSTTAAAATSSTSSLSSSSSSSSSTSSSTSSASPTAGASSTATCPASS SSSSGNGSGGKSGSIKQEHTEIHSSSSAISAAAASTVMSPPPAEATRSSPATPEGGGP AGDGSGATGGGNTSGGSTAGVAINEHQNNGNGSGGSSRASPDSLEEKPSTTTTTGRPT LTPTNGVLSSASAGTGISTGSSAKLSEAGMSVIRSVKEERLLNVSSKMLVFHQQREQE TKAVAAAAAAAAAGHVTVLVTPSRIKSEPPPPASPSSTSSTQRERERERDRERDRERE RERDRDREREREQSISSSQQHLSRVSASPPTQLSHGSLGPNIVQTHHLHQQLTQPLTL RKSSPPTEHLLSQSMQHLTQQQAIHLHHLLGQQQQQQQASHPQQQQQQQHSPHSLVRV KKEPNVGQRHLSPHHQQQSPLLQHHQQQQQQQQQQQQHLHQQQQQQQHHQQQPQALAL MHPASLALRNSNRDAAILFRVKSEVHQQVAAGLPHLMQSAGGAAAAAAAAVAAQRMVC FSNARINGVKPEVIGGPLGNLRPVGVGGGNGSGSVQCPSPHPSSSSSSSQLSPQTPSQ TPPRGTPTVIMGESCGVRTMVWGYEPPPPSAGQSHGQHPQQQQQSPHHQPQQQQQQQQ QQSQQQQQQQQQQSLGQQQHCLSSPSAGSLTPSSSSGGGSVSGGGVGGPLTPSSVAPQ NNEEAAQLLLSLGQTRIQDMRSRPHPFRTPHALNMERLWAGDYSQLPPGQLQALNLSA QQQQWGSSNSTGLGGVGGGMGGRNLEAPHEPTDEDEQPLVCMICEDKATGLHYGIITC EGCKGFFKRTVQNRRVYTCVADGTCEITKAQRNRCQYCRFKKCIEQGMVLQAVREDRM PGGRNSGAVYNLYKVKYKKHKKTNQKQQQQAAQQQQQQAAAQQQHQQQQQHQQHQQHQ QQQLHSPLHHHHHQGHQSHHAQQQHHPQLSPHHLLSPQQQQLAAAVAAAAQHQQQQQQ QQQQQQQAKLMGGVVDMKPMFLGPALKPELLQAPPMHSPAQQQQQQQQQQQQQQASPH LSLSSPHQQQQQQQGQHQNHHQQQGGGGGGAGGGAQLPPHLVNGTILKTALTNPSEIV HLRHRLDSAVSSSKDRQISYEHALGMIQTLIDCDAMEDIATLPHFSEFLEDKSEISEK LCNIGDSIVHKLVSWTKKLPFYLEIPVEIHTKLLTDKWHEILILTTAAYQALHGKRRG EGGGSRHGSPASTPLSTPTGTPLSTPIPSPAQPLHKDDPEFVSEVNSHLSTLQTCLTT LMGQPIAMEQLKLDVGHMVDKMTQITIMFRRIKLKMEEYVCLKVYILLNKAEVELESI QERYVQVLRSYLQNSSPQNPQARLSELLSHIPEIQAAASLLLESKMFYVPFVLNSASI R" misc_feature 5312..5581 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers; Region: NR_DBD_DHR4_like; cd07168" /db_xref="CDD:143542" misc_feature order(5336..5338,5345..5347,5387..5389,5396..5398, 5444..5446,5462..5464,5492..5494,5501..5503) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="zinc binding site [ion binding]; other site" /db_xref="CDD:143542" misc_feature order(5366..5374,5390..5395,5399..5401,5405..5407, 5414..5416,5423..5425,5483..5488,5495..5497,5504..5506, 5537..5539,5546..5548) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative DNA binding site [nucleotide binding]; other site" /db_xref="CDD:143542" misc_feature 6341..7120 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4; Region: NR_LBD_DHR4_like; cd06953" /db_xref="CDD:132751" misc_feature order(6431..6436,6446..6448,6548..6550,6560..6562, 6569..6571,6767..6769,6836..6838) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative ligand binding site [chemical binding]; other site" /db_xref="CDD:132751" misc_feature order(6461..6463,6470..6472,6482..6484,6497..6499, 