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LOCUS NM_001272233 10003 bp mRNA linear INV 26-DEC-2023 (Hr4), mRNA. ACCESSION NM_001272233 VERSION NM_001272233.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 10003) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 10003) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 10003) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 10003) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 10003) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 10003) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 10003) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 10003) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 10003) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 10003) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 10003) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 10003) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 10003) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 10003) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 10003) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 10003) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 10003) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 10003) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 10003) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 10003) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 10003) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 10003) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 10003) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_001272233.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..10003 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..10003 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /exception="dicistronic gene" /note="Hormone receptor 4" /map="2B16-2C1" /db_xref="FLYBASE:FBgn0264562" /db_xref="GeneID:31162" CDS 1550..7081 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="CG43934 gene product from transcript CG43934-RJ; CG43934-PJ; Hr4-PJ" /codon_start=1 /product="hormone receptor 4, isoform J" /protein_id="NP_001259162.1" /db_xref="FLYBASE:FBpp0305536" /db_xref="GeneID:31162" /db_xref="FLYBASE:FBgn0264562" /translation="MNAQQPLILEPGSKASSVVAAAAELEAATTTAALATSSATEASA ADSYPAVQQNGGHEEQRLNGNHGCRREQPDDRTDQPEQLDQQDEPEPVKDVANKLTII KTPLNKTLLKKCNSNGSLQMPHANNGSSININNRNNTNNTNNNNSNNNNNAASNDVCD SGLQSGNSNEQEPFANNDRHHHIYHHHHHHYHHHHGGDKSEASGDVASSSSADPNSQV KDEPTAQDSQDNQAAGAAEAGGATAVAATCSPSKCNKCNSHNNNSNCNNNNNTISNNN NNTSSNTNTNSNSNNNANNNNNNNNNNHYNNYNNYYKKKSRMPPICRIMTLSRGPYSE LDKMSLFQDLKLKRRKIDSRCSSDGESIADTSTSSPDLLAPMSPKLCDSGSAGASLGA SLPLPLALPLPMALPLPMSLPLPLTAASSAVTVSLAAVVAAVAETGGAGAGGAGTAVT ASGAGPCVSTSSTTAAAATSSTSSLSSSSSSSSSTSSSTSSASPTAGASSTATCPASS SSSSGNGSGGKSGSIKQEHTEIHSSSSAISAAAASTVMSPPPAEATRSSPATPEGGGP AGDGSGATGGGNTSGGSTAGVAINEHQNNGNGSGGSSRASPDSLEEKPSTTTTTGRPT LTPTNGVLSSASAGTGISTGSSAKLSEAGMSVIRSVKEERLLNVSSKMLVFHQQREQE TKAVAAAAAAAAAGHVTVLVTPSRIKSEPPPPASPSSTSSTQRERERERDRERDRERE RERDRDREREREQSISSSQQHLSRVSASPPTQLSHGSLGPNIVQTHHLHQQLTQPLTL RKSSPPTEHLLSQSMQHLTQQQAIHLHHLLGQQQQQQQASHPQQQQQQQHSPHSLVRV KKEPNVGQRHLSPHHQQQSPLLQHHQQQQQQQQQQQQHLHQQQQQQQHHQQQPQALAL MHPASLALRNSNRDAAILFRVKSEVHQQVAAGLPHLMQSAGGAAAAAAAAVAAQRMVC FSNARINGVKPEVIGGPLGNLRPVGVGGGNGSGSVQCPSPHPSSSSSSSQLSPQTPSQ TPPRGTPTVIMGESCGVRTMVWGYEPPPPSAGQSHGQHPQQQQQSPHHQPQQQQQQQQ QQSQQQQQQQQQQSLGQQQHCLSSPSAGSLTPSSSSGGGSVSGGGVGGPLTPSSVAPQ NNEEAAQLLLSLGQTRIQDMRSRPHPFRTPHALNMERLWAGDYSQLPPGQLQALNLSA QQQQWGSSNSTGLGGVGGGMGGRNLEAPHEPTDEDEQPLVCMICEDKATGLHYGIITC EGCKGFFKRTVQNRRVYTCVADGTCEITKAQRNRCQYCRFKKCIEQGMVLQAVREDRM PGGRNSGAVYNLYKVKYKKHKKTNQKQQQQAAQQQQQQAAAQQQHQQQQQHQQHQQHQ QQQLHSPLHHHHHQGHQSHHAQQQHHPQLSPHHLLSPQQQQLAAAVAAAAQHQQQQQQ QQQQQQQAKLMGGVVDMKPMFLGPALKPELLQAPPMHSPAQQQQQQQQQQQQQQASPH LSLSSPHQQQQQQQGQHQNHHQQQGGGGGGAGGGAQLPPHLVNGTILKTALTNPSEIV HLRHRLDSAVSSSKDRQISYEHALGMIQTLIDCDAMEDIATLPHFSEFLEDKSEISEK LCNIGDSIVHKLVSWTKKLPFYLEIPVEIHTKLLTDKWHEILILTTAAYQALHGKRRG EGGGSRHGSPASTPLSTPTGTPLSTPIPSPAQPLHKDDPEFVSEVNSHLSTLQTCLTT LMGQPIAMEQLKLDVGHMVDKMTQITIMFRRIKLKMEEYVCLKVYILLNKAEVELESI QERYVQVLRSYLQNSSPQNPQARLSELLSHIPEIQAAASLLLESKMFYVPFVLNSASI R" misc_feature 5258..5527 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers; Region: NR_DBD_DHR4_like; cd07168" /db_xref="CDD:143542" misc_feature order(5282..5284,5291..5293,5333..5335,5342..5344, 5390..5392,5408..5410,5438..5440,5447..5449) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="zinc binding site [ion binding]; other site" /db_xref="CDD:143542" misc_feature order(5312..5320,5336..5341,5345..5347,5351..5353, 5360..5362,5369..5371,5429..5434,5441..5443,5450..5452, 5483..5485,5492..5494) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative DNA binding site [nucleotide binding]; other site" /db_xref="CDD:143542" misc_feature 6287..7066 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4; Region: NR_LBD_DHR4_like; cd06953" /db_xref="CDD:132751" misc_feature order(6377..6382,6392..6394,6494..6496,6506..6508, 6515..6517,6713..6715,6782..6784) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative ligand binding site [chemical binding]; other site" /db_xref="CDD:132751" misc_feature order(6407..6409,6416..6418,6428..6430,6443..6445, 6458..6463,6467..6472,6479..6484) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative coactivator recognition site [active]" /db_xref="CDD:132751" ORIGIN 1 gtgtatccca cgagctagtc gcgcgcggaa agcaaacgct tcgaaaatca aacgatattt 61 ccgttgtggg ttcccaagaa ataaaataat aacacaaaac gaaataacta tttttttacg 121 ttttttttgt tgcctctcca ggattttgtt gaccatcgta gattggatat gtgaaacaaa 181 ttttaagggc ctccactttc tctatctcgc cctagcagca aggtgcactg tgtgtgtgtg 241 cgacaatttt acaagtgcaa catgaataaa tgcaaagaaa attttttttt taattgttga 301 caacaagaat ttgcaagcat