6512..6517,6521..6526,6533..6538) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative coactivator recognition site [active]" /db_xref="CDD:132751" ORIGIN 1 gtgtatccca cgagctagtc gcgcgcggaa agcaaacgct tcgaaaatca aacgatattt 61 ccgttttgac gtttaacccc cacccaccca aataaagcaa atctaactaa agagtcctgc 121 aaaaaaatca acagctgctt gatcttgaag cctccatatc ttgaaatcct gcatcagcca 181 acagccccaa aacaaaacaa aacaaaacga atgcaaatac actaatgtga acaacaacta 241 aattgctagt gaaatgtttt aagccaaatg ctgtgagtgt gtaacaaaaa aaaaaaaaaa 301 aaaaaaaaaa aaagaagagt gattcaaagc aaccgcaagc aatcaacttg taacggtagt 361 cggatactcg cttgcccgcg gagcatggat atcgccccag ttccgccacc accattatcg 421 atatccgtat cgctttcggc tccaggatca acggtattcg caaacgctgg ccactagaga 481 agcgtcagcc gaatgcctca aagatgacac cgctgcaacg ggaccaattg aaccaccaac 541 aatttgtgca ccactatttg caaagtcaac ctgtcaataa caaaattgac agctttgata 601 ttaaacatat acgtaaaacc caaaacccga ccacaaaccc aaagtttcga actgaagacc 661 gtttcaagac aagcagcaag agcaagatta ccaacccgga gagcggaaat acccaactcc 721 attttcattt gagtgaaacg ccagacttat ccgcctcaac ttcgctgttg ccgtcagcat 781 ttgttgcatc ctccgccgcc ttggtgaatg tgacatgcca ggcggaggaa ggacaaagtt 841 cagcaggatc acactacaca gttcatagag ggaatgacgc aggcatttct tttgcagcgt 901 tggactttcg ttttataagt ttcagtggcc agtggctaaa gtgcggcgat atcgggcgaa 961 acggttaacg gctcacggct catggctaac ggttgacagc cagcggttca tcacgcgcca 1021 aatccttttt tttcaagttt gtcaatgttt ttagtggtac taaagaaaac acatcattat 1081 atgtaaacta taggcaagaa tctaaagcca agagtggtat gtgcccttag ttttgaccca 1141 agacctacaa gtccctagaa gacccctgac agccagaacc acccacccac acaccacgca 1201 taaacacacg cacacacaca aacacactca ttcgccaccc acccacacag tctcatatct 1261 cagtctcagt ctcagtttca atctcagttc caatctcagt tccaatccaa tctcaatctc 1321 atttcgagga tcaaaaacgg agcagcaaca tcaatcgatt cattatgttt acatattttt 1381 ttcgagtgat ttaagttttg gcaatggacg cagacttctt ctccatctaa tcgaaccgag 1441 tgacttcgca tcatgctgta gaagaagaag ttgactaaca aatggttgtt gtgatcgaaa 1501 gtgtcttttg agatgtgttt aaaactcggt gtttgcccag ccaaaatggc ccagcatcgt 1561 tcgcttgtcc gtctctacct gcccacctag aagagctgcc cagatgaatg cccagcagcc 1621 gctgatcctg gagcctggat ccaaggccag cagtgttgtt gcggcagctg ccgagctaga 1681 ggcagcaaca accacggcag cgctggccac gtcctccgcc acggaggctt ctgcagcgga 1741 cagctatcct gccgtacagc agaacggcgg ccacgaggag cagcggctca atggcaacca 1801 cggatgtcgc cgcgagcagc cggatgatcg gacggaccag ccggagcagt tggatcagca 1861 ggatgagccc gagccagtca aggacgtggc caacaagctg accattatca agacgccgtt 1921 gaacaagact ctgctgaaga agtgcaacag caacgggagc ctgcagatgc cgcacgccaa 1981 caatggcagc agcatcaaca tcaataatcg