cttcaaagat ccaacagaaa attggcttgt ttttgttttg 361 tgtgtgtgtg tacgtgtgcg tgcgtgcgtg tgtgtgtgcg gcgcaaatat aaaaaaaatg 421 cataacgaca ccttggcact gacgctattt ttttaattct attttttatg tgtgtgttcc 481 gttgcagttg acgtttaacc cccacccacc caaataaagc aaatctaact aaagagtcct 541 gcaaaaaaat caacagctgc ttgatcttga agcctccata tcttgaaatc ctgcatcagc 601 caacagcccc aaaacaaaac aaaacaaaac gaatgcaaat acactaatgt gaacaacaac 661 taaattgcta gtgaaatgtt ttaagccaaa tgctgtgagt gtgtaacaaa aaaaaaaaaa 721 aaaaaaaaaa aaaaagaaga gtgattcaaa gcaaccgcaa gcaatcaact tgtaacggta 781 gtcggatact cgcttgcccg cggagcatgg atatcgcccc agttccgcca ccaccattat 841 cgatatccgt atcgctttcg gctccaggat caacggtatt cgcaaacgct ggccactaga 901 gaagcgtcag ccgaatgcct caaagatgac accgctgcaa cgggaccaat tgaaccacca 961 acaatttgtg caccactatt tgcaaagtca acctgtcaat aacaaaattg acagctttga 1021 tattaaacat atacgtaaaa cccaaaaccc gaccacaaac ccaaagtttc gaactgaaga 1081 ccgtttcaag acaagcagca agagcaagat taccaacccg gagagcggaa atacccaact 1141 ccattttcat ttgagtgaaa cgccagactt atccgcctca acttcgctgt tgccgtcagc 1201 atttgttgca tcctccgccg ccttggtgaa tgtgacatgc caggcggagg aaggacaaag 1261 ttcagcagga tcacactaca cagttcatag agggaatgac gcaggcattt cttttgcagc 1321 gttggacttt cgttttataa gttttggcaa tggacgcaga cttcttctcc atctaatcga 1381 accgagtgac ttcgcatcat gctgtagaag aagaagttga ctaacaaatg gttgttgtga 1441 tcgaaagtgt cttttgagat gtgtttaaaa ctcggtgttt gcccagccaa aatggcccag 1501 catcgttcgc ttgtccgtct ctacctgccc acctagaaga gctgcccaga tgaatgccca 1561 gcagccgctg atcctggagc ctggatccaa ggccagcagt gttgttgcgg cagctgccga 1621 gctagaggca gcaacaacca cggcagcgct ggccacgtcc tccgccacgg aggcttctgc 1681 agcggacagc tatcctgccg tacagcagaa cggcggccac gaggagcagc ggctcaatgg 1741 caaccacgga tgtcgccgcg agcagccgga tgatcggacg gaccagccgg agcagttgga 1801 tcagcaggat gagcccgagc cagtcaagga cgtggccaac aagctgacca ttatcaagac 1861 gccgttgaac aagactctgc tgaagaagtg caacagcaac gggagcctgc agatgccgca 1921 cgccaacaat ggcagcagca tcaacatcaa taatcgcaac aacacaaaca acaccaacaa 1981 caacaatagc aacaataaca acaatgcggc cagcaacgac gtctgcgatt ccggtttgca 2041 aagcggaaat agcaatgaac aagaaccatt tgccaacaac gatcgccatc accacatcta 2101 ccaccaccac caccatcact atcatcatca ccatggcggc gataagagcg aggcgagcgg 2161 cgacgttgca tcctcgtcct ccgcggaccc caactcgcag gtcaaggacg agcccacagc 2221 gcaggatagc caggacaatc aagcggccgg agctgcagag gctggaggag ctactgcggt 2281 tgcagccacg tgcagcccca gcaagtgcaa caagtgcaac tcgcacaata acaacagcaa 2341 ctgcaacaat aacaataata ccatcagcaa caacaacaat aatacaagca gtaataccaa 2401 tacgaacagc aacagcaaca acaatgccaa caacaataat aataataaca ataataacca 2461 ttacaacaac tacaataact attataagaa aaagtctcgt atgccgccca tttgccgaat 2521 tatgacactg agccgtggcc cgtacagcga gctcgataaa atgagccttt ttcaagacct 2581 caaactcaaa cggcgcaaaa tcgattcgcg atgcagcagt gacggcgagt ccatagcgga 2641 cacgtccacc tcgtcgccgg acctgctggc gcccatgtcg ccgaagctct gcgacagcgg 2701 ctcggcgggg gcgtcgctgg gggcatcgct gcccctgccg ctggccctgc ccctgccaat 2761 ggccctgcca ctgcccatgt cgctgcccct gcccctcacg gcggcatctt cggcggtcac 2821 cgtttcgctg gcagcggtcg tggccgcggt ggccgagacg ggtggcgcgg gcgcgggagg 2881 agctgggaca gcagtaacag cgtcgggagc aggaccatgc gtctccacgt cgtctacgac 2941 ggcagcggca gccacatcct cgacctcctc gctctcgtcc tcctcctctt cgtcatcctc 3001 cacgtcctcc agcacttcct ccgcctcgcc gacagctgga gcctcctcca cggccacctg 3061 ccccgccagc agcagcagca gcagtggaaa cggaagtggg ggcaaaagtg gtagcatcaa 3121 gcaggagcac acggagatac actcgtcgag cagtgcgatt tcggcggccg ccgcctcaac 3181 ggtgatgtca ccgccgcccg ctgaggcgac gagatccagt ccagccacgc ccgagggagg 3241 cggaccagct ggcgacggaa gtggagcaac gggaggcgga aacacgagcg gcggatcaac 3301 ggctggagtg gccattaatg aacaccaaaa caatggcaat ggcagcggcg ggagcagtcg 3361 agcctctccc gattcgctgg aagagaagcc ctctaccaca acgaccacag gtcgtccaac 3421 gctcacgccc acgaatgggg tgctgtcctc cgcctcggcg ggcacgggga tttccacagg 3481 aagcagcgcc aagctgagcg aggctggtat gagtgtgata cggtccgtga aggaggagcg 3541 cttgctcaac gtatccagca agatgctggt gttccatcag cagcgggagc aagagaccaa 3601 agcagtggcg gctgcagcag cagcagcagc ggcgggccat gtgacggttc tagtgacgcc 3661 atcgcgcatc aaatcggagc caccgccgcc ggcttcaccc tcctctacat ccagcacaca 3721 aagggaaagg gaacgggaac gcgatcgaga gagggatcgc gaaagggaac gcgagcggga 3781 ccgggaccgg gaacgggaac gggaacagtc catcagctcc tcgcagcagc acctaagtcg 3841 ggtctccgcc agtccaccca ctcagctgtc ccacggcagc ctgggaccca acattgtgca 3901 gacgcaccat cttcaccagc aactcacaca gccgctgacg ctgcgcaaga gcagcccgcc 3961 cacagagcac ctgctcagtc agtccatgca acatctcaca cagcagcagg cgatccacct 4021 gcatcaccta cttggccagc agcagcagca gcagcaggcg tcgcatcccc agcagcaaca 4081 gcagcagcaa cactcgcccc actccctggt gcgggtgaaa aaggaaccga atgttggtca 4141 gcggcactta tcgccgcatc accaacaaca gtcgccactc ctgcagcacc accaacagca 4201 gcagcagcag caacaacaac agcaacagca tctgcatcag caacagcaac agcagcagca 4261 tcaccagcag cagccccagg cactggccct gatgcatccg gcttccctgg cgctaaggaa 4321 cagcaatcgg gatgcggcca ttctgtttcg ggtgaagagc gaagtgcacc agcaggtggc 4381 cgccgggctg ccgcatctga tgcagtccgc tggtggggca gcggccgccg ccgcagcagc 4441 tgtggccgct cagcgaatgg tatgcttcag caatgccagg atcaatggcg ttaagccgga 4501 ggtgattgga ggaccgctgg gcaacctgcg gcccgtgggc gtcggtggcg gaaacggaag 4561 tggctccgtg cagtgcccct cgccgcatcc atcctcctcg tcgtcatcct cgcagctgtc 4621 gccgcagacg ccctcccaga cgccgccccg aggcacgccc accgtcataa tgggcgagag 4681 ctgcggggtg cgcaccatgg tctggggcta cgagcctccg ccaccctcgg cgggccagtc 4741 ccacggccag cacccgcaac agcaacagca gtcgccccac caccagccgc aacaacaaca 4801 gcagcagcaa caacagcagt cgcagcagca acagcaacag cagcagcaac agtcgctggg 4861 ccagcagcag cactgcctct cctcgccgtc ggcgggatcg ctgacgccct cctcttcgtc 4921 cggcggtggt tcggtatctg gcggcggagt gggcggacca ctcacaccct cctcggtggc 4981 gccgcagaat aacgaggagg ccgcccaact cctgctctcc ctgggacaga cacgcatcca 5041 ggacatgaga tcacggccac accccttccg cacaccgcac gcccttaata tggagcggct 5101 gtgggcggga gactactcgc aattgccgcc cggccagctg caggctctga atctcagtgc 5161 