caacaacaca aacaacacca acaacaacaa 2041 tagcaacaat aacaacaatg cggccagcaa cgacgtctgc gattccggtt tgcaaagcgg 2101 aaatagcaat gaacaagaac catttgccaa caacgatcgc catcaccaca tctaccacca 2161 ccaccaccat cactatcatc atcaccatgg cggcgataag agcgaggcga gcggcgacgt 2221 tgcatcctcg tcctccgcgg accccaactc gcaggtcaag gacgagccca cagcgcagga 2281 tagccaggac aatcaagcgg ccggagctgc agaggctgga ggagctactg cggttgcagc 2341 cacgtgcagc cccagcaagt gcaacaagtg caactcgcac aataacaaca gcaactgcaa 2401 caataacaat aataccatca gcaacaacaa caataataca agcagtaata ccaatacgaa 2461 cagcaacagc aacaacaatg ccaacaacaa taataataat aacaataata accattacaa 2521 caactacaat aactattata agaaaaagtc tcgtatgccg cccatttgcc gaattatgac 2581 actgagccgt ggcccgtaca gcgagctcga taaaatgagc ctttttcaag acctcaaact 2641 caaacggcgc aaaatcgatt cgcgatgcag cagtgacggc gagtccatag cggacacgtc 2701 cacctcgtcg ccggacctgc tggcgcccat gtcgccgaag ctctgcgaca gcggctcggc 2761 gggggcgtcg ctgggggcat cgctgcccct gccgctggcc ctgcccctgc caatggccct 2821 gccactgccc atgtcgctgc ccctgcccct cacggcggca tcttcggcgg tcaccgtttc 2881 gctggcagcg gtcgtggccg cggtggccga gacgggtggc gcgggcgcgg gaggagctgg 2941 gacagcagta acagcgtcgg gagcaggacc atgcgtctcc acgtcgtcta cgacggcagc 3001 ggcagccaca tcctcgacct cctcgctctc gtcctcctcc tcttcgtcat cctccacgtc 3061 ctccagcact tcctccgcct cgccgacagc tggagcctcc tccacggcca cctgccccgc 3121 cagcagcagc agcagcagtg gaaacggaag tgggggcaaa agtggtagca tcaagcagga 3181 gcacacggag atacactcgt cgagcagtgc gatttcggcg gccgccgcct caacggtgat 3241 gtcaccgccg cccgctgagg cgacgagatc cagtccagcc acgcccgagg gaggcggacc 3301 agctggcgac ggaagtggag caacgggagg cggaaacacg agcggcggat caacggctgg 3361 agtggccatt aatgaacacc aaaacaatgg caatggcagc ggcgggagca gtcgagcctc 3421 tcccgattcg ctggaagaga agccctctac cacaacgacc acaggtcgtc caacgctcac 3481 gcccacgaat ggggtgctgt cctccgcctc ggcgggcacg gggatttcca caggaagcag 3541 cgccaagctg agcgaggctg gtatgagtgt gatacggtcc gtgaaggagg agcgcttgct 3601 caacgtatcc agcaagatgc tggtgttcca tcagcagcgg gagcaagaga ccaaagcagt 3661 ggcggctgca gcagcagcag cagcggcggg ccatgtgacg gttctagtga cgccatcgcg 3721 catcaaatcg gagccaccgc cgccggcttc accctcctct acatccagca cacaaaggga 3781 aagggaacgg gaacgcgatc gagagaggga tcgcgaaagg gaacgcgagc gggaccggga 3841 ccgggaacgg gaacgggaac agtccatcag ctcctcgcag cagcacctaa gtcgggtctc 3901 cgccagtcca cccactcagc tgtcccacgg cagcctggga cccaacattg tgcagacgca 3961 ccatcttcac cagcaactca cacagccgct gacgctgcgc aagagcagcc cgcccacaga 4021 gcacctgctc agtcagtcca tgcaacatct cacacagcag caggcgatcc acctgcatca 4081 cctacttggc cagcagcagc agcagcagca ggcgtcgcat ccccagcagc aacagcagca 4141 gcaacactcg ccccactccc tggtgcgggt gaaaaaggaa ccgaatgttg gtcagcggca 4201 cttatcgccg catcaccaac aacagtcgcc actcctgcag caccaccaac agcagcagca 4261 gcagcaacaa caacagcaac agcatctgca tcagcaacag caacagcagc agcatcacca 4321 gcagcagccc caggcactgg ccctgatgca tccggcttcc ctggcgctaa ggaacagcaa 4381 tcgggatgcg gccattctgt ttcgggtgaa gagcgaagtg caccagcagg tggccgccgg 4441 gctgccgcat ctgatgcagt ccgctggtgg ggcagcggcc gccgccgcag cagctgtggc 4501 cgctcagcga atggtatgct tcagcaatgc caggatcaat ggcgttaagc cggaggtgat 4561 tggaggaccg ctgggcaacc tgcggcccgt gggcgtcggt ggcggaaacg gaagtggctc 4621 cgtgcagtgc ccctcgccgc atccatcctc ctcgtcgtca tcctcgcagc tgtcgccgca 4681 gacgccctcc cagacgccgc cccgaggcac gcccaccgtc ataatgggcg agagctgcgg 4741 ggtgcgcacc atggtctggg gctacgagcc tccgccaccc tcggcgggcc agtcccacgg 4801 ccagcacccg caacagcaac agcagtcgcc ccaccaccag ccgcaacaac aacagcagca 4861 gcaacaacag cagtcgcagc agcaacagca acagcagcag caacagtcgc tgggccagca 4921 gcagcactgc ctctcctcgc cgtcggcggg atcgctgacg ccctcctctt cgtccggcgg 4981 tggttcggta tctggcggcg gagtgggcgg accactcaca ccctcctcgg tggcgccgca 5041 gaataacgag gaggccgccc aactcctgct ctccctggga cagacacgca tccaggacat 5101 gagatcacgg ccacacccct tccgcacacc gcacgccctt aatatggagc ggctgtgggc 5161 gggagactac tcgcaattgc cgcccggcca gctgcaggct ctgaatctca gtgcccaaca 5221 gcagcagtgg ggcagcagca actccacggg tcttggtggc gtaggcggcg gcatgggcgg 5281 acgcaacctg gaggcgccgc acgagccgac cgacgaggac gaacagccgc tcgtttgcat 5341 gatctgcgag gacaaggcca ccggcctgca ctacggcatc atcacctgcg aggggtgcaa 5401 gggcttcttc aagcggacgg tgcagaaccg acgagtctac acctgcgtgg cggacggcac 5461 ctgcgagata accaaagcac agcgcaaccg ttgtcagtat tgtcgattta agaagtgcat 5521 cgagcagggc atggtgctgc aagccgttcg cgaggatcgc atgccgggcg gtcgcaacag 5581 tggcgccgtc tacaatttgt acaaggtgaa gtacaagaag cacaagaaga ccaatcagaa 5641 gcagcagcag caggccgccc agcagcagca gcagcaggcg gcggcgcagc agcagcacca 5701 gcaacagcag cagcatcaac agcaccagca acatcagcaa cagcagttgc actcgccgct 5761 ccaccatcac caccaccagg gccaccagtc gcaccacgcg cagcagcagc accacccaca 5821 gctgtcgccg caccacctgc tgtcgccgca gcagcagcaa cttgccgccg cggtggcagc 5881 agctgcgcag caccaacagc aacagcaaca acagcagcaa cagcagcagc aggccaagct 5941 gatgggcggc gtggtggaca tgaagcccat gttcctcggc cccgctttga agccggagtt 6001 gctgcaagca ccccccatgc acagtccggc ccagcaacaa caacagcagc agcagcagca 6061 gcagcaacag caggcctcgc cgcatctctc gcttagctca ccgcaccagc agcagcagca 6121 gcagcaggga cagcaccaaa accaccacca gcaacaaggt gggggtggcg gaggagctgg 6181 tggaggagct caactgccgc cgcacctggt gaacggaacg atactgaaga cggccctaac 6241 