ccaacagcag cagtggggca gcagcaactc cacgggtctt ggtggcgtag gcggcggcat 5221 gggcggacgc aacctggagg cgccgcacga gccgaccgac gaggacgaac agccgctcgt 5281 ttgcatgatc tgcgaggaca aggccaccgg cctgcactac ggcatcatca cctgcgaggg 5341 gtgcaagggc ttcttcaagc ggacggtgca gaaccgacga gtctacacct gcgtggcgga 5401 cggcacctgc gagataacca aagcacagcg caaccgttgt cagtattgtc gatttaagaa 5461 gtgcatcgag cagggcatgg tgctgcaagc cgttcgcgag gatcgcatgc cgggcggtcg 5521 caacagtggc gccgtctaca atttgtacaa ggtgaagtac aagaagcaca agaagaccaa 5581 tcagaagcag cagcagcagg ccgcccagca gcagcagcag caggcggcgg cgcagcagca 5641 gcaccagcaa cagcagcagc atcaacagca ccagcaacat cagcaacagc agttgcactc 5701 gccgctccac catcaccacc accagggcca ccagtcgcac cacgcgcagc agcagcacca 5761 cccacagctg tcgccgcacc acctgctgtc gccgcagcag cagcaacttg ccgccgcggt 5821 ggcagcagct gcgcagcacc aacagcaaca gcaacaacag cagcaacagc agcagcaggc 5881 caagctgatg ggcggcgtgg tggacatgaa gcccatgttc ctcggccccg ctttgaagcc 5941 ggagttgctg caagcacccc ccatgcacag tccggcccag caacaacaac agcagcagca 6001 gcagcagcag caacagcagg cctcgccgca tctctcgctt agctcaccgc accagcagca 6061 gcagcagcag cagggacagc accaaaacca ccaccagcaa caaggtgggg gtggcggagg 6121 agctggtgga ggagctcaac tgccgccgca cctggtgaac ggaacgatac tgaagacggc 6181 cctaaccaat cccagcgaga ttgtacatct gcgccaccgc ctcgactcgg cggtcagttc 6241 gtccaaggac cgacagatct cgtacgagca cgccttaggc atgatccaga cactgatcga 6301 ctgcgacgcg atggaggaca tagccacact gccgcacttc agcgagttcc ttgaggacaa 6361 gtcggagatt agcgagaaac tgtgcaacat cggcgattcc atagtccaca agctggtgtc 6421 gtggacaaaa aagttgccct tctacctgga gatcccggtg gagatacata ccaaactact 6481 gacggacaag tggcacgaga tccttatcct gaccacggcc gcctaccagg cgttgcatgg 6541 caagcggcgt ggcgagggag gaggcagcag gcatggttcg ccggcgtcaa cgccactgag 6601 cacgcccact ggtacgccgt tgagcacacc gataccctcg cccgcccagc cactgcacaa 6661 ggacgacccg gagtttgtca gcgaggtgaa ctcgcacctg agcacactgc aaacctgctt 6721 gaccacgcta atgggccagc cgatagcgat ggagcagctg aagctggacg tcgggcacat 6781 ggtggacaag atgacccaga tcaccatcat gttccggcga atcaagctca agatggagga 6841 gtacgtctgc ctgaaggttt acatactgct aaacaaagca gaagtggaac tggagagcat 6901 ccaggagcgg tacgtccagg tgctgcgctc ctacctgcaa aactcctcgc cgcagaatcc 6961 gcaggcgagg ctcagtgaac tgctctccca cataccagag atccaggctg cggctagcct 7021 gctgctcgag agcaagatgt tctatgtgcc cttcgtgctc aactcggcga gcataaggta 7081 gcagatgctt gagcacggac tgctgcccac cgccaaccat cagtcggcgc caccacctgg 7141 tcctgatacg atcccggagc ggcagcagca acagcaacag gagcggcgtc gaagcaggca 7201 gcagcagcac cagttgctgc gcaacctgcc caagatcaag atcgagatcg gttcccagcg 7261 cgatccggag gaagaggagt cggagcaaga gctagagcag gagccggagc aagagcagga 7321 tgtgcagtcc cgaccctcag ccgcatccac gtccattttg aagacttcac tgctgagcgg 7381 agcggcggcg acgttggcca ccttgacggc ggcagccgag caaatagccc gctcctcggc 7441 cagctgcgac actgccaggg attattccca aagcagcaac agcagcagca atagcaacgc 7501 tgccacagga gcaacaggaa ctatggccag cggcaggaca ggcagcagca acagtttaga 7561 agagagcaaa agacttgagc