caatcccagc gagattgtac atctgcgcca ccgcctcgac tcggcggtca gttcgtccaa 6301 ggaccgacag atctcgtacg agcacgcctt aggcatgatc cagacactga tcgactgcga 6361 cgcgatggag gacatagcca cactgccgca cttcagcgag ttccttgagg acaagtcgga 6421 gattagcgag aaactgtgca acatcggcga ttccatagtc cacaagctgg tgtcgtggac 6481 aaaaaagttg cccttctacc tggagatccc ggtggagata cataccaaac tactgacgga 6541 caagtggcac gagatcctta tcctgaccac ggccgcctac caggcgttgc atggcaagcg 6601 gcgtggcgag ggaggaggca gcaggcatgg ttcgccggcg tcaacgccac tgagcacgcc 6661 cactggtacg ccgttgagca caccgatacc ctcgcccgcc cagccactgc acaaggacga 6721 cccggagttt gtcagcgagg tgaactcgca cctgagcaca ctgcaaacct gcttgaccac 6781 gctaatgggc cagccgatag cgatggagca gctgaagctg gacgtcgggc acatggtgga 6841 caagatgacc cagatcacca tcatgttccg gcgaatcaag ctcaagatgg aggagtacgt 6901 ctgcctgaag gtttacatac tgctaaacaa agcagaagtg gaactggaga gcatccagga 6961 gcggtacgtc caggtgctgc gctcctacct gcaaaactcc tcgccgcaga atccgcaggc 7021 gaggctcagt gaactgctct cccacatacc agagatccag gctgcggcta gcctgctgct 7081 cgagagcaag atgttctatg tgcccttcgt gctcaactcg gcgagcataa ggtagcagat 7141 gcttgagcac ggactgctgc ccaccgccaa ccatcagtcg gcgccaccac ctggtcctga 7201 tacgatcccg gagcggcagc agcaacagca acaggagcgg cgtcgaagca ggcagcagca 7261 gcaccagttg ctgcgcaacc tgcccaagat caagatcgag atcggttccc agcgcgatcc 7321 ggaggaagag gagtcggagc aagagctaga gcaggagccg gagcaagagc aggatgtgca 7381 gtcccgaccc tcagccgcat ccacgtccat tttgaagact tcactgctga gcggagcggc 7441 ggcgacgttg gccaccttga cggcggcagc cgagcaaata gcccgctcct cggccagctg 7501 cgacactgcc agggattatt cccaaagcag caacagcagc agcaatagca acgctgccac 7561 aggagcaaca ggaactatgg ccagcggcag gacaggcagc agcaacagtt tagaagagag 7621 caaaagactt gagcatcaac aacaacaaca acaacagcag caacaaccac aacagcatca 7681 gcagcaacaa tatacatcaa tactacacac ggccttaatg tcacagcgtt ccatgccacc 7741 agcgacatca gctacatcag cagcagcggc ggtcacatcg acgccgacaa cggcagcaac 7801 aacatcgcct acgcctgcgc atgtgctgaa aacagcggtg accttagcca gtctaagtga 7861 gatagccaca gcacgtcagc agcagcagga gcagcagcag caacagcagc agcagcagca 7921 gcagcaacaa ttgctggcga tgcaacagca acagcaacag ctaacgaaac tgcccagaag 7981 gataatcaac tttggcagca atcacactgc caacactgcc accaaagcat tgggagcggg 8041 atcagaagca ggagcaggag caggagtggg catggccaca gcaacggcaa cagcaacagt 8101 tggacgcaat cgccaactgg gcctgagtca gggtcaagtg gtgaatggta agcagaaaga 8161 attgtgagcc ttgtgtttgc gataacgttt gtgtacccct cgttaacgct gccagtcagg 8221 acagcacgcc tgctcaatgg caactgttgc ggccgattgc aggcgacagc aggaacaggg 8281 gccagcaggg gcaccaacac tgccggcagc aacacggtca acatgcagac ccagaccgac 8341 gatgagttgc tgccgctgtt agccatgctc ccacaagacg ctcccacaac aacaggagca 8401 gcagcaggag cagcagtatc attatcatta ttagccacag ccacagccac aaccacatct 8461 tcatcatcat catcatcatc atcattatca tcatcatcga cgatttcatt agcaacacgt 8521 gcagcagcag taatgcagca gcagcaacaa tggactgccg tgtcgacgac gccagcaaca 8581 ggagtgatga tgacgacgac gacgacacaa tcacaatcac aagcaacatt agcaccacaa 8641 caacagcaac tatcactgcc acaacaaaag caacaattta atacgagaat aaacagaaaa 8701 acaacaatta caacagccac cacaacagca ccaacagcaa caacagcaac aacaacaaca 8761 acacgaaaca gcaacatcaa cttcaacagc aacaataact atatgaataa caataatata 8821 aacgccgcca ctgccagagc ctctgccttc gcctccgcct ctgccatggc cacggccacg 8881 cccacaggca cacccactgc cacgggcccg cgccagagac cggccccgca accgcccccg 8941 cccccgcgca cgcccacagc cacctcagct tctgttactg tagttgtgtt caaaacaatg 9001 ttacctgatg actgaattat tttagaatcg tacacataga gcatgtttta ttatgattac 9061 cactatgatt accacttacg atttacgatt acgattatga ttacgattat gagtatgtct 9121 ggatatcatt acctattaac tattcattag ttatggatta tcgattatta ctatttttac 9181 tattactatt gctacatgca taatgtagag cctaattgat ctatcgtgta ttttagtttg 9241 tctaattgtt ggatccctgt actatatccc acacacatac acacactctc acccatattt 9301 gatcctcacc cccaaacaat ccataagcac acactcatac acacacacac acacacacac 9361 acattgccgt tactaaggaa gggtatgcgc atatgcgaag ttgaaacatt ttaatcatgt 9421 attttttttt tttgtgtttt tgctgaacgg agatgaaagt taaggaggtc gagcaacagc 9481 aattagaagt gttaattgag taggattatg agtacgtagc gagtatgtaa cgagtatgta 9541 atgactaagt aaagtttacg tagacacaat gccacacaca gctatagcaa gcatttagga 9601 tgcgtgcata tgtcagttat ctattttttt tttttaaact aaaatctata taaagtaacg 9661 agagaggaag gaagagcgaa gcagggcggg agattcaacc acataaagta taaatagtag 9721 agcttgagcc aagtagctag tttagtgtac atccgttttg gggcagggaa gtagagcaat 9781 ttgttgacga gtcggggtgg tggggtgagc ggtaacgaag atcggtaacg gaagtggaga 9841 caaagcggaa ccggaaacgg gagctggact gccagatcgg aatcacacat caaccattat 9901 gagaacttcg ctcgcaactc ttgcagaatt atactgttag atcctgttag ttatccaacc 9961 caaaactccc aacccacaca cactatacct aagttaagaa cgcataatca catactacac 10021 ataaattacg catagtacat acaaaaaaga tgaagagaaa acgagaaaat gagaaaaaac 10081 aaagataagg aagataagaa agaaagaaag aaagaaacga aaggactttt tttttgtaag 10141 ctcgattgcg caattgtata tcgtaatcgt gttgtcttcg caaccccaaa cgccccatgg 10201 cggtattgat gcccggattg ttatcgatat cgtcgtacta cgttttattt tgtaaatgta 10261 ttaattttgt tgattttttt gctgtctgta cacatttttt ttaacaacat tttttaataa 10321 atgtaattct tgaatatgct ttatgttttt aatttactct caaaccccac cacattttga 10381 gtttcatttg gtttgtatat aaaacagata ggagtcactc cattttacaa gttttcttta 10441 tcagaattaa cgtgttgttt tcaagtcaaa