atcaacaaca acaacaacaa cagcagcaac aaccacaaca 7621 gcatcagcag caacaatata catcaatact acacacggcc ttaatgtcac agcgttccat 7681 gccaccagcg acatcagcta catcagcagc agcggcggtc acatcgacgc cgacaacggc 7741 agcaacaaca tcgcctacgc ctgcgcatgt gctgaaaaca gcggtgacct tagccagtct 7801 aagtgagata gccacagcac gtcagcagca gcaggagcag cagcagcaac agcagcagca 7861 gcagcagcag caacaattgc tggcgatgca acagcaacag caacagctaa cgaaactgcc 7921 cagaaggata atcaactttg gcagcaatca cactgccaac actgccacca aagcattggg 7981 agcgggatca gaagcaggag caggagcagg agtgggcatg gccacagcaa cggcaacagc 8041 aacagttgga cgcaatcgcc aactgggcct gagtcagggt caagtggtga atggtaagca 8101 gaaagaattg tgagccttgt gtttgcgata acgtttgtgt acccctcgtt aacgctgcca 8161 gtcaggacag cacgcctgct caatggcaac tgttgcggcc gattgcaggc gacagcagga 8221 acaggggcca gcaggggcac caacactgcc ggcagcaaca cggtcaacat gcagacccag 8281 accgacgatg agttgctgcc gctgttagcc atgctcccac aagacgctcc cacaacaaca 8341 ggagcagcag caggagcagc agtatcatta tcattattag ccacagccac agccacaacc 8401 acatcttcat catcatcatc atcatcatca ttatcatcat catcgacgat ttcattagca 8461 acacgtgcag cagcagtaat gcagcagcag caacaatgga ctgccgtgtc gacgacgcca 8521 gcaacaggag tgatgatgac gacgacgacg acacaatcac aatcacaagc aacattagca 8581 ccacaacaac agcaactatc actgccacaa caaaagcaac aatttaatac gagaataaac 8641 agaaaaacaa caattacaac agccaccaca acagcaccaa cagcaacaac agcaacaaca 8701 acaacaacac gaaacagcaa catcaacttc aacagcaaca ataactatat gaataacaat 8761 aatataaacg ccgccactgc cagagcctct gccttcgcct ccgcctctgc catggccacg 8821 gccacgccca caggcacacc cactgccacg ggcccgcgcc agagaccggc cccgcaaccg 8881 cccccgcccc cgcgcacgcc cacagccacc tcagcttctg ttactgtagt tgtgttcaaa 8941 acaatgttac ctgatgactg aattatttta gaatcgtaca catagagcat gttttattat 9001 gattaccact atgattacca cttacgattt acgattacga ttatgattac gattatgagt 9061 atgtctggat atcattacct attaactatt cattagttat ggattatcga ttattactat 9121 ttttactatt actattgcta catgcataat gtagagccta attgatctat cgtgtatttt 9181 agtttgtcta attgttggat ccctgtacta tatcccacac acatacacac actctcaccc 9241 atatttgatc ctcaccccca aacaatccat aagcacacac tcatacacac acacacacac 9301 acacacacat tgccgttact aaggaagggt atgcgcatat gcgaagttga aacattttaa 9361 tcatgtattt tttttttttg tgtttttgct gaacggagat gaaagttaag gaggtcgagc 9421 aacagcaatt agaagtgtta attgagtagg attatgagta cgtagcgagt atgtaacgag 9481 tatgtaatga ctaagtaaag tttacgtaga cacaatgcca cacacagcta tagcaagcat 9541 ttaggatgcg tgcatatgtc agttatctat tttttttttt taaactaaaa tctatataaa 9601 gtaacgagag aggaaggaag agcgaagcag ggcgggagat tcaaccacat aaagtataaa 9661 tagtagagct tgagccaagt agctagttta gtgtacatcc gttttggggc agggaagtag 9721 agcaatttgt tgacgagtcg gggtggtggg gtgagcggta acgaagatcg gtaacggaag 9781 tggagacaaa gcggaaccgg aaacgggagc tggactgcca gatcggaatc acacatcaac 9841 cattatgaga acttcgctcg caactcttgc agaattatac tgttagatcc tgttagttat 9901 ccaacccaaa actcccaacc cacacacact atacctaagt taagaacgca taatcacata 9961 ctacacataa attacgcata gtacatacaa aaaagatgaa gag