atcttcgaat tggtagcgaa tttgtaggta 10501 agggaattcc ataaataatg cccaaaatag aaaaactcgc ccttaactat aattctacac 10561 acattttacg cgctctccaa tttctacttg aaaattcctc agtggcgcca cctgtattta 10621 gagactcgaa gtgtatgcac cggaaatggc aaaatcggct tgaaagaaaa ttggaagaat 10681 ctcttgtgaa taggaaaacc cgataaaaaa aatccttgat gcccagtcct gaaacacaaa 10741 tcctcccgat tgaagctctg tcaaataaat aacgaatcct agagctgaga ggagaaacag 10801 aaatagagaa attaagaaaa aaaaaacacg aaaacaatgt ttttcgaacg aaaccgagga 10861 acagaagatg agaatatatg caagagtctg acatcaaatt gccttcaaag cgttattttt 10921 gatttttttt tccgtagagt ttttttacga gaaaacgatg caaaaaccaa tacgaaatac 10981 caaatagcaa ggatatttag agtacgtata tatgtggatt tacataagcg atgacataat 11041 aatcatatga atatggaaaa agcagcaacg gacggacggc taaaaggatt aacatttttt 11101 gtagagtaat tgcaggataa acagcatctg gaggaaaaga gtcaaaataa aatatttttg 11161 cacagcgtgt tatcgaataa gtgttagacc ttaaacgtaa ctgtaatcga gattaaaatc 11221 aatcaaagaa cccttcccct tccgttccct tccctaccca tcccttcccc acctttttca 11281 acccatcccc aaaaactgcc agtttcccac cccgcccatt tgattatcag ggctagggtc 11341 agatggacaa ttgctcccgc tgaagaagaa gaagtgtctt tgtaaataca tgagtataag 11401 cagtgggact tagtggggtc tgaagacccc aaccgtacca tctggcatct cgagatataa 11461 cattagttag ctaattttaa cgacttacac tcccggactc accaactgca gtcacctgcc 11521 tacccagctg cgacttttcg tagatacact gttttaccca aaagaacaag aatacaatga 11581 atacttaaat gctcaacttc accacatgac ccactcagcc actcagccac tcaaccacac 11641 ccgcatccaa cccactccgc ttgcctagat ccatttgcat cccgggaagg aacccatgtc 11701 caccatttcc ctatagtgta tagcgtggat gcaatatgaa cttcttatgg tgcttaatct 11761 ggatcttgat cttgagaaca acccaagcct agaactcaaa ttatgggact gatgcaatga 11821 aacaaaaaga aaacaatgaa aaaataagta aatgagctag ggaagaaatc taattaaacc 11881 catatatgta tactaggtgt atatgtgtat tgatttaaag attcaataat taaaaacgaa 11941 gtagatcctt ccatatgata aaagaaaaaa taaaaaaacg agaaaaatac agagtaaact 12001 ctagggaaag atctcgcttc tgaggccatt gttatactct ttgaatttgt gtatacccca 12061 gaatagaaaa ttgtgaaacc aaatccaaag aaaaccaaaa cacataacaa atcgccgtgg 12121 aaaattatag aaatactgtt ttttttgtgc atttctaatt ctacatagcg gtcgccagcg 12181 agttttacct tttatataag tatacaatat ggtttttgtt tcgttttgga tttgatatga 12241 atgttacacg atggattgat attgattgat tgattagtga acgtttgatg tagtggtaac 12301 caaaaagaat aatttaaatg atatattaat gtaatgcata agagacgaaa acacaaacgg 12361 caacagaacc gcaaatgata atgaaatgaa aatgaaatgt tagcaaaaat aaaaaaggac 12421 aactaaaaca aactaagccc gtaattgaga atttttaaag cacgattcga gatcacatat 12481 aaatttaata aattacacat gtattaataa tgaaatgatg tatttacgaa taaaattaat 12541 attatcacat g